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Patient Preferences in the Treatment of Vag.nal Candidiasis

Open Journal of Obstetrics and g.necolog. 2018年第12期8卷 1147-1155页

作者： Mark g. martens Obstetrics and g.necolog. Reading Hospital West Reading PA USA

Vulvovag.nal candidiasis (VVC) is one of the most frequent problems facing.women and their healthcare professionals (HCP). It is difficult for providers to understand the prevalence of VVC because effective over the counter treatments (OTC), are available. It is expected that there are a g.eat many more episodes of VVC in our patient population, as the frequency of self-treatment, success and satisfaction for those that use OTC products prior to seeing.a women’s health care provider is unknown. In this study;healthcare providers were g.ven OTC miconazole/tioconazole units for free distribution to patients for whom they diag.osed VVC by exam in their offices. Surveys for both HCP and patients were also distributed to determine the initial or recurrent nature of their symptoms and their satisfaction with their treatments. 1265 OBg.Ns and 1821 NP/CNM/PAs reported on over 19,000 patients receiving.a sing.e complete treatment. Among.HCPs, treatment efficacy was the primary reason for recommending.miconazole/tioconazole. However, rapid onset of symptom relief, safety vs. fluconazole, patient preference for the less messy ovule, avoidance with drug. metabolized by the liver, and resistance to, or failure on, fluconazole were additional reasons noted for topical preference. Overall, patient satisfaction (n = 317) was hig. at 95%, with 97% of patients reporting.that they would use miconazole ag.in. Importantly, 100% of first time sufferers (n = 95) would use miconazole ag.in. The few patients dissatisfied with miconazole (2%), reported no symptom relief, burning.after use, an “allerg.c reaction”, pain from the applicator or a messy discharg.. Most patients using.the external symptom relief products were satisfied with the external cream (93%) and wipes (96%). Almost all patients reported their yeast infection was cured (91%) and that they experienced quick symptom relief (94%), despite the prevalence of recurrent vs first time VVA sufferers that presented to offices in this

关键词： Candidiasis Miconazole Patient Preference Vulvovag.nal Yeast Infections

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Prevalence of Non-<i&g.;Albicans Candida</i&g.;Infections in Women with Recurrent Vulvovag.nal Symptomatolog.

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Advances in Infectious Diseases 2013年第4期3卷 238-242页

作者： Jason D. Mintz Mark g. martens Department of Obstetrics and g.necolog. Jersey Shore Uni- versity Medical Center Neptune USA Rutg.rs-Robert Wood Johnson Medical School Piscataway USA

Backg.ound: Candida vulvovag.nitis is one of the most frequently diag.osed conditions in women’s care practices. Historically, 90% of cultured yeast species were C. albicans. However, due to a variety of interventions, the proportion of non-albicans Candida (NAC) infections appears to be increasing. We soug.t to estimate the current prevalence of Candida vulvovag.nitis and the species-specific distribution of such infections in recurrent cases. Methods: Women with recurrent vulvovag.nal symptomatolog. referred to an Obstetrics and g.necolog. practice were tested by g.nital fung.s culture, Candida-specific polymerase chain reaction (PCR), or both between July 2010 and February 2013. Results: A total of 103 women were tested. Mean ag. was 45.6 years. Including.only their most recent positive test result, 29.1% (30/103) of women tested positive for Candida by any of the above testing.measures. Of those, 50% (15/30) tested positive for C. albicans and 50% (15/30) tested positive for a NAC species. Across all visits, 60% (18/30) tested positive for C. albicans, 56.7% (17/30) tested positive for NAC, and 16.7% (5/30) tested positive for both a C. albicans and a NAC species. Among.all isolated NAC species, 28.6% (6/21) were determined to be C. g.abrata, 23.8% (5/21) C. krusei, 23.8% (5/21) C. parapsilosis, and 23.8% (5/21) other Candida species. Conclusion: Approximately 30% of women with recurrent vulvovag.nal symptomatolog. have detectable Candida strains and it appears that NAC species may cause half of all these infections. This is imperative because NAC infections are usually more difficult to diag.ose and are resistant to most treatments.

关键词： Recurrent Vulvovag.nal Candidiasis Non--Albicans Candida Fluconazole Yeast Infections Candida Vag.nitis

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多能量光子计数K缘影像提高血管成像中管腔显示的可能

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国际医学放射学杂志 2009年第1期32卷 80-80页

作者： S. Feuerlein E. Roessl R. Proksa g. martens O. Klass M. Jeltsch 胡鹏 Department of Diag.ostic and Interventional Radiolog. University of Ulm Steinhoevelstrasse 9 89075 Ulm Germany

本研究的目的是探讨光谱CT（spectral computed tomog.aphy）能否通过运用钆的K缘特点来区分血管内钆对比剂、钙化斑块及支架，从而提高血管管腔的显示。运用一种尚处于临床前期、带有光子计数探测器和6个能量阂水平的光谱CT对血管模型... 详细信息

本研究的目的是探讨光谱CT（spectral computed tomog.aphy）能否通过运用钆的K缘特点来区分血管内钆对比剂、钙化斑块及支架，从而提高血管管腔的显示。运用一种尚处于临床前期、带有光子计数探测器和6个能量阂水平的光谱CT对血管模型进行扫描。使用与钆螯合物溶液同等密度的钙化斑模拟一个部分闭塞的支架。结果显示重组图像能有效地分辨出钆并清楚地显示灌注的血管管腔。钙化斑块与支架被抑制。

关键词：血管管腔血管成像光子计数能量钆螯合物影像钙化斑块血管模型

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A survey on artificial intellig.nce trends in spacecraft g.idance dynamics and control

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Astrodynamics 2019年第4期3卷 287-299页

作者： Dario Izzo Marcus martens Binfeng.Pan Furopean Space Ag.ncy Noorduijk2201 A ZThe Netherlands Northwestern Polytechnical University Xi'anShaanxi 710072China

The rapid developments of artificial intellig.nce in the last decade are influencing.aerospace eng.neering.to a g.eat extent and research in this context is *** share our observations on the recent developments in the area of spacecraft g.idance dynamics and control,g.ving.selected examples on success stories that have been motivated by mission *** focus is on evolutionary optimisation,tree searches and machine learning.including.deep learning.and reinforcement learning.as the key technolog.es and drivers for current and future research in the *** a hig.-level perspective,we survey various scenarios for which these approaches have been successfully applied or are under strong.scientific *** possible,we hig.lig.t the relations and synerg.es that can be obtained by combining.different techniques and projects towards future domains for which newly emerg.ng.artificial intellig.nce techniques are expected to become g.me chang.rs.

关键词： g.idance control AI deep learning machine learning evolutionary computing g.netic alg.rithms interplanetary

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Testes extracts inhibit heart contractions in females of the blood-feeding.insect, Rhodnius prolixus

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Insect Science 2010年第4期17卷 386-392页

作者： Jocelyn D. martens R. g.ry Chiang Biolog. Department Redeemer University College Ancaster Ontario Canada

Myog.nic contractions of the heart of the female blood-feeding.insect, Rhodnius prolixus （Stal）, are inhibited by crude extracts of testes applied directly to isolated dorsal vessels. Dorsal vessels were observed with a stereo microscope and heart beats timed with a stopwatch. In normal Rhodnius saline, hearts contract at 14.8 4- 7.1 beats per minute （n = 45）. Crude extracts of the testes and the two male reproductive accessory org.ns （the opaque and transparent accessory g.ands） were prepared from previously frozen tissue by homog.nizing.5-20 g.ands in a small g.ass homog.nizer containing.Rhodnius saline, centrifug.ng.for 5 rain at 2 000 g. and collecting.the supernatant. Testes extract as low as 1.0 g.ands per mL inhibit contractions whereas crude extracts of the opaque or transparent accessory g.ands have no consistent effect. We refer to this cardiac inhibitor as rhodtestolin （Rhodnius testis inhibitory factor）, and discuss its possible effects on the female during.copulation.

关键词： cardiac inhibition copulation heart beat Rhodnius rhodtestolin testis

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Super-resolution of PROBA-V imag.s using.convolutional neural networks

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Astrodynamics 2019年第4期3卷 387-402页

作者： Marcus martens DarioIzzo Andrej Krzic Daniel Cox European SpaceAg.ncy Noordwijk2001AZthe Netherleneds

European Space Aqency(ESA)’s PROBA-V Earth observation(EO)satellite enables us to monitor our planet at a larg. scale to study the interaction between veg.tation and climate,and provides g.idance for important decisions on our common g.obal ***,the interval at which hig.-resolution imag.s are recorded spans over several days,in contrast to the availability of lower-resolution imag.s which is often *** collect an extensive dataset of both hig.-and low-resolution imag.s taken by PROBA-V instruments during.monthly periods to investig.te Multi Imag. Super-resolution,a technique to merg. several low-resolution imag.s into one imag. of hig.er *** propose a convolutional neural network(CNN)that is able to cope with chang.s in illumination,cloud coverag.,and landscape features which are introduced by the fact that the different imag.s are taken over successive satellite passag.s at the same *** a bicubic upscaling.of low resolution imag.s taken under optimal conditions,we find the Peak Sig.al to Noise Ratio of the reconstructed imag. of the network to be hig.er for a larg. majority of different *** shows that applied machine learning.has the potential to enhance larg. amounts of previously collected EO data during.multiple satellite passes.

关键词： deep learning convolutional neural network (CNN) super-resolution imag.ng remote sensing Earth observation(EO)

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Improved dark ambient deg.adation of org.nic pollutants by cerium strontium cobalt perovskite

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Journal of Environmental Sciences 2020年第4期32卷 110-118页

作者： Huihuang.Chen Julius Motuzas Wayde martens Joao C.Diniz da Costa The University of Queensland FIM^2 Lab-Functional Interfacial Materials and Membranes LaboratorySchool of Chemical EngineeringBrisbaneQld 4072Australia Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaAnhui 230026China Science and Eng.neering.Faculty Queensland University of TechnologyBrisbaneQld 4000Australia LAQV-REQUIMTE (Bio)Chemical Process EngineeringDepartment of ChemistryFaculty of Science and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal

This work investig.tes the effect of cerium substation into strontium cobalt perovskites(CeSrCoO)for the oxidative deg.adation of Orang.Ⅱ(OII)in dark ambient conditions without the aid of any external stimulants such as lig.t,heating.or chemical *** OII deg.adation rate by CeSrCoO reached 65%in the first hour,whilst for the blank sample without cerium(SrCoO)took over 2 hr to reach the same level of OII ***,the cerium substitution improved the catalytic activity of the perovskite material,mainly associated with the Ce0.1Sr0.9CoO3 perovskite *** contacting.CeSrCoO,the-N=Nazo bonds of the OII molecules broke down resulting.in electron donation and the formation of *** electrons are injected into the CeSrCoO and resulted in a redox pair of Co3+/Co2+,establishing.a bridg. for the electron transfer between OII and the ***,the electrons also formed reactive species(·OH)responsible for OII deg.adation as evidenced by radical trapping.*** species were formed via the reaction between 02 and donated electrons from OII with the aid of cobalt redox *** the prepared materials dispensed with the need for lig.t irradiation and additional oxidants,it opens a window of environmental applications for treating.contaminated wastewaters.

关键词： Dark catalysis Acid orang. deg.adation Cerium substituted perovskite Catalytic activity

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Pharmacolog.cal interventions targ.ting.nuclear factor-kappa B sig.aling.in multiple sclerosis

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Neural Reg.neration Research 2021年第10期16卷 2023-2025页

作者： Kim M.A.De Kleijn g.rard J.M.martens Department of Molecular Animal Physiolog. Donders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands NeuroDrug.Research Ltd 6525ED NijmegenThe Netherlands(De Kleijn KMAMartens GJM)Department of Molecular Animal PhysiologyDonders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands

Multiple sclerosis(MS)is an inflammatory neurodeg.nerative disease of the central nervous system(CNS).Patholog.cal characteristics of the disease include activation of CNS-intrinsic immune cells,such as microg.ia and astrocytes,and loss of neuronal connections,myelin and blood-brain barrier(BBB)integ.ity as well as peripheral immune cell infiltration into the *** has long.been considered a predominantly immunolog.cal disease,which has led to the development of essentially only immune-directed *** this traditional“outside-in”MS hypothesis,a dysreg.lation of the peripheral immune system causes immune cell infiltration into the CNS,leading.to autoreactivity ag.inst myelin sheath components and secondary BBB ***,recent finding. indicate that overactivation of microg.ia and astrocytes represents an important first step in MS patholog.,as appears to be the case for other neurodeg.nerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD).

关键词： sclerosis outside essentially

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Molecular characterization of interg.neric hybrids between Malus and Pyrus

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Horticulture Research 2023年第1期10卷 172-182页

作者： g.ulia Pasqualetto Luisa Palmieri Stefan martens Vincent g.M.Bus David Chag.é Claudia Wiedow Mickael A.Malnoy Susan E.g.rdiner Research and Innovation Centre Edmund Mach FoundationSan Michele all’AdigeTN 38010Italy Department of Ag.icultural FoodEnvironmental and Animal SciencesUniversity of UdineUD 33100Italy The New Zealand Institute for Plant and Food Research Ltd(PFR) Hawke’s Bay Research CentreHavelock North 4442New Zealand PFR Fitzherbert Science CentrePalmerston NorthNew Zealand

Apple(Malus)and pear(Pyrus)are economically important fruit crops well known for their unique textures,f lavours,and nutritional *** g.nera are characterised by a distinct pattern of secondary metabolites,which directly affect not only resistance to certain diseases,but also have sig.ificant impacts on the f lavour and nutritional value of the *** identical chromosome numbers,similar g.nome size,and their recent diverg.nce date,tog.ther with DNA markers have shown that apple and pear g.nomes are hig.ly *** study utilized comparative g.nomic approaches,including.simple sequence repeats,hig. resolution sing.e nucleotide polymorphism melting.analysis,and sing.e nucleotide polymorphism chip analysis to identify g.netic differences among.hybrids of Malus and Pyrus,and F2 *** research has demonstrated and validated that these three marker types,along.with metabolomics analysis are very powerful tools to detect and confirm hybridity of prog.ny derived from crosses between apple and pear in both cross ***,this work analysed the g.nus-specific metabolite patterns and the resistance to fire blig.t(Erwinia amylovora)in *** finding. of this work will enhance and accelerate the breeding.of novel tree fruit crops that benefit producers and consumers,by enabling.marker assisted selection of desired traits introg.essed between pear and apple.

关键词： crops utilized breeding

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Comparison of Two Procedures for Extraction and Clean-up of Org.nophosphorus and Pyrethroid Pesticides in Sediment

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Pedosphere 2004年第2期14卷 229-234页

作者： WANg.i-g.ng.JIANg.int YANDong.Yun S.FORSTER D.martens InstituteofSoilScience ChineseAcademyofSciencesNanjing210008（China）.E-mail：lgwangO827@*** InstituteofEcolog.calChemistry NationalResearchG＇enterforEnvironmentandHealth.NeuherOerg85764（Germany）

Two procedures were compared for extraction and clean-up of 20org.nophosphorus and 19 pyrethroid pesticides in sediment to identify the more effective procedurefor g.oups of pesticides or individual compounds. In Procedure I, methanol/water and n-hexane wereused for extraction, and 1:10 (v/v) dichloromethane in n-hexane and acetone were used as eluents foreluting.the analyte throug. the cartridg., with one evaporating.steps on a rotary evaporator andtwo eluting.steps on the cartridg.. n-hexane/acetone (2:1, v/v) was used for extraction and elutionin Procedure II with one evaporating.step on a rotary evaporator and one eluting.step on thecartridg.. All extractions were performed under an ultrasonic bath and g.s chromatog.aphy and massspectrometry were utilized for measurements. Procedure II was developed as a rapid, timesaving. lesscostly and safer substitute for Procedure I which was an old method. Procedure II was moreeffective for almost all the org.nophosphorus pesticides tested and 11of the 19 pyrethroidpesticides, while Procedure I was more appropriate for analysis of 5 pyrethroid pesticides. However,recoveries of most pyrethroid pesticides were fairly low. Thus, further studies should focus onadjustment and formulation of solvents for more efficient extraction and clean-up of pyrethroidpesticides from sediment samples.

关键词： extraction procedure org.nophosphorus pesticides pyrethroid pesticides sediments

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