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Journal of Materials science & Technology 2013年第12期29卷 1116-1122页

作者： Z.A.Luo g.M.xie Z.Y.Ma g.L.Wang g.D.Wang state Key Laboratory of Rolling and Automation Northeastern University shenyang National Laboratory for Materials science Institute of Metal ResearchChinese Academy of Sciences

As-extruded ZK60 and ZK60-Y magnesium alloy plates were successfully processed via friction stir processing （FsP） at a tool rotation rate of 1600 r/rain and a traverse speed of 200 mm/min. FsP resulted in the formation of equiaxed recrystallized microstructures with the average grain sizes of ,-8.5 and -4.7 μm in the ZK60 and ZK60-Y alloys, respectively. Moreover, FsP broke and dispersed the MgZn2 and W-phase （Mg3Zn3Y2） particles and dissolved MgZn2 phase in the FsP ZK60 alloy. With the addition of rare earth element yttrium （Y） into the ZK60 alloy, the ratio of the high angle grain boundaries （HAgBs） in the FsP alloys increased from 64% to 90%, and a certain amount of twins appeared in the FsP ZK60-Y alloy. The maximum elongation of 1200% and optimum strain rate of 3 X 10-3 s-1 achieved at 450 °C in the FsP ZK60-Y alloy were substantially higher than those of the FsP ZK60 alloy. This is attributed to the fine grains with high ratio of HAgBs and the distribution of a large number of dispersed second phase particles with high thermal stability in the FsP ZK60-Y alloy. grain boundary sliding was identified as the primary deformation mechanism in the FsP ZK60 and ZK60-Y alloys from the superplastic data analyses and surficial morphology observations.

关键词： Magnesium alloy Friction stir processing Rare earth element Microstructure superplasticity

skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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science China Life sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu guanghui Jin Ze Li shujie Chen Xiaoshuang Dai Liujing Huang Zijing Fan guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia sun Jingxing Ou Hong Chen Liwei xie College of Life and Health sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University state Key Laboratory of Applied Microbiology southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research school of Public Health Xinxiang Medical University BgI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(sVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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植物激素对棉花蕾铃脱落的调控研究进展

作物学报 2025年第1期51卷 1-29页

作者：谢章书谢学方屠小菊刘爱玉董合忠周仲华湖南农业大学农学院/作物生理与分子生物学教育部重点实验室湖南长沙410128 中国热带农业科学院橡胶研究所海南海口571101 山东省农业科学院经济作物研究所山东济南250000

棉花蕾铃脱落是一个普遍存在的现象,有对逆境环境胁迫的主动适应性脱落,也有因品种遗传特性、环境条件、栽培措施以及生物和非生物胁迫被动的受损脱落。蕾铃脱落直接影响着棉花的产量,国内外现有公开报道多集中于20世纪50、60年代关于... 详细信息

棉花蕾铃脱落是一个普遍存在的现象,有对逆境环境胁迫的主动适应性脱落,也有因品种遗传特性、环境条件、栽培措施以及生物和非生物胁迫被动的受损脱落。蕾铃脱落直接影响着棉花的产量,国内外现有公开报道多集中于20世纪50、60年代关于乙烯和脱落酸对棉花蕾铃脱落影响的初步发现。结合其他植物的研究结果来看,蕾铃脱落似乎与生长素、赤霉素和细胞分裂素等促生长类激素的下降以及乙烯和脱落酸等抑制生长类激素的升高密切相关,激素在植物体内不仅介导新陈代谢过程,还协调着与信号通路相关的调控因子,在脱落过程中起着关键作用。本文从植物激素调控入手,综述了近年来包括脱落区形成和作用的分子调控机制以及各激素在棉花蕾铃脱落以及其他植物(生殖)器官脱落过程中的响应和调控机制等。发现目前以棉花蕾铃脱落为对象的研究非常匮乏,且多集中于少数激素对棉花生殖生长影响的有限研究,缺乏对导致蕾铃脱落的深层次机制的探究和解析。因此,未来研究方向应着重于探究棉花蕾铃脱落的遗传基础、发掘新的抗脱落基因资源和培育抗脱落棉花品种,同时加强在以棉花为模型植物下,蕾铃脱落与植物激素调节的关系研究,为提高棉花产量提供理论依据和技术支持。

关键词：棉花植物激素蕾铃脱落研究现状研究方向

Forging strength-ductility unity in a high entropy steel

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Journal of Materials science & Technology 2022年第18期113卷 158-165页

作者： s.J.Tsianikas Y.Chen J.Jeong s.Zhang Z.xie school of Mechanical Engineering The University of AdelaideSA 5005Australia Centre for Advanced Thin Film Materials and Devices Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Max-Planck-Institut für Eisenforschung Max-Planck-Straße 1Düsseldorf 40237Germany

Fe_(72.4)Co_(13.9)Cr_(10.4)Mn_(2.7)B_(0.34)high entropy steel was prepared by magnetron *** alloy exhibits a high yield strength of 2.92±0.36 gPa while achieving appreciable plasticity of 13.7±1.9%at the ultimate compressive strength(3.37±0.36 gPa).The distribution of iron and chromium shows an un-usual,characteristic spinodal-like pattern at the nanometer scale,where compositions of Fe and Cr show strong anticorrelation and vary by as much as 20 at.%.The high strength is largely attributable to the compositional modulations,combined with fine grains with body-centered cubic(BCC)crystal structure,as well as grain boundary segregation of interstitial *** impressive plasticity is accommodated by the formation and operation of multiplanar,multicharacter dislocation slips,mediated by coherent in-terfaces,and controlled by shear *** excellent strength-ductility combination is thus enabled by a range of distinctive strengthening mechanisms,rendering the new alloy a potential candidate for safety-critical,load-bearing structural applications.

关键词： Deformation mechanisms Micromechanical testing Compositional fluctuations Body-centered cubic High entropy steel

Biological systems:Reliable Functions out of Randomness

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Journal of systems science & Complexity 2021年第5期34卷 2036-2047页

作者： xie Liang-Liang University of Waterloo WaterlooOntarioCanada.Email:llxie@uwaterloo.ca.

What makes biological systems different from man-made systems?One distinction is explored in this paper:Biological systems achieve reliable functions through randomness,i.e.,by both mitigating and exploiting the effects of *** fundamental reason for biological systems to take such a random approach is the randomness of the microscopic world,which is dramatically different from the macroscopic world we are familiar *** substantiate the idea,bacterial chemotaxis is used as an example.

关键词： Bacterial chemotaxis biological systems feedback randomness reliable functions

On the electron-beam (EB) irradiation and grafting of acrylic monomers onto EVA copolymers

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Chinese science Bulletin 1997年第18期42卷 1549-1554页

作者： Zhang, s Wang, JQ xie, LQ Wen, CL BEIJINg INsT TECHNOL SCH CHEM ENGN & MAT SCISTATE KEY LAB FLAME RETARDANT MATBEIJING 100081PEOPLES R CHINA

IN an ordinary way the grafting induced by electron and gamma preirradiations widely used for improving the compatibility of polymers in composites gives rise to an enhancement of their mechanical properties. However, very few have been reported in the flame retardancy of polymers using these sorts of techniques. Wilkie investigated the flame retardancy of photo-initiation grafted polymers. An attempt is made in this paper to try to use the EB preirradiation on EVA copolymers with different VA contents and the subsequent grafting with saponification under atmosphere and to expedite the charring of polymers upon heating. Characterization of the flammability of the preirradiated EVA copolymers grafted with acrylic monomers indicates that this approach turns out to be a promising way and worthy of doing.

关键词： electron-beam irradiation grafting flame retardancy EVA copolymers.

Diffusion behavior of Cr in gradient nanolaminated surface layer on an interstitial-free steel

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Journal of Materials science & Technology 2019年第3期35卷 460-464页

作者： s.L.xie Z.B.Wang K.Lu shenyang National Laboratory for Materials science Institute of Metal Research Chinese Academy of Sciences school of Materials science and Engineering University of Science and Technology of China

Nanolaminated structures composed of low-angle grain boundaries(LAgBs) possess high thermal stability. In this paper, a gradient nanolaminated(gNL) surface layer with smooth finish was fabricated on an interstitial-free steel by means of surface mechanical rolling treatment. Microstructural observations demonstrated that the average lamellar thickness is about 80 nm in the topmost surface layer and increases with increasing depth. High thermal stability was confirmed in the gNL surface layer after annealing at 500℃. Diffusion measurements showed that effective diffusivity of Cr in gNL layer is 4–6 orders of magnitude higher than lattice diffusivity within the temperature range from 400 to 500℃. This might be attributed to numerous LAgBs or dislocation structures with a higher energy state in the gNL surface layer. This work demonstrates the possibility to advanced chromizing(or other surface alloying)processes of steels with formation of gNL surface layer, so that a thicker alloyed surface layer with a stable nanostructure is achieved.

关键词： gradient nanolaminated structure Interstitial-free steel Diffusion Low-angle grain boundary surface mechanical rolling treatment

加权共表达网络分析与机器学习识别类风湿关节炎滑膜中的关键基因

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中国组织工程研究 2025年第2期29卷 294-301页

作者：武英楷史高龙谢宗刚苏州大学附属第二医院江苏省苏州市215000 宁阳县第一人民医院山东省泰安市271000

背景:类风湿关节炎是一种全身的免疫相关性疾病,主要病理特点是关节滑膜炎性增生及关节软骨的破坏,其发病机制目前尚不明确,迫切需要发现新的具有高度敏感性和特异性的诊断标志物。目的:联合使用生物信息学技术及计算机学习算法,识别并... 详细信息

背景:类风湿关节炎是一种全身的免疫相关性疾病,主要病理特点是关节滑膜炎性增生及关节软骨的破坏,其发病机制目前尚不明确,迫切需要发现新的具有高度敏感性和特异性的诊断标志物。目的:联合使用生物信息学技术及计算机学习算法,识别并筛选类风湿关节炎患者滑膜中的关键基因,构建类风湿关节炎预测模型并进行验证。方法:从基因表达综合数据库中下载3个包含类风湿关节炎患者滑膜的数据集(gsE77298、gsE55235、gsE55457),gsE77298和gsE55235作为训练集,gsE55457作为测试集,共纳入66个样本,其中类风湿关节炎患者滑膜样本39个,正常滑膜样本27个。应用R语言筛选训练集中的差异基因,然后使用加权共表达网络将训练集中的基因模块化,选出关键模块中的特征基因,将差异表达基因和特征基因取交集,交集基因进入下一步机器学习。采用3种机器学习方法:最小绝对值收敛和选择算子算法、支持向量机-递归特征消除和随机森林算法对交集基因进一步分析获得枢纽基因,将枢纽基因再次相交即得到类风湿关节炎滑膜中的关键基因。以关键基因为变量构建预测类风湿关节炎的列线图模型,推测患者发生类风湿关节炎的危险程度,使用受试者工作特征曲线确定类风湿关节炎预测模型及其关键基因的诊断价值。结果与结论:①通过差异分析,训练集中共筛选出差异基因730个,加权共表达网络分析得到特征基因185个,两者交集基因159个;②最小绝对值收敛和选择算子发现枢纽基因4个,支持向量机-递归特征消除发现枢纽基因11个,随机森林发现枢纽基因5个,取交集后获得关键基因2个(TNs3、sDC1);③基于2个关键基因,在训练集及测试集种构建列线图,其校准预测曲线与标准曲线贴合较好,且预测类风湿关节炎发生的临床效能良好;④上述结果证实,基于生物信息及机器学习算法获得的TNs3和sDC1有可能成为类风湿关节炎诊断和治疗的关键靶点。

关键词：加权基因共表达网络机器学习算法类风湿关节炎关键基因预测模型

Composite recommendations： from items to packages

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Frontiers of Computer science 2012年第3期6卷 264-277页

作者： Min xie Laks V. s. LAKsHMANAN Peter T. WOOD Department of Computer science University of British Columbia Vancouver V6T 1Z4 Canada Department of Computer science and Information systems Birkbeck University of London London WCIE 7HX UK

Classical recommender systems provide users with a list of recommendations where each recommendation consists of a single item, e.g., a book or DVD. However, sev- eral applications can benefit from a system capable of recom- mending packages of items, in the form of sets. sample appli- cations include travel planning with a limited budget （price or time） and twitter users wanting to select worthwhile tweeters to follow, given that they can deal with only a bounded num- ber of tweets. In these contexts, there is a need for a system that can recommend the top-k packages for the user to choose from. Motivated by these applications, we consider composite recommendations, where each recommendation comprises a set of items. Each item has both a value （rating） and a cost associated with it, and the user specifies a maximum total cost （budget） for any recommended set of items. Our composite recommender system has access to one or more component recommender systems focusing on different do- mains, as well as to information sources which can provide the cost associated with each item. Because the problem of deciding whether there is a recommendation （package） whose cost is under a given budget and whose value exceeds some threshold is NP-complete, we devise several approximation algorithms for generating the top-k packages as recommen- dations. We analyze the efficiency as well as approximation quality of these algorithms. Finally, using two real and two synthetic datasets, we subject our algorithms to thorough ex- perimentation and empirical analysis. Our findings attest tothe efficiency and quality of our approximation algorithms for the top-k packages compared to exact algorithms.

关键词： recommendation algorithms optimization,top-k query processing

Experimental study on geometry Characteristics of Turbulent Premixed Flames for Natural gas/Air Mixtures

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Journal of Thermal science 2025年第1期 268-282页

作者： ZHENg Weilin WANg Qijiao XIAO Huahua CHEN Xiaoxiao xie Fan ZENg Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion system Shenyang Aerospace University state Key Laboratory of Fire science University of science and Technology of China AVIC shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

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