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The effect of Co and Cr substitutions for Ni on mechanical properties and plastic deformation mechanism of FeMnCoCrNi high entropy alloys

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Journal of Materials Science & Technology 2020年第13期47卷 146-155页

作者： H.F.Zhang H.L.Yan H.Yu Z.W.Ji q.M.Hu N.jia Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China State Key Lab Rolling&Automat Northeastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China Shen Yang University of Technology Shenyang 110870China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The elastic constants,ideal tensile strength(ITS),stacking fault energy(SFE),lattice constant and magnetic moment of FeMnCoCrNi high entropy alloys with varying Co and Cr contents at 0 and 300 K were systematically investigated by first-principle *** the alloys with Co substitution for Ni,at both temperatures the elastic stability of the face-centered cubic(fcc)phase,bulk elastic modulus(B),Young’s modulus(E),shear modulus(g)and ITS increase monotonically with increasing Co ***,the Cauchy pressure(Cp),Pugh ratio(B/g),Poisson ratio(v),Zener anisotropy ratio(AZ)and elastic anisotropy ratio(AVR)decrease *** SFE also decreases with the increase of Co,resulting in the change of plastic deformation mechanism from dislocation slip to mechanical twinning,and then to hcp-martensitic *** elucidates the underlying mechanism of the effect of Co addition on the strength and micromechanical behavior of FeMnCoCrNi *** with Co,the Cr substitution for Ni leads to the more complex change of elastic constants and *** increase of Cr shows the similar effect on SFE and deformation mechanism as that of *** variation of valence electron concentration and magnetism affect the *** increase of either Co or Cr leads to the reduced magnetic moments of Fe and *** could be responsible for the monotonic decrease of both lattice constant and SFE as the Co content ***,for the Cr addition case,multiple factors may affect the evolution of lattice constant and *** findings shed light on the deformation mechanism of the alloys with different compositions.

关键词： High entropy alloys First-principle calculations Elastic constants Ideal tensile strength Stacking fault energy

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Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein(MAPs)

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Progress in Natural Science:Materials International 2014年第5期24卷 458-465页

作者： Xuchen Xu Ming Li qian Liu Zhaojun jia Yuying Shi Yan Cheng Yufeng Zheng L.q. Ruan Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking University Department of Materials Science and Engineering College of Engineering Peking University Department of Mechanical Systems Engineering Graduate School of Science and TechnologyKumamoto University

Motivated by adhesive proteins in mussels, strategies using dopamine to modified surface have become particularly attractive. In the present work, we developed a novel and convenient method to modify the biodegradable Fe plates with heparin. Iron was first treated by a facile one-step p H-induced polymerization of dopamine, and then a high density heparin was successfully grafted onto the surface via coupling with polydopamine(PDA) active layer. Heparin immobilization contributed much longer blood clotting coagulation time than the pure Fe sample, and hence reduced the risk of thrombosis. Cell viability tests suggested that the heparin modified Fe plates were more favorable to the proliferation of ECV304 cells. In summary, the heparin modified Fe plates with good anti-thrombus properties and inhibiting the proliferation of VSMC cells provide great prospects for biodegradable iron.

关键词： Iron Heparin Dopamine Surface modification Biodegradable stent Hemocompatibility

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Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

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World Journal of Clinical Cases 2024年第16期12卷 2713-2721页

作者： Bin Yang Ao He Bin-Bin Bu gong Zhuo qing-Zhu Zhou jia-Hang He Liu Liu Wen-Li Huang Xian Zhao Department of Plastic and Cosmetic Surgery The Affiliated Calmette Hospital of Kunming Medical UniversityThe First People's Hospital of KunmingCalmette Hospital KunmingKunming 650224Yunnan ProvinceChina Department of Dermatology The People's Hospital of Chuxiong Yi Autonomous PrefectureChuxiong Yi Autonomous Prefecture 675099Yunnan ProvinceChina

BACKgROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation *** treatments may have limitations in high-altitude areas like Yunnan *** Col Ⅰ injections stimulate collagen production,potentially improving skin *** study aims to assess the efficacy and safety of this treatment for *** To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating *** This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan *** six treatment sessions were conducted every 4 wk±3 *** and after each treatment,facial skin characteristics were quantified using a VISIA skin *** thickness data were assessed using the ultrasound probes of the Dermalab skin *** Face-q scale was used for subjective evaluation of the treatment effect by the *** The skin thickness of the right cheek consistently increased after each treatment session compared with *** skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with *** skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment *** skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(Pgs were also supported by skin ultrasound *** feature count for the red areas and wrinkle feature count decreased following the treatment(PqSatisfaction with Facial Appearance Overall and Face-q-Satisfaction with Skin scores significantly increased after each treatment ***

关键词： Photoaging TypeΙcollagen Face-q High-altitude area Skin photodamage Patient satisfaction

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封闭处理对超声波辅助制备的锌系磷化膜耐蚀性的影响

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电镀与精饰 2024年第9期46卷 48-55页

作者：贾春燕刘海涛黄河水利职业技术学院河南开封475004 河南理工大学河南焦作454003

在q345钢磷化过程中引入超声波以改善锌系磷化膜表面平整度和致密性,为进一步提高超声波辅助制备的锌系磷化膜耐蚀性,分别采用油性封闭剂、硝酸铈溶液、硅酸钠溶液进行封闭处理。结果表明:硅酸钠溶液的封闭效果好于油性封闭剂和硝酸铈溶... 详细信息

在q345钢磷化过程中引入超声波以改善锌系磷化膜表面平整度和致密性,为进一步提高超声波辅助制备的锌系磷化膜耐蚀性,分别采用油性封闭剂、硝酸铈溶液、硅酸钠溶液进行封闭处理。结果表明:硅酸钠溶液的封闭效果好于油性封闭剂和硝酸铈溶液,封闭后超声锌系磷化膜的物相组成为Zn_(3)(PO_(4))_(2)·4H_(2)O、Zn_(2)Fe(PO_(4))_(2)·4H_(2)O、ZnSiO_(3)和Na_(2)Si O_(3),并且呈现良好的致密性和耐蚀性,其耐硫酸铜点滴时间超过150 s,腐蚀电流密度低至3.20×10^(-6)A/cm^(2),较未封闭超声锌系磷化膜的腐蚀电流密度降低幅度接近一个数量级。在硅酸钠溶液封闭过程中发生腐蚀整平现象,同时生成ZnSiO_(3)并析出Na_(2)Si O_(3)起到填补孔隙的作用,使超声锌系磷化膜的致密性得到更大程度改善,从而显著增强抗腐蚀能力。

关键词：锌系磷化膜超声波封闭处理耐蚀性硝酸铈溶液硅酸钠溶液

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零中频接收数字阵列镜像抑制的性能分析与方法

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雷达科学与技术 2024年第2期22卷 199-208,217页

作者：贾可新吴瑞荣中国电子科技集团公司第三十八研究所安徽合肥230088

为了解决零中频接收数字阵列波束合成的镜像抑制问题,从推导单通道零中频接收模型出发,首先给出了零中频接收数字阵列的数学模型,然后对同时存在通道间幅相误差、通道内I/q不平衡误差时的阵列波束图、波束合成的镜像抑制性能进行理论分... 详细信息

为了解决零中频接收数字阵列波束合成的镜像抑制问题,从推导单通道零中频接收模型出发,首先给出了零中频接收数字阵列的数学模型,然后对同时存在通道间幅相误差、通道内I/q不平衡误差时的阵列波束图、波束合成的镜像抑制性能进行理论分析。依据分析结果,阵列各通道引入随机辅助相位,提出了一种无需对通道内I/q不平衡误差进行测量、波束合成输出镜像抑制比与阵元个数有关、适合于大规模数字阵列的波束合成镜像抑制方法。仿真实验验证了本文理论分析和所提方法的正确性。

关键词：零中频接收机数字阵列波束合成镜像抑制比 I/q不平衡

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Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction

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Chinese Medical Journal 2014年第4期127卷 627-632页

作者： Wu Nq guo YL Li XL Liu J qing P Xu RX Zhu Cg jia Y J Liu g Dong.q.jiang LX Li J J Ma FL Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology First Hospital of Hohhot Hohhot Inner Mongolia 010030 China

Backround N-terminal pro-brain natriuretic peptide （NT-proBNP） is a reliable predictor in acute coronary artery disease （CAD）. Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms： CAD group （n=484） and angiographic normal control group （n=174）. The severity of CAD was evaluated by modified gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus （DM）, dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD （OR：1.66 （95% CI： 1.06-2.61）, P 〈0.05）. In a receiver operating characteristic （ROC）curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD （area under curve （AUC）=0.56, 95% CI： 0.51-0.61）. Furthermore, NT-proBNP was positively correlated with gensini score （r=0.14, P 〈0.001） in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD.

关键词： N-terminal pro-brain natriuretic peptide coronary artery disease risk factors modified gensini score

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Electrical conductivity of wood biochar monoliths and its dependence on pyrolysis temperature

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Biochar 2020年第3期2卷 369-378页

作者： Randeep gabhi Luca Basile Donald W.Kirk Mauro giorcelli Alberto Tagliaferro Charles q.jia Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Applied Science and Technologies Politecnico di TorinoC.so Duca Degli AbruzziTurin 10129Italy

Biochar is traditionally used as solid fuel and for soil amendment where its electrical conductivity is largely irrelevant and ***,electrical conductivity is critical to biochar’s performance in new applications such as supercapacitor energy storage and capacitive deionization of *** this study,sugar maple and white pine were carbonized via a slow pyrolysis process at 600,800 and 1000°C and conductivities of monolithic biochar samples along the radial direction were measured using the 4-probe *** were characterized using an elemental analyzer,scanning electron microscopy,X-ray diffraction and Raman *** solid carbon in biochar samples was found to consist primarily of disordered carbon atoms with small graphitic nanocrystallites that grow with increasing *** bulk conductivity of biochar was found to increase with pyrolysis temperature-1 to~1000 S/m for maple and 1 to~350 S/m for pine,which was accompanied by an increase in carbon content-91 to 97 wt%and 90 to 96 wt%for maple and pine,*** skeletal conductivity of biochar samples carbonized at 1000°C is about 3300 S/m and 2300 S/m for maple and pine,respectively(assuming solid carbon is amorphous);both values are above that of amorphous carbon(1250-2000 S/m).This work demonstrated the importance of carbonization and graphitization to electrical conductivity and suggested electron hopping as a likely mechanism for electric conduction in biochar-an amorphous carbon matrix embedded with graphitic nanocrystallites.

关键词： Biochar Electrical conductivity Pyrolysis temperature graphitization

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基于颜色-特征成分关联分析及网络药理学的金银花质量标志物(q-Marker)研究

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中草药 2024年第14期55卷 4882-4896页

作者：刘艳萍王云贾哲张伟张村中国中医科学院中药研究所北京100700 封丘县金银花产业发展领导小组办公室河南封丘453321

目的基于颜色-特征成分关联分析及网络药理学探讨金银花Lonicerae Japonicae Flos中潜在的质量标志物(quality markers,q-Marker)。方法收集山东、河南和河北3个产地共30批金银花样品,建立金银花HPLC特征图谱方法,得到金银花中的非挥发... 详细信息

目的基于颜色-特征成分关联分析及网络药理学探讨金银花Lonicerae Japonicae Flos中潜在的质量标志物(quality markers,q-Marker)。方法收集山东、河南和河北3个产地共30批金银花样品,建立金银花HPLC特征图谱方法,得到金银花中的非挥发性特征成分,将其与实验室前期得到的含量较高、具有产地特异性的挥发性成分相结合,作为金银花潜在的q-Marker候选物;采用色彩分析仪测定金银花的颜色与q-Marker进行相关性分析,筛选出与颜色相关的成分;结合网络药理学方法,从金银花的适应证和功效2个层面对q-Marker候选物的药理活性进行预测,进一步确定潜在q-Marker。结果建立了金银花非挥发性成分HPLC特征图谱,指认了9个特征峰,结合实验室前期对挥发性成分研究结果,最终从金银花中得到了16种特征性成分;相关性分析结果表明,与金银花颜色具有显著相关性的成分有10个,包括绿原酸、当药苷、断氧马钱子苷、芦丁、(Z)-二聚断马钱苷烯醛、异绿原酸B、异绿原酸C、α-亚麻酸甲酯、正己醛、(E,E)-2,4-癸二烯醛;网络药理学研究得到11种与疾病和药效关联的q-Marker,分别为当药苷、断氧马钱子苷、芦丁、(Z)-二聚断马钱苷烯醛、异绿原酸B、异绿原酸A、芳樟醇、肉豆蔻酸、α-亚麻酸甲酯、α-橙花醇、月桂醛。通路富集分析结果显示,这些成分主要通过丝裂原活化蛋白激酶1(mitogen-activated protein kinase 1,MAPK1)、丝裂原活化蛋白激酶激酶1(recombinant mitogen activated protein kinase kinase 1,MAP2K1)、丝裂原活化蛋白激酶14(mitogen-activated protein kinase 14,MAPK14)、肿瘤坏死因子(tumor necrosis factor,TNF)等62个关键靶点作用于细胞凋亡(apoptosis)、表皮生长因子受体(epidermal growth factor receptor,EgFR)、松弛素(relaxin)、C型凝集素(C-type lectin receptor)、白细胞介素17(interleukin 17,IL-17)、结合免疫球蛋白E的Fc受体(Fc epsilon RI)、T细胞抗原受体(T cell receptor)等多种信号通路。将颜色和药理活性成分取交集,最终得到6种与颜色关联的q-Marker,包括当药苷、断氧马钱子苷、芦丁、异绿原酸B、(Z)-二聚断马钱苷烯醛、α-亚麻酸甲酯。因此,为提高金银花的质量标准,可以考虑在《中国药典》标准基础上,将芦丁、异绿原酸B、α-亚麻酸甲酯、芳樟醇和肉豆蔻酸纳入金银花的质量评价体系。结论从理论层面出发,筛选出能够体现其质量的q-Marker,为全面控制金银花的质量提供依据,为进一步研究金银花的活性物质及其作用机制提供参考。

关键词：金银花质量标志物绿原酸当药苷断氧马钱子苷芦丁 (Z)-二聚断马钱苷烯醛异绿原酸B 异绿原酸C α-亚麻酸甲酯正己醛 (E,E)-2,4-癸二烯醛网络药理学

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A survey of the development of biomimetic intelligence and robotics

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Biomimetic Intelligence & Robotics 2021年第1期1卷 1-12页

作者： jiankun Wang Weinan Chen Xiao Xiao Yangxin Xu Chenming Li Xiao jia Max q-H.Meng Department of Electronic and Electrical Engineering Southern University of Science and TechnologyShenzhenChina Department of Electronic Engineering The Chinese University of Hong KongShatin N.T.Hong Kong SARChina Shenzhen Research Institute of the Chinese University of Hong Kong ShenzhenChina

Biomimetics is the development of novel theories and technologies by emulating the models and systems of *** transfer of function from biological science into engineering promotes emerging research areas across many disparate ***,advances in biomimetic intelligence and robotics have gained great *** robotics are designed with biological characteristics and functions to be applied in different scenarios,such as humanoid robot in the home environment,quadruped robot in the field,and bird-like flying robot in the *** intelligence aims to solve many complex problems by studying the principles of biological systems,resulting in a series of efficient algorithms,such as the genetic algorithm and neural *** intelligence further facilitates the performance of biomimetic robotics,making it possible to be deployed in more and more practical *** survey introduces the development of biomimetic intelligence and biomimetic *** survey different biomimetic robots,biomimetic sensors and sensing technologies,and popular biomimetic intelligence *** conclusion is drawn by discussing current challenges and future research directions.

关键词： Biomimetics Robotics Biomimetic intelligence Biomimetic robotics

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MDCK细胞成瘤性相关环状RNA的筛选与验证

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农业生物技术学报 2024年第9期32卷 2088-2099页

作者：杨迪石嘉琛黄玲巍王家敏马玉梅乔自林崔燕甘肃农业大学动物医学院西北民族大学生物医学研究中心细胞基质疫苗关键技术与产业化教育部工程研究中心西北民族大学生物医学研究中心甘肃省动物细胞技术创新中心西北民族大学实验教学部兰州民海生物工程有限公司甘肃省生物工程材料工程研究中心

在应用犬(Canis lupus familiaris)肾细胞系MDCK (Madin-Darby canine kidney)制备禽流感等兽用疫苗中发现，MDCK细胞系存在成瘤性。本研究以高成瘤性和无成瘤性的MDCK细胞为研究对象，通过RNA-seq高通量测序技术筛选获得差异表达的环状... 详细信息

在应用犬(Canis lupus familiaris)肾细胞系MDCK (Madin-Darby canine kidney)制备禽流感等兽用疫苗中发现，MDCK细胞系存在成瘤性。本研究以高成瘤性和无成瘤性的MDCK细胞为研究对象，通过RNA-seq高通量测序技术筛选获得差异表达的环状RNA (circular RNA, circRNA)，并对差异表达circRNA的来源基因进行gO和KEgg分析；进一步使用数据库StarBase和mirTarBase分别预测成瘤性相关差异circRNA的靶标微小RNA (microRNA, miRNA)和mRNA，使用Cytoscape软件绘制circRNAmiRNA-mRNA共表达网络。利用TRIzol法提取高成瘤性和无成瘤性的MDCK细胞总RNA，利用q PCR验证6个差异circRNA的表达水平。结果显示，从高成瘤性和无成瘤性的MDCK细胞中鉴定出3 491个circRNA，长度为200～800 nt；共筛选出27个差异表达的circRNA，其中18个上调表达、9个下调表达。gO、KEgg和Reactome富集分析表明，差异表达的circRNA与ATP和氨基酸代谢相关酶的活性及结合等相关，主要富集的信号通路为黏附连接、细胞迁移以及多种代谢相关信号通路；内源竞争RNA(competing endogenous RNA, ceRNA)网络构建得到4组MDCK细胞成瘤性相关的关键circRNA-miRNAmRNA调控网络，分别为novel＿circ＿002222/novel-m0145-3p/动力蛋白激活蛋白1 (dynactin 1, Dctn1)、novel＿circ＿002222/miR-197-x/Dctn1、novel＿circ＿001205/novel-m0580-5p/膜联蛋白A11 (annexin A11,ANXA11)和novel＿circ＿003257/novel-m0675-3p/RNA结合蛋白48 (RNA-binding protein 48, RBM48)。上述结果表明，MDCK细胞成瘤性相关的差异表达circRNA主要富集在跨膜物质运输和能量代谢相关通路，可能在MDCK细胞能量摄入和代谢过程中发挥作用。本研究为揭示circRNA参与MDCK细胞成瘤的机制、建立基因工程无成瘤性MDCK细胞系提供研究基础和技术支持。

关键词： MDCK (Madin-Darby canine kidney) 环状RNA (circRNA) 成瘤性

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