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Cyphellophora and its relatives in Phialophora: biodiversity and possible role in human infection

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Fungal Diversity 2014年第2期65卷 17-45页

作者： Peiying Feng Qiaoyun Lu M.J.Najafzadeh A.H.g.gerrits van den Ende Jiufeng sun Ruoyu Li Liyan Xi V.A.Vicente Wei Lai Chun Lu g.s.de Hoog Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity CentreP.O.Box 851673508 AD Utrechtthe Netherlands Xiangyang Central Hospital XiangyangChina Peking University Health science Center Research Center for Medical MycologyBeijingChina department of Parasitology and Mycology and Cancer Molecular Pathology Research CenterGhaem HospitalSchool of MedicineMashhad University of Medical SciencesMashhadIran Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamthe Netherlands Key Laboratory of Tropical Disease Control Department of ParasitologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina department of Basic Pathology Federal University of ParanáCuritibaPRBrazil

Cyphellophora is a genus of black yeast-like fungi characterised by having simple phialides with multiseptate,curved *** from ssU and LsU data,Cyphellophora was found to be located in a well-supported clade within the Chaetothyriales comprising a number of species occurring on human skin and *** is phylogenetically close to Phialophora europaea,*** and ***,though morphologically these species produce singlecelled phialoconidia rather than multiseptate *** suttonii and *** have dark colonies and phylogenetically fit in with Cyphellophora;the type species of Pseudomicrodochium,***,has similar,septate conidia but has a hyaline *** the present study,multilocus phylogenetic analyses were combined with morphology and *** of the internal transcribed spacer region,the DNA dependent RNA polymerase II largest subunit and the partial beta tubulin gene were analysed for a set of 30 *** novel species,Cyphellophora pauciseptata and Phialophora ambigua were *** eucalypti was reduced to synonymy of *** role of the studied fungi between colonization and infection of human skin was *** virulence factors for these black yeast-like fungi were hypothesized to be the ability to assimilate monoaromatic hydrocarbons,to produce melanin pigments,and to tolerate the temperature of epidermal human skin.

关键词： Black yeasts Chaetothyriales Cyphellophora Phialophora superficial infection Taxonomy

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNs),have attracted considerable attention in conditions where cortical spreading depolarizations(CsDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CsDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CsDs,particularly emphasizing TNs,and to underscore TNs’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： debra s.MacDonald Jay Penney department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.sangeetha department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-KDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Families： Influences in Children＇s development and Behaviour, From Parents and Teachers＇ Point of View

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Psychology Research 2012年第12期2卷 693-705页

作者： Claudia Rodrigues sequeira de figueiredo Filomena Valadao Dias Instituto Universitario de Psicologia Aplicada (IU) Research Unit in Psychology and Health (UIPEs) Lisboa Portugal

Mayaro fever:A brief review on the immune profile

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 95-100页

作者： Jean Moisés Ferreira Danielly santos Campos-Ferreira Elaine Virgínia Martins de sousa figueiredo Jose Luizde Lima Filho Laboratório de Imunopatologia Keizo Asami-LIKA Centro de BiociênciasUniversidade Federal de Pernambuco(UFPE)50670-901RecifePernambucoBrazil Laboratório de Biologia Molecular e Expressao genica-LABMEg Departamento de Ciências BiológicasUniversidade Federal de Alagoas(UFAL)Campus Arapiraca57300-970ArapiracaAlagoasBrazil

Mayaro virus is an emergent alphavirus that infects humans,leading to Mayaro *** fifty percent of infected patients develop arthritis symptoms in the recovery phase,a phase that can last up to a *** literature about Mayaro virus infection and its immune response is scarce,which may hamper the development of treatment *** summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients,and relate this molecular characterization with the immune *** and IL-12/p70 show pronounced changes in patients in the acute phase,suggesting the development of cellular immunity and Th1 ***-6,IL-7,CXCL8/IL-8,IL-13,IL-17,and IFN-γare elevated in patients with arthritis symptoms in the long-term recovery phase,which may be related to the continuous inflammatory process,a possible Th2 inhibiting and promoting Th17 *** few studies discuss the issue,with a small number of patients and different backgrounds,inflammatory and immune response and manifestations seem to be closely *** information may help to develop the appropriate treatment strategies in Mayaro virus ***,we analyzed and summarized data available in literature.

关键词： Emergent virus Mayaro virus Cytokines Chemokine Molecular characterization

Induced pluripotent stem cells throughout the animal kingdom:Availability and applications

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World Journal of stem Cells 2019年第8期11卷 491-505页

作者： Lais Vicari de figueiredo Pessoa Fabiana Fernandes Bressan Kristine Karla Freude group of stem Cell Models for studies of Neurodegenerative Diseases Section for Pathobiological Sciences Department of Veterinary and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen Frederiksberg 1870 Denmark department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of Sao Paulo Pirassununga 13635-000 Sao Paulo Brazil

Up until the mid 2000s, the capacity to generate every cell of an organism was exclusive to embryonic stem cells. In 2006, researchers Takahashi and Yamanaka developed an alternative method of generating embryonic-like stem cells from adult cells, which they coined induced pluripotent stem cells (iPsCs). such iPsCs possess most of the advantages of embryonic stem cells without the ethical stigma associated with derivation of the latter. The possibility of generating “custom-made” pluripotent cells, ideal for patient-specific disease models, alongside their possible applications in regenerative medicine and reproduction, has drawn a lot of attention to the field with numbers of iPsC studies published growing exponentially. IPsCs have now been generated for a wide variety of species, including but not limited to, mouse, human, primate, wild felines, bovines, equines, birds and rodents, some of which still lack well-established embryonic stem cell lines. The paucity of robust characterization of some of these iPsC lines as well as the residual expression of transgenes involved in the reprogramming process still hampers the use of such cells in species preservation or medical research, underscoring the requirement for further investigations. Here, we provide an extensive overview of iPsC generated from a broad range of animal species including their potential applications and limitations.

关键词： Pluripotency Embryonic stem cell Reprogramming Animal Wild Induced pluripotency

Partition coefficient prediction of Baker's yeast invertase in aqueous two phase systems using hybrid group method data handling neural network

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Chinese Journal of Chemical Engineering 2017年第5期25卷 652-657页

作者： Carlos Eduardo de Araújo Padilha sérgio Dantas de Oliveira Júnior Domingos Fabiano de santana souza Jackson Araújo de Oliveira gorete Ribeiro de Macedo Everaldo silvino dos santos Laboratory of Biochemical Engineering Chemical Engineering DepartmentFederal University of Rio Grande do Norte (UFRN)

A hybrid gMDH neural network model has been developed in order to predict the partition coefficients of invertase from Baker's yeast. ATPs experiments were carried out changing the molar average mass of PEg(1500–6000 Da), p H(4.0–7.0), percentage of PEg(10.0–20.0 w/w), percentage of MgsO_4(8.0–16.0 w/w), percentage of the cell homogenate(10.0–20.0 w/w) and the percentage of MnsO_4(0–5.0 w/w) added as cosolute. The network evaluation was carried out comparing the partition coefficients obtained from the hybrid gMDH neural network with the experimental data using different statistical metrics. The hybrid gMDH neural network model showed better fitting(AARD = 32.752%) as well as good generalization capacity of the partition coefficients of the ATPs than the original gMDH network approach and a BPANN model. Therefore hybrid gMDH neural network model appears as a powerful tool for predicting partition coefficients during downstream processing of biomolecules.

关键词： Partitioning Invertase Aqueous Two Phase system gMDH Neural network