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单光子发射电子计算机扫描在中枢白塞病中的作用

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中华内科杂志 1997年第4期36卷 262-262页

作者：孙凌云潘锡金张杏书 F.Trotta g.ciancio 南京鼓楼医院意大利费拉拉大学风湿科

单光子发射电子计算机扫描在中枢白塞病中的作用孙凌云潘锡金Ｆ．ＴｒｏｔａＧ．Ｃｉａｎｃｉｏ张杏书白塞病是以粘膜、皮肤和眼部损害为主要表现的自身免疫病，可侵犯中枢神经系统（ＣＮＳ）和周围神经，ＣＮＳ受侵犯的白塞病也称为神... 详细信息

单光子发射电子计算机扫描在中枢白塞病中的作用孙凌云潘锡金Ｆ．ＴｒｏｔａＧ．Ｃｉａｎｃｉｏ张杏书白塞病是以粘膜、皮肤和眼部损害为主要表现的自身免疫病，可侵犯中枢神经系统（ＣＮＳ）和周围神经，ＣＮＳ受侵犯的白塞病也称为神经白塞病（ＮＢＤ）。目前诊断ＮＢＤ...

关键词：白塞氏病 NBD SPECT 诊断

Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2275-2296页

作者： Javaid Ali Armando ciancio Kashif Ali Khan Nauman Raza Haci Mehmet Baskonus Muhammad Luqman Zafar-Ullah Khan Department of Mathematics Govt.Graduate College TownshipLahore54770Pakistan Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy Department of Mathematics University of Engineering and TechnologyLahore54890Pakistan Department of Mathematics University of the PunjabLahore54590Pakistan Mathematics Research Center Near East University TRNCMersin 10Nicosia99138Turkey Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Department of Dermatology Rashid Latif Medical CollegeLahore54600Pakistan

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic(CCE)*** underlying CCE model lacks a closed-form exact *** solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties,such as positivity,boundedness,and ***,the development of structure-preserving semi-analytical approaches is always *** research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization ***-free safe Padérational functions approximate the mathematical shape of state variables,while the model’s physical requirements are treated as problem *** primary model of the governing differential equations is imposed to minimize the error between approximate *** evolutionary algorithm,the genetic Algorithm with Multi-Parent Crossover(gA-MPC),executes the optimization *** resulting method is the Evolutionary Safe PadéApproximation(ESPA)*** proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical *** performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padéapproximants.

关键词： Nonlinear cervical cancer epidemic non-singular Padéapproximants approximate solutions computational biology

Transcriptome Analysis Provides Novel Insights into Salt Stress Response in Two Egyptian Rice Varieties with Different Tolerance Levels

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Rice science 2022年第6期29卷 499-502页

作者： Shehab MOHAMED Iovene MARINA ciancio AURELIO Colagiero MARIANTONIETTA Finetti-Sialer MARIELLA Rice Research and Training Center Field Crops Research InstituteAgriculture Research CenterSakha Kafr El-Sheikh 33717Egypt Institute of Biosciences and Bioresources National Research CouncilBari 70126Italy Sustainable Plant Protection Institute National Research CouncilBari 70126Italy

The response of rice to salt stress(200 mmol/L NaCl)was investigated at the transcription level in Egyptian varieties giza 177(salt sensitive variety)and giza 178(salt tolerant variety).We applied a genome-wide RNA-Se... 详细信息

关键词： varieties Egyptian stress

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加筋夯土墙片的平面内抗剪性能试验

中南大学学报（自然科学版） 2016年第8期47卷 2835-2841页

作者：李志华周明卿陈伟康 ciancio Daniela 扬州大学建筑科学与工程学院江苏扬州225009 西澳大学土木和能源工程学院

对由废弃混凝土夯筑而成的试件进行抗压试验、劈裂试验及墙片斜压试验,研究水泥稳定夯土材料在静载作用下的破坏特征及强度特性,并着重研究夯土墙片的平面内抗剪性能及各种加筋形式对其抗剪性能的影响。此外,根据试验结果,参考澳大利亚... 详细信息

对由废弃混凝土夯筑而成的试件进行抗压试验、劈裂试验及墙片斜压试验,研究水泥稳定夯土材料在静载作用下的破坏特征及强度特性,并着重研究夯土墙片的平面内抗剪性能及各种加筋形式对其抗剪性能的影响。此外,根据试验结果,参考澳大利亚混凝土结构设计规范AS 3600—2009建议的抗剪强度计算公式,探讨水泥稳定夯土材料抗压强度与抗剪强度之间的相互关系。研究结果表明：这种材料的抗压强度、抗剪强度、抗强度可分别达到8.68-10.11,1.55和1.01-1.23 MPa;加筋夯土墙片的抗剪强度、延性可分别提高6%-42%和35%-92%;采用聚丙烯纤维可使墙片的刚度提高49%;钢筋的位置及布置方向对其与夯土间的黏结性能有明显影响。且对于竖向分层夯筑的试件,按规范AS 3600—2009公式计算的抗剪强度比试验结果的抗剪强度大。

关键词：夯土墙片抗剪性能斜压试验加筋废弃混凝土

Retroperitoneal kidney transplantation with liver and native kidney mobilization:a safe technique for pediatric recipients

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World Journal of Pediatrics 2023年第5期19卷 489-501页

作者： Juliano Riella Raphealla Ferreira Marina M.Tabbara Phillipe Abreu Lucas Ernani Marissa Defreitas Jayanthi Chandar Jeffrey J.gaynor Javier gonzález gaetano ciancio Department of Surgery University of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Department of Urology University of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Department of Pediatrics Division of NephrologyUniversity of Miami Miller School of MedicineJackson Memorial HospitalMiamiFLUSA Miami Transplant Institute University of Miami Miller School of MedicineJackson Memorial Hospital1801 NW 9Th Ave7Th FloorMiamiFL 33136USA Servicio de Urología Unidad de Trasplante RenalHospital General Universitario Gregorio MarañónMadridSpain

Background Pediatric kidney transplant(KT)using larger,deceased or living donor adult kidneys can be challenging in the pediatric population due to limited space in the *** and native kidney(L/NK)mobilization techniques can be used in smaller and younger transplant recipients to aid in retroperitoneal placement of the renal ***,we compare the clinical outcomes of pediatric retroperitoneal KT with and without L/NK *** We retrospectively analyzed pediatric renal transplant recipients treated between January 2015 and May *** and recipient demographics,intraoperative data,and recipient outcomes were *** were divided into two groups according to the surgical technique utilized:with L/NK mobilization(group 1)and without L/NK mobilization(group 2).Baseline variables were described using frequency distributions for categorical variables and means and standard errors for continuous *** of association with the likelihood of using L/NK mobilization were performed using standardχ2 tests,t tests,and the log-rank *** Forty-six pediatric recipients were evaluated and categorized into group 1(n=26)and group 2(n=20).Recipients in group 1 were younger(6.7±0.8 years vs.15.3±0.7,Pghed less(21.4±2.0 vs.48.6±3.4 kg,Pgroup *** baseline characteristics did not difer between groups 1 and *** urologic complication was encountered in group 2;no vascular or surgical complications were observed in either ***,no stents or drains were used in any of the *** were no cases of delayed graft function or graft primary *** median follow-up of the study was 24.6 months *** patients developed death-censored graft failure(both in group 2,P=0.22),and there was one death with a functioning graft(in group 2,P=0.21).Conclusions Retroperitoneal liver/kidney mobilization is a feasible an

关键词： Extraperitoneal approach Liver and kidney mobilization Pediatric kidney surgical technique Transplantation

Is positivity for hepatitis C virus antibody predictive of lower risk of death in COVID-19 patients with cirrhosis?

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World Journal of Clinical Cases 2020年第22期8卷 5831-5834页

作者： Alessandra Mangia giovanni Cenderello gabriella Verucchi Alessia ciancio Andrea Fontana Valeria Piazzolla Nicola Minerva Maria Maddalena Squillante Massimiliano Copetti Liver Unit Department of Medical SciencesFondazione IRCCS“Casa Sollievo della Sofferenza”San Giovanni Rotondo 71013Italy Department of Infectious Disease ASL1 ImperieseSanremo 18038Italy Department of Infectious Disease University of BolognaBologna 40138Italy Department of gastroenterology University of TurinTorino 10156Italy Department of Biostatistics Fondazione IRCCS“Casa Sollievo della Sofferenza”San Giovanni Rotondo 71013Italy Department of Internal Medicine Ospedale BonomoAndria 76123Italy

Liver injury has been reported in coronavirus disease 2019(COVID-19)cases but the impact of pre-existing liver damage and related etiology have not been completely *** research interests include the potential reciprocal influence of COVID-19 and pre-existing liver damage related to hepatitis C virus(HCV)infection,in *** this end,we have evaluated three cohorts of patients admitted at three Italian hospitals during the coronavirus pandemic;these included 332 patients with COVID-19 and 1527 patients with HCV who were from established real-world antiviral treatment study cohorts(sofosbuvir/velpatasvir),with either liver disease(various severities;n=1319)or cirrhosis(n=208).Among the COVID-19 patients,10 had cirrhosis(3%),including 7 of metabolic origin and 3 of viral *** among the COVID-19 patients was 27.1%,with 70%of those with cirrhosis of metabolic etiology having ***,older age,low white blood cell count and lymphocyte count being identified as risk predictors of death[odds ratio(OR)=13.7,95%confidence interval(CI):2.59-83.01,P=0.006;OR=1.05,95%CI:1.03-1.08,P=0.0001;OR=1.09,95%CI:1.36-1.16,P=0.001;OR=0.61,95%CI:0.39-0.93,P=0.023,respectively].In the two cohorts of HCV patients,COVID-19 diagnosis was made in 0.07%of those with liver disease and 1%of those with ***,the prevalence of HCV antibodies among COVID-19-infected patients was comparable to that currently reported for the general population in *** the COVID-19 patients,pre-existing metabolic cirrhosis appears to be associated with higher mortality,while HCV antibodies may be suggestive of“protection”against COVID-19.

关键词： Hepatitis C virus Hepatitis B virus Cirrhosis COVID-19 Sofosbuvir Velpatasvir

IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients

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World Journal of gastroenterology 2014年第36期20卷 13146-13152页

作者： Chiara Rosso Maria Lorena Abate Alessia ciancio Silvia Strona gian Paolo Caviglia Antonella Olivero giovanni Antonio Touscoz Mario Rizzetto Rinaldo Pellicano Antonina Smedile Department of Medical Science University of Turin 10123 Turin Italy Department of gastroenterology and Hepatology Molinette Hospital 10126 Turin Italy

AIM: To clarify the association of interleukin-28B (IL28B) single nucleotide polymorphisms (SNPs) with hepatitis C virus (HCV) viremia changes for assessment of interferon (IFN) response.

关键词： Hepatitis C virus-g1 Interleukin-28B rs12979860 Interleukin-28B rs8099917 Interferon sensitivity Triple therapy

Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women

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World Journal of gastroenterology 2014年第44期20卷 16726-16733页

作者： Veronica Bernabucci Alessia ciancio Salvatore Petta Aimilia Karampatou Laura Turco Silvia Strona Rosina Critelli Paola Todesca Caterina Cerami Caterina Sagnelli Mario Rizzetto Calogero Cammà Erica Villa Division of gastroenterology Azienda Ospedaliero-Universitaria Policlinico di Modena Italy Università degli Studi di Modena e Reggio Emilia Division of gastroenterology University of Turin Division of gastroenterology Di Bi MIS University of Palermo Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi-A. Lanzara" Second University of Naples

AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus(HCV)-g1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-g1, 46% F3-F4, and previous PEg-α/RBV failure(7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEg-IFNα2b/RBV followed by PEgIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEg-IFN-α-2b/RBV if patients were HCV-RNApositive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virological response(SVR)(HCV RNA undetectable at 24 wk of follow-up) rate of at least 20% could be obtained. The secondary objective was the evaluation of the percent of patients with negative HCV RNA at week 4(RVR), 8(RVR BOC), 12(EVR), or at the end-of-treatment(ETR) that reached SVR. To assess the relationship between SVR and clinical and biochemical parameters, multiple logistic regression analysis was ***: After lead-in, only two patients had RVR; HCV-RNA was unchanged in all but 62% who had ≤1 log10 decrease. After Boceprevir, HCV RNA became undetectable at week 8 in 32/56(57.1%) and at week 12 in 41/56(73.2%). Of these, 53.8% and 52.0%, respectively, achieved SVR. Overall, SVR was obtained in 25/56(44.6%). SVR was achieved in 55% previous relapsers vs. 41% non-responders(P = 0.250), in 44% F0-F2 vs 54% F3-F4(P = 0.488), and in 11/19(57.9%) of patients with cirrhosis. At univariate analysis for baseline predictors of SVR, only previous response to antiviral therapy(OR = 2.662, 95%CI: 0.957-6.881, P = 0.043), was related with SVR. When considering "on treatment" factors, 1 log10 HCV RNA decline at week 4(3.733, 95%CI: 1.676-12.658, P = 0.034) and achievement of RVR BOC(7.347, 95%CI: 2.156-25.035, P = 0.001) were significantly related with the SVR, although RVR BOC only(6.794

关键词： Hepatitis C virus treatment Pegylated In-terferon Viral Hepatitis Menopause genotype 1

Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study

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World Journal of Transplantation 2021年第4期11卷 114-128页

作者： Nicholas V Mendez Yehuda Raveh Joshua J Livingstone gaetano ciancio giselle guerra george W Burke III Vadim B Shatz Fouad g Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu Department of Anesthesiology University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Department of Surgery Miami Transplant Institute/University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Division of Nephrology of the Department of Medicine University of Miami/Jackson Memorial HospitalMiamiFL 33136United States

BACKgROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney *** exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is *** To identify risk factors associated with delayed graft function(DgF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 *** primary outcome was the occurrence of *** The incidence of DgF was 27%.Under logistic regression,eight independent risk factors for DgF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressureg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/*** We delineate the association between DgF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine.

关键词： Delayed graft function Outcome Kidney transplant Risk factors Phenylephrine Mean arterial pressure