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Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts:A single-center experience

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世界骨科杂志:英文版 2023年第9期14卷 698-706页

作者： Kolja Sebastian Weber Claus Lindkær Jensen Michael Mørk petersen Department of Orthopedic Surgery RigshospitaletCopenhagen 2100Denmark

BACKgROUND Aneurysmal bone cysts(ABC)are benign cystic bone tumors of an osteolytic and locally aggressive *** an alternative to the primary treatment of choice,which consists of curettage with bone grafting,alternative treatment methods with promising results have been *** our department,we have,in recent years,used percutaneous sclerotherapy with *** objective of this study was to identify the healing rate and safety of sclerotherapy with *** To identify the efficacy and safety of sclerotherapy with polidocanol in primary and recurrent *** Twenty-two consecutive patients(median age 12.5 years;range 1-27)with 23 ABCs treated with sclerotherapy with polidocanol from 2016-2021 were included *** patients(48%)had undergone different forms of previous treatment with *** general anesthesia and fluoroscopic guidance,repeated percutaneous injections of 4mg polidocanol/kg body weight were *** review of the electronic medical records,the following were identified:healing and recurrence rate,number of treatments,gender,age,comorbidity,location of the tumor and side effects/complications,as well as any previous surgery for *** median length of radiographic follow-up was 19.5 *** All ABCs except one(96%)showed healing or stable disease after a median of 4(range 1-8)*** clinical and radiographic healing was observed in 16 cysts(70%),while partial radiographic healing with resolution of pain was seen in 6 cases(26%)and considered as stable *** cyst that failed to heal had previously undergone curettage twice with *** patient with a large pelvic ABC experienced,right after two injections,a sudden drop in blood pressure,which could quickly be *** patient with a juxtaphyseal ABC in the femoral neck showed a minor limb length discrepancy because of *** that,no complications were *** Percutaneous sclerotherapy

关键词： Aneurysmal bone cyst Bone tumor Sclerotherapy Polidocanol Healing rate Complications

Realization Feature of Mesenchymal Dermal Cells Tissue Engineering Construction Response in granulating Wound Transplantation in Relation with Time-Frame

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 126-129页

作者： Elena petersen Moscow Scientific Research Center of Dermatovenerology and Cosmetology of Moscow City Moscow Russia

Derma is progenitor cells sours, that are able to differentiate further in several mesodermal lineage and neural and endodermal lineage. Culture conditions, skin taking site and culture medium composition considerably contribute to it. Spheroid cultured mesenchymal dermal cells contribution to skin regeneration in granulating wound in rat model was estimated.

关键词： Brief Report 3D Cultivated Tissue Engineering Construction Skin Mesenchymal Dermal Cells Sprouting Capillary-Like Structures

Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice

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Animal Models and Experimental Medicine 2020年第2期3卷 160-168页

作者： Kare Kryger Vols Mads Kjelgaard-Hansen Carsten Dan Ley Axel Kornerup Hansen Maj petersen global Drug Discovery Novo Nordisk A/SMaaloevDenmark Veterinary and Animal Sciences University of CopenhagenFrederiksbergDenmark Veterinary Clinical Sciences University of CopenhagenFrederiksbergDenmark

Background: Hemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic ***: FVIII knock-out(F8-KO) mice were dosed with a micro-CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography(micro-CT) and recombinant FVIII treatment initiated. On Day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On Day 14, knee pathology was characterized by micro-CT and histopathology. In a second study, contrast agent was injected into the knee of wild-type(WT) mice, followed by histopathological evaluation on Day ***: The average joint bleed volume before treatment was 3.9 mm3. The inflammation-related fluorescent intensities in the injured knees were significantly increased on Day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un-injured knees. However, no cartilage-or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on Day 8. In F8-KO and WT mice, persistence of contrast agent in the joint elicited morphological ***: When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment.

关键词： Animal models arthropathy hemarthrosis haemophilia A in vivo imaging micro-CT

HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C

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World Journal of gastroenterology 2002年第3期8卷 562-566页

作者： Rainer P.Woitas Uwe petersen Dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler Department of Intemal Medicine I University of Bonn53105 BonnGermany Institute of Experimental Hematology University of Bonn53105 BonnGermany Institute of Medical Microbiology and Immunology University of Bonn53105 BonnGermany

AIM:Cytokine release by macrophages critically determines the type of immune response to an ***,we studied hepatitis C virus(HCV)-specific induction of interleukins-1β,-10,-12(IL-1β,IL-10,IL-12),and tumor necrosis factor-α(TNF-α)in monocytes. METHODS:Intracallular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear calls with recombinant core,NS3,NS4,NSSa and NSSb proteins. RESULTS:Patients with HCV viremia revealed greater spontaneous expression of IL-1β,TNF-α,and IL-10. Furthermore,greater than twofold higher IL-10 expression was induced by the HCV antigens in chronic hepatitis C than in the other two groups(Pgen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 *** may contribute to persistent viral replication.

关键词： Adult Cytokines Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interleukin-1 Interleukin-10 Interleukin-12 Male Middle Aged Monocytes Research Support, Non-U.S. gov't Tumor Necrosis Factor-alpha Viremia

Establishment of PEEK-Associated Drug Delivery Systems—Limits and Perspectives

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Journal of Materials Science and Chemical Engineering 2020年第10期8卷 32-41页

作者： Marius Behnecke Svea petersen Laboratory for Chemistry and Surface Modification Hochschule Osnabrück University of Applied Sciences Osnabrück Germany

In order to enhance promising properties of polyethertherketone (PEEK) for biomedical application, we evaluate two different strategies for the provision of PEEK with a drug delivery system at the example of the model drug chlorhexidine diacetate. On one hand we discuss the deposition of a biodegradable polymeric drug-release coating, based on well-established poly(L-lactide) (PLLA), on PEEK and on the other hand the modification of PEEK via sulfonation and its subsequent drug loading. Results are compared to pure PLLA-associated drug delivery systems and limits and perspectives are shown.

关键词： Polyethertherketone Drug Chlorhexidine

Identifying contextual determinants of problems in tuberculosis care provision in South Africa: a theory-generating case study

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Infectious Diseases of Poverty 2021年第3期10卷 82-94页

作者： Jamie Murdoch Robyn Curran Andre Jvan Rensburg Ajibola Awotiwon Audry Dube Max Bachmann Inge petersen Lara Fairall School of Health Sciences University of East AngliaNorwich NR47TJUK. University of Cape Town Lung Institute Knowledge Translation UnitUniversity of Cape TownMowbray 7700South Africa Centre for Rural Health University of KwaZulu NatalDurbanSouth Africa Norwich Medical School University of East AngliaNorwich NR47TJUK. King's global Health Institute King's College LondonLondon SE19NHUK. Knowledge Translation Unit Department of MedicineUniversity of Cape Town Lung InstituteUniversity of Cape TownMowbray 7700South Africa.

Background:Despite progress towards End TB Strategy targets for reducing tuberculosis(TB)incidence and deaths by 2035,South Africa remains among the top ten high-burden tuberculosis countries globally.A large challenge lies in how policies to improve detection,diagnosis and treatment completion interact with social and structural drivers *** understanding and theoretical development of the contextual determinants of problems inTB care is required for developing effective *** article reports findings from the pre-implementation phase of a study ofTB care in South Africa,contributing to HeAlth System StrEngThening in Sub-Saharan Africa(ASSET)-a five-year research programme developing and evaluating health system strengthening interventions in sub-Saharan *** study aimed to develop hypothetical propositions regarding contextual determinants of problems inTB care to inform intervention development to reduce TB deaths and incidence whilst ensuring the delivery of quality integrated,person-centred ***:Theory-building case study design using the Context and Implementation of Complex Interventions(CICI)framework to identify contextual determinants of problems in TB *** February and November 2019,we used mixed methods in six public-sector primary healthcare facilities and one public-sector hospital serving impoverished urban and rural communities in the Amajuba District of KwaZulu-Natal Province,South *** data included stakeholder interviews,observations and documentary *** data included routine data on sputum testing andTB *** were inductively analysed and mapped onto the seven CICI contextual ***:Delayed diagnosis was caused by interactions between fragmented healthcare provision;limited resources;verticalised care;poorTB screening,sputum collection and *** nurse responsible forTB care,with limited integration ofTB with other conditions,and policy focused o

关键词： Tuberculosis Health systems strengthening Primary healthcare Person-centred care Context

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

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World Journal of Diabetes 2017年第1期8卷 18-27页

作者： Kristina S petersen Jennifer B Keogh Peter J Meikle Manohar L garg Peter M Clifton School of Pharmacy and Medical Sciences University of South Australia Baker IDI Heart and Diabetes Institute Nutraceuticals Research group University of NewcastleCallaghan

AIM To determine the clinical and dietary predictors of common carotid artery intima media thickness(CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes. METHODS Participants with type 1(n = 23) and type 2 diabetes(n = 127) had mean and mean maximum CCA IMT measured using B mode ultrasound. Dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maximum CCA IMT were determined using linear regression analysis adjusted for potential confounders. RESULTS The main predictors of mean and mean maximum CCA IMT were age and weight. After multivariate adjustment there were no dietary predictors of CCA IMT. However,in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA IMT after multivariate adjustment. No difference existed in CCA IMT between subjects with type 1 or type 2 diabetes once age was adjusted for. CONCLUSION CCA IMT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA IMT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

关键词： Diabetes Carotid intima media thickness Arterial structure Diet Lipidomics Carotenoids

Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-IR chalcogenide fibers [Invited]

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Chinese Optics Letters 2021年第3期19卷 46-52页

作者： Christian R.petersen Mikkel B.Lotz Christos Markos getinet Woyessa David Furniss Angela B.Seddon Rafael J.Taboryski O.Bang DTU Fotonik Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark DTU Nanolab Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark NORBLIS DK-2830 VirumDenmark Mid-Infrared Photonics group University of NottinghamNottingham NG72RDUK NKT Photonics DK-3460 Bi「ke「0dDenmark

Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(IR) supercontinuum laser.

关键词： nanoimprint lithography anti-reflection hot imprint chalcogenide glass optical fiber mid-infrared supercontinuum

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疼痛研究中反安慰剂效应量级的Meta分析

中国疼痛医学杂志 2015年第6期21卷 404-405页

作者： g.L.petersen 王晓雷韩奇

1.背景安慰剂效应（placeboeffect）是安慰剂治疗后产生的效应。安慰剂治疗往往会有临床症状改善的口头暗示，因此会令患者期望症状缓解。与之对应的是反安慰剂效应（noceboeffects）。反安慰剂效应最初被用来描述安慰剂治疗的副作用，

关键词：安慰剂效应 Meta分析疼痛症状改善症状缓解治疗副作用