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Junctional epithelium and hemidesmosomes:Tape and rivets for solving the“percutaneous device dilemma”in dental and other permanent implants

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Bioactive Materials 2022年第12期7卷 178-198页

作者： Nicholas g.fischer Conrado Aparicio MDRCBB-Minnesota Dental Research Center for Biomaterials and Biomechanics University of Minnesota16-212 Moos Tower515 Delaware St.SEMinneapolisMN55455USA Division of Basic Research Faculty of OdontologyUIC Barcelona-Universitat Internacional de CatalunyaC/.Josep Trueta s/n08195Sant Cugat del VallesBarcelonaSpain Institute for Bioengineering of Catalonia(IBEC) The Barcelona Institute of Science and Technology(BIST)C/.Baldiri Reixac 10-1208028BarcelonaSpain

The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.

关键词： Percutaneous device Percutaneous implant Hemidesmosome Junctional epithelium Bioinspired surfaces

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Biomimetic mineralized hybrid scaffolds with antimicrobial peptides

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Bioactive Materials 2021年第8期6卷 2250-2260页

作者： Zhou Ye Xiao Zhu Isha Mutreja Sunil Kumar Bod Nicholas g.fischer Anqi Zhang Christine Lui Yipin Qi Conrado Aparicio The State Key Laboratory Breeding Base of Basic Science of Stomatology&Key Laboratory of Oral Biomedicine Ministry of Education School of StomatologyWuhan UniversityWuhan430079China Minnesota Dental Research Center for Biomaterials and Biomechanics Department of Restorative SciencesSchool of DentistryUniversity of MinnesotaMN55455USA Department of Operative Dentistry and Endodontics Guanghua School of StomatologyHospital of StomatologyGuangdong Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou510000China

Infection in hard tissue regeneration is a clinically-relevant *** of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the *** we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic *** highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial *** amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in *** developed scaffolds were potent by contact killing of gram-negative Escherichia coli and gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal *** process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.

关键词： Biomimetic mineralization Antimicrobial Cationic and amphipathic peptides Hard tissue cytocompatibility

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在中国使用条件下汽车零部件设计谱和试验谱的确定

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汽车工程 1996年第2期18卷 65-71页

作者：顾柏良鲁三才 g.fischer V.grubisic 郦明东风汽车公司德国LBF 中国科技大学

本文总结了中德合作研究项目“在中国使用条件下货车零部件优化设计方法”的主要成果。该项目是由中国东风汽车公司技术中心和德国费朗霍夫协会工作强度研究所(LBF)1986年～1991年共同完成的。该项目是根据LBF在西欧和美国道路载荷测量... 详细信息

本文总结了中德合作研究项目“在中国使用条件下货车零部件优化设计方法”的主要成果。该项目是由中国东风汽车公司技术中心和德国费朗霍夫协会工作强度研究所(LBF)1986年～1991年共同完成的。该项目是根据LBF在西欧和美国道路载荷测量方面的多年经验对中国的使用条件所进行的第一次系统研究,它将促进中国使用条件下汽车零部件的优化设计。本文根据使用载荷测量的结果和所建立的设计谱,得到了车轮、轮毂耐久试验的载荷程序,并研制出汽车前轴的多轴向模拟试验设备。

关键词：货车零部件设计谱试验谱汽车

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法拉第光隔离器

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光通信技术 1987年第4期 54-57页

作者： g.fischer 甄丽华

本文介绍了法拉第旋转光隔离器。讨论了该器件设计问题及最大隔离度的极限因素。还介绍了我们研制的1.523μm波长的两种隔离器的测试数据。

关键词：光隔离器法拉第旋转光无源器件磁光效应内反射

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何杰金病侵犯脑及脊髓的放射治疗

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放射学实践 1987年第1期 35-38页

作者： Von L.Schertel g.fischer R.Mohring S.Ritter 罗汉超同济医科大学附属协和医院

如果经治疗后的何杰金病患者(有时在多年后)出现神经障碍,则应考虑中枢神经受累。在发生不完全的或完全截瘫时就必须阐明这是否何杰金病放疗的后果(放射脊髓病)。病例资料及结果我们总结报告Mnster大学放射医院在1960年l月1日一l984年... 详细信息

如果经治疗后的何杰金病患者(有时在多年后)出现神经障碍,则应考虑中枢神经受累。在发生不完全的或完全截瘫时就必须阐明这是否何杰金病放疗的后果(放射脊髓病)。病例资料及结果我们总结报告Mnster大学放射医院在1960年l月1日一l984年3月31日回顾性观察的病例资料。

关键词：何杰金病脑部病变何杰金氏病恶性肉芽肿淋巴瘤脊髓病变

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不同牙科材料表面获得性膜吸附和细菌黏附的研究

不同牙科材料表面获得性膜吸附和细菌黏附的研究

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2019年中华口腔医学会口腔材料专业委员会第十四次全国口腔材料学术年会

作者：桑婷叶舟 Nicholas g.fischer Erik P.Skoe Constanza Echeverría Conrado Aparicio 伍军南昌大学附属口腔医院江西省口腔生物医学重点实验室明尼苏达大学口腔生物材料与生物力学研究中心塔尔卡大学口腔康复系龋病科

目的:易于附着菌斑的牙科材料会增加罹患与口腔生物膜相关疾病的风险。牙科材料表面的物理化学特性会影响获得性膜的吸附和细菌的黏附,但目前尚未见研究报道他们之间的关系。本研究旨在探讨材料表面特性对获得性膜吸附的影响,从而进一... 详细信息

目的:易于附着菌斑的牙科材料会增加罹患与口腔生物膜相关疾病的风险。牙科材料表面的物理化学特性会影响获得性膜的吸附和细菌的黏附,但目前尚未见研究报道他们之间的关系。本研究旨在探讨材料表面特性对获得性膜吸附的影响,从而进一步探讨其对早期定植菌-戈登链球菌黏附的影响。材料与方法:采用耗散型石英晶体微天平(QuartzCrystalMicrobal-ancewithDissipation,QCM-D)监测获得性膜在四种牙科常见材料金(gold,Au)、不锈钢(StailessSteel,SS)、氧化铝(Aluminumoxide,Al2O3)和氧化锆(Zirconiumoxide,ZrO2)芯片表面的吸附过程,并计算吸附的获得性膜的最终厚度。通过X射线光电子能谱(X-ray Photoelectron Spectrosco-py,XPS),原子力显微镜(Atomic Force Microscopy,AFM)和水接触角(WaterContactAngles,WCA)对获得性膜吸附前后的芯片表面进行表征。在无获得性膜和吸附了获得性膜的芯片表面静态培养戈登链球菌,通过双染法评价细菌活性,并采用扫描电子显微镜(Scanning Electron Microscopy,SEM)可视化评价不同材料芯片表面戈登链球菌黏附的差异及有无获得性膜对细菌黏附的影响。通过检测细菌和材料表面的附着功分析不同材料界面、有无获得性膜对细菌黏附差异的原因。结果:四种材料对获得性膜的吸附动力学相似(图1.A),材料表面吸附的获得性膜的最终厚度相似(图1.B)。获得性膜的吸附使四种材料表面的亲水性、表面能和与细菌的黏附功均增加(图1.C)。有获得性膜的表面比没有获得性膜的表面黏附更多的细菌,但是牙科材料的物理-化学特性并没有显著改变细菌的黏附(图1.D,E)。结论:获得性膜是增加戈登链球菌在牙科材料表面黏附的关键因素,原因是获得性膜吸附后,细菌和材料界面之间的附着功增加。本研究提示,开发新的降低细菌黏附的牙科材料时,需要考虑新材料是否能改变获得性膜的厚度、成分和结构。

关键词：细菌黏附 QCM-D 附着功表面能口腔材料界面不锈钢氧化锆金氧化铝

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Effects of the urban landscape on heatwave-mortality associations in Hong Kong: comparison of different heatwave definitions

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 145-156页

作者： Jinglu Song Yi Lu Thomas fischer Kejia Hu Department of Urban Planning and Design Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Architecture and Civil Engineering City University of Hong KongKowloon TongHong Kong 999077China Environmental Assessment and Management Research Centre School of Environmental SciencesUniversity of LiverpoolLiverpool L35TRUK Research Unit for Environmental Sciences and Management Faculty of Natural and Agricultural SciencesNorth West UniversityPotchefstroom 31750South Africa Institute of Big Data in Health Science School of Public HealthZhejiang UniversityZijingang CampusHangzhou 310058China

Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.

关键词： Urban landscape Heatwave Mortality Effect modification Intra-urban differences Health risk reduction

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Inhibition of tubulin detyrosination:a novel strategy to promote central nervous system regeneration

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Neural Regeneration Research 2024年第12期19卷 2557-2558页

作者： Charlotte Zeitler Marco Leibinger Dietmar fischer Center of Pharmacology Institute for PharmacologyMedical Faculty and University of CologneCologneGermany

The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and ***,injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to *** insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure.

关键词： injuries sensation diseases

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Estimating wood quality attributes from dense airborne LiDAR point clouds

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Forest Ecosystems 2024年第2期11卷 226-235页

作者： Nicolas Cattaneo Stefano Puliti Carolin fischer Rasmus Astrup Norwegian Institute of Bioeconomy Research(NIBIO) Division of Forest and Forest ResourcesHøgskoleveien 81433ÅsNorway

Mapping individual tree quality parameters from high-density LiDAR point clouds is an important step towards improved forest *** present a novel machine learning-based workflow that uses individual tree point clouds from drone laser scanning to predict wood quality indicators in standing *** object reconstruction methods,our approach is based on simple metrics computed on vertical slices that summarize information on point distances,angles,and geometric attributes of the space between and around the *** models use these slice metrics as predictors and achieve high accuracy for predicting the diameter of the largest branch per log (DLBs) and stem diameter at different heights (DS) from survey-grade drone laser *** show that our models are also robust and accurate when tested on suboptimal versions of the data generated by reductions in the number of points or emulations of suboptimal single-tree segmentation *** approach provides a simple,clear,and scalable solution that can be adapted to different situations both for research and more operational mapping.

关键词： UAV laser scanning Wood quality Machine learning Point cloud metrics

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Dieback of managed spruce stands in western germany promotes beetle diversity

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Journal of Forestry Research 2024年第3期35卷 55-71页

作者： Eva Plath Chantal Trauth Jan gerhards Laura griebel Klaus fischer Department Biology Institute of Integrated Natural SciencesKoblenz-Landau University56070 KoblenzGermany

Biodiversity loss is a significant problem at a global scale and may be amplified by climate *** recent years,coniferous forests have had substantial die-back across Europe due to drought and subsequent bark-beetle *** many studies on the consequences of disturbance and subsequent management have focused on natural stands,management implications for managed spruce stands are not well understood,even though such stands are widespread throughout *** this study,beetle taxonomy,conservation value,and community com-position are compared among spruce plantations and four post-disturbance management approaches:standing dead-wood,lying deadwood,clear cuts,and long-term *** and community composition differed significantly among management categories,while different beetle fami-lies responded *** spruce stands harbored the lowest beetle diversity while the highest taxonomic diver-sity and conservation value was on clear cuts and stands with lying or standing *** proportion of forest specialists was highest in successional *** summary,different forest management categories harbored distinct beetle communities at the family-,species-,and ecological guild ***,post-disturbance management should consider the landscape scale and include different management *** enhances landscape heterogeneity and thus overall biodiversity but could also mitigate negative impacts of natural disturbances on ecosystem services.

关键词： Bark-beetle outbreak Forest dieback Spruce Deadwood Nature conservation Beetle biodiversity-Coleoptera Coniferous forests

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