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直肠子宫内膜异位症：节段性肠切除的预测性MRI征象

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国际医学放射学杂志 2021年第2期44卷 246-246页

作者： P.Rousset g.buisson J.C.Lega M.Charlot C.gallice E.Cotte 郑福玲

摘要目的回顾性研究直肠和直肠旁MRI征象在预测直肠病变节段切除必要性中的准确性。方法 2名有妇科MRI经验的阅片者盲法对连续5年接受直肠子宫内膜异位

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Vegetation Composition and Structure of Some NeotropicaMountain grasslands in Brazil

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Journal of Mountain Science 2015年第4期12卷 864-877页

作者： LE STRADIC Soizig.buisson Elise FERNANDES g.Wilson gembloux Agro-Bio Tech Université de Liège Biodiversité et paysage Passage des Déportés 2 5030 Gembloux Belgium Institut Méditerranéen de Biodiversité et d’Ecologie marine et continentale (IMBE) Université d’Avignon et des Pays de Vaucluse UMR CNRS IRD Aix Marseille Université IUT site Agroparc BP 61207 F-84911 Avignon cedex 09 France Ecologia Evolutiva & Biodiversidade/Instituto de Ciências Biológicas Universidade Federal de Minas Gerais 30161-970 Belo Horizonte MG CP 486 Brazil Department of Biology Stanford University

The description and understanding of plant communities is fundamental for the implementation of conservation or restoration programs, especially when these communities are highly threatened and need to be *** rupestres, some Neotropical mountain grasslands located in central Brazil and part of the Cerrado biome(covering 2 million km2) host unique plant communities, currently threatened by quarrying and *** grassy matrix of campos rupestres, has long been considered a rich mosaic under the control of local topography and the nature of substrate, but this affirmation has not been well *** analyzed whether plant communities varied in relation to edaphic factors within the stony substrate and the sandy substrate of this grassy *** selected 5 sites where occur both grasslands on stony substrate and on sandy substrate, and we carried out vegetation surveys and soil *** counted 222 plant species within our communities, among which38.6% are exclusively found on campos *** results show that both soil-types are strongly acidic, nutrient poor and exhibit a seasonal *** increases and p H and organic carbon decrease during the dry *** soils areslightly richer in nutrients than sandy soils and differences in soil granulometry and composition have led to the formation of distinct plant *** species are confined to either one or the other grassland-type, which makes the plant composition of each community *** in edaphic factors generate heterogeneous grasslands favorable to a high plant *** programs and restoration actions have to maintain or recreate this *** presence of distinct plant communities implies that different strategies might be adopted to improve the restoration of these ecosystems.

关键词： Biodiversity Campos rupestres Herbaceous community Rupestrian grassland Edaphic factor Serra do Cipó

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Involvement of CRF2 signaling in enterocyte differentiation

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World Journal of gastroenterology 2017年第28期23卷 5127-5145页

作者： Benjamin Ducarouge Marjolaine Pelissier-Rota Rebecca Powell Alain buisson Bruno Bonaz Muriel Jacquier-Sarlin Equipe de l’apoptose du cancer et du développementCentre Léon Bérard Equipes des"Neuro-pathologies et Dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" UniversitéGrenoble Alpes Equipes des"Neuropathologies et dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" Université Grenoble Alpes and Grenoble Institut des Neurosciences-Inserm U1216 Service d’hépato-gastroentérologie Centre Hospitalier Universitaire de Grenoble

To determine the role of corticotropin releasing factor receptor (CRF2) in epithelial permeability and enterocyte cell *** this purpose, we used rat Sprague Dawley and various colon carcinoma cell lines (SW620, HCT8R, HT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon and then by western blot in dissociated colonic epithelial cells and in the lysates of colon carcinoma cell lines or during the early differentiation of HT-29 cells (ten first days). To assess the impact of CRF2 signaling on colonic cell differentiation, HT-29 and Caco-2 cells were exposed to Urocortin 3 recombinant proteins (Ucn3, 100 nmol/L). In some experiments, cells were pre-exposed to the astressin 2b (A2b) a CRF2 antagonist in order to inhibit the action of Ucn3. Intestinal cell differentiation was first analyzed by functional assays: the trans-cellular permeability and the para-cellular permeability were determined by Dextran-FITC intake and measure of the transepithelial electrical resistance respectively. Morphological modifications associated to epithelial dysfunction were analyzed by confocal microscopy after fluorescent labeling of actin (phaloidin-TRITC) and intercellular adhesion proteins such as E-cadherin, p120ctn, occludin and ZO-1. The establishment of mature adherens junctions (AJ) was monitored by following the distribution of AJ proteins in lipid raft fractions, after separation of cell lysates on sucrose gradients. Finally, the mRNA and the protein expression levels of characteristic markers of intestinal epithelial cell (IEC) differentiation such as the transcriptional factor krüppel-like factor 4 (KLF4) or the dipeptidyl peptidase IV (DPPIV) were performed by RT-PCR and western blot respectively. The specific activities of DPPIV and alkaline phosphatase (AP) enzymes were determined by a colorimetric ***2 protein is preferentially expressed in undifferentiated epithelial cel

关键词： Urocortin3 Colon carcinoma cell lines Intercellular adhesion complexes Cell permeability Epithelial cell differentiation Corticotrophin releasing factor 2

16-350 gHz ANTENNAS MEASUREMENTS WITH A NEW SCALAR NETWORK ANALYZER

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16-350 GHz ANTENNAS MEASUREMENTS WITH A NEW SCALAR NETWORK A...

Combined evaluation of biomarkers as predictor of maintained remission in Crohn's disease

International Conference on Millimeter Wave and Far-Infrared Technology

作者： P.goy J.g.buisson ENS Dept. de Physique 24 rue Lhomond 75231 Paris Cedex 05France AB Millimetre 61-71 rue Benoit Frachon Z.I.du Prunay 78500 SartrouvilleFrance

＜正＞Millimeter Antennas have been measured with a new Millimeter Scalar Network Analyzer covering the entire 16-350 gHz *** patterns are rapidly obtained with an unprecedented dynamic range.

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World Journal of gastroenterology 2019年第19期25卷 2354-2364页

作者： Elisa Sollelis Régine Minet Quinard guillaume Bouguen Marion goutte Félix goutorbe Damien Bouvier Bruno Pereira gilles Bommelaer Anthony buisson Inserm 3i HP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 M2i SH USC-INRA 2018 Université Clermont Auvergne Biochemistry laboratory University Hospital G.Montpied CHU Rennes Univ Rennes INSERM CIC1414 Institut NUMECAN (Nutrition Metabolisms and Cancer) gastroenterology Department Hospital of Bayonne Biostatistics Unit DRCI University Hospital

BACKgROUND The individual performances and the complementarity of Crohn's disease(CD)activity index(CDAI), C-reactive protein(CRP) and faecal calprotectin(Fcal) to monitor patients with CD remain poorly inves-tigated in the era of "tight control"and "treat to target" *** To assess CDAI, CRP and Fcal variation, alone or combined, after 12 wk(W12) of anti-tumor necrosis factor(TNF) therapy to predict corticosteroids-free remission(CFREM = CDAI g/L and Fcal g/g with no therapeutic intensification and no surgery) at *** CD adult patients needing anti-TNF therapy with CDAI > 150 and either CRP >2.9 mg/L or Fcal > 250 μg/g were prospectively *** Among the 40 included patients, 13 patients(32.5%) achieved CFREM at W52. In univariable analysis, CDAI g/L at W12(P = 0.001) and Fcal improvement at W12(Fcal g/g; or, for patients with initial Fcal g/g, at least 50% decrease of Fcal or normalization of Fcal(g/g)(P = 0.001) were predictive of CFREM at W52. Combined endpoint(CDAI g/L and FCal improvement) at W12 was the best predictor of CFREM at W52 with positive predictive value = 100.0%(100.0-100.0)and negative predictive value = 87.1%(75.3-98.9). In multivariable analysis, Fcal improvement at W12 [odd ratio(OR) = 45.1(2.96-687.9); P = 0.03] was a better predictor of CFREM at W52 than CDAI g/L(0.77-278.0; P = 0.073).CONCLUSION The combined monitoring of CDAI, CRP and Fcal after anti-TNF induction therapy is able to predict favorable outcome within one year in patients with CD.

关键词： Biomarkers Crohn's disease Faecal calprotectin Crohn's disease activity index C-reactive protein Tight control Anti-tumor necrosis factor

Attainability and Set Analysis for Uncertain PWA Systems with Parameter Variations and Bounded Disturbance

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Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence

2009中国控制与决策会议

作者： Jean Thomas Sorin Olaru Jean buisson Didier Dumur Faculty of Industrial Education Beni-Sueif UniversityEgypt

＜正＞This paper considers discrete-time,uncertain Piecewise Affine（PWA） systems affected by both parameter variations and bounded *** are interested in the characterization of attainability,understood as the reachability of a state space region,associated to a certain invariance *** approach computes in the first stage the maximal set in the state space from which states can be driven to the target region while taking into account the system uncertainties.A polyhedral approach to find the minimum safety horizon（cyclic invariance set） to maintain the system states within the given target region is then presented.A new polyhedral algorithm is proposed to reduce the number of polyhedral regions and decrease the required memory size and consequently the robust control computation load.

关键词： Uncertain Piecewise Affine System Attainability Set Analysis Cyclic Invariance Set

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World Journal of gastroenterology 2018年第5期24卷 641-650页

作者： Pierre Baillet guillaume Cadiot Marion goutte Felix goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-guilhen Benoit Magnin gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony buisson Université Clermont Auvergne CHU Clermont-Ferrand Service de radiologie CHU de Reims Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm 3iHP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 CH de Bayonne Service d’Hépato-Gastro Entérologie CHU de Reims Service de radiologie CHU Clermont-Ferrand DRCI Unité de Biostatistiques

AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical *** Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC gative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high perfor

关键词： Faecal calprotectin Magnetic resonance imaging Postoperative recurrence Crohn’s disease Clermont score Magnetic resonance index of activity

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巴林国家大剧院

世界建筑导报 2015年第3期30卷 109-115页

作者： Nicolas buisson 法国AS建筑工作室

巴林国家大剧院,巴林麦纳麦在庆祝巴林首都麦纳麦成为2012年阿拉伯文化之都的节日气氛中,巴林国家大剧院于同年11月12日正式对外开放,跻身王国最大型的工程项目之列。巴林在阿拉伯语中意为＂两个海洋之间＂：描绘了这颗波斯湾明珠孤独... 详细信息

巴林国家大剧院,巴林麦纳麦在庆祝巴林首都麦纳麦成为2012年阿拉伯文化之都的节日气氛中,巴林国家大剧院于同年11月12日正式对外开放,跻身王国最大型的工程项目之列。巴林在阿拉伯语中意为＂两个海洋之间＂：描绘了这颗波斯湾明珠孤独地坐落在海天相交的极度水平面上的生动画面,这一寓意也正是大剧院的灵感来源之一：用与海洋的结合来演绎一道水平线的风景。

关键词：国家大剧院建筑工作室灵感来源最大型文化之都环礁湖阿拉伯世界国家博物馆建筑设计意大利风格

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Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease

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World Journal of gastroenterology 2016年第21期22卷 5068-5078页

作者： Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion goutte Felix goutorbe Anne Dubois Johan gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte gilles Bommelaer Anthony buisson gastroenterology Department University Hospital Estaing 63000 Clermont-Ferrand France DRCI Biostatistics Unit GM Clermont-Ferrand University and Medical Center 63000 Clermont-Ferrand France Pathology Department University Hospital Estaing 63000 Clermont-Ferrand France Microbes Intestine Inflammation and Susceptibility of the Host UMR 1071 Inserm/Universite d'Auvergne USC-INRA 2018 63000 Clermont-Ferrand France Digestive Surgery Department University Hospital Estaing 63000 Clermont-Ferrand France Pediatrics Department University Hospital Estaing 63000 Clermont-Ferrand France

AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative ***: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn’s disease (CD) in our center (1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy (median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of ***: From 205 patients who underwent surgery, 161 patients (follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype (B3) were postoperative risk factors. Previous perianal abscess/fistula (other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management (n = 49/161) prevented clinical (HR = 0.4, 95%CI: 0.25-0.66, P gical postoperative recurrence (HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation.

关键词： Crohn’ s disease Postoperative recurrence Endoscopy Prevalence Risk factors