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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Flood basalt hosted palaeosols:Potential palaeoclimatic indicators of global climate change

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geoscience Frontiers 2014年第6期5卷 791-799页

作者： m.R.g.Sayyed Department of geology Poona College (University of Pune)CampPune 411 001MaharashtraIndia

Since continental sediments （in addition to the marine geological record） offer important means of deciphering environmental changes, the sediments hosted by the successive flows of the continental flood basalt provinces of the world should be treasure houses in gathering the palaeoclimatic data. Palaeosols developed on top of basalt flows are potentially ideal for palaeoenvironmental reconstructions because it is easy to determine their protolith geochemistry and also they define a definite time interval. The present paper summarizes the nature of the basalt-hosted palaeosols formed on the flood basalts provinces from different parts of the ~lobe havin~ different ages.

关键词： Continental flood basalts Palaeosols Weathering Palaeoclimates global change

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Impact of carbon paper structural parameters on the performance of a polymer electrolyte fuel cell cathode via lattice Boltzmann method

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Acta mechanica Sinica 2020年第2期36卷 367-380页

作者： m.Nazemian g.R.molaeimanesh Research Laboratory of Automotive Fluids and Structures Analysis Automotive Engineering SchoolIran University of Science and TechnologyTehran 16846-13114Iran

Polymer electrolyte fuel cells(PEFCs)being employed in fuel cell electric vehicles(FCEVs)are promising power generators producing electric power from fuel stream via porous *** of carbon paper gas diffusion layers(gDLs)applying in the porous electrodes can greatly affect the PEFC performance,especially at the cathode side where electrochemical reaction is more *** discover the role of carbon paper gDL structure on the mass transfer properties,different cathode electrodes with dissimilar structural parameters are simulated via lattice Boltzmann method(LBm).3D contours of oxygen and water vapor concentration through the gDL as well as the 2D contours of current density on the catalyst layer are illustrated and *** results indicate that the carbon fiber diameter has a negligible impact on the current density while the impact of carbon paper thickness and porosity is *** fact,increasing of carbon paper thickness or porosity leads to lack of cell performance.

关键词： Polymer electrolyte fuel cell(PEFC) Lattice Boltzmann method(LBm) microstructure reconstruction Carbon paper mass transfer properties

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Singularities of noncompact charged objects

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Chinese Physics B 2013年第3期22卷 192-195页

作者： m.Sharif g.Abbas Department of mathematics University of the PunjabQuaid-e-Azam CampusLahore-54590Pakistan

We formulate a model for noncompact spherical charged objects in the framework of noncommutative field *** Einstein-maxwell field equations are solved with charged anisotropic *** choose matter and charge densities as functions of the two parameters,instead of defining these quantities in terms of the gaussian distribution *** is found that the corresponding densities and the Ricci scalar are singular in origin,whereas the metric is nonsingular,indicating a spacelike *** numerical solution of the horizon equation implies that there are two or one or no horizon（s）,depending on the *** also evaluate the Hawking temperature and find that a black hole with two horizons is evaporated to an extremal black hole with one horizon.

关键词： noncommutative geometry electromagnetic field spacetime singularity

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Phantom Energy Accretion by a Stringy Charged Black Hole

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Chinese Physics Letters 2012年第1期29卷 28-30页

作者： m.Sharif g.Abbas Department of mathematics University of the PunjabQuaid-e-Azam CampusLahore-54590Pakistan

We investigate the dynamical behavior of phantom energy near a stringy magnetically charged black *** this purpose,we derive equations of motion for steady-state spherically symmetric flow of phantom energy onto the stringy magnetically charged black *** is found that phantom energy accreting onto a black hole decreases its ***,the location of the critical points of accretion is explored,which yields a mass to charge *** ratio implies that accretion process cannot transform a black hole into an extremal black hole or a naked singularity,hence cosmic censorship hypothesis remains valid here.

关键词： singularity hence implies

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Thermal instability and dynamic response analysis of a tensioned carbon nanotube under moving uniformly distributed external pressure

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Nano materials Science 2021年第1期3卷 75-88页

作者： A.A.Yinusa m.g.Sobamowo Department of mechanical Engineering University of LagosAkokaLagos StateNigeria

Single-walled carbon nanotubes(SWCNTs)are receiving immense research attention due to their tremendous thermal,electrical,structural and mechanical *** this paper,an exact solution of the dynamic response of SWCNT with a moving uniformly distributed load is *** SWCNT is modelled via the theories of Bernoulli-Euler-thermal elasticity mechanics and solved using Integral *** developed closed-form solution in the present work is compared with existing results and excellent agreements are *** parametric studies show that as the magnitude of the pressure distribution at the surface increases,the deflection associated with the single walled nanotube increases at any mode whilst a corresponding increase in temperature and foundation parameter have an attenuating effect on ***,an increase in the Winkler parameter,as well as a decrease in the SWCNT mass increases its frequency of ***,an increase in the speed of the external agent decreases the total external pressure as a result of the removal of dead *** present work is envisaged to improve the application of SWCNT as nanodevices for structural,electrical and mechanical systems.

关键词： Thermal and moving external uniform pressure Tensioned carbon nanotube Dynamic and stability analysis Integral transform

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Ion acoustic shock and periodic waves through Burgers equation in weakly and highly relativistic plasmas with nonextensivity

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Plasma Science and Technology 2017年第1期19卷 7-19页

作者： m g HAFEZ N C ROY m R TALUKDER m HOSSAIN ALI Department of of Applied mathematics University of Rajshahi Rajshahi-6205 Bangladesh Department of mathematics Chittagong University of Engineering and Technology Chittagong-4349Bangladesh Plasma Science and Technology Lab Department of Applied Physics and Electronic EngineeringUniversity of Rajshahi Rajshahi-6205 Bangladesh

A comparative study is carried out for the nonlinear propagation of ion acoustic shock waves both for the weakly and highly relativistic plasmas consisting of relativistic ions and qdistributed electrons and *** Burgers equation is derived to reveal the physical phenomena using the well known reductive perturbation *** integration of the Burgers equation is performed by the（g￠/g）-expansion *** effects of positron concentration,ion–electron temperature ratio,electron–positron temperature ratio,ion viscosity coefficient,relativistic streaming factor and the strength of the electron and positron nonextensivity on the nonlinear propagation of ion acoustic shock and periodic waves are presented graphically and the relevant physical explanations are provided.

关键词： electron-positron-ion plasmas ion acoustic shock and periodic waves weakly and highly relativistic effects Burgers equation

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The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER mULLA YOUSEF KATIB ASIm m.ALmUgHAmSI DUAA S.ALKHAYAT mOHAmED mOSAAD SAmIR T.ALFOTIH RAWAN ALAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz medical City Madinah42311Saudi Arabia Prince mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNm staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

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The adsorption and corrosion inhibition of 8-hydroxy-7-quinolinecarboxaldehyde derivatives on C-steel surface in hydrochloric acid

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1256-1265页

作者： A.m.Eldesoky S.g.Nozha Engineering Chemistry Department High Institute of Engineering & Technology Al-Qunfudah Center for Scientific Research (QCSR) Al-Qunfudah University College Umm Al-Qura University ministry of Health Domyat Laboratory

The protection influence of 8-hydroxy-7-quinolinecarboxaldehyde derivatives against C-steel corrosion was studied in 2 mol·L^(-1)HCl solutions at 30 °C. measurements were conducted under various experimental conditions using weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy(EIS) and electrochemical frequency modulation(EFm) techniques. These studies have shown that 8-hydroxy-7-quinolinecarboxaldehyde derivatives are very good "green", mixed-type inhibitors. Corrosion rates obtained from both EFm and EIS methods are comparable with those recorded using Tafel extrapolation method, confirming validation of corrosion rates measured by the latter. The inhibitive action of these 8-hydroxy-7-quinolinecarboxaldehyde derivatives was discussed in terms of blocking the electrode surface by adsorption of the molecules through the active centers contained in their structures following Langmuir adsorption isotherm. Quantum chemical method was also employed to explore the relationship between the inhibitor molecular properties and its protection efficiency.

关键词： 8-Hydroxy-7-quinolinecarboxaldehyde derivatives C-steel HCl EFm

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modeling and Simulation of microstructurally Small Crack Formation and growth in Notched Nickel-base Superalloy Component

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Journal of materials Science & Technology 2014年第3期30卷 203-212页

作者： g.m.Owolabi H.A.Whitworth Department of mechanical Engineering Howard University

Studies on microstructurally small fatigue cracks have illustrated that heterogeneous microstructural features such as inclusions, pores, grain size distribution as well as precipitate size distribution and volume fraction create stochasticity in their behavior under cyclic loads. Therefore, to enhance safe-life and damage-tolerance approaches, accurate modeling of the influence of these heterogeneous microstructural features on microstructurally small crack formation and growth from stress raisers is necessary. In this work, computational micromechanics was used to predict the high cycle fatigue of microstructurally small crack formation and growth in notched polycrystalline nickel-base superalloys and to quantify the variability in the driving force for formation and growth of microstructurally small crack from notch root in the matrix with non-metallic inclusions. The framework involves computational modeling to obtain three-dimensional perspectives of microstructural features influencing fatigue crack growth in notched nickel-base superalloys, which accounts for the effects of nonlocal notch root plasticity, loading, microstructural variability, and extrinsic defects on local cyclic plasticity at the microstructure-scale level. This approach can be used to explore sensitivity of minimum fatigue lifetime to microstructures. The simulation results obtained from this framework were calibrated to existing experimental results for polycrystalline nickel-base superalloys.

关键词： microstructuraliy small crack Crystal plasticity Nickel-base superalloy Fatigue life

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