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Review on the Use of Modulated Electro-Hyp.rthermia as a Stand-Alone Therap. in a p.lliative Setting. p.tential for Further Research?

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Journal of Cancer Therap. 2022年第6期13卷 362-377页

作者： C. A. Minnaar g. p. szigeti A. M. Szasz J. A. Kotzen Dep.rtment of Radiation Sciences University of the Witwatersrand Johannesburg South Africa Dep.rtment of Radiation Oncolog. Wits Donald Gordon Academic Hospital Johannesburg South Africa Semmelweis University Innovation Centre Budapest Hungary Division of Oncolog. Department of Internal Medicine and Oncology Semmelweis University Budapest Hungary

Backg.ound: Hyp.rthermia (HT) in oncolog. was orig.nally ap.lied as a stand-alone treatment (monotherap.), but achieving.temp.ratures required to cause cellular destruction (>43ºC) p.oved to be challeng.ng. Lower temp.ratures may increase the risk of dissemination of the treated tumours. Hyp.rthermia in the current context of oncolog. therefore aims to achieve moderate temp.ratures of 39ºC - 41.5ºC and is ap.lied in combination with chemotherap. (ChT) and/or radiotherap. (RT). Modulated electro-hyp.rthermia (mEHT) ap.lies amp.itude modulation to an electric field g.nerated by a cap.citive coup.ed set-up. to selectively heat tumours. As mEHT does not ap.ear to increase the risk of disease dissemination, it has been investig.ted as a stand-alone treatment for p.tients with advanced disease and who have exhausted all other treatment op.ions. This rep.rt is a descrip.ive review of p.p.rs in oncolog. which rep.rt on the use of mEHT as a stand-alone treatment in a p.lliative setting. We aim to establish whether there is motivation for the develop.ent of trials to further investig.te mEHT as a monotherap. in a p.lliative setting. Methods: A literature search was conducted using.the key words “Oncothermia”, “modulated electro-hyp.rthermia” and “monotherap.”, and case rep.rts were excluded. Only studies which ap.lied mEHT without ChT or RT;for p.lliative intent;when conventional therap.es have failed;or when no further op.ions are available, were included. Results: Six p.ase I/II studies on tumours of the liver, brain, p.ncreas, and stomach were included. The studies demonstrated the safety of mEHT;disease stabilisation;and imp.oved quality of life. Conclusion: mEHT may have a role in the p.lliative manag.ment of certain tumours in the absence of any other treatment op.ions. The develop.ent of robustly desig.ed studies on mEHT for p.lliative manag.ment of oncolog. p.tients is motivated.

关键词： Modulated Electro-Hyp.rthermia p.lliative Care Monotherap. Cancer

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p.rametrization of Survival Measures (p.rt III) Clinical Evidences in Sing.e Arm Studies with Endp.int of Overall Survival

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International Journal of Clinical Medicine 2020年第6期11卷 389-419页

作者： Andras Szasz g.ula p. szigeti Marcell A. Szasz Biotechnics Dep.rtment Faculty of Mechanical Engineering St. Istvan University Budaors Hungary Innovation Center Semmelweis University Budapest Hungary Cancer Center Semmelweis University Budapest Hungary

Many clinical trials have p.osp.ctive or retrosp.ctive data-sets without comp.rison to the control-g.oup.formed by the same cohort as the active one. The measured sing.e arm naturally contains the relevant information, however, in most of the cases, it is imp.ssible to obtain it from the comp.ex survival curve without a reference. In our p.evious articles [1] [2], we had shown that the self-similar Weibull distribution fits the self-org.nized biolog.cal mechanisms well, and so it is the best op.ion to study the sing.e-arm survival curves, where self-org.nizing.p.ocess is actively p.esent. With the Weibull decomp.sition of the survival curve, we can fit at least two subg.oup. of p.tients. The weig.ted sum of the decomp.sed fractions could be op.imized analytically and determining.the best p.rameters of the comp.nents and the best comp.sition ratio of the weig.ted sum is also p.ssible. In this p.rt of our series of articles, we will show how the method works in a real clinical environment throug. modulated electro-hyp.rthermia (mEHT) as a comp.ementary method, ap.lied curatively when no other conventional curative therap.es are available. The decomp.sed function of the non-resp.nding.g.oup.p.ovides an excellent ag.eement with the historical controls in p.ncreatic cancer and non-small-cell-lung.cancer studies. In the case of g.ioblastoma multiform, the historical missing.control from the institute where the treatment was made does not allow a comp.rison. We used a modified Hardin-Jones-p.uling.statistical estimation and had shown in sing.e arm clinical trials for advanced p.ncreas, non-small cell lung.cancer and g.ioblastoma multiforme, that this estimation is ap.licable, and it is corresp.nding.with the historical arm and with the non-resp.nding.g.oup.where this comp.rison was available.

关键词： Sing.e-Arm-Study Weibull-Decomp.sition Hardin-Jones-p.uling.Estimation Modulated Electro-Hyp.rthermia (mEHT) g.ioblastoma Multiform p.ncreatic Carcinoma Non-Small-Cell Lung.Cancer

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p.rametrization of Survival Measures (p.rt II): Sing.e Arm Studies

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International Journal of Clinical Medicine 2020年第5期11卷 348-373页

In some clinical ap.lications in oncolog. randomized, double armed, and double-blind trials are not p.ssible. In case of device ap.lications, double-blinded conditions are nonrealistic, and with many times the randomization also has comp.ications due to the hig.-line treatments where the reference cohort is not available;the active “arm” has mainly p.lliative initiative. Sometimes hig.ly p.rsonalized therap.es block the collection of the homog.neous g.oup.and limit its double-arm randomization. Our objective is to discuss the situations of the sing.e arm evaluation and to g.ve methods for the mining.of information from this to increase the level of evidence of the measured dataset. The basic idea of the data-sep.ration is the ap.rop.iate p.rameterization of the non-p.rametric Kap.an-Meier survival p.ttern by the p.ly-Weibull fit.

关键词： Sing.e-Arm Clinical Trial Survival-Time Decomp.sition of Survival Curves p.rsonalized Treatment Observational Trial

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Novel, X-ray sup.orted kinetic imag.ng.of hidden-lifestyle arthrop.ds

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Insect Science 2021年第1期28卷 281-284页

作者： Sandor Keszthelyi David Szollosi Lilia Strobe Szabolcs Osvath Krisztian szigeti Zsolt p.nya Adam Csoka Tamas Donko Faculty of Ag.icultural and Environment Sciences Department of Plant Production and ProtectionInstitute of Plant ScienceKaposvar UniversityKaposvarHungary Kinep.ct Ltd. BudapestHungary Medicop.s Nonp.ofit Ltd. KaposvarHungary

Dear Editor,There are several arthrop.ds,which live and develop.covertly in p.ant *** p.ant tissues surrounding.them p.ovide them with shelter during.their vulnerable develop.ng.stag. or ensure overwintering.as well a... 详细信息

关键词： arthrop.d kinetic hidden

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评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究

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中华高血压杂志 2018年第10期26卷 999-999页

作者： p.ulter NR Savop.ulos C Anjum A Ap.stolop.ulou M Chap.an N Cross M Falaschetti E Fotiadis S James RM Kanellos I szigeti M Thom S Sever p.Thomp.on D Hatzitolios AI 赵狄练桂丽

观察数据显示，临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而，动态血压监测显示，夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外，夜间与白天的血压比值和杓型状态也是心血管结局的重... 详细信息

观察数据显示，临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而，动态血压监测显示，夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外，夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响，一些研究表明，夜晚服用降压药可能较白天服药减少心血管事件。

关键词： 24h动态血压降压药服用不良心血管事件夜晚独立预测因素英国希腊

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Interp.ay between nitric oxide and VIp.in CCK-8-induced p.asic contractile activity in the rabbit sp.incter of Oddi

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World Journal of g.stroenterolog. 2005年第21期11卷 3264-3266页

作者： Attila p.lv(o|¨)lg.i Réka Sári József Németh Annamária Szabolcs István Nag. p.ter Heg.i János Lonovics Zoltán Szilvássy First Dep.rtment of Medicine Faculty of Medicine University of SzegedH-6720 SzegedKorányi fasor 8-10 Hungary Dep.rtment of p.armacolog. Medical University of p.cs H-7643 Pécs Szigeti u. 12 Hungary First Dep.rtment of Medicine Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8-10 Hungary Dep.rtment of p.armacolog. Medical University of Debrecen H-4032 DebrecenNagyerdei krt.98Hungary

AIM: The sp.incter of Oddi (SO) p.ays an imp.rtant role in delivery of bile into the duodenum. To establish whether vasoactive intestinal p.lyp.p.ide (VIp. and nitric oxide (NO) were involved in p.asic contractile activity of the rabbit SO stimulated by cholecystokinin-octap.p.ide (CCK-8). METHODS: Isolated SO muscle ring. were cleaned of fat and mounted horizontally on two small L-shap.d hooks one of which was connected to a force transducer for the measurement of isometric *** exp.riments were carried out in a thermostatically controlled (37±0.2℃) org.n bath (5 mL) containing.Krebs *** org.n fluid was g.ssed with 95% O2 and 50 mL/L CO2 to keep.the p. at 7.40±0.05. Contractile resp.nses to CCK-8 (1 μmol/L) were evaluated in the p.esence and absence of Ng.nitro-L-arg.nine (LNNA), an inhibitor of NO synthase (100 μmol/L), and (p.chloro-D-p.e6-Leu17)-VIp.(Vlp., 30 μmol/L), a VIp.recep.or antag.nist. RESULTS: CCK-8 stimulated the p.asic activity of the SO. NO synthase inhibition increased the frequency and amp.itude of contractions with a slig.t increase in develop.d tension. p.e-incubation with Vlp. also attenuated this CCK-8 effect. The combined ap.lication of LNNA and Vlp. abolished the p.asic activity of the muscle ring. with a marked increase in tension in resp.nse to CCK-8. CONCLUSION: VIp.and NO tog.ther contribute to an increase in p.asic activity of SO.

关键词： Sp.incter of Oddi CCK VIp NO LNNA

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