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难处理金矿浸出预处理过程的FeS_2-FeAsS-h_2O系电位-ph图

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材料与冶金学报 2011年第2期10卷 120-124页

作者：金创石张廷安牟望重曾勇刘燕吕国志蒋孝丽东北大学多金属共生矿生态化利用教育部重点实验室沈阳110819 金策工业综合大学物理化学教研室朝鲜平壤999093

难处理金矿中,金为微细浸染型嵌布在黄铁矿和毒砂的晶格中而不能被充分浸出.本文通过热力学计算绘制了298.15KFeS2-FeAsS-h2O系的电位-ph图,由图可知黄铁矿和毒砂均可以被O2等氧化剂分解.FeAsS的稳定区完全包含在FeS2的稳定区范围内,说... 详细信息

难处理金矿中,金为微细浸染型嵌布在黄铁矿和毒砂的晶格中而不能被充分浸出.本文通过热力学计算绘制了298.15KFeS2-FeAsS-h2O系的电位-ph图,由图可知黄铁矿和毒砂均可以被O2等氧化剂分解.FeAsS的稳定区完全包含在FeS2的稳定区范围内,说明在酸性条件下毒砂比黄铁矿的稳定性差,更容易被分解.当电位及酸度较高时,黄铁矿及毒砂中的硫以稳定的hSO4-、SO42-形式存在,而砷以h3AsO4的形式存在,表明预处理过程能够将包裹在金表面的硫化矿物解离脱除.热力学计算的结果为难处理金矿的浸出预处理过程提供了理论依据.

关键词：难处理金矿预处理电位-ph图黄铁矿毒砂 FeS2-FeAsS-h2O系

Current systematic reviews and meta-analyses of COVID-19

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World Journal of Virology 2021年第4期10卷 182-208页

作者： Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin kim Dawa Ongyal gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura guzman Perez Riki Ranat Carlos gonzalez harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar gondal Sameen hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo Department of Internal Medicine Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States Department of Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt(IDCARE)Cairo 11221Outside of the USEgypt Department of Medicine Division of NephrologyUniversity of Tennessee Health Science CenterKnoxville CityTN 38103United States Department of Medical St.George's UniversityWest Indies 38901Grenada Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11221Egypt Department of Oncology Broomfiled HospitalMid and South Essex NHS Foundation TrustESSEXChelmsford 12422United Kingdom Department of Critical Care Unit Icahn School of Medicine at Mount Sinai/NYC H&H QueensNew YorkNY 11432United States

BACKgROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million *** the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of *** To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be *** We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS *** included studies were extracted from Embase,Medline,and Cochrane *** publication timeframe of included studies ranged between January 01,2020,to October 30,*** that were published in languages other than English were not considered for this systematic *** finalized full-text articles are freely accessible in the public *** Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 *** inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 *** screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and ***,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stro

关键词： Systematic review Meta-analyses COVID-19 Review Coronavirinae

Science:研究鉴定出导致脑细胞死亡的罪魁祸首

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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An george K Umanah hyejin Park Kalyani Nambiar Stephen M Eacker BongWoo kim Lei Bao Maged M harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi Seth Blackshaw heng Zhu hongjun Song guoLi Ming Valina L Dawson Ted M Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology of huashan hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. Solomon h. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for high-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达

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时珍国医国药 2006年第6期17卷 912-913页

作者：柳明洙张学武高圭永金善姬延边大学基础医学院韩国科学技术大学韩国全北大学校医科大学南开大学吉林延吉133000 韩国大田305-701 韩国全州560-180 天津300071

目的探讨血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达,为构建药物筛选的在体模型提供依据。方法采用多聚酶链式反应,扩增了长约280bp的斑马鱼血管发生素-1 cDNA部分序列,作为探针,以原位杂交法测定了... 详细信息

目的探讨血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼早期胚胎发育过程中的表达,为构建药物筛选的在体模型提供依据。方法采用多聚酶链式反应,扩增了长约280bp的斑马鱼血管发生素-1 cDNA部分序列,作为探针,以原位杂交法测定了血管内皮细胞生长因子和血管发生素-1及其相应受体flk-1和Tie-2的表达。结果从受精卵胚胎发育第12小时可见血管内皮细胞生长因子和血管发生素-1及其相应受体flk-1和Tie-2的表达;在受精卵胚胎发育的第16小时,血管内皮细胞生长因子和血管发生素-1主要在头部和尾部胚芽表达;第24小时在眼球、视窝、中脑、后脑的腹前侧和肌节中表达,Tie2和F lk-1主要在肌间背部动脉血管、躯干新生血管芽和轴向静脉中表达。结论血管内皮细胞生长因子和血管发生素-1及其受体在斑马鱼胚胎发育早期的血管发生过程中可能相互作用,并协调血管发生过程。斑马鱼是研究胚胎发育早期微血管发生和血管发生的极佳动物模型,可用于促血管发生或抑制血管发生药物筛选。

关键词：斑马鱼血管发生素-1 血管内皮生长因子受体

Daxx/Atrx复合体在DNA低甲基化细胞中通过提升h3K9三甲基化保护串联重复序列

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科学新闻 2016年第1期 63-63页

作者： Quanyuan he hyeung kim Rui huang Weisi Lu Mengfan Tang Fengtao Shi Dong Yang Xiya Zhang Junjiu huang Dan Liu 松阳洲中山大学生命科学学院

文章简介哺乳动物基因组在漫长的进化过程中由于受到各种病毒的入侵,形成了许多具有重复性序列特征的转座因子(Transposable elements,TEs),主要包括反转录转座子和DNA转座子。尽管这些元件在物种长期的进化过程中丰富了遗传物质的来源... 详细信息

文章简介哺乳动物基因组在漫长的进化过程中由于受到各种病毒的入侵,形成了许多具有重复性序列特征的转座因子(Transposable elements,TEs),主要包括反转录转座子和DNA转座子。尽管这些元件在物种长期的进化过程中丰富了遗传物质的来源,但是对于特定的个体,这些转座因子的表达和随机插入会导致基因组基因的突变,从而引发肿瘤等严重的疾病。

关键词： Daxx/Atrx 低甲基化 h3K9 三甲基化转座因子可移动的遗传因子 DNA 细胞

增强CT检查不会造成肾损伤分子-1和中性粒细胞明胶酶相关脂质运载蛋白的增加

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国际医学放射学杂志 2015年第5期 491-491页

作者： J.Kooiman W.R.Peppel Y.W.J.Sijpkens h.F.h.Brulez P.M.Vries M.A.Nicolaie 李伟 Department of Thrombosis and haemostasis Leiden University Medical Center

摘要目的评价增强CT检查是否会造成慢性肾疾病病人肾损伤分子-1(kim-1)和中性粒细胞明胶酶相关脂质运载蛋白(N-gAL)的分泌量增加。材料与方法病人来自一项使用水化法防止增强后导致的急性肾损伤(CI-AKI)的试验。病人的血液及尿液样本分... 详细信息

摘要目的评价增强CT检查是否会造成慢性肾疾病病人肾损伤分子-1(kim-1)和中性粒细胞明胶酶相关脂质运载蛋白(N-gAL)的分泌量增加。材料与方法病人来自一项使用水化法防止增强后导致的急性肾损伤(CI-AKI)的试验。病人的血液及尿液样本分别于增强CT扫描前、扫描后4～6 h及48～96 h采集。kim-1和N-gAL被换算成尿肌酸酐水平,测量数据结果用中位数表示。结果在所有511例入组

关键词：中性粒细胞明胶酶相关脂质运载蛋白病人肾损伤 AKI CT 分子

聚醚醚酮制作可摘义齿人工牙耐磨性及硬度的研究

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口腔颌面修复学杂志 2018年第4期19卷 236-240页

作者：金智文韩建民刘云松尹祯敏孙玉春叶红强周永胜北京大学口腔医学院·口腔医院修复科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院口腔材料研究室国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院口腔医学数字化中心卫生计生委口腔医学计算机应用工程技术研究中心国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081

目的:比较聚醚醚酮制作的可摘义齿人工牙与两种临床常用的可摘义齿树脂人工牙的耐磨性及硬度。方法:用聚醚醚酮制作可摘义齿人工牙(A组),以普通合成树脂牙(拜耳牙,B组)和复合树脂牙(Endura塑钢牙,C组)为对照进行二体磨耗实验和硬度测试... 详细信息

目的:比较聚醚醚酮制作的可摘义齿人工牙与两种临床常用的可摘义齿树脂人工牙的耐磨性及硬度。方法:用聚醚醚酮制作可摘义齿人工牙(A组),以普通合成树脂牙(拜耳牙,B组)和复合树脂牙(Endura塑钢牙,C组)为对照进行二体磨耗实验和硬度测试。用TCML-II咀嚼模拟疲劳试验机进行磨耗实验,以滑石瓷为对磨物,加载力50N,循环加载30万次,并经5℃/55℃冷热水循环。用口内扫描仪扫描磨耗前后的人工牙形态,计算磨耗前后的体积变化,并用扫描电镜观察其磨耗表面。用显微硬度仪测量人工牙的维氏硬度。结果:三种树脂牙磨耗量分别为A组0.90±0.33 mm^3、B组2.42±0.99 mm^3、C组4.23±1.33 mm^3,三者之间有显著性差异(Phv1/15、B组26.89±1.96 hv1/15、C组35.24±1.90h v1/15,三者之间显著性差异(P<0.05)。结论:相比于普通合成树脂牙和复合树脂牙,PEEK树脂牙具有适中的硬度和良好的耐磨性。

关键词：聚醚醚酮人工牙耐磨性硬度

中国中风患者情绪失控的诊断、发病率及临床表现和影像学的相关性研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 14-14页

作者： Wai K.T. Chan S.S.M. Chiu h.F.K. 江山 Department of Psychiatry Shatin Hospital Shatin N. T. Hong Kong Dr.

Of the few studies published on poststroke emotional incontinence(PSEI), none has investigated a consecutive stroke cohort in a Chinese patient population. The objective of this study was to examine the frequency and the clinical and radiological correlates of PSEI in Chinese stroke patients in hong Kong, Three months after their admission, a psychiatrist interviewed 127 stroke patients who were consecutively admitted to the medical wards of a university affiliated regional hospital. The presence of PSEI was defined according to both kim’ s and house’ s criteria. The frequency of PSEI was 17.9% according to kim’ s criteria and 6.3 % according to house’ s criteria. The kappa between the two sets of criteria was 0.34. Univariate analysis found that PSEI was associated with a younger age, previous history of depression, a higher National Institute of health Stroke Scale total score and cortical infarcts. Multivariate logistic regression suggested that past history of depression and cortical infarcts were independent predictors for PSEI. In conclusion, PSEI is relatively common among Chinese stroke survivors. A previous history of depression or cortical lesions were independent predictors for PSEI. There is a need for a revision of the diagnostic criteria for PSEI.

关键词：中风患者影像学情绪失控中风评分脑中风郁症中国香港地区医院病房大样本研究精神科医师

心肌缺血再灌注损伤中心肌免疫细胞单细胞图谱绘制及具有心肌保护效应的Ym-1hi中性粒细胞的鉴定

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Science Bulletin 2024年第7期69卷 949-967页

作者：董亚兰康真玉张子力张永强周海锋刘艳飞帅欣欣李君仪殷梁青青王埙埙马彦范恒 Feng Jiang 林志豪丁从珠金渊真 Alexey Sarapultsev 李芳菲张戈谢天尹长军程翔罗珊珊刘玥胡德胜 Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Nanjing Drum Tower hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210008China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing 100091China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of International Education Tianjin University of Traditional Chinese MedicineTianjin 300193China Institute of Neuroscience School of MedicineXiamen UniversityXiamen 361102China School of Traditional Chinese Medicine Xiamen University MalaysiaSepang 43900Malaysia School of Medical Biology South Ural State UniversityChelyabinsk 620049Russia Shum Yiu Foon Sum Bik Chuen Memorial Centre for Cancer and Inflammation Research(CCIR) School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Division of Vascular Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunich 80336Germany Institute of hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China China-Russia Medical Research Center for Stress Immunology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Myocardial ischemia–reperfusion injury(MIRI)is a major hindrance to the success of cardiac reperfusion *** increased neutrophil infiltration is a hallmark of MIRI,the subtypes and alterations of neutrophils in this process remain ***,we performed single-cell sequencing of cardiac CD45^(+)cells isolated from the murine myocardium subjected to MIRI at six-time *** identified diverse types of infiltrating immune cells and their dynamic changes during *** neutrophils showed the most immediate response and largest changes and featured with functionally heterogeneous subpopulations,including Ccl3^(hi)Neu and Ym-1^(hi)Neu,which were increased at 6 h and 1 d after reperfusion,***-1^(hi)Neu selectively expressed genes with protective effects and was,therefore,identified as a novel specific type of cardiac cell in the injured *** analysis indicated that neutrophils and their subtypes orchestrated subsequent immune responses in the cardiac tissues,especially instructing the response of *** abundance of Ym-1^(hi)Neu was closely correlated with the therapeutic efficacy of MIRI when neutrophils were specifically targeted by anti-Lymphocyte antigen 6 complex locus g6D(Ly6g)or anti-Intercellular cell adhesion molecule-1(ICAM-1)neutralizing *** addition,a neutrophil subtype with the same phenotype as Ym-1^(hi)Neu was detected in clinical samples and correlated with ***-1 inhibition exacerbated myocardial injury,whereas Ym-1 supplementation significantly ameliorated injury in MIRI mice,which was attributed to the tilt of Ym-1 on the polarization of macrophages toward the repair phenotype in myocardial ***,our findings reveal the antiinflammatory phenotype of Ym-1^(hi)Neu and highlight its critical role in myocardial protection during the early stages of MIRI.

关键词： Myocardial ischemia-reperfusion injury Neutrophil Ym-1 Cardiac immune response Single-cell sequencing