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应用动态磁敏感增强MRI无创评估贝伐单抗治疗后复发性胶质母细胞瘤的肿瘤血管生成和氧合作用：来自欧洲癌症研究与治疗组织26101试验的二次分析

国际医学放射学杂志 2020年第6期 741-741页

作者：周慧 P.Kickingereder g.brugnara M.B.Hansen M.Nowosielski I.Pflüger M.Schell Department of Neuroradiology Heidelberg University Hospital

摘要因为在随机对照的Ⅲ期临床试验中无进展病人的生存期益处不能转化为总生存期(OS)益处,具有抗血管生成作用的贝伐单抗治疗胶质母细胞瘤的实质功效存在争议。

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Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil

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World Journal of gastroenterology 2020年第25期26卷 3611-3624页

作者： Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa brugnara Columbano Junqueira Neto Stefania Burjack gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes gilaad g Kaplan Cyrla Zaltman Division of gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Institute for Studies in Public Health Federal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Multidisciplinary Research Laboratory Clementino Fraga Filho HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Division of gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of PiauíPiauí64049-550Brazil Almeida Division of GastroenterologyInflammatory Bowel Disease Outpatient ClinicRoberto Santos General Hospital(HGRS)of the Bahia State Department of HealthBahia 40110-060Brazil Division of gastroenterology Inflammatory Bowel Disease Outpatient ClinicIrmandade Santa Casa da Misericórdia of São PauloSão Paulo 01221020Brazil Division of gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of Juiz de ForaMinas Gerais 36036-247Brazil Division of gastroenterology Inflammatory Bowel Disease Outpatient ClinicFederal District Base HospitalBrasília 70330-150Brazil gastrointestinal Physiology Institute of Nutritional ScienceNestle Research CenterLausanne 1000Switzerland Departments of Medicine and Community Health Sciences University of CalgaryCalgary T2N4Z6Canada

BACKgROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be *** hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated *** To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development *** A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was *** regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),*** This is the first examining environmental exposures as risk factors for inflammatory bowel disease in *** of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

关键词： Crohn’s disease Ulcerative colitis Risk factors Environmental factors Hygiene hypothesis

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用于提高发动机部件效率的摩擦催化Mo-X-N涂层系统

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汽车与新动力 2021年第2期4卷 39-41页

作者： [德]L.DOBRENIZKI [德]R.H.brugnara [德]S.TREMMEL [德]S.WARTZACK 李媛媛(译) 不详

采用表面涂层是减少内燃机摩擦损失的有效措施之一。在配气机构中,优化挺柱和凸轮轴之间的摩擦接触具有较高的技术潜力。Schaeffler公司提出了1种采用纳米结构的摩擦催化物理气相沉积(PVD)涂层系统,可在受应力作用的表面形成保护性摩擦膜。

关键词：摩擦磨损涂层挺柱效率

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声波辐射脉冲(ARFI)观察膀胱输尿管反流儿童肾实质硬度的初步研究

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国际医学放射学杂志 2014年第1期 101-101页

作者： C.Bruno g.Caliari M.Zaffanello M.brugnara M.Zuffante M.Cecchetto 袁涛 Department of Radiology University of VeronaP.le L.A.Scuro 1037134 VeronaItaly

目的前瞻性研究声波辐射脉冲(ARFI)对无慢性肾病患儿的肾脏进行检查。方法28例原发或继发性膀胱输尿管反流(≥Ⅲ级)的儿童(9～16岁)行同位素与ARFI超声

关键词： ARFI成像肾脏肾功能衰竭慢性膀胱输尿管返流弹性成像技术

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