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Role of multi-parametric MRI of the prostate for screening and staging:Experience with over 1500 cases

Asian journal of Urology 2017年第1期4卷 68-74页

作者： geoffrey gaunay Vinay Patel Paras Shah Daniel Moreira simon j.Hall Manish A.Vira Michael Schwartz jessica Kreshover Eran ben-Levi Robert Villani Ardeshir Rastinehad Lee Richstone Department of Urology The Smith Institute for UrologyNorthwell HealthNew Hyde ParkNYUSA Department of Urology University of Illinois ChicagoChicagoILUSA Department of Urology&Interventional Radiology Mount Sinai Health SystemNew York CityNYUSA

Objective:Contemporary prostate cancer(PCa)screening modalities such as prostate specific antigen(PSA)and digital rectal examination(DRE)are limited in their ability to predict the detection of clinically significant ***-parametric magnetic resonance imaging(mpMRI)of the prostate has been explored as a staging modality for *** is known regarding its utility as a primary screening *** examined our experience with mpMRI as both a screening and staging ***:mpMRI studies performed between 2012 and 2014 in patients without PCa were cross-referenced with transrectal ultrasonography(TRUS)biopsy *** analyses were performed to determine association of mpMRI findings with overall cancer diagnoses and clinically significant(gleason score≥7)*** analyses were then performed on patients with a history of prior negative biopsy and those without a history of TRUS *** studies were also cross-referenced with RP *** analyses determined predictive ability of extracapsular extension(ECE),seminal vesicle involvement(SVI),and pathologic evidence of clinically significant disease(gleason score7).Results:Four hundred biopsy naive or prior negative biopsy patients had positive mpMRI *** sensitivity,specificity,positive and negative predictive values were 94%,37%,58%,and 87%,respectively and 95%,31%,42%,and 93%,respectively for overall cancer detection and gleason score≥7 *** patients with no prior biopsy history,mpMRI sensitivity,specificity,positive and negative predictive values were 94%,36%,65%,and 82%,for all cancers,and 95%,30%,50%,and 89%for gleason score7 lesions,*** those with prior negative biopsy sensitivity,specificity,positive and negative predictive values were 94%,37%,52%,and 90% for all cancers,and 96%,32%,36%,and 96% for gleason score7 lesions,***-four patients underwent radical prostatectomy(RP)after *** size on mpMRI corr

关键词： Prostate cancer Magnetic resonance imaging Staging Prostatectomy Screening Margins gleason score Novel use

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An efficient strategy enabling solution processable thermally activated delayed fluorescence emitter with high horizontal dipole orientation

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Chinese journal of Structural Chemistry 2024年第2期43卷 4-5页

作者： Zheng Zhao ben Zhong Tang School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangdong518172China

Organic light-emitting diodes(OLEDs)based on highly efficient aggregate emitters present a significant breakthrough in realizing low-cost displays and solid-state lighting,thus drawing considerable research interest i... 详细信息

关键词： emitter breakthrough dipole

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The complexity of sediment recycling as revealed by common Pb isotopes in K-feldspar

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geoscience Frontiers 2018年第5期9卷 1515-1527页

作者： simon P.johnson Christopher L.Kirkland Noreen j.Evans Brad j.McDonald Huntly N.Cutten geological Survey of Western Australia Mineral House100 Plain StreetEast PerthWestern Australia6004Australia Centre for Exploration Targeting-Curtin Node The Institute for Geoscience ResearchDepartment of Applied GeologyWestern Australian School of MinesCurtin UniversityPerthWestern Australia6102Australia john de Laeter Centre The Institute for Geoscience ResearchDepartment of Applied Geology and Applied PhysicsCurtin UniversityPerthWestern Australia6102Australia

Detrital zircon U-Pb geochronology has become the gold standard in evaluating source to sink relationships in sedimentary basins. However, the physical and chemical robustness of zircon, which make it such a useful mineral for provenance studies, is also a hindrance as zircon can be recycled through numerous sedimentary basins, thus obscuring the first cycle source to sink relationship. An elegant approach to addressing this potential issue is to compare the Pb isotope composition of detrital K-feldspar, a mineral which is unlikely to survive more than one erosion-transport-deposition cycle, with that of magmatic K-feldspar from potential basement source terranes. Here we present new in situ Pb isotope data on detrital K-feldspar from two Proterozoic arkosic sandstones from Western Australia, and magmatic K-feldspar grains from potential igneous source rocks, as inferred by the age and Hf isotope composition of detrital zircon grains. The data indicate that the detrital zircon and K-feldspar grains could not have been liberated from the same source rocks, and that the zircon has most likely been recycled through older sedimentary basins. These results provide a more complete understanding of apparently simple source to sink relationships in this part of Proterozoic Western Australia.

关键词： Detrital zircon K-feldspar Pb isotopes Sediment provenance Sediment recycling

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Measurement and Interpretation of Connectivity of Chinese Cities in World City Network,2010

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Chinese geographical Science 2013年第3期23卷 261-273页

作者： ben DERUDDER Peter j TAYLOR Michael HOYLER NI Pengfei LIU Xingjian ZHAO Miaoxi SHEN Wei Frank WITLOX Department of geography Ghent University School of the Built and Natural Environment Northumbria University Department of geography Loughborough University Chinese Academy of Social Sciences Department of geography University of Cambridge South China University of Technology ESSCA School of Management

This is an empirical paper that measures and interprets the position of Chinese cities in the world city network in 2010. Building on a specification of the world city network as a′interlocking network′in which business services firms play the crucial role in city network formation, information is gathered about the presence of global service firms in cities. This information is converted into data to provide the′service value′of a city for a firm′s provision of corporate services in a 526(cities)×175(firms) matrix. These data are then used as the input to the interlocking network model in order to measure cities′connectivity and its predominant geographical orientation. Here we focus on the position of some key Chinese cities in this regard, and discuss and interpret results in the context of the urban dimensions of the′opening up′of the Chinese economy.

关键词： world city network advanced producer services Shanghai Hong Kong Beijing

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Three-dimensional modelling of shear keys in concrete gravity dams using an advanced grillage method

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Water Science and Engineering 2020年第3期13卷 223-232页

作者： Mahdi ben Ftima Steephane Lafrance Pierre Leeger Polytechnique Montreal Montreal University CampusMontrealH3C 3A7Canada

Contraction joint shear keys are resilient features of gravity dams that can be considered to increase the sliding safety factors or minimise seismic residual sliding displacements,allowing costly remedial actions to be *** paper presents a novel,robust,and computationally efficient three-dimensional(3D)modelling and simulation strategy of gravity dams,using a series of adjacent cantilever beam elements to represent individual *** monoliths are interconnected in the longitudinal direction by 3D no-tension link elements representing the lumped shear key stiffness contributions at a particular *** objective is to assess the shear key internal force demands,including the axial force,shear,and moment *** key demand-capacity ratios can then be assessed with related multi-axial failure *** 3D link element stiffness coefficients were derived from a series of 3D finite element(FE)solid models with a detailed representation of geometrical features of multiple shear *** results from the proposed method based on advanced grillage analysis show strong agreement with reference solutions from 3D FE solid models,demonstrating high accuracy and performance of the proposed *** application of the proposed advanced grillage method to a dam model with two monoliths clearly shows the advantage of the proposed method,in comparison to the classical approach used in practise.

关键词： gravity dam Shear keys Seismic analysis grillage analysis Finite element model Multi-scale approach

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jejunal diverticulosis is not always a silent spectator:A report of 4 cases and review of the literature

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World journal of gastroenterology 2008年第38期14卷 5916-5919页

作者： Vishal Arun Patel Helen jefferis ben Spiegelberg Quamar Iqbal Ashish Prabhudesai simon Harris Department of Colorectal Surgery Hillingdon Hospital UxbridgeMiddlesex UB8 3NN United Kingdom

jejunal diverticulosis (jD) is a rare clinical entity. The potential complications of this condition are discussed here through a series of cases presented to our centre. A retrospective analysis of four cases, which were diagnosed and treated, was performed. These included two cases of gastrointestinal haemorrhage, one case of perforation and one case of enterolith obstruction. All of these cases were secondary to jejunal diverticulosis and treated surgically. This was accompanied by a literature search to identify the different modalities for diagnosis and treatment of this condition. jD is rare and may lead to a diagnostic delay. Awareness of the wide spectrum of potential complications can prevent this delay.

关键词： jejunum Diverticulosis gastrointestinal Haemorrhage Perforation Enterolith Obstruction

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A review of dual-spin projectile stability

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Defence Technology（防务技术） 2020年第1期16卷 1-9页

作者： james Norris Amer Hameed john Economou simon Parker Centre for Defence Engineering Cranfield UniversityDefence Academy of the United KingdomShrivenhamSN68LA United Kingdom BAE Systems United Kingdom

This paper gives a succinct review of dual-spinprojectile stability and some technologies relating to *** describes how the traditional stability factors from linear projectile theory are modified to better describe a controlled dual-spin ***,it reviews works which have investigated how different aspects of a controlled dual-spin design can affect flight stability,primarily airframe structure and canard properties.A conclusion is given,highlighting important guidelines from the enclosed discussions.

关键词： guided projectiles Dual-spin gyroscopic Dynamic Stability Canards

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Moving magnesium

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Molecular Plant 2022年第5期15卷 796-798页

作者： Arkadipta Bakshi simon gilroy Department of Botany University of Wisconsin-MadisonBirge Hall430 Lincoln DriveMadisonWI 53076USA

Magnesium is required for multiple processes that are critical for plant growth and *** is an integral component of the chlorophyll molecule,is required for CO_(2) assimilation,acts as a cofactor for numerous enzymes,... 详细信息

关键词： development. magnesium component

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使用cDNA微阵列和组织微阵列对三种上皮性卵巢肿瘤基因表达的分析

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癌症 2004年第7期23卷 771-776页

作者：郑敏 simon R Kononen j Sauter g Mihatsch Mj Moch H 中山大学肿瘤防治中心妇科广东广州510060 瑞士巴塞尔大学病理所

背景与目的卵巢癌是在妇科恶性肿瘤中死亡率最高的肿瘤,主要原因是由于缺乏有效的早期诊断方法。为了发现新的、特异性癌基因和进一步探索上皮性卵巢癌的临床意义,本文探索出一种新方法,通过结合cDNA微阵列和RNA原位杂交冰冻组织微阵列... 详细信息

背景与目的卵巢癌是在妇科恶性肿瘤中死亡率最高的肿瘤,主要原因是由于缺乏有效的早期诊断方法。为了发现新的、特异性癌基因和进一步探索上皮性卵巢癌的临床意义,本文探索出一种新方法,通过结合cDNA微阵列和RNA原位杂交冰冻组织微阵列的方法寻找特异性卵巢癌基因。方法利用cDNA微阵列筛选在3种不同卵巢癌中(卵巢浆液性交界性肿瘤、卵巢浆液性腺癌和卵巢子宫内膜样腺癌)显示有意义表达的基因,并由RNA原位杂交冰冻组织微阵列证实其结果。结果40个基因和ESTs显示出在卵巢浆液性交界性肿瘤、浆液性和子宫内膜样卵巢癌3种类型之间基因表达有明显的差异;EPHB6、PTPRF、gFER、ERg25、PLRP1,FLj22060和WISP2被进一步用于RNA原位杂交冰冻组织微阵列研究,其结果与cDNA微阵列研究结果相符合。结论cDNA微阵列和RNA原位杂交冰冻组织微阵列相结合是一种理想的寻找癌相关基因的方法,EPHB6,PTPRF,gFER,ERg25,PLRP1,FLj22060和WISP2有可能成为新的上皮性卵巢癌候选基因。

关键词：上皮性卵巢癌 cDNA微阵列 RNA原位杂交冰冻组织微阵列

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Surface morphology and electrochemical characterization of electrodeposited Ni-Mo nanocomposites as cathodes for hydrogen evolution

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Chinese Physics B 2015年第10期24卷 559-563页

作者： Elhachmi guettaf Temam Hachemi ben Temam Said benramache Laboratoire de Physique des Couches Minces et Applications Université de Biskra

In this work, we study the influences of current density on surface morphology and electrochemical characterization of electrodeposited Ni-Mo. The Ni-Mo composite coatings are deposited on pretreated copper substrates by electrolytic deposition. The Ni-Mo solution is taken from nickel sulfate fluid and ammonium heptamolybdate with 10 g/l. The Ni-Mo composite coatings are deposited at a temperature of 303 K with an applied current density of j dep= 10 A/dm2-30 A/*** find that the corrosion resistance is improved by incorporating Mo particles into Ni matrix in 0.6-M Na Cl solution. From the potentiodynamic polarization curve of electrodeposited Ni-Mo it is confirmed that the corrosion resistance decreases with increasing applied current density. The x-ray diffraction（XRD） analyses of Ni-Mo coatings indicate three phases of Mo Ni4, Mo1.24Ni0.76, and Ni3 Mo phases crystallites of nickel and molybdenum. The scanning electronic microscopy（SEM） tests indicate that Ni-Mo coatings present cracks and pores.

关键词： Ni-Mo electrolytic deposition corrosion resistance potentiodynamic polarization plating current density

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