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The Impact of a Prior norwood Procedure on Cardiac Transplantation in Failed Fontan Physiology

Congenital Heart Disease 2024年第3期19卷 257-266页

作者： Ryan g.McQueen nikki M.Singh Ronald K.Woods Medical College of Wisconsin Herma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiology Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiothoracic Surgery Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA

Objective:The objective of this study was to compare cardiac transplant operative and postoperative courses of patients with failed Fontan physiology who were initially palliated with a norwood(ffn)to those without a prior norwood(ff).Methods:A single-institution retrospective review of all patients with Fontan failure who under-went cardiac transplantation from 2003–2021 was completed-22 underwent prior norwood(ffn)and 11 did not(ff).Descriptive and inferential statistics were calculated for operative course and patient ***:The operative course of the ffn cohort appeared to be more complex(not statistically significant,but clinically relevant)-this group exclusively experienced sternal re-entry events(3 of 22 patients)and concomitant neo-aor-tic reconstruction(6 patients),had a longer duration of surgery(median of 682 min vs.575.5 min),more time on circulatory arrest(median of 25.5 min vs.12.5 min),and more frequent use of open sternal management[50%of patients(11/22)vs.27.3%of patients(3/11)].Postoperatively,these patients underwent more mediastinal explora-tions[other than sternal closure;40.9%of patients(9/22)vs.18.2%of patients(2/11)],spent more time on mechanical ventilation(median of 5 days vs.2 days),had a longer length of stay(median of 30 days vs.19 days),and required more catheter-based re-interventions[22.7%of patients(5/22)vs.9.1%of patients(1/11)].Conclu-sion:Although underpowered,our results suggest that the operative course of ffn patients is more challenging,based mostly on neo-aortic arch *** turn,this likely leads to a more complex postoperative *** are currently collaborating with other institutions to increase the cohort size and power of the study.

关键词： Fontan Fontan failure norwood cardiac transplantation

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On the development of optical peripheral nerve interfaces

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neural Regeneration Research 2019年第3期14卷 425-436页

作者： Hans E.Anderson Richard F.ff.Weir Department of bioengineering University of Colorado Denver|Anschutz Medical Campus

Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected individuals with means to interact in the world. These techniques are both dependent on a robust interface with the peripheral nerve. Current methods for interfacing with the peripheral nerve tend to suffer from low specificity, high latency and insufficient robustness for a chronic implant. An optical peripheral nerve interface may solve some of these problems by decreasing invasiveness and providing single axon specificity. In order to implement such an interface three elements are required:(1) a transducer capable of translating light into a neural stimulus or translating neural activity into changes in fluorescence,(2) a means for delivering said transducer and(3) a microscope for providing the stimulus light and detecting the fluorescence change. There are continued improvements in both genetically encoded calcium and voltage indicators as well as new optogenetic actuators for stimulation. Similarly, improvements in specificity of viral vectors continue to improve expression in the axons of the peripheral nerve. Our work has recently shown that it is possible to virally transduce axons of the peripheral nerve for recording from small fibers. The improvements of these components make an optical peripheral nerve interface a rapidly approaching alternative to current methods.

关键词： peripheral nerve interfaces optogenetics optical neural interface optical peripheral nerve interface gCaMP ArcLight adenoassociated viral vector lentiviral vectors viral vectors implantable microscopy

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The future of adenoassociated viral vectors for optogenetic peripheral nerve interfaces

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neural Regeneration Research 2021年第7期16卷 1446-1447页

作者： Hans EAnderson Richard F.ff.Weir Department of bioengineering University of Colorado–Anschutz Medical CampusAuroraColoradoUSA

Prostheses have a several thousand year history for treating limb *** time, these prostheses have become more sophisticated and closer to replicating the natural *** advances have culminated in the myoelectrically con... 详细信息

关键词： closer advances thousand

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Knowledge of aflatoxin contamination in groundnut and the risk of its ingestion among health workers in Ibadan,nigeria

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Asian Pacific Journal of Tropical biomedicine 2011年第6期1卷 493-495页

作者： Ilesanmi ff Ilesanmi OS nigerian Stored Products Research Institute Department of Community Medicine University College Hospital

Objective:To assess the awareness and knowledge of aflatoxin contamination in groundnut and the risk of its ingestion among health workers in ***:The study was a descriptive cross-sectional *** instrument was a semi-structured self administered questionnaire. The respondents were health workers from a public health ***:A total of 417 health workers participated out of which males were 60.2%.The mean age of respondents was(28.0±4.9) years *** made up 83.0%while others were nurses.95%of the respondents had previous awareness of aflatoxin and class room lectures was the most common source of information(56%).Occupation and religion both showed a significant association with previous awareness of aflatoxin(Pnowledge regarding aflatoxin contamination in groundnut and the risk of its ingestion was obtained showing knowledge score range of 0 to *** all,80.6%had good scores of 11 to *** of the respondents had ever told their patients about the risk of aflatoxin ingestion. Conclusions:There is a need to explore the possibility of incorporating aflatoxin awareness into routine health talk to increase the level of awareness of patients and their relatives.

关键词： Mycotoxins groundnut Contamination Health risks Ingestion neoplasm Aflatoxin

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Relationship between interleukin-1 type I and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors

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Cellular & Molecular Immunology 2015年第2期12卷 222-230页

作者： ff Vasilyev An Silkov SV Sennikov Laboratory of Molecular Immunology Federal State Budgetary Institution 'Research Institute of Clinical Immunology' Russian Academy of Medical Sciences Siberian Branch. Novosibirsk. Russia

The biological activity of the multifunctional cytokine interleukin-1 （IL-1） is mediated by its receptors. The aim of this study was to determine if an association exists between single nucleotide polymorphisms （SnPs） in the IL-1 type I and 2 receptor genes （ILIR1 and ILIR2） and the expression level of membrane-bound ILIRs on subpopulations of mononuclear cells or serum levels of soluble IL-1 receptors. It was observed that healthy individuals with the genotype TT in SnP rs2234650.C〉T had a lower percentage of intact CD14＋ monocytes expressing ILIR1 on their surface. The SnP rs4141134-T〉C in ILIR2 has also been associated with the percentage of intact CD3＋ T cells expressing ILIR2. Furthermore, individuals carrying the CC allele of SnP rs4141134.T〉C and the TT allele of SnP rs2071008-T〉g in ILIR2 had a lower density of ILIR2s on the surface of CD14＋ monocytes in lipopolysaccharide （LPS）-stimulated PbMC cultures. In summary, this study demonstrated that IL-1 receptor gene polymorphisms could be one of the factors influencing the expression of membrane-bound IL-1 receptors （ILIR） on immunocompetent cells.

关键词： interleukin-1 membrane-bound receptor SnPs soluble receptor

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Long-term outcomes of urethral balloon dilation for anterior urethral stricture: A prospective cohort study

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Asian Journal of Urology 2024年第3期11卷 480-485页

作者： Ahmed M.Abdel gawad Abhijit Patil Abhishek Singh Arvind P.ganpule Ravindra b.Sabnis Mahesh R.Desai Department of Urology Muljibhai Patel Urological HospitalNadiadIndia Department of Urology Faculty of MedicineAl-Azhar UniversityDamiettaEgypt

Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(bD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to ***:This study included men who had urethral bD for significant anterior urethral stricture disease between January 2017 and March *** about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative ***,information about the self-calibration procedure was collected and where available,free flow(ff)measurements during the follow-up period were recorded and *** was defined as a lack of symptoms and acceptable ff rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 *** mean follow-up period was 37 *** long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our *** time to recurrence ranged from 91 days to 1635 days,with a mean of 670 *** stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(pbration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after bD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(pbut also improved the overall stricture-free survival and ff parameters.

关键词： balloon dilation Internal urethrotomy Recurrence Self-calibration Urethral stricture

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人白细胞髓过氧化物酶代谢活化致癌物4－氨基联苯

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中国药理学与毒理学杂志 1994年第3期8卷 221-226页

作者：林东昕 Kadl.,ff 福建医学院卫生系

本文研究人白细胞髓过氧化物酶（ＭＰＯ）体外代谢芳胺类致癌物４－氨基联苯（４－ＡＢＰ〕在Ｈ２Ｏ２存在下，ＭＰＯ代谢活化４－ＡＢＰ生成二种可与ＤＮＡ共价结合的代谢产物。高效液相色谱和质谱分析表明。在没有ＤＮＡ存在时４－Ａ... 详细信息

本文研究人白细胞髓过氧化物酶（ＭＰＯ）体外代谢芳胺类致癌物４－氨基联苯（４－ＡＢＰ〕在Ｈ２Ｏ２存在下，ＭＰＯ代谢活化４－ＡＢＰ生成二种可与ＤＮＡ共价结合的代谢产物。高效液相色谱和质谱分析表明。在没有ＤＮＡ存在时４－ＡＢＰ的主要代谢产物是偶氮二联苯。抗坏血酸和谷胱甘肽显著抑制活化的４－ＡＢＰ与ＤＮＡ结合。而且可将活化产物还原成４－ＡＢＰ．这些结果结合质谱资料提示活性中间产物可能是４－ＡＢＰ自由基。３２Ｐ－后标记实验证实ＤＮＡ加合物形成，用此种方法检测出８个４－ＡＢＰ－ＤＮＡ加合物。并表明ＭＰＯ介导产生的４－ＡＢＰ－ＤＮＡ加合物与细胞色素Ｐ４５０代谢产物Ｎ－羟基－４－ＡＢＰ和ＤＮＡ反应产生的加合物性质不同．这些结果提示。ＭＰＯ代谢活化途径可能在４－ＡＢＰ诱发肝外组织肿瘤过程中起一定的作用．

关键词：致癌物氨基联苯髓过氧化物酶

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Impacts of Anthropogenic Forcings and El nio on Chinese Extreme Temperatures

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Advances in Atmospheric Sciences 2018年第8期35卷 98-106页

作者： n. FREYCHET S. SPARROW S. F. b. TETT M. J. MInETER g. C. HEgERL D. C. H. WALLOM School of geosciences University of Edinburgh Crew Building The King's Buildings Edinburgh EH9 3FF UK Oxford e-Research Centre University of Oxford Oxford OX1 2JD United Kingdom

This study investigates the potential influences of anthropogenic forcings and natural variability on the risk of summer extreme temperatures over China. We use three multi-thousand-member ensemble simulations with different forcings （with or without anthropogenic greenhouse gases and aerosol emissions） to evaluate the human impact, and with sea surface temperature patterns from three different years around the E1 nino-Southern Oscillation （EnSO） 2015/16 event （years 2014, 2015 and 2016） to evaluate the impact of natural variability. A generalized extreme value （gEV） distribution is used to fit the ensemble results. based on these model results, we find that, during the peak of EnSO （2015）, daytime extreme tem- peratures axe smaller over the central China region compared to a normal year （2014）. During 2016, the risk of nighttime extreme temperatures is largely increased over the eastern coastal region. both anomalies are of the same magnitude as the anthropogenic influence. Thus, EnSO can amplify or counterbalance （at a regional and annual scale） anthropogenic effects on extreme summer temperatures over China. Changes are mainly due to changes in the gEV location parameter. Thus, anomalies are due to a shift in the distributions and not to a change in temperature variability.

关键词： extreme temperatures EnSO anthropogenic impact climate risk

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Spectral Response and Photoelectrochemical Properties of Cd1-xZnxSe Films

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Chinese Physics Letters 2010年第5期27卷 200-203页

作者： n. J. Suthan Kissinger g. ghana Kumar K. Perumal J. Suthagar Department of Physics Loyola Institute of Technology and Sciences Loyola Nager Thovalai India Specialized graduate School of Hydrogen and Fuel Cell Engineering Chonbuk National University Jeonju 561-756 Republic of Korea Department of Physics SRMV College of Arts and Science Coimbatore India Department of Physics Karunya University Coimbatore India

Cd1-xZnxSe films with different zinc contents are deposited by an electron beam evaporation technique onto glass substrates for applications in solid-state photovoltalc devices. The structural, optical and photoelectrochemical （PEC） properties of Cd1-xZnxSe films are studied. The host material Cd1-xZnxSe is prepared by the physical vapor deposition method of electron beam evaporation technique （PVD： EbE） under a pressure of 1 × 10^-5 mbar. The x-ray diffractogram indicates that these alloy films are polycrystalline in nature, hexagonal structure with strong preferential orientation of the crystallites along （002） direction. The optical properties shows that the band gap Eg varies from 2.08 to 2.84eV as zinc content varies from 0.2 to 0.8. A PEC cell of the configuration n-Cd1-xZnxSe/na2S-S-naOH is fabricated and the dynamic current-voltage characteristics in the dark atmosphere have been examined at room temperature. It has been found that both Voc and Iac decrease with the photoelectrode composition x. Efficiency η and fill factor （ff） also show similar variations. The material properties would be altered and excellently controlled by controlling the system composition x.

关键词： SPECTRAL sensitivity PHOTOELECTROCHEMISTRY ZInC selenide THIn films -- Optical properties EVAPORATIOn (Chemistry) SOLID state electronics PHOTOVOLTAIC cells MOLECULAR structure PHYSICAL vapor deposition

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梦想与现实的连线——nVIDIA geForceFX

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大众软件 2002年第24期 57-63页

作者： ff

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