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Exploring the potential of Lactobacillus and Saccharomyces for biofunctionalities and the release of bioactive peptides from whey protein fermentate

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Food bioscience 2022年第4期48卷 320-338页

作者： Chopada Kevalkumar Dineshbhai bethsheba basaiawmoit Amar A.Sakure Ruchika Maurya Mahendra bishnoi Kanthi Kiran Kondepudi g.b.patil Maunil Mankad Zhenbin Liu Subrota Hati Dept.of Dairy Microbiology Anand Agricultural UniversityAnand388110GujaratIndia Dept.of Rural Development and Agricultural Production North-Eastern Hill UniversityTura CampusTura794002MeghalayaIndia Dept.of Agriculture biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for biotechnology FaridabadHaryana121001India Healthy gut Research group Food&Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Dept.of Tissue Culture Anand Agricultural UniversityAnand388110GujaratIndia School of Food and biological Engineering Shaanxi University of Science and Technology18Xi’an710021China

Whey protein concentrate-80(WPC-80)fermented with ***(KgL4)(37℃)and ***(WbS2A)(25℃)was tested for ACE-inhibitory and antioxidant activities over different periods(12,24,36 and 48 h).Proteolytic activity(OPA method)was used to optimize the growth conditions(inoculation rate,*** 1.5%,2.0%,and 2.5%and incubation time,i.e.12,24,36,and 48 h)for peptide *** indicated that the highest amount of peptides was obtained at 7.24 mg/mL for KgL4(37℃,48 h)and 8.59 mg/mL for WbS2A(25℃,48 h).The whey protein fermentate inhibited the LPS-induced NO production,while enhanced production concentrations of TNF-α,IL-6,and IL-1β.Subsequently,SDS-PAgE,as well as Two-Dimensional(2D)gel electrophoresis methods,were applied for protein purification using water-soluble extracts(WSEs)of WPC-80 fermented by a combination of *** and *** SDS-PAgE,protein bands were observed in the range of 10-55 kDa,whereas on the 2D page,protein spots were in the range of 10-70 *** the 2D spots were analyzed using RPLC/*** of 3 kDa and 10 kDa permeates were used in RP-HPLC to identify distinct peptide *** data from LC/MS was also characterized by utilizing ProteinPilot ***,different functional groups were also analyzed using FTIR *** research aims to isolate and characterize novel ACE-inhibitory and antioxidative peptides from fermented WPC-80 produced by Lactobacillus fermentum and ***.

关键词： ACE-Inhibitory Antioxidative activity Anti-inflammatory SDS FTIR RP-HPLC L.fermentum S.cerevisiae Whey protein fermentate

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A comparative study of fermented buffalo and camel milk with anti-inflammatory, ACE-inhibitory and anti-diabetic properties and release of bio active peptides with molecular interactions: In vitro, in silico and molecular study

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Food bioscience 2023年第2期52卷 687-721页

作者： Ruchita Khakhariya Amar A.Sakure Ruchika Maurya Mahendra bishnoi Kanthi Kiran Kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu g.b.patil Maunil Mankad Subrota Hati Dept.of Dairy Microbiology SMC College of Dairy ScienceKamdhenu UniversityAnand388110GujaratIndia Dept.of Agriculture biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for biotechnology FaridabadHaryana121001India Healthy gut Research group Food&Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Institute of bioresources and Sustainable Development Regional CentreTadong737102SikkimIndia School of Food and biological Engineering Shaanxi University of Science and TechnologyXi’an710021China Dept.of Tissue Culture Anand Agricultural UniversityAnand388110GujaratIndia

The aim of this study is to compare ACE inhibitory,anti-diabetic and Anti-inflammatory activity of buffalo and camel milk using Lacticaseibacillus paracasei(M11)in combination with yeast Saccharomyces cerevisiae(WbS2A)and to release peptides with antihypertensive and anti-diabetic *** buffalo and camel milk were considered for the evaluation of Angiotensin-converting enzyme(ACE)inhibitory and anti-diabetic activities at specific time intervals(12,24,36 and 48 h)at 37℃.For the growth condition optimization,proteolytic activity was evaluated with specific inoculation rates(1.5%,2.0%,and 2.5%)and at specific incubation periods(12,24,36,and 48 h).The highest peptides were produced at 2.5%inoculation rate and at 48 h of incubation in both buffalo and camel milk at 37℃.Further,camel and buffalo milk fermented with M11+WbS2A significantly lower the overproduction of TNF-α,IL-6,IL-1βand Nitric oxide(NO),that was induced by lipopolysaccharide(LPS)stimulation in RAW 267.4 *** protein purification,2D gel electrophoresis and SDS-PAgE were *** and buffalo milk that had not been fermented displayed protein bands between 10 and 100 kDa and 10 and 75 kDa respectively,whereas all the fermented samples showed bands between 10 and 75 *** SDS-PAgE,in permeates,there were no apparent protein *** fermented buffalo and camel milk were electrophoresed in 2D gel,a total of 26 and 25 protein spots were *** 2D gel electrophoresis,protein spots had sizes between 10 and 37 *** RP-HPLC,water-soluble extracts(WSEs)of ultra-filtered fractions were used to distinguish different fractions of a *** software was used to characterize the LC/MS *** transform-infrared spectroscopy(FTIR)was used to evaluate various functional groups of fermented *** molecular docking study,the peptide sequences identified from the fermented buffalo milk(FbM)and camel milk(FCM)were examined for their binding affinity against the binding sites of

关键词： ACE inhibitory Anti-diabetic activity buffalo milk Camel milk SDS FTIR RP-HPLC LC/MS Molecular docking

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Progeny evaluation of Jatropha curcas and Pongamia pinnata with comparison to bioproductivity and biodiesel parameters

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Journal of Forestry Research 2015年第1期26卷 137-142页

作者： Vinod Kumar patil Prithviraj bhandare Pramod b. Kulkarni g.R.Naik Department of biotechnology Gulbarga University

Progeny studies of Jatropha curcas and Pongamia pinnata were carried with respect to bioproductivity,pod and seed characters which is one of the selection methods in tree improvement programmes. Variations in bioproductivity and biodiesel parameters of both the plants were compared every 6 months for 4 years of investigation and analyzed by analysis of variance and correlation coefficient by Pearson＇s method using software graphpad instat 3.06（for Windows and Mac）. P. pinnata has better germination rate（71.4 %）, 100 pod weight（PW）（311.59 g） and 100 seed weight（SW）（173.46 g） as compared to J. curcas for germination rate（43.2 %）, 100 PW（111.29 g） and 100 SW（67.46 g）. P. pinnata has strong correlation for plant height to canopy growth（Cg）（0.948）, collar diameter（CD）（0.994）, number of branches per plant（NbP）（0.995） and to number of leaves per branch（NLb）（0.862） as compared to *** which showed good correlation among plant height to Cg（0.976）, CD（0.970）, NbP（0.988）, NLb（0.920） and to number of pods per branch（0.657）. However, J. curcas depicted negative correlation for pod breadth to seed length（SL）（-0.447）, seed breadth（-0.248） and to seed thickness（ST）（-0.364） and among the 100 PW to SL（-0.199）, ST（-0.220） and to 100 SW（-0.704）. About 4 kg of P. pinnata seeds were required for each liter of crude oil which yields896 ml of biodiesel on transesterification as compared to5.66 kg of J. curcas seeds for a liter of crude oil, producing about 663 ml of biodiesel. The quality of biodiesel meets the major specification of American Society for Testing and Materials（ASTM） standards for biodiesel. The crude glycerin and seed cake obtained as byproduct during biodiesel production were also measured which can be purified and used in composting, animal feeds, pharmaceuticals and cosmetic industries.

关键词： biodiesel biofuel plants bioproductivity Jatropha curcas Pongamia pinnata

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Efficient and recyclable palladium enriched magnetic nanocatalyst for reduction of toxic environmental pollutants

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Journal of Environmental Sciences 2021年第3期33卷 189-204页

作者： Manjunatha Kempasiddaiah Vishal Kandathil Ramesh b.Dateer Mahiuddin baidya Shivaputra A.patil Siddappa A.patil Centre for Nano and Material Sciences Jain UniversityJain Global CampusKanakapuraRamanagaramBangalore 562112India Department of Chemistry Indian Institute of Technology MadrasChennai 600036Tamil NaduIndia Pharmaceutical Sciences Department College of PharmacyRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

In this paper,highly stable,powerful,and recyclable magnetic nanoparticles tethered Nheterocyclic carbene-palladium(Ⅱ)((CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4))as magnetic nanocatalyst was successfully synthesized from a simplistic multistep synthesis under aerobic conditions through easily available low-cost *** synthesized(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst was characterized from various analytical tools and catalytic potential of the(CH_(3))_(3)-NHC-Pd@Fe_3 O_4 magnetic nanocatalyst was studied for the catalytic reduction of toxic 4-nitrophenol(4-NP),hexavalent chromium(Cr(Ⅵ)),Methylene blue(Mb)and Methyl Orange(MO)at room temperature in aqueous ***-Visible spectroscopy was employed to monitor the reduction ***(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst exhibited excellent catalytic activity for the reduction of toxic environmental ***,(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst could be easily and rapidly separated from the reaction mixture with the help of an external magnet and recycled minimum five times in reduction of 4-NP,Mb,MO and four times in Cr(Ⅵ)without significant loss of catalytic potential and remains stable even after reuse.

关键词： Magnetic nanocatalyst Wastewater treatment Chemical kinetics Catalyst recyclability

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gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

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Asian Pacific Journal of Tropical biomedicine 2019年第6期9卷 263-270页

作者： Pukar Khanal b.M.patil Department of Pharmacology and Toxicology KLE College of Pharmacy Belagavi KLE Academy of Higher Education and Research (KAHER)

Objective:To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein ***:The phytoconstituents of Ficu.s *** were queried for inhibitors of alphaglucosidase,also identified as aldose reductase *** score,absorption,distribution,metabolism,excretion and toxicity profile,biological spectrum,and gene expression were predicated for each *** study was performed to predict the binding affinity with alpha-glucosidase and aldose reductase and compared with clinically proven *** Encyclopedia of genes and genomes pathway analysis was performed for the regulated genes to identify the modulated ***:Apigenin,3,4’,5,7-tetrahydroxy-3’-methoxyflavone,and kaempferol were identified as inhibitors of alpha-glucosidase and aldose *** was predicted to possess the highest binding affinity with both *** p53 signaling pathway was predicted to modulate the majority of protein molecules in diabetes *** the alpha-glucosidase inhibitors were also predicted as membrane integrity agonist and anti-mutagenic ***:The current study indicates alpha-glucosidase inhibitors from Ficus benghale,nsis can act as aldose reductase inhibitors after absorption from the intestinal ***,these phytoconstituents are involved in the regulation of numerous protein molecules and ***,the anti-diabetic efficacies of these compounds are due to their action on multiple protein molecules and synergistic effects which should be confirmed by future investigations.

关键词： Ficus benghalensis gene set enrichment Kaempferol Network pharmacology Type 2 diabetes mellitus

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Fluorimetric study of the interaction between ATP and ciprofloxacin-Y^(3+) complex and its application

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Journal of Rare Earths 2010年第3期28卷 329-332页

作者： Shailaja R.patil Umesh S.Mote Shivajirao R.patil Sang-Hak Lee govind b.Kolekar Fluorescence Spectroscopy Research Laboratory Department of ChemistryShivaji UniversityKolhapur-416 004MaharashtraIndia Department of Chemistry Kyungpook National UniversityDaeguS.Korea 133-791)

A simple spectrofluorimetric method was developed for determination of trace amount of adenosine disodium triphosphate(ATP).Under the optimum conditions,we studied the interaction between CIP-Y3+-ATP complex by using absorption and fluorescence *** was observed that ATP remarkably enhanced the fluorescence intensity of the CIP-Y3+ complex at λem=415 nm and the enhanced fluorescence intensity of Y3+ ion remained proportional to the concentration of *** developed method was successfully applied for...

关键词： adenosine disodium triphosphate(ATP) ciprofloxacin(CIP) yttrium(Y3+) spectrofluorimetric method rare earths

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A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives

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Chinese Chemical Letters 2015年第10期26卷 1273-1277页

作者： Yogesh b.Wagh Yogesh A.Tayade Swapnil A.Padvi bhupesh S.patil Nilesh b.patil Dipak S.Dalal School of Chemical Sciences North Maharashtra University

A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available Cs F as a catalyst in the reaction of malononitrile and aryl aldehydes or isatins with 1,3-cyclohexanediones. The major advantages of this methodology are excellent yield at ambient temperature, very short reaction time（5–10 min）, and use of an inexpensive catalyst.

关键词： Cesium fluoride 2-Amino-3-cyano-4H-pyrans Spirooxindoles Rapid synthesis Multicomponent reactions

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Computer-aided diabetic retinopathy diagnostic model using optimal thresholding merged with neural network

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International Journal of Intelligent Computing and Cybernetics 2020年第3期13卷 283-310页

作者： Ambaji S.Jadhav Pushpa b.patil Sunil biradar Department of Electrical and Electronics B.L.D.E.A’s V.P.Dr.P.G.Halakatti College of Engineering and Technology(Affiliated to Visvesvaraya Technological University)VijayapurIndia Department of Ophthalmology Shri B.M.Patil Medical College and Research Center(Deemed to be University)VijayapurIndia

Purpose-Diabetic retinopathy(DR)is a central root of blindness all over the *** DR is tough to diagnose in starting stages,and the detection procedure might be time-consuming even for qualified ***,intelligent disease detection techniques are extremely acceptable for progress analysis and recognition of various ***,a computer-aided diagnosis scheme based on intelligent learning approaches is intended to propose for diagnosing DR effectively using a benchmark ***/methodology/approach-The proposed DR diagnostic procedure involves four main steps:(1)image pre-processing,(2)blood vessel segmentation,(3)feature extraction,and(4)***,the retinal fundus image is taken for pre-processing with the help of Contrast Limited Adaptive Histogram Equalization(CLAHE)and average *** the next step,the blood vessel segmentation is carried out using a segmentation process with optimized gray-level *** the blood vessels are extracted,feature extraction is done,using Local binary Pattern(LbP),Texture Energy Measurement(TEM based on Laws of Texture Energy),and two entropy computations-Shanon’s entropy,and Kapur’s *** collected features are subjected to a classifier called Neural Network(NN)with an optimized training *** the gray-level thresholding and NN is enhanced by the Modified Levy Updated-Dragonfly Algorithm(MLU-DA),which operates to maximize the segmentation accuracy and to reduce the error difference between the predicted and actual outcomes of the ***,this classification error can correctly prove the efficiency of the proposed DR detection ***-The overall accuracy of the proposed MLU-DA was 16.6%superior to conventional classifiers,and the precision of the developed MLU-DA was 22%better than LM-NN,16.6%better than PSO-NN,gWO-NN,and ***,it is concluded that the implemented MLU-DA outperformed state-of-the-art algorithms in detecting ***

关键词： Diabetic retinopathy detection gray-level thresholding Optimal trained neural network Dragon fly algorithm Levy update Performance metrics

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Impact of La^(3+)substitution on electrical,magnetic,dielectric and optical properties of Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(0

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Journal of Rare Earths 2023年第5期41卷 740-746,I0004页

作者： b.b.patil A.D.Pawar S.S.barate J.S.ghodake J.b.Thorat T.J.Shinde P.g.Department of Physics Smt.KRP Kanya MahavidyalayaIslampurMS415409India Department of Physics Shivaji UniversityKolhapurMS416004India Departments of Physics PDVP MahavidyalayaMahavidyalayaTasgaonMS416312India Department of Physics Sadguru Gadage Maharaj CollegeKaradMS415110

The oxalate co-precipitation method was used to synthesize the La3+substituted Ni-Cu-Zn(La-NCZ)nanoferrites having chemical composition Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(x=0.015,0.025 and 0.035).DC resistivity study of nanoferrites shows both the conducting and semiconducting *** room temperature DC electrical resistivity of Ni-Cu-Zn(NCZ)nanoferrites decreases,whereas Curie temperature increases with increasing La^(3+)*** the temperature range of 30-170℃nanoferrites show p-type semiconducting behavior except x=0.015;thereafter,they show n-type *** frequency dispersive initial permeability(μi)associated with its real and imaginary(μ’andμ")parts are attributed to the domain wall movement and magnetic spin ***μi,u’andμ"of La-NCZ nanoferrites are higher than those of pure NCZ *** constant(ε’),dielectric loss(ε")and AC resistivity(ρAC)of La-NCZ nanoferrites show normal dielectric *** is found thatε’of NCZ nanoferrites decreases with the increasing content of La3+*** bandgap energy of La-NCZ nanoferrites is achieved in the range 1.36-1.70 eV confirming the semiconducting nature of materials.

关键词： Ni-Cu-La-Zn nanoferrites DC electrical Resistivity Permeability Dielectric properties bandgap energy Rare earths

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Antifertility effect of ethanolic extract of Amalakyadi churna in male albino mice

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Asian Journal of Andrology 2003年第3期5卷 247-250页

作者： Y.N.Seetharam H.Sujeeth g.Jyothishwaran Arvind barad g.Sharanabasappa b.Umareddy M.b.Vijaykumar Saraswati b.patil biosyatematics and Medicinal Plants Laboratory Department of Botany Department of Zoology Gulbarga University Gulbarga-585106 India

Aim: To evaluate the antifertility activity of the ethanolic extract of Amalakyadi churna by oral administration in male albino mice. Methods: The ethanol extract of Amalakyadi churna at the dose of 250 mg/kg and 400 mg/ kg body weight was administered orally for 30 days to adult male mice. On day 31, the mice were sacrificed and the testis and accessory reproductive organs were removed and weighed. The organs were processed for biochemical estimation and histological work. Results: Treatment with Amalakyadi churna resulted in decrease in the weights of testis and accessory reproductive organs. The diameters of testis, seminiferous tubules and Leydig cell nucleus were decreased. The spermatogenic elements, like spermatogonia, spermatocytes and spermatids in the testis were reduced significantly as well as the sperm count in cauda epididymis. There was a significant reduction in the protein, glycogen, DNA and RNA contents and the activity of acid phosphatase in the testis of extract treated mice compared with the control. The cholesterol content and the alkaline phophatase activity were increased significantly in treated mice. Conclusion: Amalakyadi churna extract arrests spermatogenesis in male mice without noticeable side effects.

关键词： Amalakyadi churna testis accessory organs reproduction spermatogenesis

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