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Internet（共创软件） 2002年第10期 87-87页

作者： sriram Srinivasan Perlish

第8期我们给大家推荐了一本《Perl语言编程》第三版。相信大家对Perl语言的编程环境、语句结构有了一些了解。现在再给大家介绍另一本Perl图书————《高级Perl编程》。

关键词：《高级Perl编程》 Perl语言编程语言书评

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驾驭的快乐翱翔的幸福

大市场.广告导报 2006年第6期 107-107页

作者： D·sriram 星传媒体亚太区 CEO

采用MRI对乳腺导管内原位癌病人排除肿瘤浸润的研究

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国际医学放射学杂志 2012年第5期 496-497页

作者： E.E.Deurloo J.D.sriram H.J.Teertstra C.E. Loo J.Wesseling.E.J.T.Rutg.rs 王梅 Department of Radiolog. Academic Medical CenterAmsterdamThe Netherlands

摘要目的术前针刺活检对导管内原位癌有无浸润漏诊在20%以上。术前诊断为无浸润征象的导管内原位癌(即纯导管内原位癌)的病人中,20%以上病人的针刺活检低估了浸润。本研究的目的是评价MRI鉴别术前导管原位癌浸润性高低的能力。方法对12... 详细信息

摘要目的术前针刺活检对导管内原位癌有无浸润漏诊在20%以上。术前诊断为无浸润征象的导管内原位癌(即纯导管内原位癌)的病人中,20%以上病人的针刺活检低估了浸润。本研究的目的是评价MRI鉴别术前导管原位癌浸润性高低的能力。方法对125例术前针刺活检诊断为纯导管内原位癌(128个病灶,3个为双侧)病人进行前瞻性研究。所有病人均进行了乳腺手术。分别对乳腺X线摄影、组织学(活检)和MRI表现进行评估,分析其侵犯特征。

关键词：乳腺导管原位癌 MRI 浸润性导管癌腋窝淋巴结清扫术

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肺癌全基因组测序

国际病理科学与临床杂志 2013年第4期33卷 277-285页

作者： Marissa Daniels Felicia g.h Casey M. Wrig.t Krishna B. sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig.Rayleen V. Bowman Ian A Yang.Kwun M. Fong.孙岚何建行 Thoracic Research Laboratory Department of Thoracic Medicine The Prince Charles Hospital UQ Thoracic Research Centre School of Medicine The University of Queensland Patholog. Queensland Department of Anatomical PathologyThe Prince Charles Hospital 重庆市璧山县人民医院肿瘤科重庆402760 广州医学院第一附属医院心胸外科广州510120 广州呼吸疾病研究所广州510120

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的Ng.技术(next-g.neration sequencing.是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。... 详细信息

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的Ng.技术(next-g.neration sequencing.是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的Ng.技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。Ng.技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有Ng.技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免"无辜"患者受无效治疗带来的高额费用和不良反应。Ng.的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver g.ne)突变和传递基因(passeng.r g.ne)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。Ng.技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,Ng.技术无疑将会成为肺癌研究的绝佳选择。

关键词：高通量核苷酸测序 DNA序列分析肺肿瘤非小细胞肺癌小细胞肺癌

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抗生素治疗影响RRMS患者MRI预后的初步研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 39-39页

作者： sriram S. Stratton C. 谢琰臣 Multiple Sclerosis Research Laboratory 1222H Vanderbilt Stallworth Rehabilitation Hospital 2201 Children’s Way Nashville TN 37212 United States

This trial examined the safety and possible MRI and clinical effects of anti - chlamydial antibiotic therapy in relapsing. remitting.MS (RRMS). Newly diag. osed MS patients were selected to participate if they showed Chlamydia pneumonia e g.ne in their CSF and had one or more enhancing.lesions on brain mag.etic reso nance imag.ng.(MRI). After a 4- month run in phase of monthly MRI, patients wer e randomized to receive rifampin (300 mg.twice daily) and azithromycin (500 mg.e very other day) for 6 months or placebo (PBO). Patients then had monthly MRI on therapy and two additional scans on months 12 and 14. Lumbar punctures were repe ated between months 7 and 8 and within 2 weeks of termination of the study. Data on 4 patients on treatment and 4 on PBO were available for analysis. The primar y outcome measure of showing.a beneficial effect on enhancing.lesions was not me t. However, there was a sig.ificant difference in brain parenchymal fraction los s favoring.those patient receiving.antibiotics compared with PBO (p ≤ 0.02). Th ree of the four patients on antibiotic therapy cleared the org.nism from the CSF by month 12; in the PBO g.oup one patient cleared the org.nism. The reduction i n atrophy in patients receiving.antibiotics must be viewed with caution, due to the small number of patients studied.

关键词： MRI RRMS 多发性硬化症肺炎衣原体阿齐霉素安慰剂脑萎缩腰椎穿刺磁共振成像样本量

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超声引导下内镜引流合并门脉高压或有侧副管的胰腺假性囊肿

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 17-17页

作者： sriram P.V.J Kaffes A.J Reddy D.N 王志宇 Asian Institu te of g.stroenterolog. 6-3-652 Somajiguda 500-082 Hyderabad India.Dr

Backg.ound and Study Aims: Portal hypertension often coexists with pancreatic pseudocysts and is potentially dang.rous if a collateral vessel is in the vicini ty of the needle puncture pathway. Hitherto, there have been no reports of pseud ocyst drainag. in this setting. Patients and Methods: Patients who underwent end oscopic ultrasound (EUS)-g.ided pancreatic pseudocyst drainag. complicated by i ntervening.vessels were assessed for success and outcomes. An Olympus mechanical linear-array video echo endoscope g.-UM 140D was used for the drainag. proced ure in all patients. Either a “hot"diathermy technique was employed or a “cold " technique using.direct aspiration with a 19-g.needle, followed by deployment of a nasocystic catheter. Results: Eig.t patients with a symptomatic pseudocyst and intervening.vessels underwent drainag. that was g.ided (n = 6) or assisted ( n = 2) by EUS. All were found to have successful resolution of the cyst at follo w-up 6 weeks later, while seg.ental portal hypertension had disappeared in one patient. There were no major *** patient had transient hemorrhag.c drainag. that resolved by itself. Conclusions: Pseudocysts complicated by porta l hypertension or by intervening.vessels can be safely drained under EUS g.idanc e, even in the absence of color Doppler imag.ng.

关键词：内镜引流门脉高压侧副管胰腺假性囊肿假性囊肿引流门静脉高压症流管潜在危险鼻囊热透

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