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国际医学放射学杂志 2009年第2期32卷 199-200页

作者： A.A.K.A.Razek g.gaballa g.Elhawarey A.S.Megahed M.Hafez N. Nada 高欣 Diagnostic Radiology Department Mansoura Faculty of Medicine

本研究的目的是评价由扩散加权平面回波MR成像计算出的表观扩散系数对儿童头、颈部肿瘤肿块的临床价值。研究包括78例头、颈部肿块儿童（男46例、女32例，年龄范围3个月～15岁，平均为6岁）。在1．5T MR设备上行常规MRI和扩散加权成像... 详细信息

本研究的目的是评价由扩散加权平面回波MR成像计算出的表观扩散系数对儿童头、颈部肿瘤肿块的临床价值。研究包括78例头、颈部肿块儿童（男46例、女32例，年龄范围3个月～15岁，平均为6岁）。在1．5T MR设备上行常规MRI和扩散加权成像，采用单次激发平面回波成像（EPI），b值为0．500和1000s／mm^2,测量ADC值。

关键词：扩散加权MRI 头颈部肿块婴儿和儿童

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Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

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Oncology Research 2024年第6期32卷 1031-1036页

作者： CONSTANTINE N.LOgOTHETIS NATHAN P.HORVAT TONY KURIAN CELESTE BELLO JULIO CHAVEZ LEIDY ISENALUMHE BIJAL SHAH LUBOMIR SOKOL HAYDER SAEED JAVIER PINILLA SAMEH gaballa Department of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone *** bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline BR prospectively in *** retrospective study reports outcomes among EMZL patients receiving frontline ***-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not *** estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

关键词： Extranodal marginal zone lymphoma Bendamustine Rituximab Front-line therapy

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基于粗粒度离散元方法的离心泵冲蚀磨损特性研究

基于粗粒度离散元方法的离心泵冲蚀磨损特性研究

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作者： EMAN YASSER HUSSEIN gaballa 江苏大学

学位级别：硕士

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The Impact of Obesity on Performing Lymphadenectomy and Its Outcome in Ovarian Cancer Patients

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Journal of Cancer Therapy 2018年第7期9卷 568-575页

作者： Basel Refky Mosab Shetiwy Ahmed Zaki Mohamed Elmetwally Hanan Nabil Islam Abdou Ahmed Abdallah Amr Soliman Khaled Abdelwahab Anas gamal Essam Elshiekh Khaled gaballa Oncology Center Mansoura University Mansoura Egypt Mansoura University Hospitals Mansoura Egypt Oldenburg University Oldenburg Germany Tanta Cancer Center Tanta Egypt

Background: This study discusses the effect of obesity on the number of lymph nodes harvested during systematic LND and the LND-related complications in ovarian cancer patients. Methods: This retrospective study enrolled women with ovarian cancer who were consecutively subjected to open surgical resection that included systematic LND (pelvic and para-aortic) in the Oncology Center in Mansoura University (OCMU) during the period between January 2012 and June 2017. Patients were categorized according to the recommendations of World Health Organization by their BMI as non-obese (BMI 30.0 kg/m2) and obese (BMI ≥ 30.0 kg/m2). Results: Seventy-seven women with ovarian cancer were enrolled in the study according to our inclusion and exclusion criteria. 43 females (55.8%) were grouped as obese and 34 (44.2%) as non-obese. Lymph nodes retrieved in total and in different stations separately (pelvic and para-aortic) were all similar among patients in both groups. LND-related intraoperative complications were observed in 8 patients (18.6%) in the obese group and 3 patients in the non-obese group (8.8%) (P = 0.347). Hospital stay was the same in the two groups with a median of 4 days (IQR 3 - 5). Postoperative complications occurred in 13 patients (30.2%) in the obese group and only in one patient (3%) in the non-obese group (P = 0.004). Conclusion: Obese ovarian cancer patients may safely undergo comprehensive staging involving extensive lymph node dissection in open surgeries without significant increase in the rates of intraoperative complications. Whereas, postoperative complications (wound infection and thromboembolic events) tend to occur at higher rates with obese patients. Trial registration: This study was retrospectively registered and approved at faculty of Medicine Mansoura University, Egypt with IRB approval number R.18.02.46.

关键词： Lymphadenectomy Obesity Ovarian Cancer

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Frozen Section in Postmenopausal Women Presented with Suspicious Ovarian Masses, Does It Have a Role?

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Journal of Cancer Therapy 2015年第14期6卷 1192-1195页

作者： Basel Refky Anas gamal Emad Hamed Adel Fathi Mohammad Arafa Sameh Roshdy Khaled gaballa Essam Attia Mohamed Abdelkhalek Mohamed T. Hafez Fayz Shahatto Shadi Awny Doaa Shokry gehad Tawfik Surgical Oncology Unit Oncology Center Mansoura University Mansoura Egypt gynecology Department Mansoura University Hospitals Mansoura Egypt Pathology Department Mansoura University Mansoura Egypt Public Health Department Mansoura Faculty of Medicine Mansoura Egypt Medical Intern Mansoura University Hospitals Mansoura Egypt

Background: Frozen section (FS) has a valuable role in the diagnosis of ovarian tumors. It is considered a pivotal point in guiding the surgical therapy, particularly in premenopausal women. In postmenopausal women, it may be required as well to avoid unnecessary surgical staging in benign ovarian tumors. Aim: This study aims to evaluate the accuracy of intraoperative frozen section in ovarian neoplasms in postmenopausal women. Materials and Methods: A retrospective analysis was done for intraoperative FS for suspected ovarian neoplasms. The study was conducted in Oncology Center, Mansoura University from March 2008 to December 2014. The frozen and paraffin section reports were compared, and overall accuracy, sensitivity, specificity, positive and negative predictive values were determined. Results: The study included 105 patients and the overall accuracy of FS in determining malignancy was 81.7%. The sensitivity for malignant tumors was 75.32% with specificity of 100%. For benign tumors, the sensitivity and specificity were 100% and 93%, respectively. Borderline tumors had the lowest sensitivity of 100% with specificity of 95.19%. Conclusion: The present study concurs that frozen section is an accurate test for diagnosis of benign and malignant tumors in postmenopausal women thus determining the extent of surgery done for them. On the other hand, accuracy rates for borderline tumors are low.

关键词： Frozen Section Ovarian Cancer Surgical Staging

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