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Accumulation of Polyphenolic Compounds and Osmolytes under Dehydration Stress and Their Implication in redox regulation in Four Indigenous Aromatic rice Cultivars

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rice science 2020年第4期27卷 329-344页

作者： Nivedita dey Soumen BHATTACHArJEE Plant Physiology and Biochemistry research Laboratory/University grants Commission Centre for Advanced Study Department of BotanyUniversity of BurdwanBurdwan 713104West BengalIndia

Present work was undertaken to screen some drought tolerant indigenous aromatic rice cultivars(IArCs),commonly cultivated in West Bengal,India,based on their capacity to produce osmolytes,redox-sensitive phenolic acids and flavonoids,as contrivances for redox-regulation under drought *** glycol induced post imbibitional dehydration stress mediated changes in redox regulatory properties of the germinating seeds of the four IArCs(Jamainadu,Tulaipanji,Sitabhog,Badshabhog),which were assessed in terms of changes in prooxidant accumulation(in-situ localization of reactive oxygen species(rOS)by confocal microscopy,DCFDA(2′,7′-dichlorofluorescin diacetate)oxidation,O2-and H2O2 accumulation),cumulative antioxidative defense(radical scavenging property and total thiol content),rOS scavenging phenolic acids(gallic acid,protocatechuic acid,gentisic acid,para-hydroxy benzoic acid,chlorogenic acid,caffeic acid,syringic acid,salicylic acid,sinapic acid and p-coumaric acid)and flavonoids(catechin,naringin,rutin,quercetin,kaempferol,myricetin and apigenin).The capability of germinating seeds to accumulate osmolytes(like glycinebetaine,proline,soluble carbohydrates and K+ion)and polyphenolic compounds was also correlated with their corresponding redox status and redox biomarkers(conjugated diene,hydroperoxide,thiobarbituric acid reactive substances and free carbonyl content)produced under the same *** results in general showed that accumulation of osmolytes along with the redox-sensitive phenolics and flavonoids conferred the ability to maintain the redox homeostasis under drought stress for the tolerant IArCs(Badshabhog and Tulaipanji).

关键词： aromatic rice drought polyphenolic compounds osmolytes redox regulation

Controlled drug release of 5-amino salicylic acid by poly（2- hydroxyethylmethacrylate） grafted agar

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Frontiers of Chemical Science and Engineering 2014年第4期8卷 465-470页

作者： g. Usha rANI Kartick Prasad dey Srijita BHArTI Sumit MISHrA Department of Chemistry Birla Institute of Technology Mesra Ranchi 835215 Jharkhand India

The utilization of poly （2-hydroxyethylmetha- crylate） grafted agar （Ag-g-P（HEMA）） as a matrix for the controlled release of 5-aminosalicylic acid was investi- gated. grafted copolymers of 2-hydroxyethylmethacrylate （HEMA） monomers on agar were synthesized by micro- wave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. tso （the time taken for release of 50% of the enclosed drug） value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P（HEMA） appears to be a useful matrix for controlled release.

关键词： agar controlled drug release 5-Amino sal-icylic acid poly(2-hydroxyethylmethacrylate) grafted agar

Statistical Inference of Exponentiated Moment Exponential Distribution Based on Lower record Values

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Communications in Mathematics and Statistics 2017年第3期5卷 231-260页

作者： Devendra Kumar Tanujit dey Sanku dey Department of Statistics Central University of HaryanaJant-PaliMahendergarh 123031HaryanaIndia Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44121USA Department of Statistics St.Anthony’s CollegeShillongMeghalayaIndia

Based on lower record values,we first derive the exact explicit expressions as well as recurrence relations for the single and product moments of record values and then use these results to compute the means,variances and coefficient of skewness and kurtosis of exponentiated moment exponential distribution(EMED),a new extension of moment exponential distribution,recently introduced by Hasnain(Exponentiated moment exponential ***,2013).Next we obtain the maximum likelihood estimators of the unknown parameters and the approximate confidence intervals of the ***,we consider Bayes estimation under the symmetric and asymmetric loss functions using gamma priors for both shape and scale *** have also derived the Bayes interval of this distribution and discussed both frequentist and the Bayesian prediction intervals of the future record values based on the observed record *** Carlo simulations are performed to compare the performances of the proposed methods,and a data set has been analyzed for illustrative purposes.

关键词： Lower record values Single and product moments recurrence relations Bayes estimator general entropy loss function Maximum likelihood estimator

Optimum lateral extent of soil domain for dynamic SSI analysis of rC framed buildings on pile foundations

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 62-81页

作者： Nishant SHArMA Kaustubh DASgUPTA Arindam dey Department of Civil Engineering Indian Institute of Technology GuwahatiGuwahati 781039India

This article describes a novel approach for deciding optimal horizontal extent of soil domain to be used for finite element based numerical dynamic soil structure interaction(SSI)*** model for a 12 storied building frame,supported on pile foundation-soil system,is developed in the finite element based software framework,*** different structure-foundation configurations are analyzed under different ground motion *** extent of soil domain,along with the soil properties,were varied exhaustively for a particular structural *** on the reduction in the variation of acceleration response at different locations in the SSI system(quantified by normalized root mean square error,NrMSE),the optimum lateral extent of the soil domain is prescribed for various structural widths,soil types and peak ground acceleration levels of ground *** to the past studies,error estimation analysis shows that the relationships prescribed in the present study are credible and more inclusive of the various factors that influence *** relationships can be readily applied for deciding upon the lateral extent of the soil domain for conducting precise SSI analysis with reduced computational time.

关键词： soil structure interaction optimum lateral extent of soil domain length multi-storyed framed building pile foundation OpenSEES L-K boundaries dynamic analysis

role of Interferon-γ in gVHD and gVL

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Cellular & Molecular Immunology 2005年第5期2卷 323-329页

作者： Yong-guang Yang Hui Wang Wannee Asavaroengchai Bimalangshu r. dey Transplantation Biology research Center Surgical Service Massachusetts General Hospital Harvard Medical School MGH-East Building 149 13th Street Boston MA 02129 USA Bone Marrow Transplant Unit Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA Corresponding to： Dr. Yong-guang Yang Transplantation Biology Research Center Massachusetts General Hospital MGH East Bldg 149-5102 13th Street Boston MA 02129 USA

Interferon （IFN）-γ, a potent proinflammatory cytokine produced by multiple types of cells （e.g., activated T, NK and NKT cells）, plays important and complex roles in both innate and adaptive immune responses. There may be a correlation between the IFN-γ level and gVHD severity in patients receiving allogeneic hematopoietic cell transplantation. However, such a correlation may just reflect the presence of large numbers of activated T cells, and does not necessarily imply a harmful role of IFN-γ in the pathogenesis of gVHD. There has been increasing experimental evidence that IFN-γ is not required and may even inhibit gVHD. Paradoxically, IFN-γ facilitates graft-versus-leukemic （gVL） effects. Thus, IFN-γ blockade is likely deleterious in patients after allogeneic hematopoietic cell transplantation, and not beneficial as previously suggested.

关键词： gVHD IFN-γ leukemia transplantation T cell

Sequence Stratigraphic Model of Middle Permian Barakar Formation from a Marginal gondwana Basin, India

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Journal of Earth Science 2018年第4期29卷 745-754页

作者： Joyjit dey Souvik Sen Coal India Limited Central Mine Planning and Design Institute (CMPD1) Regional Institute-3 Jharkhand 829 103 India geologix Limited Dynasty Building Level-4 Wing-A Andheri Kurla Road Andheri (E) Mumbai 400 059 India

gondwana deposits are extensively found across the continents. Here we study the Mid- dle Permian Barakar Formation from the marginal gondwana Basin, eastern India, being deposited in a normal fault setting. Availability of extensive cores as well as geophysical log suites （gammaresistivity-density from drilled wells） from the study area helped us achieving high resolution interpretation. Core study identifies fluvial sedimentary architectures, which were correlated with the geophysical logs and modeled field-wide to understand vertical and horizontal facies disposition. The facies analysis has been used to establish a sequence stratigraphic model of the cyclic Barakar deposition. Four major fining upward depositional sequences were identified, each sequence comprises of low accommodation system tract （LAST） at base and high accommodation system tract （HAST） at top. LAST is characterized by vertically stacked, multistory amalgamated channel sandstone dominated facies, while floodplain dominated facies characterizes HAST, reflecting a gradual shift from braided to meandering depositional system from bottom to top of each cycle. Study reveals depocenter to be in the western part, supported by eastward thinning of sediment packets, all being deposited in a halfgraben setting.

关键词： fluvial sequence stratigraphy gondwana sediment Middle Permian Barakar Formation.

股前外侧或股前内侧穿支皮瓣修复皮肤鳞状细胞癌切除后皮肤软组织缺损的临床效果

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中华烧伤与创面修复杂志 2024年第6期40卷 564-571页

作者：柳若冰郑德义王宝云李伟人贵州医科大学附属金阳医院皮肤科贵阳550001 贵州医科大学临床医学院贵阳550001 贵州省人民医院烧伤整形科贵阳550002

目的探讨股前外侧或股前内侧穿支皮瓣修复皮肤鳞状细胞癌(CSCC)切除后皮肤软组织缺损的临床效果。方法该研究为回顾性观察性研究。2015年7月-2022年7月,贵州省人民医院烧伤整形科收治21例CSCC患者,其中男15例、女6例,年龄27~74岁。CSCC... 详细信息

目的探讨股前外侧或股前内侧穿支皮瓣修复皮肤鳞状细胞癌(CSCC)切除后皮肤软组织缺损的临床效果。方法该研究为回顾性观察性研究。2015年7月-2022年7月,贵州省人民医院烧伤整形科收治21例CSCC患者,其中男15例、女6例,年龄27~74岁。CSCC扩大切除后皮肤软组织缺损面积为7.5 cm×4.0 cm~23.0 cm×8.5 cm。18例患者创面采用股前外侧穿支皮瓣修复;术中观察到3例患者旋股外侧动脉降支穿支血管存在变异,采用股前内侧穿支皮瓣修复创面。皮瓣面积为8.0 cm×5.0 cm~25.0 cm×10.0 cm。将19例患者供瓣区创面直接缝合,采用对侧大腿薄中厚皮片修复2例患者供瓣区创面。观察术后皮瓣成活情况及血管危象发生情况。记录手术时长和住院天数。术后随访时,观察患者肿瘤复发情况、供受区外形、供瓣区功能等。末次随访时,评估患者对疗效的满意度。结果20例患者术后皮瓣成活;1例患者于术后48 h内发生血管危象,立即行急诊手术处理后皮瓣成活。患者手术时长为4~5 h,住院15~38 d。术后随访1~6年见局部肿瘤无复发;皮瓣色泽、质地与周围组织差异不大,弹性良好,外形较佳;2例患者供瓣区皮片存活良好,出现局部色素沉着;所有患者供瓣区仅有线状瘢痕,感觉及运动功能无明显影响。末次随访时,对疗效满意者15例、一般者6例。结论对于CSCC切除后皮肤软组织缺损,可优先采用股前外侧穿支皮瓣修复,在旋股外侧动脉降支穿支血管存在变异的情况下,选择股前内侧穿支皮瓣修复。2种皮瓣切取面积大,可根据缺损组织量调整皮瓣面积,精准有效修复CSCC切除后皮肤软组织缺损,术后外观及功能良好。

关键词：创伤和损伤穿支皮瓣癌皮肤鳞状细胞癌血管变异创面修复

Assessment of bearing capacity of interfering strip footings located near sloping surface considering artificial neural network technique

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Journal of Mountain Science 2018年第12期15卷 2766-2780页

作者： rana ACHArYYA Arindam dey Department of Civil Engineering Indian Institute of Technology Guwahati

The bearing capacity of interfering footings located near the slope face suffers from reduced bearing capacity due to the formation of the curtailed passive zone. Depending upon the position of the footing, their spacing and steepness of the slope different extents of bearing capacity reduction can be exhibited. A series of finite element investigation has been done with the aid of Plaxis 3 D v AE.01 to elucidate the influence of various geotechnical and geometrical parameters on the ultimate bearing capacity of interfering surface strip footings located at the crest of the natural soil slope. Based on the large database obtained from the numerical simulation, a6-8-1 Artificial Neural Network architecture has been considered for the assessment of the ultimate bearing capacity of interfering strip footings placed on the crest of natural soil slope. Sensitivity analyses have been conducted to establish the relative significance of the contributory parameters, which exhibited that for the stated problem, apart from shear strength parameters, the setback ratio and spacing of footing are the prime contributory parameters.

关键词： Interfering strip footing Natural slope Finite element simulation Artificial Neural Network Sensitivity analysis Prediction model

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5686-5726页

作者： Priyanka dey Talukdar Urmi Chatterji Cancer research Laboratory Department of ZoologyUniversity of Calcutta35 Ballygunge Circular RoadKolkata 700019 West BengalIndia

Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the *** of these regulatory molecules is associated with cell state transitions,which in turn is accountable for diverse maladies,including developmental disorders,metabolic disorders,and most significantly,cancer.A decade back most transcription factors,the key enablers of disease development,were historically viewed as‘undruggable’;however,in the intervening years,a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators,their confederates in various physiological and molecular *** co-activators,along with transcription factors,have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions,whereby,deregulation of such interactions may foster tissue-specific disease ***,it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other *** proposed review attempts to elaborate an in-depth account of the transcription co-activators,their involvement in transcription regulation,and context-specific contributions to pathophysiological *** review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies,where drugs targeting co-activators will have enhanced benefits and reduced side *** insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis.

关键词： therapeutic eventually potential