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chinese Physics B 2024年第10期33卷 427-433页

作者： Yang Sun Ruoshui liu Huayang gong Baogen Shen School of Rare Earths University of Science and Technology of ChinaHefei 230026China ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341119China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China Beijing National Laboratory for condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Ion substitution has significantly improved the performance of ferrite magnets,and cobalt remains a key area of *** on the mechanism of co^(2+)in strontium ferrite,especially SrFe_(2n-x)co_(x)O_(19-d)(n=6.1-5.4;x=0.05-0.20)synthesized using the ceramic method,showed that co^(2+)preferentially enters the lattice as the Fe/Sr ratio *** results in a decrease in the lattice constants a and c due to oxygen vacancies and iron ion *** impact of co substitution on morphology is minor compared to the effect of the Fe/Sr *** the Fe/Sr ratio decreases and the co content increases,the saturation magnetization *** magnetic anisotropy field exhibits a nonlinear change,generally increasing with higher Fe/Sr ratios and co *** changes in the performance of permanent magnets are attributed to the absence of Fe^(3+)ions at the 12k+2a and 2b sites and the substitution of co^(2+)at the 2b *** suggests that by adjusting the Fe/Sr ratio and appropriate co substitution,the magnetic anisotropy field of M-type strontium ferrite can be effectively optimized.

关键词： hexaferrite co substitution Raman spectra magnetic properties

A lignified-layer bridge controlled by a single recessive gene is associated with high pod-shatter resistance in Brassica napus L.

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The crop Journal 2022年第3期10卷 638-646页

作者： Wen chu Jia liu Hongtao cheng.c.ao Li Li Fu Wenxiang Wang Hui Wang Mengyu Hao Desheng Mei Kede liu Qiong Hu Oil crops Research Institute of chinese Academy of Agricultural Sciences/Key Laboratory for Biology and genetic Improvement of Oil crops Ministry of Agriculture and Rural AffairsWuhan 430062HubeiChina National Key Laboratory of crop genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina graduate School of chinese Academy of Agricultural Sciences Beijing 100081China

Pod shattering.c.uses severe yield loss in rapeseed(Brassica napus L.)under modern agricultural *** of highly shatter-resistant germplasm is desirable for the development of rapeseed cultivars for mechanical *** the present study,an elite line OR88 with strong shatter resistance and a lignified-layer bridge(LLB)structure was *** LLB structure was unique to OR88 and co-segregated with high pod-shatter *** LLB structure is differentiated at stage 12 of gynoecium development without any gynoecium *** analysis showed that LLB is controlled by a single recessive *** BSA-Seq and map-based cloning,the resistance gene location was delimited to a0.688 Mb region on chromosome *** analysis suggested Bn TcP8.c09 as the gene responsible for *** expression of Bn TcP.c09 was strongly downregulated in OR88,suppressing.c.ll proliferation in the pod valve *** markers linked to the candidate gene were *** pod shatter-resistant line could be used in rapeseed breeding programs by direct transfer of the gene with the assistance of the DNA markers.

关键词： Pod shatter Lignified-layer bridge BSA-Seq KASP marker Rapeseed

geographical origin identification of winter jujube(Ziziphus jujuba Dongzao')by using multi-element fingerprinting with chemometrics

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Journal of Integrative Agriculture 2024年第5期23卷 1749-1762页

作者： Xiabing Kong Qiusheng.c.en Min Xu Yihui liu Xiaoming Li Lingxi Han Qiang Zhang Haoliang Wan Lu liu Xubo Zhao Jiyun Nie college of Horticulture Qingdao Agricultural University/Laboratory of Quality&Safety Risk Assessment for Fruit(Qingdao)Ministry of Agriculture and Rural Affairs/National Technology Centre for Whole Process Quality Control of FSEN Horticultural Products(Qingdao)/Qingdao Key Lab of Modern Agriculture Quality and Safety EngineeringQingdao 266109China Institute of Agricultural Product Quality Safety and NutritionTianjin Academy of Agricultural SciencesTianjin 300381China college of Food Science and Engineering Northwest A&F UniversityYangling 712100China

Winter jujube(Ziziphus jujuba'Dongzao')is greatly appreciated by consumers for its excellent quality,but brand infringement frequently occurs in the ***,we first determined a total of 38 elements in 167 winter jujube samples from the main winter jujube producing areas of china by inductively coupled plasma mass spectrometer(IcP-MS).As a result,16 elements(Mg,K,Mn,cu,Zn,Mo,Ba,Be,As,Se,cd,Sb,ce,Er,Tl,and Pb)exhibited significant differences in samples from different producing *** linear discriminant analysis(LDA)and orthogonal projection to latent structures discriminant analysis(OPLS-DA)showed better performance in identifying the origin of samples than unsupervised principal component analysis(PcA).LDA and OPLS-DA had a mean identification accuracy of 87.84 and 94.64%in the testing set,*** using the multilayer perceptron(MLP)and c5.0,the prediction accuracy of the models could reach 96.36 and 91.06%,*** on the above four chemometric methods,cd,Tl,Mo and Se were selected as the main variables and principal markers for the origin identification of winter ***,this study demonstrates that it is practical and precise to identify the origin of winter jujube through multi-element fingerprint analysis with chemometrics,and may also provide reference for establishing the origin traceability system of other fruits.

关键词： winter jujube multi-element fingerprint analysis chemometrics origin traceability

genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,china,2016–2020

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Virolog.c. Sinica 2022年第2期37卷 177-186页

作者： Jiayu Wang Jiajing liu Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling liu chongshan Li Wanju Zhang Xi Zhang Zheng Teng Microbiology Department Shanghai Municipal Center for Disease Control and PreventionShanghai200336China Microbiology Department Songjiang District Center for Disease Control and PreventionShanghai201620China WHO WPRO Regional Polio Reference Laboratory NHC Key Laboratory for BiosafetyNHC Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China

coxsackievirus A10(cVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiolog.c.l characteristics as well as genetic features of cVA10 currently circulating in Shanghai,china,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December *** the past five years,cVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five *** addition to entire VP1 sequencing.c.mplete genome sequencing and recombination analysis of cVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic *** cVA10sequences in this study mainly belonged to genogroup c and presented 91%-100%nucleotide identity with other chinese isolates based on VP1 *** the first time,our study reported the appearance of cVA10 genogroup D in chinese mainland,which had led to large-scale outbreaks in Europe *** recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with cVA16 genogroup *** conclusion,cVA10 genogroup c was the predominant genogroup in Shanghai during ***10 recombinant genogroup D was firstly reported in circulating in chinese *** surveillance is needed to better understand the evolution relationships and transmission pathways of cVA10 to help to guide disease control and prevention.

关键词： coxsackievirus A10(cVA10) genogroup D Intertypic recombination Hand foot and mouth disease(HFMD)

Time serial transcriptome reveals cyp2c29 as a key gene in hepatocellular carcinoma development

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cancer Biology & Medicine 2020年第2期17卷 401-417页

作者： Qi Wang Qin Tang Lijun Zhao Qiong Zhang Yuxin Wu Hui Hu Lanlan liu Xiang liu Yanhong Zhu Anyuan guo Xiangliang Yang college of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Experimental Transplantation and Immunology Branch National Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA

Objective:Hepatocellular carcinoma(Hcc)is a severely lethal cancer that usually originates from chronic liver injury and *** progress on diagnosis and treatment is obvious,the cause of Hcc remains *** this study,we sought to determine key genes in Hcc ***:To identify key regulators during Hcc progression,we performed transcriptome sequencing to obtain time series gene expression data from a mouse model with diethylnitrosamine-induced liver tumors and further verified gene expression and function in vitro and in ***:Among the differentially expressed genes,cyp2c29 was continuously downregulated during Hcc *** of cyp2c29 suppressed N F-kB activation and proinflammatory cytokine production by increasing the production o f 14,15-epoxyeicosatrienoic acid in ***,overexpression of cyp2c29 in vivo protected against liver inflammation in mouse models of liver injury induced by both acetaminophen and *** human homologs of mouse cyp2c29,cYP2c8 and cYP2c9,were found to be downregulated in human Hcc progression,and their expression was positively correlated with overall survival in patients with Hcc(significance:P=0.046 and 0.0097,respectively).conclusions:collectively,through systematic analysis and verification,we determined that c yp2c29 is a novel gene involved in liver injury and inflammation,which may be a potential biomarker for Hcc prevention and prognosis determination.

关键词： cyp2c29 hepatocellular carcinoma NF-kB proliferation time series gene expression

The Effect of Blood Lipid Profiles on chronic Kidney Disease in a Prospective cohort:Based on a Regression Discontinuity Design

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Biomedical and Environmental Sciences 2024年第10期37卷 1158-1172页

作者： Kang Lyu Shaodong liu Yanli liu Jinlong You Xue Wang Min Jiang.c.un Yin Desheng Zhang Yana Bai Minzhen Wang Shan Zheng Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730000GansuChina Wuwei People’s Hospital Wuwei 733099GansuChina Workers’Hospital of Jinchuan group co. Ltd.Jinchang 737103GansuChina

Objective Previous studies on the association between lipid profiles and chronic kidney disease(cKD)have yielded inconsistent results and no defined thresholds for blood *** A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was *** cubic splines and cox models were used to examine the association between the lipid profiles and cKD.A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of *** Over a median follow-up time of 2.2(0.5,4.2)years,648(2.00%)subjects developed *** lipid profiles that were significantly and linearly related to cKD included total cholesterol(Tc),triglycerides(Tg),high-density lipoprotein cholesterol(HDL-c),Tc/HDL-c,and Tg/HDL-c,whereas lowdensity lipoprotein cholesterol(LDL-c)and LDL-c/HDL-c were nonlinearly correlated with ***,Tg,Tc/HDL-c,and Tg/HDL-c showed an upward jump at the cutoff value,increasing the risk of cKD by 0.90%,1.50%,2.30%,and 1.60%,respectively,whereas HDL-c showed a downward jump at the cutoff value,reducing this risk by 1.0%.Female and participants with dyslipidemia had a higher risk of cKD,while the cutoff values for the different characteristics of the population were *** There was a significant association between lipid profiles and cKD in a prospective cohort from Northwest china,while Tg,Tc/HDL-c,and Tg/HDL-c showed a stronger risk *** specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing.c.D risk.

关键词： Blood lipid profiles chronic kidney disease Regression discontinuity design Prospective cohort

Fabrication of wear-resistant layers with lamellar eutectic structure by laser surface alloying using the in situ reaction between cr and B_4c

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International Journal of Minerals,Metallurgy and Materials 2016年第11期23卷 1294-1301页

作者： You-zheng Sun Jin-bao Li Daniel Wellburn chang-sheng liu Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University

To improve the wear resistance of cr5 steel, wear-resistant layers with lamellar eutectic microstructure were fabricated by laser surface alloying（LSA）, which is dependent on the in situ reaction between cr and B_4c. Our results indicated that the hypoeutectic structures of the LSA layers were divided into interdendritic eutectic structures and dendrites. The area fraction of the eutectic structures increased with increasing laser scanning speed, which improved the hardness and wear resistance of the LSA layers. The average hardness of the LSA layer prepared at a scanning speed of 8 mm/s was HV_（0.2） 883.9, which was 1.8 times greater than that of the traditional quenched layer（approximately HV 480）. After sliding for 659.4 m, the specimen prepared at a scanning speed of 8 mm/s exhibited a volume loss of 0.0323 mm^3, which was only 29.5% of the volume loss of the traditional quenched specimen.

关键词： eutectic wear resistance laser alloying hardness

Study of steam heat transfer enhanced by cO_(2) and chemical agents: In heavy oil production

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Petroleum Science 2023年第2期20卷 1030-1043页

作者： Ya-Li liu chao Zhang Song-Yan Li Zhao-Min Li Key Laboratory of Unconventional Oil&gas Development(china University of Petroleum(East china)) Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Steam flooding with the assistance of carbon dioxide (cO_(2)) and chemicals is an effective approach for enhancing super heavy oil recovery. However, the promotion and application of cO_(2) and chemical agent-assisted steam flooding technology have been restricted by the current lack of research on the synergistic effect of cO_(2) and chemical agents on enhanced steam flooding heat transfer. The novel experiments on cO_(2)–chemicals cooperate affected steam condensation and seepage were conducted by adding.c._(2) and two chemicals (sodium dodecyl sulfate (SDS) and the betaine temperature-salt resistant foaming agent ZK-05200).According to the experimental findings, a “film” formed on the heat-transfer medium surface following the co-injection of cO_(2) and the chemical to impede the steam heat transfer, reducing the heat transfer efficiency of steam, heat flux and condensation heat transfer coefficient. The steam seepage experiment revealed that the temperature at the back end of the sandpack model was dramatically raised by 3.5–12.8 °c by adding.c._(2) and chemical agents, achieving the goal of driving deep-formation heavy oil. The combined effect of cO_(2) and SDS was the most effective for improving steam heat transfer, the steam heat loss was reduced by 6.2%, the steam condensation cycle was prolonged by 1.3 times, the condensation heat transfer coefficient was decreased by 15.5%, and the heavy oil recovery was enhanced by 9.82%. Theoretical recommendations are offered in this study for improving the cO_(2)–chemical-assisted steam flooding technique.

关键词： Steam flooding Heavy oil carbon dioxide chemical agent Enhanced oil recovery(EOR) Heat transfer

Optimal Admission and Price control in a Retrial Queueing System 36

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Optimal Admission and Price Control in a Retrial Queueing Sy...

Modeling.c.DASIL vascular pathologies with patient-derived induced pluripotent stem cells

第36届中国控制会议

作者： Zaiming liu Wei Deng gang.c.en School of Mathematics and Statistics Central South University

ISBN: (纸本)9781538629185

In this paper, we analyze the optimal control policy to minimize the average costs in a retrial queueing system. At any decision epoch, the manager uses admission probabilities a’s to control the arriving.c.stomers and determines a cancellation price c for the unsuccessful retrial customer, which will lead to him out of system with the probability of g.c. otherwise back to the orbit. We cast the problem as a Markov decision process and derive that the optimal policy has a pure threshold form. We also show that the two thresholds are monotonic in system parameters. Furthermore, based on the structure of the optimal policy,we construct a performance evaluation model for computing efficiently the optimal thresholds. The expression of the average cost is given by solving the quasi-birth-death（QBD） process. Finally, some numerical experiments are presented to illustrate the effect of the system parameters on the optimal policy.

关键词： Retrial queueing system Markov decision process Matrix analytic method Performance evaluation

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Protein & cell 2019年第4期10卷 249-271页

作者： chen Ling Zunpeng liu Moshi Song Weiqi Zhang Si Wang Xiaoqian liu Shuai Ma Shuhui Sun Lina Fu Qun chu Juan carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan guang-Hui liu Advanced Innovation center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China Department of Neurology Peking University First HospitalBeijing 100034China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of chinese Academy of Sciences Beijing 100049China gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Institute for Stem cell and Regeneration CASBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China

cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(cADASIL)is a rare hereditary cerebrovascular disease caused by a NOTcH3 ***,the underlying.c.llular and molecular mechanisms remain ***,we generated non-integrative induced pluripotent stem cells(iPScs)from fibroblasts of a cADASIL patient harboring a heterozygous NOTcH3 mutation(c.3226c>T,p.R1076c).Vascular smooth muscle cells(VSMcs)differentiated from cADASIL-specific iPScs showed gene expression changes associated with disease phenotypes,including activation of the NOTcH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell *** comparison,these abnormalities were not observed in vascular endothelial cells(VEcs)derived from the patients ***,the abnormal upregulation of NF-kB target genes in cADASIL VSMcs was diminished by a NOTcH pathway inhibitor,providing a potential therapeutic strategy for ***,using this iPScbased disease model,our study identified clues for studying the pathogenic mechanisms of cADASIL and developing treatment strategies for this disease.

关键词： cADASIL iPSc NOTcH NF-kB vascular smooth muscle