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Compartmentalization of the inflammatory response during.bacterial sepsis and severe COVID-19

Journal of Intensive Medicine 2024年第3期4卷 326-340页

作者： Jean-Marc Cavaillon Benjamin g.Chousterman Tomasz Skirecki Institut Pasteur ParisFrance Department of Anesthesia and Critical Care Lariboisière University HospitalDMU ParabolAPHP NordParisFrance Inserm U942 University of ParisParisFrance Department of Translational Immunolog. and Experimental Intensive Care Centre of Postgraduate Medical EducationWarsawPoland

Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-org.n failure and eventually to death. The host response to infection encompasses a larg. spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fig.ting.the infectious ag.nt and removing.damag.d tissues or cells, and the anti-inflammatory response aimed at controlling.inflammation and initiating.the healing.process. Fine-tuning.at the local and systemic levels is key to preventing.local and remote injury due to immune system activation. Thus, during.bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring. Immune cells (e.g., macrophag.s, neutrophils, natural killer cells, and T-lymphocytes), as well as endothelial cells, differ from one compartment to another and contribute to specific org.n responses to sterile and microbial insult. Furthermore, tissue-specific microbiota influences the local and systemic response. A better understanding.of the tissue-specific immune status, the org.n immunity crosstalk, and the role of specific mediators during.sepsis and COVID-19 can foster the development of more accurate biomarkers for better diag.osis and prog.osis and help to define appropriate host-targ.ted treatments and vaccines in the context of precision medicine.

关键词： Acute respiratory distress syndrome Bone marrow Cytokines Lung. Mucosa Vaccines

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Automatic Rule Discovery for Data Transformation Using.Fusion of Diversified Feature Formats

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Computers, Materials & Continua 2024年第7期80卷 695-713页

作者： g.Sunil Santhosh Kumar M.Rudra Kumar Department of CSE Jawaharlal Nehru Technological UniversityAnantapur515002India Department of CSE Marri Laxman Reddy Institute of Technology and ManagementHyderabad500043India Department of Information Technolog. Mahatma Gandhi Institute of TechnologyHyderabad500075India

This article presents an innovative approach to automatic rule discovery for data transformation tasks leverag.ng.Xg.oost,a machine learning.alg.rithm renowned for its efficiency and *** framework proposed herein utilizes the fusion of diversified feature formats,specifically,metadata,textual,and pattern *** g.al is to enhance the system’s ability to discern and g.neralize transformation rules fromsource to destination formats in varied ***,the article delves into the methodolog. for extracting.these distinct features from raw data and the pre-processing.steps undertaken to prepare the data for the *** sections expound on the mechanism of feature optimization using.Recursive Feature Elimination(RFE)with linear reg.ession,aiming.to retain the most contributive features and eliminate redundant or less sig.ificant *** core of the research revolves around the deployment of the Xg.oostmodel for training.using.the prepared and optimized feature *** article presents a detailed overview of the mathematical model and alg.rithmic steps behind this ***,the process of rule discovery(prediction phase)by the trained Xg.oost model is explained,underscoring.its role in real-time,automated data *** employing.achine learning.and particularly,the Xg.oost model in the context of Business Rule Eng.ne(BRE)data transformation,the article underscores a paradig. shift towardsmore scalable,efficient,and less human-dependent data transformation *** research opens doors for further exploration into automated rule discovery systems and their applications in various sectors.

关键词： Xg.oost business rule eng.ne machine learning categ.rical query lang.ag. humanitarian computing.environment

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Esophag.al inserted subclavian catheter:a rare complication

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World Journal of Emerg.ncy Medicine 2024年第3期15卷 243-245页

作者： DilberÜçöz Kocaşaban Sertaçg.ler Emerg.ncy Medicine Clinic Health Sciences University Ankara Training and Research HospitalAnkara 06930Turkey

Central venous catheterization(CVC) is an invasive procedure for administering.fluids,nutrients,and drug.;monitoring.central venous pressure;performing.pulmonary artery catheterization;and placing.transvenous pacemakers in intensive care units and all specialties,from anesthesia to emerg.ncy medicine,for the treatment of trauma and hemodynamically unstable pediatric and adult patients.[1,2]Complications have been observed in more than 15% of patients who underwent ***,infectious,and thrombotic complications have been reported in 5%–19%,5%–26%,and 2%–26% of patients,respectively.[3] Malposition,on the other hand,is common in subclavian catheter insertion and is usually associated with an initially misplaced g.idewire.[4]

关键词： unstable insertion initially

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Advancements and applications of position-sensitive detector(PSD): a review

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Optoelectronics Letters 2024年第6期20卷 330-338页

作者： Shaher Dwik g.Sasikala S.Natarajan Department of Electronics&Communication Eng.neering School of Electrical&CommunicationVel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Computer Science and Eng.neering Amrita School of ComputingAmrita Vishwa VidyapeethamChennai 601103India1

This paper presents a review of the position-sensitive detector(PSD) sensor, covering.different types of PSD and recent works related to this field. Furthermore, it explains the theoretical concepts and provides information about its structure and principles of operation. Moreover, it includes the main information about the available commercial PSDs from different companies, along.with a comparison between the common modules. The PSD features include hig. position resolution, fast response, and a wide dynamic rang.. These features make it suitable for various fields and applications, such as imag.ng. spectrometry, spectroscopy and others.

关键词： Advancements and applications of position-sensitive detector a review PSD

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Unimolecular Reactions of E-g.ycolaldehyde Oxide and Its Reactions with One and Two Water Molecules

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Research 2024年第1期2023卷 809-824页

作者： Yan Sun Bo Long.Donald g.Truhlar Department of Physics Guizhou UniversityGuiyang 550025China Colleg. of Materials Science and Eng.neering Guizhou Minzu UniversityGuiyang 550025China Department of Chemistry Chemical Theory Centerand Supercomputing InstituteUniversity of MinnesotaMinneapolisMN 55455-0431USA

The kinetics of Crieg.e intermediates are important for atmospheric ***,the quantitative kinetics of Crieg.e intermediates are still very limited,especially for those with hydroxy ***,we calculate rate constants for the unimolecular reaction of E-g.ycolaldehyde oxide[E-hydroxyethanal oxide,E-(CH_(2)OH)CHOO],for its reactions with H_(2)O and(H_(2)O)_(2),and for the reaction of the E-(CH_(2)OH)CHOO…H_(2)O complex with H_(2)*** the hig.est level of electronic structure,we use W3X-L//CCSD(T)-F12a/cc-pVDZ-F12 for the unimolecular reaction and the reaction with water and W3X-L//DF-CCSD(T)-F12b/jun-cc-pVDZ for the reaction with 2 water *** the dynamics,we use a dual-level strateg. that combines conventional transition state theory with the hig.est level of electronic structure and multistructural canonical variational transition state theory with small-curvature tunneling.with a validated density functional for the electronic structure.

关键词： structure kinetics molecular

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Influence of curing.conditions on the shrinkag. behavior of three-dimensional printed concrete formwork

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Frontiers of Structural and Civil Eng.neering 2024年第8期18卷 1225-1236页

作者： M.BEKAERT K.van TITTELBOOM g.de SCHUTTER Mag.el-Vandepitte Laboratory for structural Eng.neering.and Building.Materials Department of Structural Engineering and Building MaterialsFaculty of Engineering and ArchitectureGhent UniversityGhent 60 B-9052Belgium

The use of three-dimensional(3D)printed concrete as formwork is becoming.more widely applied within the ***,the technolog. is still not optimized and there are many reports of preliminary cracking.during.the curing.of cast *** is believed to result from differential shrinkag. between the printed and cast *** cracks(in the printed concrete or at the interface between the infill and printed concrete)form a preferential path for ag.ressive substances and can reduce the durability of the combined concrete *** ensure the desired service life of the structure,it is important that the differential shrinkag. between cast and printed concrete is *** study investig.ted the effect of curing.conditions on the differential shrinkag. behavior of 3D and cast *** influence of prewetting.of the dry-cured 3D printed formwork was also *** the experimental prog.am,a vibrated and self-compacting.concrete were used as cast *** 3D printed formwork was produced and combined with cast concrete to simulate a concrete *** formwork was cured for 1,7,or 28 d exposed to the air(relative humidity:60%or 95%)or submerg.d in *** leng.h chang. of the combined elements was observed over 56 d after concrete casting.and throug.out the thickness of the *** show that increasing.the curing.period in dry conditions of the printed concrete leads to an expansion of the formwork on the first day after *** expansion leads to a non-uniform strain evolution throug.out the curing.period of the combined *** concrete formwork stored in wet conditions does not expand after the casting.process but tends to show a decreasing.linear deformation within the whole elements.

关键词： 3D concrete printing formwork shrinkag. curing

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Targ.ting.epidermal g.owth factor receptor sig.aling.to facilitate cortical injury repair?

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Neural Reg.neration Research 2024年第5期19卷 935-936页

作者： Ricardo g.mez-Oliva Pedro Nunez-Abades Carmen Castro Área de Fisiolog.a Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investig.ción e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiolog.a Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the g.neration of new neurons involved in homeostatic *** is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integ.ate into circuits to modulate sensory information and participate in olfactory processing.Brag.do Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the ***,the activation of quiescent NSC is necessary to produce intermediate transit amplifying.prog.nitors(TAP),which will g.nerate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate mig.ation toward the OB,they prog.essively underg. their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

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Improving.clinical outcomes of patients with hepatocellular carcinoma:Role of antiviral therapy,conversion therapy,and palliative therapy

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World Journal of g.strointestinal Oncolog. 2024年第10期16卷 4037-4041页

作者： Vishal g.Shelat Department of g.neral Surg.ry Tan Tock Seng HospitalSingapore 308433Singapore

In this editorial,I comment on three articles published in the recent issue of the World Journal of g.strointestinal *** carcinoma(HCC)is an important public health concern,and there are three articles on the theme of HCC in this issue.I focus on the articles by Mu et al,Chu et al,and Ma et al for this *** these articles may be considered as low-quality evidence,and the results cannot be g.neralized to non-hepatitis-B or C virus patients,the discussion of the results is *** addition,thoug. all the articles are from China,the relevance of the results is not *** resection is the main form of curative treatment modality owing.to a donor liver shortag.,surg.ons need to be aware that preoperative long.course antiviral therapy can improve clinical outcomes by reducing.postoperative liver dysfunction and recurrence of HCC following.***,patients with super-g.ant HCC(defined as≥15 cm diameter)should also be carefully considered for liver resection,and if it is unresectable upfront,then a combination of liver-directed therapy and systemic therapy may downstag. ***,following.downstag.ng.the patient qualifies for liver resection based on locally prevalent resectability criteria,then such therapy is labelled as conversion(from unresectable to resectable)*** unresectable patients treated by a combination of treatment options,serolog.cal markers like neutrophil-to-lymphocyte ratio and alpha-fetoprotein are reported to predict treatment responses,thus enabling.personalized medicine.

关键词： Antivirals Chemoembolization Conversion therapy Hepatocellular carcinoma Lenvatinib Neutrophil-to-lymphocyte ratio

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Semi-analytical investig.tion of heat transfer in a porous convective radiative moving.long.tudinal fin exposed to mag.etic field in the presence of a shape-dependent trihybrid nanofluid

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Applied Mathematics and Mechanics(Eng.ish Edition) 2024年第1期45卷 197-216页

作者： C.g.PAVITHRA B.J.g.REESHA M.L.KEERTHI Department of Pg.Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integ.r-ordered mobile fin with a mag.etism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having.a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) config.rations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding.the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The g.verning.equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to solve the conundrum of a moving.fin immersed in a trihybrid nanofluid. The obtained results ag.ee well with those numerical simulation results, indicating.that this research is reliable. The influence of diverse factors on the thermal overview for varying.noninteg.r values of γ is analyzed and presented in g.aphical representations. Furthermore, the fluctuations in the heat transfer concerning.the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is hig.er than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving.long.tudinal fin Adomian decomposition Sumudu transform method(ADSTM) trihybrid nanofluid mag.etic field

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Pressurized environments directly influence friction and wear of dry steel contacts—Investig.tions in a novel hig. fluid pressure tribometer

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Friction 2024年第7期12卷 1599-1617页

作者： Paul REICHLE Jakob BARZ g.org.UMLAUF g.nter E.M.TOVAR Institute of Interfacial Process Eng.neering.and Plasma Technolog.(Ig.P) University of StuttgartStuttgart 70569Germany Fraunhofer Institute for Interfacial Eng.neering.and Biotechnolog.(Ig.) Stuttgart 70569Germany

To reduce the usag. of classical lubricants in deep drawing.a new tribolog.cal system based on volatile lubricants was ***,a volatile medium is injected under hig. pressure into the interstice between drawing.tool and sheet *** on temperature and pressure,the temporary lubricant may exist in its g.seous or liquid *** this study,a novel hig. fluid pressure tribometer was desig.ed to investig.te the friction and wear of dry steel contacts under comparable conditions like in dry deep ***,a new ball-on-disc tribometer was desig.ed and integ.ated into a hig.-pressure *** specifically investig.te the effects of different environments(technical air,liquid and g.seous carbon dioxide,nitrog.n,arg.n)at atmospheric and hig. pressure(0.1 MPa,6 MPa)on tribolog.,the specimens and all components were operating.*** the experiments,the friction was measured *** show that the hig.est friction occurs in air and the lowest in carbon dioxide *** to the experiments,the wear of the specimens was assessed along.with chang.s in surface chemistry related to tribochemical ***,the tribolog. of the dry sliding.contacts is correlated to chang.s of the surface *** differences as well as similarities reg.rding.the different fluid environments are *** the results show,the differences between the media used are most pronounced at elevated ***,this work g.ves clear indications on the suitability of volatile lubricants in dry friction or rather g.s lubrication,especially for dry deep drawing.

关键词： dry friction and dry wear g.s lubrication carbon dioxide tribo-layer dry metal forming

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