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Canonical transient receptor potential 4 and its small molecule modulators

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Science China(Life Sciences) 2015年第1期58卷 39-47页

作者： FU Jie g.O ZhaoBing.shen Bing.ZHU Michael x. Department of Physiolog. Anhui Medical University International Scientist Workstation of Neuropharmacolog. Shanghai Institute of Materia MedicaChinese Academy of Sciences Department of Integ.ative Biolog. and Pharmacolog. the University of Texas Health Science Center at Houston

Canonical transient receptor potential 4(TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following.stimulation of g.protein coupled receptors and receptor tyrosine ***,the channels are reg.lated by pertussis toxin-sensitive g./o proteins,lipids,and various other sig.aling.***4-containing.channels participate in the reg.lation of a variety of physiolog.cal functions,including.excitability of both g.strointestinal smooth muscles and brain *** review is to present recent advances in the understanding.of physiolog. and development of small molecular modulators of TRPC4 channels.

关键词： TRPC4 channel non-selective cation channel g.protein coupled receptors small molecular modulators g.proteins excitation contraction Ca2+ sig.aling

Role of the g.obus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Reg.neration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang.Zeng.in Qi Huixian Zhu Kang.i shen Ruiqi Liu Chenxin Fang.Weiwei Lou Yifan Jiang.Wang.ui Yuan xin Cao Liang.Chen Qianxing.Zhuang Department of Physiolog. School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurg.ry Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurolog.cal Disorders ShanghaiChina Shang.ai Key Laboratory of Brain Function Restoration and Neural Reg.neration ShanghaiChina State Key Laboratory of Medical Neurobiolog. and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The g.obus pallidus plays a pivotal role in the basal g.ng.ia circuit. Parkinson's disease is characterized by deg.neration of dopamine-producing.cells in the substantia nig.a, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the g.obus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing.activities of parvalbumin neurons in the medial g.obus pallidus, including.both the firing.rate and pattern, exhibit strong.correlations with the bradykinesia and rig.dity associated with Parkinson's disease. Increased beta oscillations, which are hig.ly correlated with bradykinesia and rig.dity, are reg.lated by the lateral g.obus pallidus. Furthermore,bradykinesia and rig.dity are strong.y linked to the loss of dopaminerg.c projections within the cortical-basal g.ng.ia-thalamocortical loop. Resting.tremors are attributed to the transmission of patholog.cal sig.als from the basal g.ng.ia throug. the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating.pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strateg.es addressing.the g.obus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stag.s of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating.symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targ.ting.the g.obus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targ.ting.the g.obus pallidus externus can alter the temporal pattern of neural activity throug.out the basal g.ng.ia–thalamus network. Therefore, the comp

关键词： anxiety basal g.ng.ia bradykinesia deep brain stimulation depression g.obus pallidus externus g.obus pallidus internus lateral g.obus pallidus medial g.obus pallidus neural circuit Parkinson's disease

Oxyg.n abundance in young.open clusters

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Oxygen abundance in young open clusters

Profile of Dr. Zhao-shen Li

中国天文学会恒星分会2004年学术年会

作者： Z.-x.shen x.-W.Liu H.-W.Zhang..N.C Lin

来源： cnki会议评论

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Science China(Life Sciences) 2018年第11期61卷 1301-1303页

作者： Li Zhao-shen

***-shen Li g.aduated from the Second Military Medical University(SMMU)in *** then,he has worked in the Department of g.stroenterolog. in Shang.ai Chang.ai Hospital(The First Affliated Hospital of SMMU).He received his Master’s Deg.ee of Medicine(supervised by ***-Yun Zhou)in Internal Medicine from SMMU in *** four years later,he served as the associate director and the chief physician of Department of g.stroenterolog..

关键词： SMMU Medicine Dr Department g.stroenterolog.

ACTIVATION MECHANISM OF AMORPHOUS Ni_(63)Zr_(32)La_5 ALLOY HYDROg.NATION CATALYST

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Acta Metallurg.ca Sinica(Eng.ish Letters) 1996年第4期9卷 291-297页

作者： Wang. x.K. shen, N.F. Lei, g.J. g., H.C.

The catalytic activity of amorphous Ni_63 Zr_32 La_5 ribbon for hydrog.nation of ethyne to ethylene can be g.eatly enhanced when the alloy ribbon is pretreated with dilute acid solution,heated under neg.tive atmosphere pressure and subjected to hydrog.n reduction successively. The chang. of surface state of the ribbon during.the activation has been analysed by AES and xPS. The surface of as-received ribbon is covered with a thin film of La_2 O_3. After pretreatment. the surface concentrations of both Ni and Zr increase obviously, whereas the surface concentration of La decreases ***, on the surface of activated catalyst the Ni and NiO disperse finely on the matrix consisting.of oxides of both Zr and La and a small amount of fluorides of Zr and La.

关键词： amorphous Ni_(63) Zr_(32) La_5 alloy catalyst activation mechanism

ON THE MONTE CARLO SIMULATION OF NORMAL g.AIN g.OWTH

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Acta Metallurg.ca Sinica(Eng.ish Letters) 2008年第4期21卷 282-288页

作者： Y.T. Liu x.J. g.an x.M. shen x.F. Ma L.J. Wang School of Materials Science and Eng.neering Shandong University Jinan 250061 China

The microstructures and their kinetics of normal g.ain g.owth are simulated using.different Monte Carlo （MC） alg.rithms. Compared with the relative fig.res and the theoretical normal g.ain g.owth exponents of n =0.5, the effects of some factors of MC alg.rithm, i.e. the lattice types, the methods of selecting.lattice sites, and the neig.bors selection for energ. calculations, on the simulation results of g.ain g.owth are studied. Two methods of reg.ession were compared, and the three-parameter nonlinear reg.ession is much more suitable for fitting.the g.ain g.owth kinetics. A better model with appropriate factors included triang.lar lattice, the attempted site randomly selected, and the first and second nearest neig.bors for energ. calculations is obtained.

关键词： g.ain g.owth Microstructure Monte Carlo method Computer simulation g.ain g.owth kinetics Nonlinear reg.ession

Photocatalytic properties of CaTi_(2)O_(5)via a facile additive-free aqueous strateg. with different pH values

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Rare Metals 2021年第7期40卷 1746-1752页

作者： Wei-xia Dong.Qi-Fu Bao x-Yg. Hui-Juan shen Peng.Yan Liu Department of Material Science and Eng.neering Jingdezhen Ceramic InstituteJingdezhen 333001China

CaTi_(2)O_(5)was selectively prepared by a solvothermal process without template and *** phase of the as-prepared samples was determined by x-ray diffraction(xRD).The microstructure was characterized by scanning.electron microscopy(SEM)and transmission electron microscopy(TEM).Results found that pH values had a crucial effect on the crystal phase and shape evolution of the ***_(2)O_(5)sample prepared at pH of 5.2 shows hig. efficient lig.t harvesting.larg. surface area and ***,CaTi_(2)O_(5)shuttle-like sample shows g.od photocatalytic activity ag.inst methyl orang. due to its long.r and thinner shuttle-like morpholog. and hig. crystallinity,enhanced lig.t harvesting.and larg. surface *** photocatalytic rate of CaTi_(2)O_(5)shuttle-like structure reaches 0.1988 min-1 for 25-min methyl orang. deg.adation under the ultraviolet lig.t irradiation and displays an excellent photostability with a deg.adation efficiency of 0.1952 min^(-1)after four cycles.

关键词： pH CaTi_(2)O_(5) Solvothermal method Photocatalytic properties

SUBSTRATE MATERIALS FOR POLY-CSiTF SOLAR CELLS: OPTIMIZATION OF SILICON SHEET FROM POWDER

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Acta Metallurg.ca Sinica(Eng.ish Letters) 2005年第3期18卷 184-188页

作者： Q.Ban H.shen x.J.Wang.x.W.Zou Z.C.Liang StateKeyLaboratoryofOptoelectronicMaterialsandTechnolog.es DepartmentofPhysicsandEngineeringZhongshan（SunYat-sen）UniversityGuangzhou510275China g.ang.houInstituteofEnerg.Conversion TheChineseAcademyofSciencesGuangzhou510275China

The optimization of silicon sheet from powder (SSP) technolog. as polycrystalli ne silicon thin film (poly-CSiTF) solar cells' substrate materials is studied by orthog.nal desig. experimental method. Based on technolog.cal optimization of S SP prepared from electronic g.ade silicon powder, SSP solar cell devices with si mple structure are prepared and the effect of SSP substrate is discussed. Up to now, the conversion efficiency of the prepared solar cells on low purity SSP sub strate with fundamental structure has reached 8.25% (with area of 1cm×1cm).

关键词： poly-CSiTF SSP substrate material

基于格网尺度的黄河中游地区经济城镇化与PM_(2.5)浓度的脱钩关系研究

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生态经济 2025年第1期41卷 132-139页

作者：沈威曹威威洛阳师范学院地理与旅游学院河南洛阳471022 河南大学地理与环境学院河南开封475004

针对当前经济城镇化参量公里网格数据的缺乏,以黄河中游地区为例,提出一种利用1995—2018年高精度土地利用栅格数据和统计年鉴数据的经济城镇化参量空间化模拟方法,并分析格网尺度下黄河中游地区经济城镇化与PM2.5浓度的脱钩关系演变。... 详细信息

针对当前经济城镇化参量公里网格数据的缺乏,以黄河中游地区为例,提出一种利用1995—2018年高精度土地利用栅格数据和统计年鉴数据的经济城镇化参量空间化模拟方法,并分析格网尺度下黄河中游地区经济城镇化与PM2.5浓度的脱钩关系演变。结果表明:(1)黄河中游地区经济城镇化水平呈现出以兰西城市群、西安城市圈、太原城市圈、郑州—洛阳城市带为核心的多核心圈层结构。(2)在空间格局演变上,不同区域经济城镇化的扩张模式存在差异。受地形限制和水文条件限制,洛河流域、汾河流域、关中平原、太原城市圈经济城镇化呈现以中心城市为核心的带状扩张特征;兰西城市群、郑州—洛阳城市带、呼和浩特市呈现以中心城市为核心的圈层式扩张特征。(3)2005年之后,黄河中游中东部地区开始出现脱钩转折点;2010年之后,黄河中游西部地区开始出现脱钩转折点,但由于西部大开发战略的实施,导致2015—2018年甘肃和宁夏南部扩张负脱钩区面积显著增加,经济城镇化与环境污染的脱钩关系再次发生转变。

关键词：经济城镇化土地利用回归模型 PM2.5浓度脱钩状态