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Compartmentalization of the inflammatory response during bacterial sepsis and severe COVID-19

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Journal of Intensive Medicine 2024年第3期4卷 326-340页

作者： Jean-Marc Cavaillon Benjamin g.Chousterman Tomasz Skirecki Institut Pasteur ParisFrance Department of Anesthesia and Critical Care Lariboisière University HospitalDMU ParabolAPHP NordParisFrance Inserm U942 University of ParisParisFrance Department of Translational Immunology and Experimental Intensive Care Centre of Postgraduate Medical EducationWarsawPoland

Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-organ failure and eventually to death. The host response to infection encompasses a large spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fighting the infectious agent and removing damaged tissues or cells, and the anti-inflammatory response aimed at controlling inflammation and initiating the healing process. Fine-tuning at the local and systemic levels is key to preventing local and remote injury due to immune system activation. Thus, during bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring. Immune cells (e.g., macrophages, neutrophils, natural killer cells, and T-lymphocytes), as well as endothelial cells, differ from one compartment to another and contribute to specific organ responses to sterile and microbial insult. Furthermore, tissue-specific microbiota influences the local and systemic response. A better understanding of the tissue-specific immune status, the organ immunity crosstalk, and the role of specific mediators during sepsis and COVID-19 can foster the development of more accurate biomarkers for better diagnosis and prognosis and help to define appropriate host-targeted treatments and vaccines in the context of precision medicine.

关键词： Acute respiratory distress syndrome Bone marrow Cytokines Lungs Mucosa Vaccines

Cretaceous crown male ant reveals the rise of modern lineages

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Zoological Research 2024年第5期45卷 983-989页

作者： Qiong Wu Alexander g.Radchenko Michael S.Engel Xiao-Qin Li Hong-Ru Yang Xing-Ru Li Chung-Kun Shih Dong Ren Tai-Ping gao College of Life Sciences Capital Normal UniversityBeijing 100048China I.I.Schmalhausen Institute of Zoology NAS of UkraineKiev 01054Ukraine Division of Invertebrate Zoology American Museum of Natural HistoryNew York 10024-5192USA Facultad de Ciencias Biológicas Universidad Nacional Mayor de San MarcosLima 11-0058Perú Departamento de Entomología Museo de Historia NaturalUniversidad Nacional Mayor de San MarcosLima 15072Perú Department of Chemistry Analytical and Testing CenterCapital Normal UniversityBeijing 100048China Department of Paleobiology National Museum of Natural HistorySmithsonian InstitutionWashington DC 20013-7012USA

Most described Mesozoic ants belong to stem groups that existed only during the Cretaceous ***,the earliest known crown ants were dated to the Turonian(Late Cretaceous,ca.94-90 million years ago(Ma))deposits found in the USA,Kazakhstan,and ***,the recent discovery of an alate male ant in Kachin amber from the earliest Cenomanian(ca.99 Ma),representing a new genus and species,Antiquiformica alata,revises the narrative on ant *** can be distinctly differentiated from all known male stem ants by its geniculate antennae with elongated scape,extending far beyond the occipital margin of the head and half the length of the funiculus,as well as its partly reduced forewing ***,the combination of a one-segmented waist with a well-developed node,elongated scape extending beyond the occipital margin,and reduced forewing venation,particularly the completely reduced m-cu and rs-m crossveins and absence of rm and mcu closed cells,firmly places the fossil within the extant subfamily *** transform infrared spectroscopy(FTIR)confirmed that the amber containing Antiquiformica alata originated from the Kachin mines in *** discovery significantly revises our understanding of the early evolution of *** presence of Antiquiformica in Cenomanian amber indicates that the subfamily Formicinae emerged at least by the start of the Late Cretaceous,with crown ants likely originating earlier during the earliest Cretaceous or possibly the Late Jurassic,although paleontological evidence is lacking to support the latter hypothesis.

关键词： Formicidae Formicinae Morphology Taxonomy Antiquiformica alata Paleontology Kachin amber

Emotion Detection Using ECg Signals and a Lightweight CNN Model

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Computer Systems Science & Engineering 2024年第5期48卷 1193-1211页

作者： Amita U.Dessai Hassanali g.Virani Department of Electronics and Telecommunication Engineering Goa College of EngineeringGoa UniversityPonda403401India

Emotion recognition is a growing field that has numerous applications in smart healthcare systems and Human-Computer Interaction(HCI).However,physical methods of emotion recognition such as facial expressions,voice,and text data,do not always indicate true emotions,as users can falsify *** the physiological methods of emotion detection,Electrocardiogram(ECg)is a reliable and efficient way of detecting ***-enabled smart bands have proven effective in collecting emotional data in uncontrolled *** use deep machine learning techniques for emotion recognition using ECg signals,but there is a need to develop efficient models by tuning the ***,most researchers focus on detecting emotions in individual settings,but there is a need to extend this research to group settings aswell since most of the emotions are experienced in *** this study,we have developed a novel lightweight one dimensional(1D)Convolutional Neural Network(CNN)model by reducing the number of convolution,max pooling,and classification *** optimization has led to more efficient emotion classification using *** tested the proposed model’s performance using ECg data from the AMIgOS(A Dataset for Affect,Personality and Mood Research on Individuals andgroups)dataset for both individual and group *** results showed that themodel achieved an accuracy of 82.21%and 85.62%for valence and arousal classification,respectively,in individual *** group settings,the accuracy was even higher,at 99.56%and 99.68%for valence and arousal classification,*** reducing the number of layers,the lightweight CNNmodel can process data more quickly and with less complexity in the hardware,making it suitable for the implementation on the mobile phone devices to detect emotions with improved accuracy and speed.

关键词： Emotions AMIgOS ECg lightweight 1D CNN

Prothrombotic state and thrombotic events in COVID-19 pandemic period,including portal vein and splenic artery thromboses

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World Journal of Clinical Cases 2024年第33期12卷 6595-6603页

作者： Ozgur Karcioglu Canan Akman göksu Afacan Ozturk Department of Emergency Medicine University of Health SciencesIstanbul Education and Research HospitalIstanbul 34140BakırkoyTürkiye Department of Emergency Medicine Canakkale Onsekiz Mart UniversityCanakkale 17000ÇanakkaleTürkiye Department of Emergency Medicine Istanbul Aydin UniversityIstanbul 34295KucukcekmeceIstanbulTürkiye

This editorial article is intended to perform a discussion on the manuscript entitled“Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient:A case report and review of literature”written by Abramowitz et *** article focuses on the diagnostic processes in a 77-year-old-male patient with a simultaneous portal vein and splenic artery thrombosis accompanying coronavirus disease 2019(COVID-19).The authors postulated that splanchnic thrombosis should be on the list of differential diagnoses in a patient presenting with abdominal pain in presence of a COVID-19 *** tendency for venous and arterial thrombosis in COVID-19 patients is encountered,largely attributed to *** general,venous thromboembolism mostly manifest as deep vein thrombosis(DVT),pulmonary embolism(PE)or catheterrelated thromboembolic *** PE,DVT,cerebrovascular events and myocardial infarction are seen as the most common thromboembolic complications in COVID-19 ***-19-associated hemostatic abnormalities include mild thrombocytopenia and increased D-dimer *** to other coagulopathies,the treatment of the underlying condition is the *** of antiplatelet agents can be considered in critically ill patients at low bleeding risk,not on therapeutic anticoagulation,and receiving gastric acid suppression Early administration of antithrombotic drugs will have a beneficial effect in both the prevention and treatment of thrombotic events,especially in non-ambulatory *** molecular weight heparin(LMWH)should be started if there is no contraindication,including in non-critical patients who are at risk of hospitalization LMWH(enoxaparin)is preferred to standard heparin.

关键词： Prothrombotic state Thrombotic events COVID-19 Pandemic Thromboembolism

Colorful facial markings are associated with foraging rates and affiliative relationships in a wild group-living cichlid fish

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Current Zoology 2024年第1期70卷 70-78页

作者： Brett M.Culbert James B.Barnett Isaac Y.Ligocki Matthew g.Salena Marian Y.L.Wong Ian M.Hamilton Sigal Balshine Department of Integrative Biology University of GuelphGuelphOntarioCanada Department of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonOntarioCanada Department of Evolution Ecologyand Organismal BiologyThe Ohio State UniversityColumbusOHUSA Department of Biology Millersville UniversityMillersvillePAUSA School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNew South WalesAustralia Department of Mathematics The Ohio State UniversityColumbusOHUSA

Many animals use color to signal their quality and/or behavioral *** signals have been well studied in the contexts of competi-tion and mate choice;however,the role of these signals in nonsexual,affiliative relationships is not as well ***,we used wild social groups of the cichlid fish Neolamprologus pulcher to investigate whether the size of a brightly colored facial patch was related to 1)individual quality,2)social dominance,and/or 3)affiliative *** with larger patches spent more time foraging and tended to perform more aggressive acts against conspecific territory *** did not find any evidence that the size of these yellow patches was related to social rank or body size,but dominant males tended to have larger patches than dominant ***,patch size had a rank-specific relationship with the number of affiliative interactions that individuals engaged *** males with large patches received fewer affiliative acts from their groupmates compared to dominant males with small ***,subordinates with large patches tended to receive more affiliative acts from their groupmates while performing fewer affiliative acts *** together,our results suggest that patch size reflects interindividual variation in foraging effort in this cichlid fish and offer some of the first evidence that colorful signals may shape affiliative relationships withinwildsocialgroups.

关键词： affiliation foraging Lake Tanganyika Neolamprologus pulcher visual signals

Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.Hernandez gabriel A.Zayas Eduardo E.Rodriguez Kaitlyn M.Sarlo Davila Fahad Rafiq Andrea N.Nunez Cristiane goncalves Titto Raluca g.Mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food Engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine ggP F250K,and BLUPF90 software was used to estimate genetic parameters and for genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step gWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADgRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAMP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA gWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： gWAS Heritability Skin Thermotolerance

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKgROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(Pgnitive scores(Pgnificant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

Tracking the Ti^(4+)substitution in phlogopite by spectroscopic imaging:A tool for unravelling the growth of micas at HP-HT conditions

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geoscience Frontiers 2024年第3期15卷 1-13页

作者： g.Della Ventura N.El Moutaouakkil B.Boukili S.Bernardini A.Sodo L.Pronti M.Cestelli-guidi F.Holtz F.Lucci Dipartimento di Scienze UniversitàRoma TreRomaItaly INFN-LNF via Fermi 200040 FrascatiRomaItaly INgV Via di Vigna Murata 60500143 RomaItaly Laboratory of géosciences Water and Environment.Department of Earth Sciences.Faculty of SciencesUniversity Mohammed VRabatMorocco Leibnitz Universität Hannover Institute of MineralogyCallinstr 330167 HannoverGermany Dipartimento di Scienze della Terra e geoambientali Universitàdi Bari“Aldo Moro”BariItaly

Phlogopite solid-solutions have a wide pressure-temperature(P-T)stability field and are ubiquitous in a wide variety of geological settings,from deep lithosphere magmatic environments to upper crust metamorphic *** composition represents therefore a valuable physical-chemical archive and may provide important information regarding its crystallization and the petrogenesis of the *** this paper we examine the phlogopite phenocrysts from the well-known Fort Regent mica-bearing lamprophyre minette from ***(Island of Jersey,UK).Phlogopite phenocrystals from lamprophyres generally show normal-step and continuous compositional zoning,however those from the Fort Regent minette show a peculiar texture characterized by dark brown high-Ti(average TiO_(2)≈8.5 wt.%)cores enveloped by euhedral low-to mid-amplitude zonation due to oscillatory contents in Ti,Fe and ***-barometry modelling based on biotite-only composition yields relatively high P-T estimates(T≈970±54℃at P≈0.73±0.13 gPa)for cores whereas lower values(T≈790±54℃at P≈0.29±0.13 gPa)are obtained for the outer *** temperatures(T≈1075±54℃)but extremely high and anomalous pressure values(P≈1.82±0.13 gPa)are obtained for the yellowish inner *** combination of electron micro probe(EMP)analysis and single-crystal infra-red(FTIR)imaging in the OH-stretching region shows that the exceptional and oscillatory Ti contents are due to the Ti-vacancy substitution,typical of crystallization and growth processes of HP/HT *** imaging provides additional insight for this process,confirming the dominant dioctahedral nature for the Ti-Fe-rich cores and outer *** of thermobaric estimates obtained from the phlogopite compositiononly model,based on the fine-scale compositional evolution,shows that pressure-temperature values from low-Ti high-Mg domains should be carefully evaluated because the substitution mechanisms during the dark mica growth are not univocal

关键词： Ti-phlogopite Jersey minette(UK) Ti-substitution FTIR imaging Raman imaging Thermobarometric modelling

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.Hudson Anastasios g.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven L.Spitalnik Vassilis L.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA Laboratory of Reliability and Quality Control in Laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain