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Ecology and phylogeny of black yeast-like fungi: diversity in unexplored habitats

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Fungal Diversity 2014年第2期65卷 1-2页

作者： g.s.de Hoog Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity CentreP.O.Box 851673508 AD UtrechtThe Netherlands

The known biodiversity of black yeasts and their allies has exploded over the last *** even applies to medically significant genera such as Exophiala and Cladophialophora,where the number of accepted species has grown since the 1990s of the previous century from 9 to 44 and from 5 to 34,respectively.A first source of change no doubt is dissection of many supposed ubiquitous generalists into series of narrowly circumscribed molecular siblings,which often appear to be specialists with ecological preferences differing significantly between *** early example of subdivision of classical species in black yeasts,using DNA homology techniques,concerned Exophiala *** of its siblings today is known to be a biofilm former in drinking water networks,while *** sensu stricto is thus far only known from subcutaneous infections in humans.

关键词： habitat phylogeny black

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

global ITs diversity in the sporothrix schenckii complex

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Fungal Diversity 2014年第3期66卷 153-165页

作者： Xun Zhou Anderson M.Rodrigues Peiying Feng g.s.de Hoog department of dermatology Affiliated Hospital of Chongqing Medical UniversityChongqingChina Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity Centre PO Box 851673508 AD UtrechtThe Netherlands department of Microbiology Immunology and Parasitology-DMIPCellular Biology DivisionFederal University of São Paulo-UNIFESPSão PauloBrazil Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina sun Yat-sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Peking University Health science Center Research Center for Medical MycologyBeijingChina

Molecular phylogeny has revealed that sporotrichosis is caused by several sporothrix species which differ in clinical *** complex is embedded within Ophiostoma,a genus mainly comprising fungi that live in association with bark beetles,but differs by a high virulence towards humans and other *** different ecology is corroborated by phylogenetic *** aim of the present study was to determine the validity of the rDNA internal transcribed spacer(ITs)region as a marker for diagnostics of species in the clinical group,using betatubulin sequences to calibrate species *** topology of the two gene trees was concordant,and all clinically relevant sporothrix species could easily be recognized by means of the ITs *** increased geographic sampling did not affected delimitation success in the clinical clade of the *** complex.

关键词： sporothrix schenckii sporotrichosis Taxonomy Phylogeny ITs Barcoding

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

A multigene phylogeny reveals that Ochroconis belongs to the family sympoventuriaceae (Venturiales,Dothideomycetes)

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Fungal Diversity 2014年第2期65卷 77-88页

作者： M.Machouart K.samerpitak g.s.de Hoog C.gueidan service de Parasitologie-Mycologie CHU de NancyHôpital Brabois11 allée du Morvan54511 Vandoeuvre-les-NancyFrance CBs-KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD UtrechtThe Netherlands department of Microbiology Faculty of MedicineKhon Kaen University123 Mittraparp HighwayMuang DistrictKhon Kaen 40002Thailand department of Life sciences Division of Genomic&Microbial DiversityThe Natural History MuseumCromwell roadLondon SW75BDUnited Kingdom

Ochroconis is a genus of ascomycete fungi that includes oligotrophic saprobes and some opportunistic species causing infections in *** most important of these opportunists is the neurotropic species Ochroconis gallopava,which occurs in birds and occasionally in immunocompromised *** Ochroconis species have been isolated from superficial infections of cats,dogs and *** their natural environment,these species are found in litter,soil,and on moist *** thermophilic species have been isolated from hot springs,industrial effluents,and self-heated plant *** their ecology and epidemiology has been investigated,their classification within the ascomycetes is still ***,the phylogenetic placement of Ochroconis is investigated using a four-gene phylogeny(nuLsU,nussU,mtssU and RPB2).The results show that Ochroconis and its recently described sister genus Verruconis belong to the order Venturiales(Dothideomycetes)and are nested within the sympoventuriaceae,a family recently erected for a group of plant-saprobes or-pathogens sister to the *** form a well-supported monophyletic group together with five species of the anamorphic genus Fusicladium isolated from leaf and needle litters.

关键词： Dactylaria Fusicladium Classification Molecular phylogenetics Opportunistic vertebrate pathogens

Diversity and delimitation of Rhizopus microsporus

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Fungal Diversity 2014年第1期64卷 145-163页

作者： somayeh Dolatabadi grit Walther A.H.g.gerrits van den Ende g.s.de Hoog CBs-KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Institute of Microbiology Department of Microbiology and Molecular BiologyUniversity of JenaJenaGermany Leibniz-Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute Jena Microbial Resource CollectionJenaGermany Research Center for Medical Mycology Peking University Health Science CenterBeijingChina sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina shanghai Institute of Medical Mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina

Rhizopus microsporus has been used for centuries in the production of oriental fermented foods,but the species is also known as a toxin producer and from severe human *** study the diversity and species delimitation of Rhizopus microsporus,48 isolates from the reference collection of the CBs-KNAW Fungal Biodiversity Centre,comprising nine environmental,ten clinical,and 23 foodborne strains,in addition to six strains from unknown sources and representing all existing varieties of the species,were *** diversity was based on the internal transcribed spacer(ITs),and on a part of the actin(ACT)and translation elongation factor 1-α(TEF)*** in physiological properties were assessed including temperature *** morphology was studied,mating type tests were performed,and MALDI-ToF profiles were *** and food-associated strains as well as members of different varieties mated successfully and consequently they belong to a single biological *** differences did not match with any other parameter *** on these results the varieties of Rhizopus microsporus are reduced to synonyms.

关键词： Rhizopus microsporus Phylogeny Taxonomy Physiology MALDI-ToF Mating type Foodborne fungi Medical mycology sporulation

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Extremotolerant rock inhabiting black fungi from Italian monumental sites

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Fungal Diversity 2016年第1期76卷 75-96页

作者： D.Isola L.Zucconi s.Onofri g.Caneva g.s.de Hoog L.selbmann deB Universitàdegli Studi della TusciaLargo dell’UniversitàViterboItaly department of sciences UniversitàRoma TreViale Marconi 44600146 RomeItaly CBs-KNAW Fungal Biodiversity Centre Uppsalalaan 83584 CT UtrechtThe Netherlands

A wide sampling for isolating highly destructive and extremotolerant black fungi was performed from Italian monuments in selected historical sites which include the "Cortile della Pigna",Vatican Museum and the st Peter colonnade(Vatican City state),the monumental cemetery of Bonaria(Cagliari),and other monuments in the city of *** out of seventy-four strains isolated were identified basing on ITs Blastn *** on multilocus phylogeny and morphological data,one new genus and species Lithophila guttulata,five new species Knufia marmoricola,***,***,*** and Exophiala bonariae,order Chaetothyriales and one new genus and species,saxophila tyrrhenica,and two new species Vermiconia calcicola and devriesia sardiniae,order Capnodiales,were *** considerations are put forward.

关键词： Extremotolerance Monuments Microcolonial fungi Multilocus phylogeny