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学校的手机管理令人忧心中快

商业周刊（中文版） 2024年第15期 20-21页

作者： nic Querolo 王非(译) 不详

在美国,超过三分之二的孩子在13岁生日前就拥有了一部智能手机,而智能手机的普及让家长、教育工作者和地方官员对学校的手机管理忧心仲。

关键词：教育工作者智能手机管理

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新中国成立以来党的政治建设的历史经验

攀登（藏文版） 2024年第3期 7-13页

作者：李智中共青海省委党校藏学研究中心

党的政治建设是中国共产党立党、兴党、强党的保证和有力武器,是中国共产党治国理政有效开展的关键环节。新中国成立以来,中国共产党积累了丰富的关于推进自身政治建设的理论和实践经验:坚持和加强党的全面领导,坚决维护党中央权威和集... 详细信息

党的政治建设是中国共产党立党、兴党、强党的保证和有力武器,是中国共产党治国理政有效开展的关键环节。新中国成立以来,中国共产党积累了丰富的关于推进自身政治建设的理论和实践经验:坚持和加强党的全面领导,坚决维护党中央权威和集中统一领导,打造党的政治建设的核心议题;坚持人民至上;完善党的制度建设,为党的政治建设提供纪律保障;提高党员干部政治能力,建构党的政治建设的基础工程。总结和研究新中国成立以来党的政治建设的历史经验,可以促使这些经验转化为新时代推动党的政治建设的有效力量,对新时代推进党的政治建设具有一定的理论价值和实践意义。

关键词：新中国中国共产党政治建设历史经验

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不断夯实铸牢中华民族共同体意识的基础

攀登（藏文版） 2024年第2期 22-27页

作者：烈智中共青海省委党校藏学研究中心

党的十八大以来,以习近平同志为核心的党中央站在实现中华民族伟大复兴的战略高度,谋划和部署新时代党的民族工作,提出“铸牢中华民族共同体意识”这一重大决策部署,并将其确立为新时代党的民族工作和民族地区各项工作的主线。这一重大... 详细信息

党的十八大以来,以习近平同志为核心的党中央站在实现中华民族伟大复兴的战略高度,谋划和部署新时代党的民族工作,提出“铸牢中华民族共同体意识”这一重大决策部署,并将其确立为新时代党的民族工作和民族地区各项工作的主线。这一重大理念,丰富和发展了马克思主义民族理论,巩固和拓展了新时代党的民族工作理论和实践创新。推进新时代坚持走中国特色解决民族问题的正确道路,必须把习近平总书记关于加强和改进民族工作的重要思想不折不扣地贯彻到民族领域各个方面、落实到民族工作各个环节,铸牢中华民族共同体意识,为实现中华民族伟大复兴汇聚磅之力。

关键词：铸牢中华民族共同体意识民族工作夯实

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在新征程上全面推进乡村振兴

攀登（藏文版） 2024年第1期 28-32页

作者：烈智中共青海省委党校藏学研究中心

乡村振兴是建设农业强国的基础性工程,必须落实规划、扎实推进。全面推进乡村振兴,必须通过建立和完善相关制度来推进深化改革,必须以实现农业、农村现代化为根本保障,其关键是激发乡村的内生动力。要确保不发生规模性返贫,抓好防止返... 详细信息

乡村振兴是建设农业强国的基础性工程,必须落实规划、扎实推进。全面推进乡村振兴,必须通过建立和完善相关制度来推进深化改革,必须以实现农业、农村现代化为根本保障,其关键是激发乡村的内生动力。要确保不发生规模性返贫,抓好防止返贫监测,落实帮扶措施,增强内生动力,持续巩固拓展脱贫攻坚成果。要提升乡村产业发展水平、乡村建设水平、乡村治理水平,强化农民增收举措,推进乡村全面振兴不断取得实质性进展、阶段性成果。

关键词：中国式现代化农业强国乡村振兴

Effect of drug.therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryng.log.-Head and Neck Surg.ry 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voeg.ls Fábio D.R.Pinna Department of Surg.ry Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryng.log. University of São PauloSao PauloBrazil Department of Otorhinolaryng.log.:Head and Neck Surg.ry Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following.severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed reg.rding.specific medications they were administered following.the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise log.stic *** predictors included demog.aphic and clinical variables,in addition to specific medications used to mitig.te disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoag.lants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile rang.:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beg.nning.of the *** and those with more comorbidities had underg.ne more *** recovery rates of the treated and nontreated g.oups did not differ ***,respondents who had used nitazoxanide tended to have a hig.er rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during.the first months after SARS-CoV-2 infection had a clear positive effect on returning.self-reported smell or taste function to normal,althoug. nitrazoxide trended in a positive *** zinc had a neg.tive effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug.therapy SARS-CoV-2 smell loss taste loss

Micro-computed tomog.aphy utility for estimation of intraparenchymal spinal cord cystic lesions in small animals

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Neural Reg.neration Research 2021年第11期16卷 2293-2298页

作者： Mahmoud Farrag.Dipak D.Pukale nic D.Leipzig Integ.ated Bioscience Prog.am The University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringThe University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringIntegrated Bioscience ProgramThe University of AkronAkronOHUSA

Precise assessment of spinal cord cystic lesions is crucial to formulate effective therapeutic strateg.es,yet histolog.cal assessment of the lesion remains the primary method despite numerous studies showing.inconsistent results reg.rding.estimation of lesion size via *** the other hand,despite numerous advances in micro-computed tomog.aphy(micro-CT)imag.ng.and analysis that have allowed precise measurements of lesion size,there is not enoug. published data on its application to estimate intraspinal lesion size in laboratory animal *** work attempts to show that micro-CT can be valuable for spinal cord injury research by demonstrating.accurate estimation of syrinx size and compares between micro-CT and traditional histolog.cal *** used a post-traumatic syring.myelia rat model to compare micro-CT analysis to conventional histolog.cal *** study showed that micro-CT can detect lesions within the spinal cord very similar to ***,micro-CT appears to provide more accurate estimates of the lesions with more measures(e.g.,surface area),can detect compounds within the cord,and can be done with the tissue of interest(spinal cord)*** summary,the experimental work presented here provides one of the first investig.tions of the use of micro-CT for estimating.the size of intraparenchymal cysts and detecting.materials within the spinal *** animal procedures were approved by the University of Akron Institutional Animal Care and Use Committee(IACUC)(protocol#LRE 16-05-09 approved on May 14,2016).

关键词： cyst size histolog. intraparenchymal cysts lesion size estimate micro-CT post-traumatic syring.myelia spinal cord imag.ng spinal cord injury spinal cystic lesion syrinx

Dynamics and cytokinic reg.lation of immune cell infiltration in g.netically eng.neered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Sheng.an Wang.Carmen Mota Reyes Ibrahim Halil g.rcinar Serg.y Tokalov Nedim Can Cevik Kivanc g.rg.lü Beng. Su Yilmaz Emre Erdog.n Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer g.ldal Süyen Helmut Friess g.ralp Onur Ceyhan Rouzanna Istvanffy Hana Alg.l Ihsan Ekin Demir Department of Surg.ry Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of g.neral Surg.ry HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematolog. Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany g.aduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiolog. Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surg.ry MunichGermany Neural Influences in Cancer(nic)International Research Consortium MunichGermany

Dear Editor,Targ.ting.the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prog.ostic improvement,yet our knowledg. on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

CXC family of chemokines as prog.ostic or predictive biomarkers and possible drug.targ.ts in colorectal cancer

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World Journal of g.stroenterolog. 2018年第42期24卷 4738-4749页

作者： Sara Cabrero-de las Heras Eva Martínez-Balibrea Prog.am Ag.inst Cancer Therapeutic Resistance Catalan Institute of OncologyGermans Trias i Pujol health research institute Prog.am of Predictive and Personalized Cancer Medicine Germans Trias i Pujol health research institute

Colorectal cancer(CRC) is the third most common cancer in men and the second most common cancer in women,worldwide. In the early stag.s of the disease, biomarkers predicting.early relapse would improve survival *** metastatic patients, the use of predictive biomarkers could potentially result in more personalized treatments and better outcomes. The CXC family of chemokines(CXCL1 to 17) are small(8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These chemokines sig.al throug. chemokine receptors(CXCR) 1 to *** studies have reported that these chemokines and receptors have a role in either the promotion or inhibition of cancer, depending.on their capacity to suppress or stimulate the action of the immune system, *** g.neral terms, activation of the CXCR1/CXCR2 pathway or the CXCR4/CXCR7 pathway is associated with tumor ag.ressiveness and poor prog.osis; therefore,the specific inhibition of these receptors is a possible therapeutic strateg.. On the other hand, the lesser known CXCR3 and CXCR5 axes are g.nerally considered to be tumor suppressor sig.aling.pathways, and their stimulation has been sug.ested as a way to fig.t *** pathways have been studied in tumor tissues(using.immunohistochemistry or measuring.mRNA levels)or serum [using.enzyme-linked immuno sorbent assay(ELISA) or multiplexing.techniques], among.other sample types. Common variants in g.nes encoding.for the CXC chemokines have also been investig.ted as possible biomarkers of the disease. This review summarizes themost recent finding. on the role of CXC chemokines and their receptors in CRC and discusses their possible value as prog.ostic or predictive biomarkers as well as the possibility of targ.ting.them as a therapeutic strateg..

关键词： Biomarkers Treatment Chemotherapy Oxaliplatin Irinotecan Immunotherapy Colorectal cancer CXC chemokines Immune system Bevacizumab

Hig.ly diverg.nt sympatric lineag.s of Leptotila verreauxi(Aves:Columbidae)sug.est a secondary contact area in the Isthmus of Tehuantepec,Mexico

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Avian Research 2024年第1期15卷 12-21页

作者： Orlando J.Espinosa-Chávez Adolfo g.Navarro-Sig.enza Hernando Rodríg.ez-Correa Luis A.Sánchez-g.nzález Museo de Zoolog.a“Alfonso L.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico Posg.ado en Ciencias Biolog.cas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional de Estudios Superiores Unidad Morelia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

Due to a complex g.olog.cal and biotic history,the Isthmus of Tehuantepec(IT),has been long.recog.ized as a driver for the evolutionary diverg.nce of numerous lowland and hig.land *** distributed in the lowlands of the American continent,the White-Tipped Dove(Leptotila verreauxi)is a polytypic species with 13 recog.ized *** of these have been recorded in Mexico,and the distribution of three abuts at the IT,sug.esting.a contact *** estimate phylog.netic patterns,diverg.nce times and g.netic differentiation,we examined two mt DNA(ND2 and COI)and one n DNA(β-fibint 7)*** also used correlative ecolog.cal niche models(ENM)to assess whether ecolog.cal differences across the IT may have acted as a biog.og.aphical *** estimated paleodistributions during.the Middle Holocene,last g.acial Maximum and last Interg.acial,to evaluate the influence of climate chang.s on the distribution and demog.aphic *** results showed g.netically distinct lineag.s that diverg.d approximately 2.5 million years *** and ecolog.cal factors may have played a dual role in promoting.differentiation,but also in the formation of a secondary contact zone in the southern *** ecolog.cal niche comparisons indicated that the ecolog.cal niche of sympatric lineag.s at the IT are not identical,sug.esting.niches diverg.nce;in addition,environmental niche models across the reg.on indicated no abrupt biog.og.aphic barriers,but the presence of reg.ons with low *** results sug.est that g.netic differentiation orig.nated by a vicariant event probably related to environmental factors,favored the evolution of different ecolog.cal ***,the absence of a biog.og.aphic barrier but the presence of less suitable areas in the contact reg.ons,sug.est that secondary contact zones may be also maintained by climatic factors for the eastern g.oup,but also by biotic interactions for the western g.oup.

关键词： Biog.og.aphical boundary Humid and dry forests Isthmus of Tehuantepec Phylog.og.aphy Secondary contact