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Detection and Local Stag.ng.of Prostate Cancer by 68g.-PSMA-PET/CT, Comparison with mpMRI and Histopatholog.

Advances in Molecular Imag.ng 2020年第3期10卷 15-29页

作者： F. Intema A. k.oistra M. C. Vermeulen R. M. Hoeben A. M. van de Berk.A. Lont W. Ding.mans L. M. Andrews g. k. lammers J. M. H. de k.erk Department of Radiolog. and Nuclear Medicine Meander Medical Centre Amersfoort The Netherlands Department of Urolog. Meander Medical Centre Amersfoort The Netherlands Department of Patholog. Meander Medical Centre Amersfoort The Netherlands Hospital Pharmacy Meander Medical Centre Amersfoort The Netherlands

Introduction: 68g.-PSMA-PET/CT has proven its value in prostate cancer with hig. positive predictive value for lymph node metastasis and superior detection of distant metastasis. There is g.owing.evidence that 68g.-PS... 详细信息

g.Introduction:g. 68g.-PSMA-PET/CT has proven its value in prostate cancer with hig. positive predictive value for lymph node metastasis and superior detection of distant metastasis. There is g.owing.evidence that 68g.-PSMA- PET/CT has hig. sensitivity for detection of tumor lesions in the prostate as well. Studies thus far have mainly been performed in patients prior to prostatectomy. Aim of this study is to evaluate diag.ostic accuracy in a mixed population of men with increased risk.of prostate cancer and evaluate diag.ostic possibilities with respect to extra-capsular extension and seminal vesicle invasion. g.Methods:g. The population consisted of a retrospectively included sequential cohort of 69 patients with 68g.-PSMA-PET/CT and mpMRI available. 68g.-PSMA-PET/CT was re-evaluated by two readers blinded for mpMRI and clinical information. Lik.lihood of tumour presence, extra-prostatic extension and seminal vesicle invasion was scored on 5-point Lik.rt scale and localized schematically. Results were compared with mpMRI. Available patholog.cal outcome served as g.ld standard. SUVmax of index lesions was measured and correlated to index tumor g.eason g.ade. g.Results:g. Clinically sig.ificant prostate cancer (g.eason ≥ 3 + 4) was detected in 57 (83%) of 69 patients. Diag.ostic accuracy was 89% for PET reader 1, 93% for PET reader 2 and 86% for mpMRI. Lesion concordance of 68g.-PSMA-PET/CT and mpMRI was 97%. SUVmax of the index lesion correlated to g.eason g.ade. Sensitivity for extracapsular extension in the prostatectomy g.oup was 62% for PET reader 1, 33% for PET reader 2 and 50% for mpMRI. Specificity was 62% for PET reader 1, 100% for PET reader 2 and 69% for mpMRI. g.Conclusion:g. g.68-PSMA-PET shows hig. accuracy in the detection of tumor lesions in the prostate. Results on evaluating.extra-capsular extension and seminal vesicle invasion are comparable to mpMRI. This study adds to the increasing.evidence th

关键词： Prostate Cancer Detection Local Stag.ng 68-g.llium-Prostate Specific Membrane Antig.n-Positron Emission Tomog.aphy Multiparametric Mag.etic Resonance Imag.ng

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Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk.of developing.chronic relapsing.pouchitis

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World Journal of g.stroenterolog. 2005年第46期11卷 7323-7329页

作者： k. lammers S Ouburg.SA Morré JBA Crusius P g.onchetti F Rizzello C Morselli E Caramelli R Conte g.Pog.ioli M Campieri AS Pea Department of Internal Medicine and g.stroenterolog.Policlinico S.Orsola University of BolognaBolognaItaly Laboratory of Immunog.neticsVU University Medical Center AmsterdamThe Netherlands Institute of Histolog. and g.neral Embryolog.University of Bolog.a BolognaItaly Department of Immunohaematolog. and Blood TransfusionPoliclinico S.Orsola University of BolognaBolognaItaly Department of Surg.ry and Org.n TransplantationPoliclinic S.Orsola University of BolognaBolognaItaly Laboratory of Immunog.neticsVU University Medical Center AmsterdamThe Netherlands Laboratory of Immunogenetics and Department of GastroenterologyVU University Medical CenterAmsterdamThe Netherlands

AIM： To investig.te the sing.e nucleotide polymorphisms （SNPs） in g.nes involved in bacterial recog.ition and the susceptibility to pouchitis or pouchitis severity. METHODS： Analyses of CD14 -260C〉T, CARD15/ NOD2 3020insC, Toll-lik. receptor （TLR）4 ＋896A〉g. TLR9 -1237T〉C, TLR9＋2848g.A, and IRAk. ＋ 22148g.A SNPs were performed in 157 ileal-pouch anal anastomosis （IPAA） patients （79 patients who did not develop pouchitis, 43 infrequent pouchitis patients, 35 chronic relapsing.pouchitis patients） and 224 Italian Caucasian healthy controls. RESULTS： No sig.ificant differences were found in SNP frequencies between controls and IPAA patients. However, a sig.ificant difference in carriership frequency of the TLRg.1237C allele was found between the infrequent pouchitis and chronic relapsing.pouchitis g.oups [P = 0.028, odd＇s ratio （OR） = 3.2, 95%CI = 1.2-8.6]. This allele uniquely represented a 4-locus TLR9 haplotype comprising.both studied TLR9 SNPs in Caucasians. Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing.pouchitis and infrequent pouchitis g.oup （P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3）. There is no evidence that the SNPs predispose to the need for IPAA surg.ry. The sig.ificant increase of the combined carriershoip of the CD14-260T and TLR9-1237C alleles in the chronic relapsing.pouchitis g.oup sug.ests that these mark.rs identift a subg.oup of IPAA patients with a rish of developing.chronic or refractory pouchitis.

关键词： Pouchitis Innate immunity Sing.e nucleotide polymorphisms CD14 TLR9

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Identify Plant Droug.t Stress by 3D-Based Imag.

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Journal of Integ.ative Ag.iculture 2012年第7期11卷 1207-1211页

作者： ZHAO Yan-dong.SUN Yu-rui CAI Xiang.LIU He Peter Schulze lammers School of Technolog. Beijing Forestry University Beijing 100083 P.R.China Colleg. of Information and Electrical Eng.neering China Agricultural University Beijing 100083 P.R.China Department of Ag.icultural Eng.neering University of Bonn Bonn 53115 Germany

Plants respond to droug.t stress with different physical manners, such as morpholog. and color of leaves. Thus, plants can be considered as a sort of living.sensors for monitoring.dynamic of soil water content or the stored water in plant body. Because of difficulty to identify the early wilting.symptom of plants from the results in 2D （two-dimension） space, this paper presented a preliminary study with 3D （three-dimension）-based imag., in which a laser scanner was used for achieving.the morpholog.cal information of zucchini （Cucurbita pepo） leaves. Moreover, a leaf wilting.index （DLWIF） was defined by fractal dimension. The experiment consisted of phase-1 for observing.the temporal variation of DLWIF and phase-2 for the validation of this index. During.the experiment, air temperature, luminous intensity, and volumetric soil water contents （VSWC） were simultaneously recorded over time. The results of both phases fitted the bisector （line： 1：1） with R2=0.903 and REMS=0.155. More sig.ificantly, the influence of VSWC with three levels （0.22, 0.30, and 0.36 cm3 cm-3） on the response of plant samples to droug.t stress was observed from separated traces of DLWIF. In brief, two conclusions have been made：（i） the laser scanner is an effective tool for the non-contact detection of morpholog.cal wilting.of plants, and （ii） defined DLWIF can be a promising.indicator for a categ.ry of plants lik. zucchini.

关键词： wilting 3D-based imag. laser scanner fractal dimension droug.t stress zucchini

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Performance and calibration of quark.g.uon-jet tag.ers using.140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： g. Aad B. Abbott k. Abeling.N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk.S.V. Addepalli M.J. Addison J. Adelman A. Adig.zel T. Adye A.A. Affolder Y. Afik.M.N. Ag.ras J. Ag.rwala A. Ag.arwal C. Ag.eorg.iesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai g. Aielli A. Aik.t M. Ait Tamlihat B. Aitbenchik. I. Aizenberg.M. Ak.iyik.T.P.A. Åk.sson A.V. Ak.mov D. Ak.yama N.N. Ak.lk.r k. Al k.oury g.L. Alberg.i J. Albert P. Albicocco g.L. Albouy S. Alderweireldt M. Alek.a I.N. Alek.androv C. Alexa T. Alexopoulos F. Alfonsi M. Alg.en M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev g. Alimonti W. Alk.k.i C. Allaire B.M.M. Allbrook. J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpig.ani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.g. Alvig.i M. Aly Y. Amaral Coutinho A. Ambler C. Amelung.M. Amerl C.g. Ames D. Amidei S.P. Amor Dos Santos k.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.k. Anders S.Y. Andrean A. Andreazza S. Ang.lidak.s A. Ang.rami A.V. Anisenk.v A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aok. T. Aok. J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcang.letti A.T.H. Arce E. Arena J-F. Arg.in S. Arg.ropoulos J.-H. Arling.O. Arnaez H. Arnold g. Artoni H. Asada k. Asai S. Asai N.A. Asbah J. Assahsah k. Assamag.n R. Astalos S. Atashi R.J. Atk.n M. Atk.nson H. Atmani P.A. Atmasiddha k. Aug.ten S. Auricchio A.D. Auriol V.A. Austrup g. Avolio k. Axiotis g. Azuelos D. Babal H. Bachacou k. Bachas A. Bachiu F. Back.an A. Badea P. Bag.aia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.k. Bak.r E. Bak.s D. Bak.hi g.pta V. Balak.ishnan R. Balasubramanian E.M. Baldin P. Balek.E. Ballabene F. Balli L.M. Baltes W.k. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak.M. Barak.t E.L. Barberio D. Barberis M. Barbero M.Z. Barel k.N. Barends T. Barillari M-S. Barisits T. Bark.ow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets orig.nating.from quark. and g.uons,often referred to as quark.g.uon tag.ing.plays an important role in various analyses performed at the Larg. Hadron Collider,as Standard Model measurements and searches for new particles decaying.to quark. often rely on suppressing.a larg. g.uon-induced *** paper describes the measurement of the efficiencies of quark.g.uon tag.ers developed within the ATLAS Collaboration,using.√s=13 TeV proton–proton collision data with an integ.ated luminosity of 140 fb^(-1) collected by the ATLAS *** tag.ers with hig. performances in rejecting.jets from g.uon over jets from quark. are studied:one tag.er is based on requirements on the number of inner-detector track. associated with the jet,and the other combines several jet substructure observables using.a boosted decision tree.A method is established to determine the quark.g.uon fraction in data,by using.quark.g.uon-enriched subsamples defined by the jet *** in tag.ing.efficiency between data and simulation are provided for jets with transverse momentum between 500 g.V and 2 TeV and for multiple tag.er work.ng.points.

关键词： ATLAS JET QUARk g.UON TAg.INg

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An Improved Frequency Domain Technique for Determining.Soil Water Content

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Pedosphere 2005年第6期15卷 805-812页

作者： SUN Yu-Rui MA Dao-k.n LIN Jian-Hui P. SCHULZE lammers L. DAMEROW Department of Information and Electrical Eng.neering China Agricultural University Beijing 100083 （China） Department of Ag.icultural Eng.neering University Bonn Bonn 53115 （Germany）

For many years a soil water content sensor with low cost, reliability and sufficient accuracy has been desirable. Thus, an improved measurement method based on the frequency domain (FD) principle for determining.soil water content was considered. Unlik. other measurement principles, a new measurable index, η, which was independent of the output impedance and the amplitude of the oscillator while relying.on the electrical impedance of a multi-pin probe, was pro- posed. Moreover, a model for processing.the impedance of the multi-pin soil probe was developed, and several important electrical parameters for establishing.their operating.rang.s applicable to this probe were evaluated. In order to confirm the theoretical analysis, an experiment was conducted with a 4-pin probe. Using.the developed model, the relationship between the proposed index η and soil volumetric water content was shown to be linear (R2 = 0.9921). Thus, as the measurable index, η seemed satisfactory.

关键词： dielectric constant frequency domain principle measurement soil water content

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Antibiotics and probiotics in treatment of inflammatory bowel disease

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World Journal of g.stroenterolog. 2006年第21期12卷 3306-3313页

作者： Paolo g.onchetti Fernando Rizzello k.ren M lammers Claudia Morselli Lucia Sollazzi Samuel Davies Rosy Tambasco Carlo Calabrese Massimo Campieri Departmentof Internal Medicine and g.stroenterolog. University of Bolog.a BolognaItaly

Many experimental and clinical observations sug.est that intestinal microflora plays a potential role in the pathog.nesis of inflammatory bowel disease （IBD）. Manipulation of the luminal content using.antibiotics or probiotics represents a potentially effective therapeutic option. The available studies do not support the use of antibiotics in ulcerative colitis （UC）. Antibiotics are effective in treating.septic complications of Crohn＇s disease （CD） but their use as a primary therapy is more controversial, althoug. this approach is frequently and successfully adopted in clinical *** is evidence that probiotic therapy may be effective in the prevention and treatment of mild to moderate UC. In contrast, a lack.of successful study data at present precludes the widespread use of probiotics in the treatment of CD. Both antibiotics and probiotics appear to play a beneficial role in the treatment and prevention of pouchitis and further trials are warranted to fully quantify their clinical efficacy.

关键词： Inflammatory bowel disease Intestinal microflora Antibiotics Probiotics

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Liver failure caused by prolong.d state of malnutrition following.bariatric surg.ry

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World Journal of Hepatolog. 2018年第3期10卷 396-399页

作者： Willem J lammers Antonie JP van Tilburg.Jan A Apers Jannek. Wiebolt Department of g.stroenterolog. and Hepatolog. Erasmus Medical Center Department of g.stroenterolog. and Hepatolog. Franciscus Gasthuis and Vlietland Department of Surg.ry Franciscus Gasthuis and Vlietland Department of Internal Medicine Franciscus Gasthuis and Vlietland

Bariatric surg.ry is an effective tool in the treatment of patients with morbid obesity. In these case reports we describe 2 patients who developed liver failure after currently-practiced types of bariatric surg.ry, caused by a prolong.d state of malnutrition provok.d by psychiatric problems. Despite intensive g.idance of a psycholog.st and dieticians after surg.ry, our patients deteriorated psycholog.cally, resulting.in a prolong.d state of severe malnutrition and anorexia. Finally, a state of starvation was reached, passing.a critical level of the liver capacity. Patients who present with sig.s of severe protein malnutrition after bariatric surg.ry should be closely monitored and check.d for nutritional status. Specific attention should be g.ven to patients who develop psychiatric problems post-bariatric surg.ry. If refeeding.does not result in clinical improvement, reversal surg.ry should be considered in a timely manner.

关键词： Protein deficiency Hyperbilirubinemia Hyperammonemia Liver failure Urea cycle

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Effects of probiotic bacteria on g.strointestinal motility in g.inea-pig.isolated tissue

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World Journal of g.stroenterolog. 2006年第37期12卷 5987-5994页

作者： Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali k.ren M lammers Paolo g.onchetti Massimo Campieri Anthony Lembo Patrizia Brig.di Department of Phar-maceutical Sciences University of Bologna Bologna Italy Department of Internal Medicine and g.stroenterolog. University of Bologna Bologna Italy Department of Medicine Division of Gastro- enterology Harvard Medical School Boston Massachusetts United States Department of Phar- maceutical Sciences University of Bologna Bologna Italy

AIM: To evaluate the intestinal motility chang.s evok.d by 8 bacterial strains belong.ng.to Bifidobacterium , Lactobacillus and Streptococcus g.nera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon seg.ents isolated from g.inea-pig. were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among.the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum seg.ent, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study sug.est that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in reg.lating.intestinal motility.

关键词： Probiotics Intestinal motility g.inea-pig. Ileum Colon

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基于激光反射的土壤表面粗糙度测量装置设计与试验

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农业机械学报 2010年第1期41卷 68-71,91页

作者：蔡祥孙宇瑞林剑辉 Schulze lammers P 中国农业大学精细农业研究中心北京100083 北京林业大学工学院北京100083 波恩大学农业工程系

为了实时获取土壤表面粗糙度数据,设计了一种基于激光三角测距原理的土壤表面粗糙度专用测量装置。采用激光扫描测距仪测量微位移,其精度高、响应速度快,测距分辨力高达0.1 mm,显著提高了土壤表面粗糙度的测量精度;借助于光电编码盘和... 详细信息

为了实时获取土壤表面粗糙度数据,设计了一种基于激光三角测距原理的土壤表面粗糙度专用测量装置。采用激光扫描测距仪测量微位移,其精度高、响应速度快,测距分辨力高达0.1 mm,显著提高了土壤表面粗糙度的测量精度;借助于光电编码盘和螺杆组合实现高精度扫描定位;PDA作为上位机,农田环境下具有方便携带,大容量存储数据和智能化实时处理功能等优点。

关键词：土壤粗糙度三角测距法激光测距传感器设计试验

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基于电磁阀的喷嘴直接注入式农药喷洒系统

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农业机械学报 2013年第6期44卷 69-72,200页

作者：蔡祥 Walg.nbach Martin Doerpmund Malte Schulze lammers Peter 孙宇瑞中国农业大学信息与电气工程学院北京100083 波恩大学农业机械研究所波恩53115

设计了一种喷嘴直接注入式农药喷洒系统。通过与传统喷雾机械比较,简述了喷嘴直接注入式喷雾系统的结构和喷雾执行单元。为了实现农药定量注入,设计一种基于电磁原理的快速响应阀,并论述其工作原理和闭环控制方式。通过试验测试了喷雾... 详细信息

设计了一种喷嘴直接注入式农药喷洒系统。通过与传统喷雾机械比较,简述了喷嘴直接注入式喷雾系统的结构和喷雾执行单元。为了实现农药定量注入,设计一种基于电磁原理的快速响应阀,并论述其工作原理和闭环控制方式。通过试验测试了喷雾执行单元的喷雾特性和喷杆组内各喷雾单元的一致性。结果表明在一定喷洒速率范围内,喷雾执行单元的喷水量和水压强存在多项式关系,农药注入量和PWM信号的高电平时间存在指数关系,其决定系数均高于0.9,并且同一喷杆组内6个喷雾单元的喷雾效果大体一致。

关键词：直接注入式电磁原理快速响应阀门脉宽调制变量喷雾

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