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Microstructure and Mechanical Properties of Friction Stir Lap Welded Aluminum Alloy AA2014

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Journal of Materials Science & Technology 2012年第5期28卷 414-426页

作者： S. Babu g.d. Janaki Ram P.V. Venkitakrishnan g. Madhusudhan Reddy K. Prasad Rao dept. of Metallurgical and Materials Engineering Indian Institute of Technology Madras Chennai India Liquid Propulsion Systems Centre Indian Space Research Organisation Tiruvananthapuram India defence Metallurgical Research Laboratory Hyderabad India

Friction stir lap welds were produced in 3 mm thick Alclad sheets of Al alloy 2014-T4 using two different tools （with triangular and threaded taper cylindrical pins）. The effects of tool geometry on weld microstructure, lap-shear performance and failure mode were investigated. The pin profile was found to significantly influence the hook geometry, which in turn strongly influenced the joint strength and the failure mode. Welds produced in alloy 2014-T4 Alclad sheets by using triangular and threaded taper cylindrical tools exhibited an average lap-shear failure load of 16.5 and 19.5 kN, respectively, while the average failure load for standard riveted joints was only 3.4 kN. Welds produced in alloy 2014-T6 Alclad sheets and in alloy 2014-T4 bare sheets （i.e., no Alclad） were comparatively evaluated with those produced in alloy 2014-T4 Alclad sheets. While the welds made （with threaded taper cylindrical tool） in T6 and T4 conditions showed very similar lap-shear failure loads, the joint efficiency of the welds made in T6 condition （43%） was considerably lower （because of the higher base material strength） than those made in T4 condition （51%）. The Alclad layers were found to present no special problems in friction stir lap welding. Welds made with triangular tool in alloy 2014-T4 Alclad and bare sheets showed very similar lap-shear failure loads. The present work provides some useful insights into the use of friction stir welding for joining Al alloys in lap configuration.

关键词： Aluminum alloys Friction stir welding Lap joints Lap-shear testing

Zircon U-Pb geochronology Recorded Late Cretaceous Fluid Activation in the Central Aldan gold Ore district, Aldan Shield, Russia: First data

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Journal of Earth Science 2020年第3期31卷 481-491页

作者： Vasilii i.Leontev Sergey g.Skublov Nadezhda V.Shatova Alexey V.Berezin Faculty of geological Prospecting Saint Petersburg Mining University199106 St.PetersburgRussia institute of Precambrian geology and geochronology of Russian Academy of Sciences 199034 St.PetersburgRussia Karpinsky Russian geological Research institute 199106 St.PetersburgRussia institute of Earth Science St.Petersburg State University199034 St.PetersburgRussia

The gold mineralization in the Central Aldan ore district is genetically related to potassic calc-alkaline and alkaline magmatism dated at 115–150 *** objective of this study is to establish the age of hydrothermal processes that accompanied the formation of Au-Te mineralization at the Samolazovsky *** on the isotope-geochemical study of zircons from quartz-feldspar metasomatic rocks of the deposit,the granitoids and charnokites of the Nimnyr Complex(1900–1960 Ma)at the contact with the Yukhta monzonite-syenite massif(~127 Ma)were *** U-Pb dating was performed on a SHRiMP-ii ion microprobe,and rare-earth and trace elements analyses of zircon were carried out in the same craters by secondary-ion mass spectrometry on a Cameca iMS-4f ion *** is revealed that the studied zircons have heterogeneous structures:dark core and lighter rim,which differ greatly in isotope-geochemical *** rims are cut by a network of fractures,extending into the central part of zircon *** rims yield a subconcordant age of 1937±24 Ma,with an average total REE content of 550 ppm,which corresponds to the formation age of the Nimnyr *** zircon cores yield a discordant age of 83±11 Ma and are characterized by a higher total REE content(~1812 ppm),as well as higher contents of U and non-formula elements(Ca,Sr,and Y)with respect to rims,due to the effect of fluid on *** the limited number of zircon grains,the additional geochronological study of zircons from syenites of the ore-bearing Ryabinovy Massif has revealed the presence of two distinct age clusters:~125–138 and 76–83Ма.The older ages of zircons from syenites are typical for the Central Aldan ore *** now,there is still no explanation for an age range(76–83 Ma)of single zircon grains from ore-bearing syenites of the Ryabinovy *** obtained data suggest that the processes of activation(the effect of fluid)within the Central Aldan ore district continued unt

关键词： U-Pb geochronology REE geochemistry zircon Samolazovskoe deposit Ryabinovoe deposit Aldan Shield

Clinical-based phenotypes in children with pediatric post-COVid-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud i.Abdel-Aziz Johannes B.van goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro department of Pediatric pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands department of pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands department of Paediatric pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVid-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVid symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVid symptoms in children.

关键词： Adolescents Clusters Long COVid Pediatric Phenotypes Post-COVid syndrome

5-methoxytryptophan induced apoptosis and Pi3K/Akt/FoxO3a phosphorylation in colorectal cancer

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World Journal of gastroenterology 2023年第47期29卷 6148-6160页

作者： Tian-Lei Zhao Yue Qi Yi-Fan Wang Yi Wang Hui Liang Ya-Bin pu department of general Surgery Naval Medical Center of PLAShanghai 200052China department of gastroenterology Naval Medical Center of PLAShanghai 200052China

BACKgROUNd Colorectal cancer(CRC)is a highly prevalent malignancy worldwide,and new therapeutic targets urgently need to be found to prolong patient survival.5-methoxytryptophan(5-MTP)is a tryptophan metabolite found in animals and ***,the effects of 5-MTP on proliferation and apoptosis of CRC cells are currently *** To investigate the effects of 5-MTP on the proliferation,migration,invasion,and apoptosis abilities of CRC ***,we seek to explore whether 5-MTP has the potential to be utilized as a drug for the treatment of *** in order to evaluate the effect of 5-MTP on CRC cells,a series of experiments were conducted for *** formation assay and Cell Counting Kit 8 assays were used to investigate the impact of 5-MTP on the proliferation of CRC cell *** cycle assays were employed to examine the effect of 5-MTP on cellular *** addition,we investigated the effects of 5-MTP on apoptosis and reactive oxygen species in HCT-116 *** obtain a deeper understanding of how 5-MTP affects CRC,we conducted a study to examine its influence on the Pi3K/Akt signaling pathway in CRC *** This article showed that 5-MTP promoted apoptosis and cell cycle arrest and inhibited cell proliferation in CRC *** many articles,it has been reported that Pi3K/Akt/FoxO3a signaling pathway is one of the most important signaling pathways involved in internal regulating cell proliferation and differentiation. Nevertheless, 5-MTP combined with Pi3K/Akt/FoxO3a signaling pathway inhibitors significantly promotedapoptosis and cell cycle arrest and inhibited cell proliferation in CRC cells compared with 5-MTP alone in ***, there is strong evidence that 5-MTP can be used as an effective medicine for CRC treatment.

关键词： Colorectal cancer 5-methoxytryptophan Apoptosis Cell cycle arrest Pi3K/Akt signaling pathway

improving surface integrity when drilling CFRPs and Ti-6Al-4V using sustainable lubricated liquid carbon dioxide

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Chinese Journal of Aeronautics 2023年第7期36卷 129-146页

作者： in˜igo ROdRigUEZ Pedro Jose´ARRAZOLA Mikel CUESTA Luka STERLE Franci puSˇAVEC Faculty of Engineering Mondragon UnibertsitateaArrasate-Mondragon 20500Spain Faculty of Mechanical Engineering University of LjubljanaLjubljana 1000Slovenia

in the quest for decreasing fuel consumption and resulting gas emissions in the aeronautic sector,lightweight materials such as Carbon Fiber Reinforced Polymers(CFRPs)and Ti-6Al-4V alloys are being *** materials,with excellent weight-to-strength ratios,are widely used for structural applications in aircraft *** date,several studies have been published showing that the use of metalworking fluids(MWFs),special tool geometries,or advanced machining techniques is required to ensure a surface quality that meets aerospace component *** MWFs pose a number of environmental and worker health hazards and also degrade the mechanical properties of CFRPs due to water absorption in the ***,a transition to more environmentally friendly cooling/lubrication techniques that prevent moisture problems in the composite is *** research shows that lubricated LCO_(2) is a viable option to improve the quality of drilled CFRP and titanium aerospace components compared to dry machining,while maintaining clean work *** results show that the best combination of tool geometry and cooling conditions for machining both materials is drilling with Brad point drills and lubricated LCO_(2).drilling under these conditions resulted in a 90%improvement in fiber pullout volume compared to dry machined CFRP *** addition,a 33% reduction in burr height and a 15% improvement in surface roughness were observed compared to dry drilling of titanium.

关键词： Carbon fibers Cryogenics green manufacturing Machining Solid lubricants Surface morphology Titanium alloys

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犬细小病毒样颗粒的制备及免疫原性分析

中国兽医科学 2024年第1期54卷 19-25页

作者：王傲陈欢苗雨润赵普李家俊郑龙三戴建君印春生钱莺娟南京农业大学动物医学院教育部动物健康与食品安全国际合作联合实验室江苏省外国专家工作室江苏南京210095 中国兽医药品监察所北京100081

犬细小病毒病是由犬细小病毒(canine parvovirus,CPV)引起犬的一种急性、高度传染性和致死性的病毒性疾病。该病主要通过接种疫苗预防,没有特效治疗方法。为了制备犬细小病毒样颗粒(virus like particles,VLPs),本研究通过杆状病毒表达... 详细信息

犬细小病毒病是由犬细小病毒(canine parvovirus,CPV)引起犬的一种急性、高度传染性和致死性的病毒性疾病。该病主要通过接种疫苗预防,没有特效治疗方法。为了制备犬细小病毒样颗粒(virus like particles,VLPs),本研究通过杆状病毒表达系统表达CPV VP2蛋白。将表达后的蛋白经过蔗糖密度梯度离心法纯化后,负染色处理置于透射电子显微镜下观察。结果显示VP2蛋白组装成直径25 nm左右的六边形或圆形样VLPs。血凝试验表明,该VLPs可以凝集猪红细胞,血凝价为27。进一步将该VLPs经弗氏佐剂乳化后免疫小鼠,血凝抑制试验结果显示VLPs可诱导小鼠产生211的血凝抑制抗体。因此,通过杆状病毒表达系统表达VP2蛋白,VP2蛋白可在细胞内组装成与病毒粒子类似的VLPs,该VLPs可以诱导小鼠产生血凝抑制抗体,为CPV VLPs疫苗的制备奠定了基础。

关键词：犬细小病毒 VP2蛋白杆状病毒病毒样颗粒

Efficient Humoral and Cellular immune Responses induced by a Chimeric Virus-like Particle displaying the Epitope of EV71 without Adjuvant

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Biomedical and Environmental Sciences 2018年第5期31卷 343-350页

作者： LiANg pu Yi Yao SU Qiu dong QiU Feng FAN Xue Ting LU Xue Xin Bi Sheng Li National institute for Viral disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China institute of infectious diseases Beijing Ditan HospitalCapital Medical UniversityBeijing Key Laboratory of Emerging Infectious DiseasesBeijing 100015China

Objective To eliminate the side effects of aluminum adjuvant and His-tag,we constructed chimeric VLPs displaying the epitope of EV71（SP70） without *** evaluating whether the VLPs could efficiently evoke not only humoral but also cellular immune responses against EV71 without *** The fusion protein was constructed by inserting SP70 into the MiR of truncated HBc Ag sequence,expressed in ***,and purified through ion exchange chromatography and density gradient *** were immunized with the VLPs and sera were collected *** specific antibody titers,ig g subtypes and neutralizing efficacy were detected by ELiSA,neutralization assay,and EV71 lethal ***-γ and iL-4 secreted by splenocytes were tested by ELiSPOT *** HBc-SP70 proteins can self-assemble into empty *** immunization with HBc-SP70 VLPs,the detectable anti-EV71 antibodies were effective in neutralizing EV71 and protected newborn mice from EV71 lethal *** was no significant difference for the immune efficacy whether the aluminum adjuvant was added or *** specific ig g subtypes were mainly igg1 and igg2 b and splenocytes from the mice immunized produced high levels of iFN-γ and *** The fusion proteins without His-tagged was expressed and purified as soluble chimeric HBc-SP70 VLPs without *** the absence of adjuvant,they were efficient to elicit high levels of Th1/Th2 mixed immune response as well as assisted by aluminum ***,the chimeric VLPs have potential to prevent HBV and EV71 infection simultaneously.

关键词： Virus-like particles Enterovirus 71 Neutralizing antibody Humoral and cellular immunity Adjuvant Vaccine

Facile synthesis of chromium chloride/poly(methyl methacrylate) core/shell nanocapsules by inverse miniemulsion evaporation method and application as delayed crosslinker in secondary oil recovery

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Petroleum Science 2023年第1期20卷 396-406页

作者： Jing-Yang pu Keith P.Johnston Ping-Keng Wu Muaaz Ahmad Ming-Liang Luo Na Zhang Ju-Tao He School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Key Laboratory of Unconventional Oil&gas development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina Mcketta department of Chemical Engineering The University of Texas at AustinAustinTX78712USA department of Energy and Mining Engineering Shandong University of Science and TechnologyQingdao266590ShandongChina No.7 Oil Production Plant of PetroChina Changqing Oilfield Branch Qingyang745100GansuChina

Cr(iii)ehydrolyzed polyacrylamide(HPAM)gels have been extensively studied as a promising strategy controlling waste water production for mature ***,the gelation time of the current technologies is not long enough for in-depth *** this study,we report a novel synthesis method to obtain chromium chloride/poly(methyl methacrylate)(PMMA)nanocapsules which can significantly delay the gelation of HPAM through encapsulating the chromium chloride *** chromium chloride-loaded nanocapsules(CreNC)are prepared via a facile inverse miniemulsion evaporation method during which the hydrophobic PMMA polymers,pre-dispersed in an organic solvent,were carefully controlled to precipitate onto stable aqueous miniemulsion *** stable aqueous nanodroplets(W)containing Cr(iii)are dispersed in a mixture of organic solvent(O1)with PMMA and nonsolvent medium(O2)to prepare an inverse *** the evaporation of the O1,PMMA forms CreNCs around the aqueous *** CreNCs are readily transferred into water from the organic nonsolvent *** CreNCs exhibit the tunable size(358-983 nm),Cr loading(7.1%-19.1%),and Cr entrapment efficiency(11.7%-80.2%),with tunable zeta potentials in different PVA *** CreNCs can delay release of Cr(iii)and prolong the gelation time of HPAM up to 27 days.

关键词： Nanocapsules inverse miniemulsion evaporation Chromium chloride crosslinker HPAM gelation Secondary oil recovery

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加氢装置循环氢脱硫塔腐蚀分析

石油化工腐蚀与防护 2024年第5期41卷 25-31页

作者：夏永生张磊苗普张宏飞于凤昌中石化炼化工程(集团)股份有限公司洛阳技术研发中心河南洛阳471003 中国石油化工股份有限公司金陵石化分公司江苏南京210033

加氢过程对提高原油加工深度、产品质量和生产效率至关重要,但加氢生成的H_(2)S会导致后序管道设备产生腐蚀以及循环氢中的氢分压降低,为此常需设置循环氢脱硫塔来脱除循环氢中的H_(2)S。循环氢脱硫塔中存在多种腐蚀介质和腐蚀风险,该... 详细信息

加氢过程对提高原油加工深度、产品质量和生产效率至关重要,但加氢生成的H_(2)S会导致后序管道设备产生腐蚀以及循环氢中的氢分压降低,为此常需设置循环氢脱硫塔来脱除循环氢中的H_(2)S。循环氢脱硫塔中存在多种腐蚀介质和腐蚀风险,该文结合加氢装置工艺特点对循环氢脱硫塔中的腐蚀类型、影响因素和腐蚀控制措施进行了分析和讨论,对某企业渣油加氢装置循环氢脱硫塔现场勘验后发现的腐蚀问题,也进行了分析论证,提出了腐蚀防控措施,从而为加氢装置的安全运行提供了借鉴和技术支撑。

关键词：加氢装置循环氢脱硫塔腐蚀分析腐蚀防控