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是否需要对黑色素瘤病人行全身扩散加权成像以检出转移灶

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国际医学放射学杂志 2014年第1期 101-101页

作者： g.petralia A.Padhani P.Summers S.Alessi S.Raimondi A.Testori 袁涛 Department of Radiology European Institute of OncologyVia Ripamonti 43520141 MilanItaly

目的探讨仅用全身扩散加权成像(WB-DWI)是否适于检出黑色素瘤转移,以及是否需要行常规全身(WB)对比增强MRI。方法19例晚期黑色素瘤病人每季度行一次

关键词：全身成像扩散加权MRI 黑色素瘤转移对比增强MRI

机器人辅助的根治性前列腺切除术:多参数MR成像引导的手术中冰冻切片分析可以降低外科手术边缘的阳性率

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国际医学放射学杂志 2015年第2期 178-178页

作者： g.petralia g.Musi A.R.Padhani P.Summers g.Renne S.Alessi 郭凌飞 Divisions of Radiology European Institute of OncologyVia Ripamonti 435 20141 Milan Italy

摘要目的研究在保留神经的机器人辅助根治性前列腺切除术中,使用多参数MR成像引导的手术中冰冻切片(IFS)分析是否可以降低外科手术边缘的阳性率。材料与方

关键词：术中冰冻切片 IFS 前列腺切除术多参数根治性阳性率 MR 外科手术

超声导引下经皮tru-cut针喉-下咽病变活检

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国际医学放射学杂志 2010年第4期 406-406页

作者： L.Preda.E.De Fiori C.Rampinelli M.Ansarin g.petralia F.Maffini 李宁 Department of Radiology European Institute of OncologyVia Ripamonti 43520141 MilanItaly

目的评价超声导引下经皮tru-cut针活检(US-gTCB)对未经治疗或曾经治疗而可疑喉-下咽肿块的特定病人(存在气道狭窄或插管困难或常规喉镜检查禁忌)的可行性及可信

关键词：超声导引 tru-cut 经皮

Proficiency score as a predictor of early trifecta achievement during the learning curve of robot-assisted radical prostatectomy for high-risk prostate cancer:Results of a multicentric series

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Current Urology 2024年第2期18卷 110-114页

作者： Umberto Anceschi Rocco Simone Flammia Antonio Tufano Michele Morelli Antonio galfano Lorenzo giuseppe Luciani Leonardo Misuraca Paolo Dell’Oglio gabriele Tuderti Aldo Brassetti Maria Consiglia Ferriero Alfredo Maria Bove Riccardo Mastroianni Francesco Prata Isabella Sperduti giovanni petralia SilviaSecco Ettore Di Trapani DanieleMattevi Tommaso Cai Aldo Massimo Bocciardi giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic Clinic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda Ca’granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistical Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Background:Recently,an innovative tool called“proficiency score”was introduced to assess the learning curve for robot-assisted radical prostatectomy(RARP).However,the initial study only focused on patients with low-risk prostate cancer forwhompelvic lymph node dissection(PLND)was not *** address this issue,we aimed to validate proficiency scores of a contemporarymulticenter cohort of patients with high-risk prostate cancer treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-cancer datasets weremerged and queried for“RARP”and“high-risk prostate cancer.”High-risk prostate cancer was defined according to the most recent European Association of Urology guidelines as follows:prostate-specific antigen>20 ng/mL,International Society ofUrological Pathology≥4,and/or clinical stage(cT)≥2c on preoperative *** selected cohort(n=144)included clinical cases performed by trainee surgeons(n=4)after completing their RARP learning curve(50 procedures for low-risk prostate cancer).The outcome of interest,the proficiency score,was defined as the coexistence of all the following criteria:a comparable operation time to the interquartile range of the mentor surgeon at each center,absence of any significant perioperative complications Clavien-Dindo grade 3–5,no perioperative blood transfusions,and negative surgical margins.A logistic binary regression model was built to identify the predictors of 1-year trifecta achievement in the trainee *** all statistical analyses,a 2-sided pge,nerve-sparing,and surgical technique,the proficiency score independently predicted 1-year trifecta achievement(odds ratio,9.58;95%confidence i

关键词： Trifecta Learning curve Robot-assisted radical prostatectomy High-risk prostate cancer

Au,Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration

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Regenerative Biomaterials 2020年第5期7卷 461-469页

作者： giovanna Calabrese Salvatore petralia Claudia Fabbi Stefano Forte Domenico Franco Salvatore guglielmino Emanuela Esposito Salvatore Cuzzocrea Francesco Traina Sabrina Conoci Department of Chemistry Biology Pharmacy and Environmental Science University of MessinaPiazza Pugliatti198122 MessinaSiciliaItaly Research and Development Applied Chemical WorksPaternoCataniaItaly Department of Chemical Science Fin-Ceramica FaenzaVia Granarolo 177/3Faenza 48018Italy Istituto Oncologico del Mediterraneo Ricerca ViagrandeCatania 95029Italy Dipartimento Biomorf Universita degli Studi di MessinaMessinaItaly Rizzoli Orthopedic Institute IRCSSBolognaItaly Distretto Tecnologico Micro e Nano Sistemi Sicilia CataniaItaly

Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTE)allowing the incorporation of nanomaterials able to improve cell proliferation and *** this study,Mg-HA-Coll type I scaffolds(Mg-HA-based scaffolds)were nanofunctionalized with gold nanorods(Au NRs),palladium nanoparticles(Pd NPs)and maghemite nanoparticles(MAg NPs).Nanofunctionalized Mg-HA-based scaffolds(NF-HA-Ss)were tested for their ability to promote both the proliferation and the differentiation of adipose-derived mesenchymal stem cells(hADSCs).Results clearly highlight that MAg nanofunctionalization substantially improves cell proliferation up to 70% compared with the control(Mg-HA-based scaffold),whereas both Au NRs and Pd NPs nanofunctionalization induce a cell growth inhibition of 94% and 89%,*** evidences were found for the osteoinductive properties showing relevant calcium deposits(25% higher than the control)for MAg nanofunctionalization,while a decreasing of cell differentiation(20% lower than the control)for both Au NRs and Pd NPs *** results are in agreement with previous studies that found cytotoxic effects for both Pd NPs and Au *** excellent improvement of both osteoconductivity and osteoinductivity of the MAg NF-HA-S could be attributed to the high intrinsic magnetic field of superparamagnetic MAg *** findings may pave the way for the development of innovative nanostructured scaffolds for BTE.

关键词： bone regeneration hydroxyapatite scaffold tissue engineering gold nanoroads Pd nanoparticles maghemite nanoparticles

Psychopathological outcomes and defence mechanisms in clinically healed adults with a paediatric cancer history: an exploratory study

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general Psychiatry 2021年第4期34卷 60-68页

作者： Antonino petralia Emanuele Bisso Ilaria Concas Antonino Maglitto Nunzio Bucolo Salvatore Alaimo Andrea Di Cataldo Maria Salvina Signorelli Alfredo Pulvirenti Eugenio Aguglia Department of Clinical and Experimental Medicine Psychiatry UnitUniversity of CataniaSchool of MedicineCataniaItaly Department of Mathematics and Computer Science University of CataniaCataniaItaly Department of Clinical and Experimental Medicine Pediatric Hemato-Oncology UnitUniversity of CataniaSchool of MedicineCataniaItaly

Background The incidence of paediatric cancers has increased in recent years;however,with advances in the treatment of paediatric cancer,almost 80%of children and adolescents who receive a diagnosis of cancer become long-term *** the high stress levels associated with cancer,it becomes important to ascertain the risk and likelihood of psychiatric disorders in adult paediatric cancer *** This study aims to investigate the relationship between defence styles and predisposition to psychiatric diseases in adults with a history of paediatric *** We performed an explorative study on a sample of 66 clinically healed adults with a history of paediatric cancer(survivors)during follow-up visits at the University Hospital‘Policlinico g Rodolico’of Catania(Italy)and 98 healthy controls among medicine *** administered the Defence Mechanism Inventory(DMI)to assess defence *** Symptom Checklist-90-Revised(SCL-90-R)and the Davidson Trauma Scale(DTS)were administered to assess psychopathological *** conducted comprehensive statistical analysis based on correlation analysis and mediation analysis to investigate the relationship between defence styles and psychopathological outcomes in survivors compared with *** The survivors obtained statistically significant lower values in TAO,PRO and TAS defence styles and a higher value in *** groups showed non-pathlogical mean scores in DTS and SCL-90-R(with an exception of the obsessive-compulsive subscale),with lower mean values among *** results of mediation analysis showed that TAS had mediation effects on interpersonal sensitivity,anxiety,PSDI,gSI and avoidance,while TAO had mediation effects on DTS total score and ***,for these psychopathological indices,the effect of the oncological pathology was indirect and mediated by TAO or *** analysis exlcluded mediation effects between the remaining variables and defence *** Integrati

关键词： clinically pathological TAO