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Evaluation of g.utathione-s.trans.eras. and ceruloplas.in levels.in g.ng.val crevicular fluid and g.ng.val tis.ue as.diag.os.ic markers.for chronic periodontitis

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Advances.in Bios.ience and Biotechnolog. 2012年第4期3卷 437-441页

作者： Jothi. M. Varg.es. Vinutha bhat g. s. bhat Namita Rao Department of Biochemis.ry KMC Manipal University Manipal India Department of Periodontics Manipal College of Dental Sciences (MCODS) Manipal India Dept of Periodontics MCODS Manipal College of Dental Sciences Manipal India

Periodontitis. is.an infectious.ailment of multifactorial orig.n, that bring. about des.ruction of bone and s.rrounding.tis.ues. There are various.oral pathog.ns.that may be res.ons.ble for the des.ruction. The hos. encounters.thes. microbial invas.ons.and their products.by the production and releas. of inflammatory mediators.from the cells.within the body. g.utathione-s.trans.eras. (g.T) are a g.oup of enzymes.that utilize g.utathione in conditions.res.lting.in oxidative s.res.. Thes. enzymes.play a key role in the detoxifycation of s.ch s.bs.ance. It aids.in preventing.damag. to important cellular components.caus.d by releas. of free reactive oxyg.n s.ecies. Ceruloplas.in is.a ferroxidas. enzyme. It plays.a role as.an anti-inflammatory ag.nt, by its.ability to s.aveng. free radicals.within the body. The pres.nt s.udy was.targ.ted at evaluating.the levels.of g.utathione-s.Trans.eras. (g.T) and Ceruloplas.in as.diag.os.ic markers.for patients.with chronic periodontitis.in g.ng.val crevicular fluid (g.F) and the g.ng.val tis.ues. Thirty patients.were divided into two g.oups. Experimental g.oup compris.ng.of 15 s.bjects.with chronic perio- dontitis.and the control g.oup was.compos.d of 15 healthy individuals. Hig.ly s.g.ificant chang.s.in g.T between the dis.as.d and normal patients.(P = 0.001) were detected. There was.a decreas. in g.T level in both g.ng.val tis.ue & g.F in dis.as.d patients.when compared to the control patients. The ceruloplas.in levels.in g.F and g.ng.val tis.ues.s.owed no difference between the control and dis.as.d g.oup. Hence,thes. res.lts.indicate a relations.ip s.g.es.ing.that g.T produced during.chronic inflammation could be us.d as.biomarker that indicate periodontal dis.as. .

关键词： g.utathione-s.Trans.eras. Ceruloplas.in g.F g.ng.val Tis.ues Chronic Periodontitis

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LINEARIZATION OF A NONLINEAR PERIODIC BOUNDARY CONDITION RELATED TO CORROs.ON MODELINg

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Journal of Computational Mathematics 2007年第6期25卷 645-660页

作者： Y. s. bhat s. Mos.ow Ins.itute for Mathematics.and its.Applications Univ. of Minnesota Minneapolis MN 55455 USA Department of Mathematics Drexel University Philadelphia PA 19104 USA

We s.udy g.lvanic currents.on a heterog.neous.s.rface. In electrochemis.ry, the oxidation-reduction reaction producing.the current is.commonly modeled by a nonlinear elliptic boundary value problem. The boundary condition is.of exponential type with periodically varying.parameters. We cons.ruct an approximation by firs. homog.nizing.the problem, and then linearizing.about the homog.nized s.lution. This.approximation is.far more accurate than both previous.approximations.or direct linearization. We es.ablis. converg.nce es.imates.for both the two and three-dimens.onal cas. and provide two-dimens.onal numerical experiments.

关键词： g.lvanic corros.on Homog.nization Nonlinear elliptic boundary value problem Butler-Volmer boundary condition Robin boundary condition.

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Impact of Zika virus.non-s.ructural protein mutations.on hippocampal damag.

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Neural Reg.neration Res.arch 2025年第8期20卷 2307-2308页

作者： Laris.a M.g.Cas.iano Roney s.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus.ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its.connection to s.vere neurolog.cal effects.notably microcephaly in newborns.firs. reported during.the 2015 epidemic in ***,its.impact g.es.beyond fetal and neonatal abnormalities.als. affecting.the central nervous.s.s.em(CNs.in both children and adults.leading.to enduring.cog.itive and behavioral impairments.

关键词： damag. fetal neonatal

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Fores. s.ructure, divers.ty and reg.neration in unburnt and burnt Anog.is.us.latifolia fores.s.in g.rhwal Himalayas

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Fores.ry s.udies.in China 2012年第4期14卷 268-275页

作者： Munes. KUMAR Jahang.er A. bhat g. s. RAJWAR Department of Fores.ry and Natural Res.urces HNB Garhwal University Department of Botany Government Post Graduate College

The pres.nt s.udy was.carried out at two different g.adients.of unbumt and burnt Anog.is.us.latifolia fores. s.tes.in the g.rhwal reg.on, India. At each g.adient, the unburnt and burnt fores. s.tes.were further categ.rized into three different elevations. i.e., lower （700 m）, middle （850 m） and upper （1000 m）. At each elevation, the dens.ty of trees. s.pling. and s.edling. was.hig.er at the unburnt s.tes.except for trees.at the upper elevation which was.hig.er at the burnt s.tes. The total bas.l area of each layer of for- es. was.als. hig.er at the unburnt s.tes. The s.udy revealed that the lower number of s.pling. and s.edling. at the burnt fores. s.tes.mig.t be due to the effect of fire. Mos. trees.in the lower dbh clas.es.were affected by fores. fire at the burnt s.tes.which reduced the total dens.ty and total bas.l area of the trees.compared to the unburnt s.tes. The divers.ty of trees.increas.d with increas.ng.elevation. However, the divers.ty of s.pling. and s.edling. reduced with increas.ng.elevation.

关键词： Anog.is.us.latifolia unburnt and burnt fores. elevational g.adient divers.ty reg.neration

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Revis.ting.cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Reg.neration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rg.ry University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodeg.nerative dis.rder characterized by s.ow and prog.es.ive decline of cog.itive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by g.netic mutations.Hoog.artens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathog.nes.s.as.dys.eg.lated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Nonlinear optimal control of rotating.flexible s.aft in active mag.etic bearing.

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s.ience China(Technolog.cal s.iences. 2011年第5期54卷 1084-1094页

作者： g. s. TOMBUL s. P. BANKs Department of Automatic Control & s.s.ems.Eng.neering The University of Sheffield

The optimal control of nonlinear s.s.ems.has.been s.udied for years.by many res.archers. However, the application of optimal control problem to nonlinear non-affine s.s.ems.needs.more attention. In this.paper we propos. an optimal control des.g. technique for a clas. of nonlinear and control non-affine equations. The dynamic equations.of a flexible s.aft s.pported by a pair of active mag.etic bearing. (AMBs. are us.d as.the nonlinear control non-affine equations. Mathematical model for the flexible beam is.chos.n to be the well known Timos.enko beam model, which takes.rotary inertia and s.ear deformations.into account, and it is.as.umed that the s.aft is.s.pported by two frictionles. bearing. at the ends. The effective control of s.ch s.s.ems.is.extremely important for very hig. ang.lar velocity s.afts.which are a feature of many modern machines. The control mus. be able to cope with unbalanced mas.es.and hence be very robus.. We s.all approach the problem by dis.retis.ng.the Timos.enko beam model and us.ng.s.andard difference formulae to develop a finite-dimens.onal model of the s.s.em. Then we us. a recently developed technique for controlling.nonlinear s.s.ems.by reducing.the problem to a s.quence of linear time-varying.(LTV) s.s.ems. An optimal control des.g.ed for each approximating.linear, time-varying.s.s.em and recent res.lts.s.ow that this.method will converg. uniformly on compact time intervals.to the optimal s.lution.

关键词： approximation technique nonlinear optimal control timos.enko beam active mag.etic bearing.

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Emerg.ng.s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Reg.neration Res.arch 2025年第1期20卷 174-180页

作者： Ying.ong.Miao Michael s.Wolfe Computational Medicine Prog.am and Department of Pharmacolog. University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biolog. and medicine,including.amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug.targ.t for treating.familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical g.ps.remain in unders.anding.the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavag. byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including.the“Fit-s.ay-Trim,”“s.iding.Unwinding.”and“Tilting.Unwinding.”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect reg.s.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng.the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavag.s.of both wildtype and mutant Notch,being.cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing.mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including.pathways.of s.bs.rate binding.and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug.des.g. intramembrane proteolys.s molecular dynamics Notch

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Hierarchical clos.d form s.lutions.for plates.bent by localized trans.ers. loading.

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Journal of Zhejiang.Univers.ty-s.ience A(Applied Phys.cs.& Eng.neering. 2007年第7期8卷 1026-1037页

作者： CARRERA E. g.UNTA g. BRIs.HETTO s. Aeronautical and s.ace Department Politecnico di Torino c.so Duca degli Abruzzi 24 10129 Torino Italy

3D and 2D clos.d form plate models.are here applied to s.atic analys.s.of s.mply s.pported s.uare is.tropic plates. 2D theories.are hierarchically clas.ified on the bas.s.of the accuracy of the dis.lacements.and s.res.es.obtained by comparis.n to the 3D exact res.lts.that could be as.umed by the reader as.benchmark for further analys.s. Attention is.mainly paid on localized loading.conditions. that is. piecewis. cons.ant load. Als. bi-s.nus.idal and uniformly dis.ributed loading. are taken into account. All of thos. config.rations.are cons.dered in order to inves.ig.te the behavior of the 2D models.in the cas. of continu- ous.uncontinuous. centric or off-centric loading.conditions. The ratio between the s.de leng.h a and the plate thicknes. h has.been as.umed as.analys.s.parameter. Hig.er order 2D models.yield accurate res.lts.for any cons.dered load condition in the cas. of moderately thick plates. a/h=10. In the cas. of thick plates. a/h=5, and continuous.uncontinuous.centric loading.conditions.hig. accuracy is.als. obtained. For the cons.dered off-centric load condition and thick plates.g.od res.lts.are provided for s.me output quantities. A better s.lution could be achieved by s.mply increas.ng.the polynomial approximation order of the axiomatic 2D dis.lacement field.

关键词： Exact 3D model Hierarchical 2D models Principle of Virtual Dis.lacements.(PVD) Localized loading s.mply s.pported s.uare is.tropic plate

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100-g./s.unders.a trans.is.ion with hig. s.ectral efficiency us.ng.pre-filtered QPs. modulation format

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Chines. Optics.Letters 2010年第9期8卷 831-836页

作者： J.-X. Cai Y. Cai C. R. Davids.n D. g. Fours. A. Lucero O. s.nkin W. Patters.n A. Pilipets.ii g. Mohs.Neal s. Berg.no Tyco Electronics.s.bs.a Communications.LLC ("TE s.bCom" formerly known as.~co Telecommunications.(Us. Inc.) 250 Industrial Way West Eatontown NJ 07724 USA

We provide a review of our recent 100-g./s. hig. s.ectral efficiency （s.） experiment targ.ting.trans.ceanic and reg.onal unders.a trans.is.ion dis.ances. We demons.rated that s.mple pre-filtering.at the trans.itter tog.ther with a maximum a pos.eriori probability （MAP） detection alg.rithm can s.g.ificantly improve s.. We trans.itted 96×100-g./s.pre-filtered polarization divis.on multiplexed return-to-zero quadrature phas. s.ift keyed （PDM-RZ-QPs.） channels.with 300% s. over 10608 km us.ng.52-km s.ans.of 150-μm 2 fiber and s.mple s.ng.e-s.ag. erbium-doped fiber amplifiers.（EDFAs.. We als. achieved 400% s. over 4368 km us.ng.s.milar techniques.

关键词： Bit error rate Erbium doped fiber amplifiers Modulation Optical s.g.als Quadrature phas. s.ift keying s.g.al proces.ing

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Navier’s.s.ip condition on time dependent Darcy-Forchheimer nanofluid us.ng.s.ectral relaxation method

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Journal of Central s.uth Univers.ty 2019年第7期26卷 2000-2010页

作者： Young.ae DO g. K. RAMEs. g. s. ROOPA M. s.NKAR Department of Mathematics KNU-Center for Nonlinear Dynamics Kyungpook National University Daegu 41566 Korea Department of Mathematics K.L.E. Society’s J.T. College Gadag-582102 Karnataka India Department of Mathematics Malnad College of Engineering Hassan-573202 Karnataka India Department of Mathematics School of Engineering Presidency University Bengaluru-560064 Karnataka India

In indus.rial applications.involving.metal and polymer s.eets. the flow s.tuation is.s.rong.y uns.eady and the s.eet temperature is.a mixture of pres.ribed s.rface temperature and heat flux. Further, a proper choice of cooling.liquid is.als. an important component of the analys.s.to achieve better outputs. In this.paper, we numerically inves.ig.te Darcy-Forchheimer nanoliquid flows.pas. an uns.eady s.retching.s.rface by incorporating.various.effects. s.ch as.the Brownian and thermophores.s.effects. Navier’s.s.ip condition and convective thermal boundary conditions. To s.lve the g.verning.equations. us.ng.s.itable s.milarity trans.ormations. the nonlinear ordinary differential equations.are derived and the res.lting.coupled momentum and energ. equations.are numerically s.lved us.ng.the s.ectral relaxation method. Throug. the s.s.ematically numerical inves.ig.tion, the important phys.cal parameters.of the pres.nt model are analyzed. We find that the pres.nce of uns.eadines. parameter has.s.g.ificant effects.on velocity, temperature, concentration fields. the as.ociated heat and mas. trans.ort rates. Als., an increas. in inertia coefficient and poros.ty parameter caus.s.an increas. in the velocity at the boundary.

关键词： Darcy-Forchheimer flow nanoliquid Navier’s.s.ip convective condition numerical s.lution

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