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混凝土破损结构的补偿收缩修补砂浆

膨胀剂与膨胀混凝土 2007年第4期 21-25页

作者： S.Collepardi g.Corazza g.fazio S.Monosi R.Troli 刘立

关键词：膨胀剂修补砂浆减缩剂

A Novel“Monte Carlo”Simulator Aimed to Model High Energy Up-to-date Radiation Sources and Radiation Transport inside Matter

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Journal of Physical Science and Application 2018年第1期8卷 30-36页

作者： g.fazio M.giaconi S.Vetruccio Electronic Engineering Department Faculty of EngineeringUniversity of Rome“Tor Vergata”Rome 00133Italy

We have faced the challenge of developing a tool devoted to simulate the transport of photons and accelerated particles(ionizing radiation entities)inside matter,where the choice of transporting medium shall be free for the user and non-homogeneities shall be modeled and *** solution has been a project that exploits fully statistical Monte Carlo approach,employing a digitalizing board to produce random *** system heredities many concepts from electronics devices simulators,but it finds different applications and we present one of them for effectiveness demonstration.

关键词： Monte Carlo automatic simulator radiation transport radiotherapy dose-depth analysis

Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5141-5142页

作者： Pietro Di fazio Department of Visceral Thoracic and Vascular SurgeryPhilipps University of MarburgBaldingerstrasse35043MarburgGermany

Two recent studies published in Nature focused on the clinical efficacy of the menin inhibitor revumenib(SNDX-5613)in KMT2A(histone-lysine N-methyltransferase 2A)-rearranged or NPM1(Nucleophosmin1)-mutant acute myeloid leukemia.1,2 These studies indicate that menin inhibition and its acquired resistance to long-term exposure to revuminib are key points for future treatment,emphasizing the role of menin as a challenging and promising target for the current treatment of leukemia.

关键词： acute clinical therapeutic

Effects of sampling frequency on node mobility prediction in dynamic networks: A spectral view

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数字通信与网络:英文版 2023年第4期9卷 1009-1022页

作者： Peppino fazio Miralem Mehic Miroslav Voznak DSMN Ca’Foscari University of VeniceVia Torino 15530172MestreVEItaly Department of Telecommunications Faculty of Electrical EngineeringUniversity of Sarajevo Zmaja od Bosne bb71000SarajevoBosnia and Herzegovina VSB–Technical University of Ostrava 17.listopadu 2172/1570800OstravaCzech Republic

The field of mobility prediction has been widely investigated in the recent past,especially the reduction of the coverage radius of cellular networks,which led to an increase in hand-over *** the cell coverage very frequently,for example,may lead to service disruptions if a predictive approach is not deployed in the *** several works examined mobility prediction in the new-generation mobile networks,all of these studies focused on studying the time features of mobility traces,and the spectral content of historical mobility patterns was not considered for prediction purposes as *** the present study,we propose a new approach to mobility prediction by analyzing the effects of a proper mobility sampling *** proposed approach lies in the mobility analysis in the frequency domain,to extract hidden features of the mobility ***,we proposed a new methodology to determine the spectral content of mobility traces(considered as signals)and,thus,the appropriate sampling frequency,which can provide numerous *** considered several types of mobility models(***,urban,and vehicular),containing important details in the time and frequency *** simulation campaigns were performed to observe and analyze the characteristics of mobility from real traces and to evaluate the effects of sampling frequency on the spectral content.

关键词： Mobile networking Frequency domain Mobility spectrum

Butein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells

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Cancer Drug Resistance 2022年第3期5卷 814-828页

作者： Mario Cioce Daniela Rutigliano Annamaria Puglielli Vito Michele fazio Department of Medicine Laboratory of Molecular Medicine and BiotechnologyUniversity Campus Bio-Medico of RomeRome 00128Italy Institute of Translational Pharmacology National Research Council of Italy(CNR)Rome 00133Italy

Aim:Malignant pleural mesothelioma is a chemoresistant tumor,and biphasic and sarcomatoid histologies portend the worst prognosis for malignant pleural mesothelioma(MPM)*** obtained the microRNA expression profile of three biphasic-sarcomatoid MPM cell lines to identify commonly expressed microRNAs and evaluate the effect of butein,a chemo-sensitizing compound,on this microRNA ***:Nanostring-based microRNA profiling and analysis through the ROSALIND platform were employed to identify the commonly modulated microRNAs and their ***-mimic transfection,Luciferase assay,and Western blotting were employed to show specific perturbation of TWIST1 levels by ***-forming assays,invasion assay,and metabolic profiling were used to assess the biological consequences of the butein-instigated miR-186-5p-mediated perturbation of TWIST1 *** analysis was used to search for the correlation between TWIST1 and miR-186-5p levels in biphasic and epithelioid MPM ***:We identified a set of perturbed microRNAs,common to three biphasic/sarcomatoid MPM cell lines,after butein *** focusing on miR-186-5p,we unraveled a butein-ignited and miR-186-5p-mediated modulation of TWIST1 levels which affected the 3D anchorage-independent growth,cisplatin resistance,invasion,and bioenergetics of the MPM cell lines *** showed that miR-186-5p and TWIST1 levels are anti-correlated in biphasic MPM specimens from ***:We unraveled a novel mechanism of action of butein,which attenuated the pro-tumorigenic features of MPM at least through a miR-186-5p-TWIST1 *** suggest that those activities converge into the chemo-sensitizing effect of this compound and may be of translational relevance.

关键词： Mesothelioma butein miR-186-5p TWIST1 pithelial-to-mesenchymal transition(EMT) chemoresistance cancer metabolism invasion anchorage-independent growth

Discoloration Range and Shroud Image Depth Values Cannot Be Satisfied by the Same Proton Energy

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Open Journal of Applied Sciences 2023年第8期13卷 1224-1232页

作者： giovanni fazio Department of Mathematical and Computer Sciences Physical Sciences and Earth Sciences University of Messina Messina Italy

The radiative hypothesis has been revisited showing other characteristics, produced by the protons used as dyes in total disagree with the ones of the Body Image that appears on the Shroud of Turin. Our investigations highlight that for the protons to reach 3.7 cm in air, the distance that measures the range of discoloration effects, must be emitted with an energy of about 1.5 MeV using Wilson and Brobeck’s empirical formula and 1.35 MeV using Bethe’s. This last formula provides a result closer to reality. Bethe shows that the penetration depth is greater than that calculated empirically. Such a value of proton energy (1.35 MeV) makes it possible to satisfy the discoloration effects range for the Shroud but it is incompatible with a depth of penetration in linen that is only 200 nm. Moreover, using the same subatomic particles, we obtained on the colored linen a distribution of energy represented by regression but not linear. Thus, also the possible I(z) correlation, between color intensity and body-sheet distance, which should be due to the oxidizing action of protons, does not agree with that extracted from the Shroud of Turin.

关键词： Shroud of Turin Body Image Formation Radiative Hypothesis Proton Model Discoloration Effects Range

Reaction mechanisms in massive nuclei collisions and perspectives for synthesis of heavier superheavy elements

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Nuclear Science and Techniques 2013年第5期24卷 98-106页

作者： gIARDINA g NASIROV A K MANDAgLIO g CURCIARELLO F De LEO V fazio g ROMANIUK M Dipartimento di Fisica e di Scienze della Terra dell'Università di Messina Istituto Nazionale di Fisica Nucleare Sezione di Catania Joint Institute for Nuclear Research Institute of Nuclear Physics Centro Siciliano di Fisica Nucleare e Struttura della Materia Catania 95125Italy

We discuss a hardship in synthesis of heaviest super heavy elements in massive nuclei reactions due to the hindrance to complete fusion of reacting nuclei caused on the onset of quasifission process which strongly competes with complete fusion and due to the strong increase of fission yields along the de-excitation cascade of the compound nucleus in comparison with the evaporation residue *** hindrance to formation of compound nucleus and evaporation residue is determined by the characteristic of the entrance channel.

关键词：超重元素反应机制合成碰撞聚变反应残余物复合核核反应

Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy

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Cancer Drug Resistance 2023年第3期6卷 447-467页

作者： gianluca Santamaria Mario Cioce Antonia Rizzuto Vito Michele fazio giuseppe Viglietto Maria Lucibello Department of Experimental and Clinical Medicine “Magna Graecia”University of CatanzaroCatanzaro 88100Italy Department of Medicine Laboratory of Molecular Medicine and BiotechnologyUniversity Campus Bio-Medico of RomeRome 00128Italy Institute of Translational Pharmacology National Research Council of Italy(CNR)Rome 00133Italy Department of Medical and Surgical Sciences “Magna Graecia”University of CatanzaroCatanzaro 88100Italy Department of Biomedical Sciences Institute for Biomedical Research and InnovationNational Research Council of Italy(CNR)Catanzaro 88100Italy

Early identification of breast cancer (BC) patients at a high risk of progression may aid in therapeutic and prognostic aims. This is especially true for metastatic disease, which is responsible for most cancer-related deaths. growing evidence indicates that the translationally controlled tumor protein (TCTP) may be a clinically relevant marker for identifying poorly differentiated aggressive BC tumors. TCTP is an intriguing protein with pleiotropic functions, which is involved in multiple signaling pathways. TCTP may also be involved in stress response, cell growth and proliferation-related processes, underlying its potential role in the initiation of metastatic growth. Thus, TCTP marks specific cancer cell sub-populations with pronounced stress adaptation, stem-like and immune-evasive properties. Therefore, we have shown that in vivo phospho-TCTP levels correlate with the response of BC cells to anti-HER2 agents. In this review, we discuss the clinical relevance of TCTP for personalized therapy, specific TCTP-targeting strategies, and currently available therapeutic agents. We propose TCTP as an actionable clinically relevant target that could potentially improve patient outcomes.

关键词： Breast cancer metastasis TCTP stem cells therapy resistance biomarker

Central Schemes and Second Order Boundary Conditions for 1D Interface and Piston Problems in Lagrangian Coordinates

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Communications in Computational Physics 2010年第9期8卷 797-822页

作者： Riccardo fazio giovanni Russo Department of Mathematics University of MessinaSalita Sperone 3198166 MessinaItaly Department of Mathematics and Computer Science University of CataniaViale Andrea Doria 695125 CataniaItaly

We study high-resolution central schemes in Lagrangian coordinates for the one-dimensional system of conservation laws describing the evolution of two gases in slab geometry separated by an *** using Lagrangian coordinates,the interface is transformed to a fixed coordinate in the computational domain and,as a consequence,the movement of the interface is obtained as a byproduct of the numerical *** main contribution is the derivation of a special equation of state to be imposed at the interface in order to avoid non-physical *** boundary conditions at the piston that guarantee second order convergence are *** compare the solution of the piston problem to other results available in the literature and to a reference solution obtained within the adiabatic approximation.A shock-interface interaction problem is also *** results on these tests are in good agreement with those obtained by other methods.

关键词： Lagrangian central schemes Euler equations interface conditions boundary conditions