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INNOVATIVE SURgICAL MANAgEMENT OF NEOVASCULAR gLAUCOMA

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国际眼科杂志 2003年第1期3卷 120-120页

作者： g.K.krieglstein University Eye Hospital Cologne Germany

A brief introduction on the essentials of etiology/pathophysiology of neovascular glaucoma precedes a review on the surgical op- tions to treat this low prognosis form of secondary glaucoma including the pros and cons... 详细信息

关键词：新生血管性青光眼手术管理改进病理引流

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克隆病的外科治疗

德国医学 1998年第4期15卷 228-229页

作者： g.Schürmann C.krieglstein C.Herfarth 张林 Klinik und Poliklinik für Allgemeine Chirurgie der Universitt Waldeyerstr. 1 D-48149 Mǜnster Germany 同济医科大学附属同济医院

克隆病是一种自发性慢性炎症性肠病,由 Crohn等于1932年据52例病例首次报道。克隆病的流行病学特点:好发于西方工业化国家,妇女发病高于男性1.5倍,好发于30多岁。在欧洲克隆病的发生据4～6位,每100 000人中有50～100人发病。克隆病可侵... 详细信息

克隆病是一种自发性慢性炎症性肠病,由 Crohn等于1932年据52例病例首次报道。克隆病的流行病学特点:好发于西方工业化国家,妇女发病高于男性1.5倍,好发于30多岁。在欧洲克隆病的发生据4～6位,每100 000人中有50～100人发病。克隆病可侵袭整个消化道,好发部位为末端回肠。肉眼观见肠粘膜疱疹样溃疡。

关键词：克隆病外科手术适应证疗效

0.005%拉坦前列素对青光眼房水流动及排出的影响:双盲、安慰剂对照临床研究

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 26-27页

作者： Dinslage S. Hueber A. Diestelhorst M. krieglstein g.K. 陈立军 Department of Ophthalmology University of CologneJoseph-Stelzmann-Strasse 9 50924 CologneGermany

Background: Fluorophotometry and pneumotonography were performed to investigat e the effect of Latanoprost 0.005%and Placebo on aqueous humor flow and total o utflow facility in human glaucomatous eyes. Methods: In a randomised doubleblind clinical study patients with POAg and OHT received either latanoprost 0.005%or placebo once in the evening. Fluorophotometry (Fluorotron Master II, Ocumetrics ) and Pneumatonography (Model 30 Classic Pneumatonometer,Mentor) was performed i n 20 eyes of 10 patients (verum) and 22 eyes of 11 patients (placebo). During a 2 week wash-out period all patients received a systemic antiglaucomatous therap y (Acetazolamide) up to 3 days before baseline measurement. Patients with an IOP higher than 28 mmHg at baseline were excluded. Fluorophotometry, tonography and IOP were measured at baseline after 1 and 2 weeks of treatment. Data was analys ed by the Students paired test. Results: All patients completed the protocol. The IOP significantly decreased (25%) after 1 and 2 weeks of treatment with Lat anoprost (P groups. Although tonographic mean C values in both groups did not show any difference over time, the estimated total outflow facility C (goldmann) increased significantly (P gnificant difference of out flow coefficient correlated to normal pressure (PO/C) was found after 2 weeks of treatment with Latanoprost (P groups showed no increase or decrease in aqueous humor dynamics as proved in many previous studies. The know n effect of Latanoprost to increase uveoscleral outflow by remodeling extracellu lar matrix and widening intermuscular spaces in the ciliary body may not be dete cted by pneumatonography after 2 weeks of tr

关键词：拉坦眼房水房水流畅系数眼压描记眼压测量基础眼压安慰剂对照气体眼压计高眼压症小梁网

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《葡萄膜炎和免疫性疾病》

国外医学情报 2006年第11期27卷 47-47,11页

作者： krieglstein, g. K. Weinreb, R. N. Pleyer, U. Mondino, B. 张承芬（译）不详中国医学科学院北京协和医院眼科

内容评介：德国著名的Springer出版社出版了一套《眼科必读丛书》，该丛书共有八卷，每卷一个专题，本书是该丛书的第三卷。过去十年里，对葡萄膜炎和免疫性疾病，特别是免疫发病机理和免疫遗传学的研究有了惊人的进展。本书将为临床医... 详细信息

内容评介：德国著名的Springer出版社出版了一套《眼科必读丛书》，该丛书共有八卷，每卷一个专题，本书是该丛书的第三卷。过去十年里，对葡萄膜炎和免疫性疾病，特别是免疫发病机理和免疫遗传学的研究有了惊人的进展。本书将为临床医生提供诊断、治疗以及最新的有关上述疾病的研究资料。本书共分十七章，包括：慢性免疫性眼病，干眼泪器系统的炎症；眼结瘢性天疱疮；

关键词：免疫性疾病葡萄膜炎免疫发病机理免疫遗传学免疫性眼病内容评介临床医生研究资料

PRIMARY TRABECULECTOMY WITH LOW -DOSE POST -OPERATIVE MITO-MYCIN

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国际眼科杂志 2003年第1期3卷 9-9页

作者： H.F.Mietz P.C.Jacobi g.Welsandt g.K.krieglstein University of Cologne GermanyUniversity of Cologne GermanyUniversity of Cologne GermanyUniversity of Cologne Germany

Objective: To assess the efficacy of a new application technique of mitomycin to enhance the outcome of filtering surgery in cases of uncontrolled glaucoma in eyes without previous filtering surgery. Methods: We performed a prospective, randomized clinical trial. Forty-two consecutive patients scheduled for glaucoma surgery in one large surgical center were included on a consecutive basis. Patients underwent routine trabeculectomy.

关键词：小梁切除术青光眼术后丝裂霉素低剂量用药

THE ROLE OF METALLOPROTEINASES IN THE PROCESS OF WOUND HEALINg FOLLOWINg FILTERINg PROCEDURES FOR gLAUCOMA

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国际眼科杂志 2003年第1期3卷 14-14页

作者： g.Welsandt A.Hueber g.Welsandt A.Hueber N.Kociok J.M.Esser A.M.Joussen g.K.krieglstein H.Mietz Department of Anterior Segment Surgery Department of Anterior Segment SurgeryDepartment of Vitreo-Retinal Surgery Center of Ophthalmology University of Cologne Germany

Purpose: Metalloproteinases (MMP) and their inhibitors (TIMP) are essential for assembly and remodelling of fibrous tissue all over the body. We aimed to detect different MMPs and TIMPs in Tenon fibroblasts to determine the presence of this mechanism in the human conjunctiva If it is possible to use the MMP and TIMP system to prevent permanent tissue alterations, this would possibly have an impact on future filtering surgery.

关键词： MMPs in of TIMPs THE ROLE OF METALLOPROTEINASES IN THE PROCESS OF WOUND HEALINg FOLLOWINg FILTERINg PROCEDURES FOR gLAUCOMA

大疱性角膜病变作为使用丝裂霉素C小梁切除术后并发症

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 45-45页

作者： Mietz H. Roters S. krieglstein g.K. 邢咏新 Aschaffenburg Eye Center Elisenstrasse 32 63739 Aschaffenburg Germany

Background: The routine use of mitomycin C to enhance glaucomatous filtering surgery has found wide acceptance. Complications of the application of mitomycin C have been repeatedly noticed. We now report a previously undescribed complication showing a toxic effect of mitomycin C to the corneal endothelium. Methods: Patients underwent routine trabe culectomy with mitomycin C. Following surgery, the eyes were examined by biomicroscopy and specular microscopy of the corneal endothelium. Results: In two cases, we observed a partial decompensation of the corneal endothelium resulting in a well-demarcated clear zone of the cornea and a second zone with thickening of the cornea and a bullous keratopathy adjacent to the filtering bleb. The specular microscopy showed marked irregularities of the endothelial cells and areas of necrosis in those parts of the cornea close to the filtering bleb. Conclusions: The two cases described here demonstrate that if the corneal endothelium is already compromised before surgery, the application of mitomycin C may have an additional toxic effect on the endothelium and may result in a partial bullous keratopathy. Surgeons should be aware of this complication.

关键词：丝裂霉素角膜内皮抗癌抗菌素眼前房小梁切除术角膜病变大疱性并发病疾病并发症