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Role of 5-HT2A Receptors in Immunomodulation in Animal Models of Ag.ressiv. Behav.or

Pharmacolog. & Pharmacy 2016年第8期7卷 313-320页

作者： g. v. idova E. L. Alperina E. N. Zhukov. M. A. Cheido R. v. Kozhemyakina Federal State Budg.tary Scientific Institution Scientific Research Institute of Physiology and Basic Medicine Novosibirsk Russia Nov.sibirsk State Univ.rsity Novosibirsk Russia Federal Research Center Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sci-ences Novosibirsk Russia

Serotonin 5-HT2A receptors are playing.an important role in the pathophysiolog. of ag.ressiv. behav.ors and in the control of immune function. In the present study, we analyzed the effects of activ.tion and blockade of 5-HT2A receptors with selectiv. lig.nds on the immune response formation in animals with ag.ressiv. behav.ors induced by g.netic factors (rats selected for the increased ag.ressiv.ness toward human) or by chronic social stress (mice of the CBA/Lac strain eng.g.d in 10 days of social confrontations). Activ.tion of 5-HT2A receptors with DOI at 1.0 mg.kg.reduced the immune response lev.l both in ag.ressiv. rats and mice compared to the corresponding.v.hicle-treated g.oups, while DOI administration did not alter the immune reaction in nonag.ressiv. animals. The blockade of 5-HT2A receptors with ketanserin at 1.0 mg.kg.resulted in immunostimulation both in mice of the CBA strain not subjected to social stress (the controls) and in nonag.ressiv. rats selected for elimination of ag.ressiv.ness. On the other hand, its administration to CBA mice demonstrating.offensiv. ag.ression enhanced the immune reaction, while the same dose of ketanserin did not modify the immune response lev.l in rats with g.netic predisposition to the increased defensiv. ag.ression. Thus, our data sug.est that the role of 5-HT2A receptors in immunomodulation depends on the specific type of ag.ression that may be taking.into account in the treatment of some neuropsychiatric disorders with the antipsychotic drug. and antidepressants targ.ting.5-HT2A receptors.

关键词： Ag.ressiv. Behav.or Serotonin 5-HT2A Receptors DOI Ketanserin Ig.-Immune Response

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