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Field survey and analysis on near-fault severely damaged high-speed railway bridge in 2022 m6.9 menyuan earthquake

Earthquake Engineering and Engineering Vibration 2024年第4期23卷 1043-1055页

作者： Lin Xuchuan liu Fuxiang Shan Wenchen Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster mitigation Ministry of Emergency ManagementHarbin 150080China Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu610000China

The 2022 m6.9 menyuan earthquake caused severe damage to a high-speed railway bridge,which was designed for high-speed trains running at speeds of above 250 km/h and is located right next to the *** of this type have been widely used for rapidly constructing the high-speed railway network,but few bridges have been tested by near-fault devastating *** potential severe impact of the earthquake on the high-speed railway is not only the safety of the infrastructure,trains and passengers,but also economic loss due to interrupted railway ***,a field survey was carried out immediately after the earthquake to collect time-sensitive *** damage to the bridge was carefully investigated,and quantitative analyses were conducted to better understand the mechanism of the bridge *** was found that seismic action perpendicular to the bridge’s longitudinal direction caused severe damage to the girders and rails,while none of the piers showed obvious deformation or *** maximum values of transverse displacement,out-of-plane rotation and twisting angle of girders reached 212.6 cm,3.1 degrees and 19.9 degrees,respectively,causing severe damage to the bearing supports and anti-seismic retaining *** observations provide a basis for improving the seismic design of high-speed railway bridges located in near-fault areas.

关键词： menyuan earthquake field survey high-speed railway bridge near fault seismic damage

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The m^(6)A reader YThDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B

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Journal of genetics and genomics 2024年第2期51卷 208-221页

作者： Yeming Yang Xiaoyan Jiang Junyao Chen Lu liu guo liu Kuanxiang Sun Wenjing liu Xianjun Zhu Qiuyue guan The Sichuan Provincial Key Laboratory for human Disease gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of geriatrics Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072China Qinghai Key Laboratory of Qinghai Tibet Plateau Biological Resources Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China henan Eye Institute Henan Eye HospitalPeople's Hospital of Zhengzhou UniversityHenan Provincial People's HospitalZhengzhouHenan 450003China

Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still elusive. N6-methyladenosine (m^(6)A) modification is the most prevalent internal modification in eukaryotic mRNA. YTh domain containing 2 (YThDC2), an m^(6)A reader protein, has recently been identified as a key player in germline development and human cancer. however, its contribution to retinal function remains unknown. here, we explore the role of YThDC2 in the visual function of retinal rod photoreceptors by generating rod-specific Ythdc2 knockout mice. Results show that Ythdc2 deficiency in rods causes diminished scotopic ERg responses and progressive retinal degeneration. multi-omics analysis further identifies Ppef2 and Pde6b as the potential targets of YThDC2 in the retina. Specifically, via its YTh domain, YThDC2 recognizes and binds m^(6)A-modified Ppef2 mRNA at the coding sequence and Pde6b mRNA at the 5′-UTR, resulting in enhanced translation efficiency without affecting mRNA levels. Compromised translation efficiency of Ppef2 and Pde6b after YThDC2 depletion ultimately leads to decreased protein levels in the retina, impaired retinal function, and progressive rod death. Collectively, our finding highlights the importance of YThDC2 in visual function and photoreceptor survival, which provides an unreported elucidation of IRD pathogenesis via epitranscriptomics.

关键词： Epitranscriptomics N^(6)-methyladenosine(m^(6)A) Inherited retinal dystrophies YThDC2 Retina function Photoreceptor degeneration

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Stress triggering effect on the 2022 honghe m_(S)5.0 earthquake with historical strong earthquakes

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geodesy and geodynamics 2024年第2期15卷 107-113页

作者： mingce Wang Zifeng liu Ruijie Luo Yunnan Earthquake Agency Kunming 650224China School of Earth Sciences Yunnan UniversityKunming 650504China

The 2022 honghe m_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than m_(S)*** elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(m≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 *** seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the honghe *** of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang ***,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings.

关键词： honghe ms5.0 earthquake Coulomb failurestress Stress triggering historical strongearthquakes

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Understanding the Activity Performance of Comets 38P/Stephan-Oterma,64P/Swift-gehrels and C/2017 m4(ATLAS)through Broadband Photometric Observations

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Research in Astronomy and Astrophysics 2024年第8期24卷 147-156页

作者： Xuan Zhang Jin-Zhong liu Le-Tian Wang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-gehrels,and C/2017 m4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and *** extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric *** morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/*** Afρvalues varied between 148.8±0.3 cm for 64P/Swift-gehrels and1118.5±6.2 cm for C/2017 m4(ATLAS)(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity *** mass loss rates were estimated from 328.1 kg s^(-1)for comet 64P/Swift-gehrels to 1395.5 kg s^(-1)for comet C/2017 m4(ATLAS).The color indices of comets 38P/Stephan-Oterma and C/2017 m4(ATLAS)closely resemble the average colors of active short-period comets and active longperiod comets,*** contrast,64P/Swift-gehrels exhibits a significantly bluer hue than typical Jupiter family comets.

关键词： comets general-comets individual(38P/Stephan-Oterma,64P/Swift-gehrels,C/2017 m4(ATLAS))-techniques photometric

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The essential roles of m^(6)A modification in osteogenesis and common bone diseases

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genes & Diseases 2024年第1期11卷 335-345页

作者： Yuxi gu Yidan Song Yihua Pan Jun liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

N6-methyladenosine(m^(6)A)is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding *** affects the fate of the modified RNA,including its stability,splicing,and translation,and plays an important role in post-transcriptional *** play a key role in supporting and pro-tecting muscles and other organs,facilitating the movement of the organism,ensuring blood production,*** diseases such as osteoarthritis,osteoporosis,and bone tumors are serious public health *** processes of bone development and osteogenic differen-tiation require the precise regulation of gene expression through epigenetic mechanisms including histone,DNA,and RNA *** a reversible dynamic epigenetic mark,m^(6)A modifications affect nearly every important biological process,cellular component,and molecular function,including skeletal development and *** recent years,studies have shown that m^(6)A modification is involved in osteogenesis and bone-related *** this review,we summarized the proteins involved in RNA m^(6)A modification and the latest progress in elucidating the regulatory role of m^(6)A modification in bone formation and stem cell direc-tional *** also discussed the pathological roles and potential molecular mech-anisms of m^(6)A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone de-fects and bone diseases.

关键词： Bone diseases m^(6)A modification Osteogenesis Regulatory role Stem cells

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Impact of Co^(2+)substitution on structure and magnetic properties of m-type strontium ferrite with different Fe/Sr ratios

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Chinese Physics B 2024年第10期33卷 427-433页

作者： Yang Sun Ruoshui liu huayang gong Baogen Shen School of Rare Earths University of Science and Technology of ChinaHefei 230026China ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341119China Ningbo Institute of materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China Beijing National Laboratory for Condensed matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Ion substitution has significantly improved the performance of ferrite magnets,and cobalt remains a key area of *** on the mechanism of Co^(2+)in strontium ferrite,especially SrFe_(2n-x)Co_(x)O_(19-d)(n=6.1-5.4;x=0.05-0.20)synthesized using the ceramic method,showed that Co^(2+)preferentially enters the lattice as the Fe/Sr ratio *** results in a decrease in the lattice constants a and c due to oxygen vacancies and iron ion *** impact of Co substitution on morphology is minor compared to the effect of the Fe/Sr *** the Fe/Sr ratio decreases and the Co content increases,the saturation magnetization *** magnetic anisotropy field exhibits a nonlinear change,generally increasing with higher Fe/Sr ratios and Co *** changes in the performance of permanent magnets are attributed to the absence of Fe^(3+)ions at the 12k+2a and 2b sites and the substitution of Co^(2+)at the 2b *** suggests that by adjusting the Fe/Sr ratio and appropriate Co substitution,the magnetic anisotropy field of m-type strontium ferrite can be effectively optimized.

关键词： hexaferrite Co substitution Raman spectra magnetic properties

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Rapid report of source parameters of 2023 m6.2 Jishishan,gansu earthquake sequence

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Earth and Planetary Physics 2024年第2期8卷 436-443页

作者： Zhigao Yang Jie liu YingYing Zhang Wen Yang Xuemei Zhang China Earthquake Networks Center Beijing 100045China

The m6.2 earthquake in Jishishan,gansu Province,on December 18,2023,caused extraordinary earthquake *** was located in the northern part of the north−south seismic zone,which is a key area for earthquake monitoring in *** newly built dense strong motion stations in this area provide unprecedented conditions for high-precision earthquake relocation,especially the earthquake focal *** paper uses the newly built strong motion and traditional broadband seismic networks to relocate the source locations of the m3.0 and above aftershocks and to invert their focal *** horizontal error of earthquake location is estimated to be 0.5−1 km,and the vertical error is 1−2 *** focal depth range of aftershocks is 9.6−14.6 km,distributed in a 12-km-long strip with SSE *** in the south are more concentrated horizontally and vertically,while aftershocks in the north are more *** focal mechanisms of the main shock and aftershocks are relatively consistent,and the P-axis orientation is consistent with the regional strain *** is a seismic blank area of m3.0 and above,about 3−5 km between the main shock and *** is suggested that the energy released by the main shock rupture is concentrated in this *** on the earthquake location and focal mechanism of the main shock,it is inferred that the Northern Lajishan fault zone is the seismogenic structure of the main shock,and the main shock did not occur on the main fault,but on a secondary *** initial rupture depth and centroid depth of the main shock were 12.8 and 14.0 km,*** source rupture depth may not be the main reason for the severe earthquake disaster.

关键词： Jishishan earthquake earthquake relocation focal mechanism strong motion data

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Exploring the ultrahigh rolling contact fatigue life of m50 bearing steel by adjusting the cryogenic sequence

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Journal of materials Science & Technology 2024年第2期169卷 243-250页

作者： Xin Cai Xiaoqiang hu Xingyu Lu hongwei liu Yanfei Cao Dianzhong Li Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The influence of different cryogenic sequences on the rolling contact fatigue(RCF)life of m50-bearing steel has been *** results show that direct cryogenic treatment after quenching can effectively improve RCF *** L_(10)life is strikingly 5 times longer than that with cryogenic treatment after *** is caused by the distinct lattice construction of martensite and the transformation of retained *** secondary nanocarbides and fine twins are formed via cryogenic treatment before tem-pering compared with cryogenic treatment after *** improvement in the RCF life of the steel is attributed to the joint effects of the secondary nanocarbides and twin boundaries with a width of 5-13 nm,which delays significantly crack initiation and *** study highlights a common method to improve the service life of high-carbon and high-alloy steels by adjusting the cryogenic se-quence.

关键词： m50 steel Cryogenic treatment Rolling contact fatigue life Carbide Twin

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Epinephrine promotes tumor progression and m2 polarization of tumor-associated macrophages by regulating the TRIm2-NF-kB pathway in colorectal cancer cells

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genes & Diseases 2024年第4期11卷 141-144页

作者： Zhengyi liu Chenxing Jian Wenzheng Yuan guiqing jia Donghui cheng Yanzhuo liu Yanling Zhang Bin Zhang Zili Zhou gaoping Zhao Department of Breast Surgery Henan Provincial People's HospitalThe People's Hospital of Zhengzhou UniversityThe People's Hospital of Henan UniversityZhengzhouHenan 450003China microbiome Laboratory Henan Provincia People's Hospital Zhengzhou University People's HospitalZhengzhouHenan 450000China Department of gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of gastrointestinal Surgeryll Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of gastrointestinal Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of hepatobiliary Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor *** the tumor microenvironment,tumor-associated macrophages(TAms)receive different stimuli and can be polarized into classically activated m1 macrophages and alternatively activated m2 *** studies have indicated that the polarization of TAms is closely related to tumor progression.

关键词： nephrin tumor inflammation

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AZgP1P2/UBA1/RBm15 Cascade mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPm1 m6A modification

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Research 2024年第3期6卷 151-167页

作者： hong Wang Jj liu Xiaojun Zhu Bin Yang Zuping he Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of model Animals and Stem Cell Biology in hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZgP1P2,a pseudogene of AZgP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZgP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZgP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZgP1P2 could bind to UBA1 and RBm15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBm15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBm15 controlled the mRNA decay of TPm1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZgP1P2 in ***,these results imply that AZgP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBm15-mediated TPm1 mRNA decay in CRPC.

关键词： Prostate TPm1 m6A

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