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MSATSI:结合可靠经典方法的新简化用户处理及可视化工具的应力反演MATLAB软件包

世界地震译丛 2014年第4期45卷 34-45页

作者： P.Martínez-garzón g.kwiatek M.Ickrath M.Bohnhoff 崔华伟防灾科技学院

根据地震震源机制估计应力场方向是理解地壳力学以及地震物理现象的一个相关方法。在全球地震学中，法向应力反演（FSI）是研究与大地震发生相关的构造过程的一个较为成熟的技术（如HardebeckandMi—chael，2004；Yoshidaetal，2012）。

关键词： MATLAB软件包应力场可视化工具经典方法反演用户地震学物理现象

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基于震源机制解反演应力场的一种改进方法

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世界地震译丛 2020年第2期51卷 161-184页

作者： P.Martínez-garzón Y.Ben-Zion N.Abolfathian g.kwiatek M.Bohnhoff 李振月(译) 李泽潇(译) 万永革(校) 不详中国地震局地球物理研究所防灾科技学院

本文发展了基于震源机制解反演二维或三维背景应力场方位和主应力相对大小R的一种可靠的、高精度的方法。所使用的震源机制解剔除了可能受到局部应力场的强烈影响、不能反映大尺度背景构造应力场信息的事件。去丛集后的数据利用k均值算... 详细信息

本文发展了基于震源机制解反演二维或三维背景应力场方位和主应力相对大小R的一种可靠的、高精度的方法。所使用的震源机制解剔除了可能受到局部应力场的强烈影响、不能反映大尺度背景构造应力场信息的事件。去丛集后的数据利用k均值算法分为若干包含最少地震个数N min到2 N min的组。人工实验测试表明,当R≈0.5时,N min≈30才能保证不同应力体系包含不同噪声水平的情况下得到稳定的结果;当R接近于0或1时,则需要N min≈45。另外的一个实验比较了两种从震源机制解中选择断层面方法的表现:(a)选择震源机制的滑动矢量和应力张量给出的剪应力矢量之间角度最小的那个节面;(b)给定应力场和摩擦系数,选择失稳系数最大的节面,它更接近最优断层。结果发现,失稳准则在所有试验的不同应力体系、主应力相对大小、噪声水平的情况下得到的结果更准确。本文改进的方法将失稳准则迭代选择断层面和加入阻尼迭代反演各震源机制分组的应力场相结合。加入阻尼反演得到的各分区应力场结果中融合了相邻区域的应力场信息,能够得到不受分区影响的高精度结果。本文方法的一些特征在基于南加州圣哈辛托断裂带震源机制解的研究中得到体现。

关键词：震源机制解南加州断层面应力场失稳准则噪声水平应力张量迭代反演

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Polarization effect in tip-enhanced infrared nanospect- roscopy studies of the selective Y5 receptor antagonist Lu AA33810

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Nano Research 2018年第8期11卷 4401-4411页

作者： Natalia Piergies Ewa Pinta Czestawa Paluszkiewicz Helena Domin Wojciech M.kwiatek Institute of Nuclear Physics Polish Academy of Sciences PL-31342 Krakow Poland Institute of Pharmacology Polish Academy of Sciences Department of Neurobiology 31-343 Krakow Smetna Street 12 Poland Natalia Piergies and Ewa Pieta contributed equally to this work.

A novel approach of combining conventional infrared spectroscopy （IR） and atomic force microscopy （AFM） is presented to better understand the behavior of a drug adsorbed on a metal substrate at the nanoscale level. Tip-enhanced infrared nanospectroscopy （TEIRA） was used for the first time to investigate Lu AA33810, a selective brain-penetrating Y5 receptor antagonist, after immobilization on gold nanopartides （gNPs）. Here, a gold coated AFM tip and gold substrate were used to obtain the near-field electromagnetic field trapping effect. Because of the huge signal enhancement, it was possible to obtain the spectral information regarding the self-assembled monolayer of the investigated molecule. The effect of two orthogonal polarizations （p- and s-polarization modulations） of the excitation laser beam on the spectral patterns is also discussed. The results show that there is a strong relationship between the state of polarization of the incident radiation and the relative infrared band intensities. Another factor affecting the observed spectral differences is the topology of the metal substrate, which may result in the induction of a cross-polarization effect. The performed analysis indicates that the C--C bond from the cyclohexyl group is oriented almost parallel to the metal surface. Conversely, the p- and s-polarized spectral variations suggest that the O=S---O angle is high enough to enable the simultaneous interaction of both oxygen atoms with the gNPs.

关键词： tip-enhanced infrared nanospectroscopy polarization modulation Y5 receptor antagonist gold nanoparticles adsorption

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Nanoscale image of the drug/metal mono-layer interaction:Tapping A FM-IR investigations

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Nano Research 2020年第4期13卷 1020-1028页

作者： Natalia Piergies Alexandre Dazzi Ariane Deniset-Besseau Jeremie Mathurin Magdalena Ocwieja Czeslawa Paluszkiewicz Wojciech M.kwiatek Institute of Nuclear Physics Polish Academy of SciencesPL-31342 KrakowPoland Laboratoire de Chimie Physique(LCP) CNRS UMR 8000Univ.of Paris-SudUniversite Paris-Saclay91405 OrsayFrance Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Niezapominajek 8PL-30239 KrakowPoland

The application of metal nanoparticles as an efficient drug delivery system is one of the directions of cancer therapy ***,this strategy requires precise information about how the drug interacts with the applied *** this study,atomic force microscopy combined with infrared spectroscopy(AFM-IR)was used for the first time to investigate the erlotinib adsorption structure on two different types of 15 nm metal nanoparticle mono-layers,namely,silver nanoparticle(AgNP)and gold nanoparticle(AuNP)*** the metal nanoparticles are loosely bound samples,only the tapping AFM-IR mode is suitable for the collection of IR maps and spectra for such a *** obtained results indicated the relevance of the AFM-IR technique for characterizing drug interactions with a metal mono-layer *** investigated drug interacts with the AgNPs mainly through phenyl rings and methoxy moieties,while quinazoline,amino,and ethoxy moieties appear to be farther from the *** the AuNPs,the interaction occurs through both the phenyl ring and the quinazoline ***,the aliphatic groups of erlotinib directly participate in this *** novelty of the present work is also related to the use of the tapping AFM-IR mode to study metal NP mono-layers with a drug adsorbed on *** collected IR maps for the most enhanced erlotinib bands show specific areas with very high signal *** connection between these areas and the"hot spots"typical for the surface plasmon resonance phenomenon of metals is considered.

关键词： metal nanoparticle mono-layer drug's adsorption infrared nanospectroscopy atomic force microscopy erlotinib

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Distal small bowel motility and lipid absorption in patients following abdominal aortic aneurysm repair surgery

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World Journal of gastroenterology 2006年第4期12卷 582-587页

作者： Robert J Fraser Marc Ritz Addolorata C Di Matteo Rosalie Vozzo Monika kwiatek Robert Foreman Brendan Stanley Jack Walsh Jim Burnett Paul Jury John Dent Department of Medicine University of AdelaideSouth Australia Department of gastroenterology Royal Adelaide HospitalAdelaide South Australia Vascular Unit Royal Adelaide Hospital AdelaideSouth Australia gastrointestinal Investigation Unit Repatriation General Hospital Daw Park South Australia Vascular Unit Repatriation General Hospital Daw Park SouthAustralia

AIM： To investigate distal small bowel motility and lipid absorption in patients following elective abdominal aortic aneurysm （AAA） repair surgery, METHODS： Nine patients （aged 35-78 years; body mass index （BMI） range： 23-36 kg/m2） post-surgery for AAA repair, and seven healthy control subjects （20-50 years; BMI range： 21-29 kg/m^2） were studied, Continuous distal small bowel manometry was performed for up to 72 h, during periods of fasting and enteral feeding （Nutrison）. Recordings were analyzed for the frequency, odgin, length of migration, and direction of small intestinal burst activity. Lipid absorption was assessed on the first day and the third day post surgery in a subset of patients using the ^13C-triolein-breath test, and compared with healthy controls. Subjects received a 20-min intraduodenal infusion of 50 mL liquid feed mixed with 200μL ^13C-triolein. End-expiratory breath samples were collected for 6 h and analyzed for ^13CO2 concentration. RESULTS： The frequency of burst activity in the proximal and distal small intestine was higher in patients than in healthy subjects, under both fasting and fed conditions （P〈 0.005）. In patients there was a higher proportion of abnormally propagated bursts （71% abnormal）, which began to normalize by d 3 （25% abnormal） *** absorption data was available for seven patients on d 1 and four patients on d 3 post surgery. In patients, absorption on d 1 post-surgery was half that of healthy control subjects （AUC ^13CO2 1323±244 vs 2646±365; P〈0.05, respectively）, and was reduced to the one-fitch that of healthy controls by d 3 （AUC ^13CO2 470±832 vs 2646±365; P〈 0.05, respectively）. CONCLUSION： Both proximal and distal small intestinal motor activity are transiently disrupted in critically ill patients immediately after major surgery, with abnormal motility patterns extending as far as the ileum. These motor disturbances may contribute to impaired absorption of enteral nutrition, especially when intralumi

关键词： Critical illness Small intestine Motility Lipid absorption

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