检索结果-南通市图书馆

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-yian guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Analysis and Inverse Substructuring Computation on Dynamic Quality of Mechanical Assembly

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2016年第3期29卷 539-548页

作者： lü guangqing yi Chuijie FANg Ke Key lab of Disasters Forecast and Control in Engineering of Ministry of Education Jinan University Research Center of Equipment Energy & Environment Qingdao Technological University

Mechanical assembly has its own dynamic quality directly affecting the dynamic quality of whole product and should be considered in quality inspection and estimation of mechanical assembly. Based on functional relations between dynamic characteristics involved in mechanical assembly, the effects of assembling process on dynamic characteristics of substructural components of an assembly system are investigated by substructuring analysis. Assembly-coupling dynamic stiffness is clarified as the dominant factor of the effects and can be used as a quantitative measure of assembly dynamic quality. Two computational schemes using frequency response functions（FRFs） to determine the stiffness are provided and discussed by inverse substructuring analysis, including their applicable conditions and implementation procedure in application. Eigenvalue analysis on matrix-ratios of FRFs before and after assembling is employed and well validates the analytical outcomes and the schemes via both a lumped-parameter model and its analogic experimental counterpart. Applying the two schemes to inspect the dynamic quality provides the message of dynamic performance of the assembly system, and therefore improves conventional quality inspection and estimation of mechanical assembly in completeness.

关键词： mechanical assembly dynamic quality substructuring analysis inverse substructuring assembly-coupling dynamic stiffness

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-yi Wang Yao Hao Zi-Jian Wang Xiu-liang Xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKgROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(Plogical types of appendicitis was different between the two groups(Pl appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;Pl appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;Pl appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

外科医师“非技术性技能”的培养

中华外科杂志 2025年第1期63卷 28-31页

作者：苗毅奚春华南京医科大学附属明基医院胰腺中心南京

外科手术是现代社会中风险性较高的活动之一, 外科医师在此高压环境下不仅需要精湛的技术, 还需具备完善的非技术性技能。非技术性技能不仅涵盖了情境感知、决策制定、沟通与团队合作、领导力、压力管理等关键能力, 还包括纠错反馈循环... 详细信息

外科手术是现代社会中风险性较高的活动之一, 外科医师在此高压环境下不仅需要精湛的技术, 还需具备完善的非技术性技能。非技术性技能不仅涵盖了情境感知、决策制定、沟通与团队合作、领导力、压力管理等关键能力, 还包括纠错反馈循环、情绪智力及适应复杂环境的能力等。这些"软技能"能够帮助外科医师更高效地应对手术中的突发状况, 优化团队协作, 确保患者安全, 并提高手术的成功率。欧美国家已将非技术性技能纳入医师的培训体系, 而在国内对此仍有待进一步重视和推广。通过建立完善的非技术性技能评估标准和系统化的培训体系, 能够提升外科医师的综合素质, 进而保障患者安全、提升临床效果, 实现外科医师的职业使命。

关键词：教育, 医学专业, 外科非技术性技能医师

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于阻尼减振材料下拖拉机车身轻量化设计

农机化研究 2025年第1期47卷 253-257页

作者：易小兰肖红吉利学院四川简阳641423 四川城市职业学院成都610101

由于农业生产环境恶劣,拖拉机在使用过程中振动和车内噪声对驾驶员的舒适性和工作效率产生负面影响,而阻尼材料能够将振动能量转化为其他形式的能量,从而减少振动的幅度和传递,同时也可以在不减少机械结构强度和稳定性的前提下减少结构... 详细信息

由于农业生产环境恶劣,拖拉机在使用过程中振动和车内噪声对驾驶员的舒适性和工作效率产生负面影响,而阻尼材料能够将振动能量转化为其他形式的能量,从而减少振动的幅度和传递,同时也可以在不减少机械结构强度和稳定性的前提下减少结构质量。为此,以拖拉机车身轻量化设计为研究对象,提出一种新兴液态可喷涂型阻尼隔音材料(liquid Apply Sound Deadener,lASD),探讨了轻量化设计在减振性能和结构强度之间的平衡,并基于拖拉机车身静态刚度、动态刚度和侧面碰撞安全性能,采用近似模型优化方法进行轻量化设计。结果表明:采用阻尼减振材料可以显著降低拖拉机车身质量4.2%,显著降低拖拉机车身的振动幅度,并改善驾驶员的舒适性和工作效率。研究结果可为提高农业机械性能和驾驶员舒适性提供一种有效途径,具有实际应用前景。

关键词：拖拉机车身轻量化阻尼减振环保

维普期刊数据库博看期刊

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying ge Tian Yu-Xuan Xiao yi lu Si-Ming Wu Wei geng ling Shen Xiao-Yu Yang State Key laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

领导倾听内涵及其多层次效应

心理科学进展 2025年第1期33卷 25-41页

作者：刘庚韩翼卢俊阳江西农业大学经济管理学院南昌330045 中南财经政法大学工商管理学院武汉430073 江西师范大学历史文化与旅游学院南昌330022

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次... 详细信息

面对错综复杂和快速变化的商业环境,组织要想做出快速响应,领导者的有效倾听显得非常重要。通过文献综述发现,现有研究尚未对领导倾听的概念形成统一界定,且理论视角和研究层次较为单一,这不利于我们深入理解领导倾听的内涵及其多层次效应。事实上,作为一种领导行为,领导倾听不仅会对领导者自身产生影响,而且会给团队及其下属带来影响。因此,本研究基于二元互动情境,从沟通信息和支持员工两方面对领导倾听的内涵进行探索性研究,并从领导力效能的评价对象(领导者、团队、员工)出发,结合多层次、多理论、多研究方法的全景研究范式逐步揭示领导倾听对不同对象的不同效应、黑箱机制及边界条件。本研究不仅开拓了倾听研究的新思路和新视角,而且为企业增强领导倾听的积极效能提供了管理启示。

关键词：领导倾听领导力效能领导工作绩效团队追随行为员工建言

维普期刊数据库博看期刊

Quantum Mechanics Version of Wavelet Transform Studied by Virtue of IWOPTechnique

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2004年第5期41卷 681-684页

作者： FANHong-yi lǖJian-Feng DepartmentofPhysics ShanghaiJiaoTongUniversityShanghai200030China

Using the technique of integral within an ordered product (IWOP) of operators we show that the wavelet transform can be recasted to a matrix element of squeezing-displacing operator between the mother wavelet state vector and the state vector to be transformed in the context of quantum mechanics. In this way many quantum optical states'wavelet transform can be easily derived.

关键词： wavelet transform IWOP technique squeezing-displacing operator