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Heterogeneity of mature oligodendrocytes in the central nervous system

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.groh Moein Yaqubi Qiao-ling Cui Jo Anne Stratton g.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Cu and Zn Isotopic Evidence for the Magnitude of Organic Burial in the Mesoproterozoic Ocean

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Journal of Earth Science 2022年第1期33卷 92-99页

作者： Yiwen lü Sheng-ao liu State Key laboratory of geological Processes and Mineral resources and Institute of Earth SciencesChina University of GeosciencesBeijing 100083China

The rate of net primary production in the Proterozoic ocean was suggested to be no more than 10% of its modern value(laakso and Schrag,2019),however,in the Mesoproterozoic Xiamaling Formation,the export production values could reach 20%-150% of the present-day Equatorial Atlantic average values(Zhang et al.,2016).Here,we report Zn and Cu isotope data for black shales from the Xiamaling Formation to illustrate the biogeochemical cycling of Zn and Cu in the Mesoproterozoic *** ^(65)Cu-enriched signature in the authigenic fraction is similar to that in bioauthigenic Cu of the modern marine *** Zn isotope ratios of sediments deposited in euxinic conditions are commonly higher than those of clastic sediments,indicating light Zn sinks in the coeval *** with previously reported Mo isotope data,the proportion of organic carbon to total carbon burial in the Mesoproterozoic was about as half as that at present,which is larger than the previous estimation―a quarter of today’s value(e.g.,Ozaki et al.,2019) and is evidenced by a wide distribution of black *** organic burial may be ascribed to the increasing phosphorus inputs from large igneous provinces and consequently high primary productivity,which has spurred the hypothesized atmosphere-ocean oxygenation at ~1.4 ga.

关键词： zinc isotopes organic carbon Xiamaling Formation

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INVESTIgATION ON HOT DUCTIlITY AND STrENgTH OF CONTINUOUS CASTINg SlAB FOr AH32 STEEl

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Acta Metallurgica Sinica(English letters) 2006年第1期19卷 75-78页

作者： g. Y. li X.F. li l.g. ao Technology Center Anshan Iron and Steel Group CorporationAnshan 114009 China

By means of gleeble-1500 testing machine, the simulation of continuous casting process forAH32 steel was carried out and hot ductility and strength were determined. The cracking sensitivity was studied under the different temperatures and strain rates. The Precipitations of AIN at different temperatures and the fractures of high-temperature tensile samples were observed by using TEM （transmission electron microscope） and SEM （scanning electron microscope）. The factors affecting the brittle temperature zone were discussed.

关键词： continuous casting slab brittle temperature zone tensile strength,ductility simulation

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An SPH Framework for Earthquake-Induced liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

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getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele l Barbeau Charys M Martin Division of general Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural regeneration research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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脂质转移蛋白SilTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SilTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SilTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SilTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SilTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SilTP1 盐胁迫谷子耐盐响应

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Development of the Convective Boundary layer Capping with a Thick Neutral layer in Badanjilin:Observations and Simulations

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Advances in Atmospheric Sciences 2012年第1期29卷 177-192页

作者： HAN Bo lÜShihua ao Yinhuan Cold and Arid regions Environmental and Engineering research Institute Chinese Academy of SciencesNo.320Donggang West RoadLanzhou 730000

In this study, the development of a convective boundary layer （CBl） in the Badaujilin region was investigated by comparing the observation data of two cases. A deep neutral layer capped a CBl that occurred on 30 August 2009. This case was divided into five sublayers from the surface to higher atmospheric elevations： surface layer, mixed layer, inversion layer, neutral layer, and sub-inversion layer. The development process of the CBl was divided into three stages： S1, S2, and S3. This case was quite different from the development of the three-layer CBl observed on 31 August 2009 because the mixed layer of the five-layer CBl （CBl5） eroded the neutral layer during S2. The specific initial structure of the CBl5 was correlated to the synoptic background of atmosphere during nighttime. The three-stage development process of the CBl5 was confirmed by six simulations using National Center for Atmospheric research （USA） large-eddy simulation （NCAr-lES）, and some of its characteristics are presented in detail.

关键词： convective boundary layer neutral layer large-scale circulation large-eddy simulation

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Extractive distillation: Advances in conceptual design, solvent selection,and separation strategies

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Chinese Journal of Chemical Engineering 2019年第6期27卷 1247-1256页

作者： Shirui Sun liping lü ao Yang Shun'an Wei Weifeng Shen School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China School of Chemistry and Chemical Engineering Yangtze Normal UniversityChongqingFuling 408100China Collaborative Innovation Center for green Development in Wuling Moutain Area Yangtze Normal UniversityChina

Extractive distillation(ED) is one of the most promising approaches for the separation of the azeotropic or closeboiling mixtures in the chemical industry. The purpose of this paper is to provide a broad overview of the recent development of key aspects in the ED process involving conceptual design, solvent selection, and separation strategies. To obtain the minimum entrainer feed flow rate and reflux ratio for the ED process, the conceptual design of azeotropic mixture separation based on a topological analysis via thermodynamic feasibility insights involving residue curve maps, univolatility lines, and unidistribution curves is presented. The method is applicable to arbitrary multicomponent mixtures and allows direct screening of design alternatives. The determination of a suitable solvent is one of the key steps to ensure an effective and economical ED process. Candidate entrainers can be obtained from heuristics or literature studies while computer aided molecular design(CAMD) has superiority in efficiency and reliability. To achieve optimized extractive distillation systems, a brief review of evaluation method for both entrainer design and selection through CAMD is presented. Extractive distillation can be operated either in continuous extractive distillation(CED) or batch extractive distillation(BED), and both modes have been well-studied depending on the advantages in flexibility and low capital costs. To improve the energy efficiency, several configurations and technological alternatives can be used for both CED and BED depending on strategies and main azeotropic feeds. The challenge and chance of the further ED development involving screening the best potential solvents and exploring the energy-intensive separation strategies are discussed aiming at promoting the industrial application of this environmentally friendly separation technique.

关键词： Extractive distillation Separation strategies Solvent selection Conceptual design

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Machine learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine learning(Ml)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected Ml techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** Ml-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and gaussian Process regression(gPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the gPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied Ml techniques provide such precise results of the solved regression analysis.

关键词： Machine learning gaussian process regression artificial neural networks support vector machine hot deformation behavior

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