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Hyperhomocysteinemia and Associated Biolog.cal Markers in a Cong.lese Population of Type 2 Diabetes Mellitus in Brazzaville

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Open Journal of Endocrine and Metabolic Diseases 2024年第6期14卷 123-134页

作者： v. R. ikia Monde A. L. M. Boumba E. Mokondjimobe H. Poaty g. loubano-v.um.i W. F. Ondong. A. g. Mayindou Kimbang. K. Onang. F. Elilie Mawa Ong.th E. Bouenizabila C. Andres H. g. Monabeka Biochemistry Laboratory Service University Hospital Center Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Congo Research Area of Pointe-Noire National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Congo Microbiolog. and Molecular Biolog. Department Loandjili General Hospital Pointe-Noire Congo LOMO Research University Kinshasa DRC Department of Statistics Health Information and Epidemiology Surveillance Departmental Directorate of Health Care and Services Brazzaville Congo Department of Endocrinolog. University Hospital Center Brazzaville Congo Department of Biochemistry and Molecular Biolog. Bretonneau Regional University Hospital Tours France

The search for new biomarkers predictive of type 2 diabetes currently constitutes a research avenue in Bioclinical. Total homocysteine remains a preferred targ.t due to its involvement in the occurrence of deg.nerative complications in type 2 diabetics. The aim of this work was to study hyperhomocysteinemia and other biochemical markers associated with T2D in the Cong.lese population. This was an analytical case-control study carried out between October 2022 and October 2023. The study population consisted of 150 subjects including.100 T2D patients and 50 control subjects. The main clinical data were collected on a pre-established form. Homocysteine determination was carried out by the sandwich ELiSA method. The other biochemical markers were measured by colorimetric enzymatic methods. Hyperhomocysteinemia was present in 27.3% (41/150) of the entire study population. Type 2 diabetics had a frequency of hyperhomocysteinemia of 36% (36/100) and control 10% (5/50) (p = 0.001). The mean hyperhomocysteinemia concentration was 31.9 μmol/l with extremes rang.ng.from 18 to 103 μmol/l. Means of biolog.cal markers between diabetics and controls showed a statistically sig.ificant difference (p = 0.01). The risk factors associated with this HHcy were: sex (OR = 3.5), ag. (OR = 9.4), sedentary lifestyle (OR = 3.4) and g.ycosylated hemog.obin (OR = 12) with a p-value ively. Our results sug.est that hyperhomocysteinemia can be considered as a predictive biomarker in the bioclinic of Cong.lese type 2 diabetic patients.

关键词： Hyperhomocysteinemia Biolog.cal Markers T2DM Brazzaville

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Hyperhomocysteinemia and Associated Biolog.cal Markers in a Cong.lese Population of Type 2 Diabetes Mellitus in Brazzaville

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Open Journal of Endocrine and Metabolic Diseases（内分泌与新陈代谢疾病期刊） 2024年第6期 123页

作者： v.R.ikia Monde A.L.M.Boumba E.Mokondjimobe H.Poaty g.loubano-v.um.i W.F.Ondong. A.g.Mayindou Kimbang. K.Onang. F.Elilie Mawa Ong.th E.Bouenizabila C.Andres H.g.Monabeka

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