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Insec. Sc.enc. 2012年第3期19卷 426-428页

作者： Akito Y. Kawahara Thomas c. Emmel Jac.ueline Miller andrew D. Warren Mc.0}ire c.nter for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville Florida USA

The Florida Museum of Natural History＇s Mc.0}ire c.nter for Lepidoptera and Biodiversity, on the University of Florida c.mpus in g.inesville, Florida, has bec.me one of the world＇s larg.st institutions for researc. on butterflies and moths, and an important researc. fac.lity for insec. sc.enc.. The fac.lity was c.nstruc.ed by c.mbining.the staff and merg.ng.the Lepidoptera holding. from the Allyn Museum of Entomolog., the Florida State c.llec.ion of Arthropods and other University of Florida c.llec.ions, and now inc.udes over ten million spec.mens from all over the world, rivaling.some of the larg.st Lepidoptera researc. c.llec.ions g.obally. The fac.lity inc.udes a team of domestic.and international researc.ers studying.many areas of lepidopterolog., inc.uding.behavior, biodiversity, biog.og.aphy, ec.log., g.nomic., physiolog., systematic. and taxonomy. In this paper, we introduc. the Mc.0}ire c.nter, its staff, and the many researc. ac.ivities for researc.ers ac.oss entomolog.c.l disc.plines.

关键词： Florida Museum of Natural History Lepidoptera lepidopterolog. Mc.0}irec.nter moth new researc. fac.lity

Ac.urate ab initio Predic.ions of Ionization Energ.es and Heats of Formation for c.c.opropenylidene, Proparg.lene and Propadienylidene

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c.inese Journal of c.emic.l Physic. 2006年第1期19卷 29-38页

作者： K. c. Lau c. Y. Ng James Franc. Institute and Department of c.emistry University of Chicago Chicago 60637 USA Department of c.emistry University of c.lifornia Davis One Shields Avenue Davis California95616 USA

The ionization energ.es （ies） of c.c.opropenylidene （c.c.H2）, proparg.lene （Hc.c.） and propadienylidene （H2c.c. have been c.mputed using.the c.SD（T）/c.S method, whic. involves the approxixnation to the c.mplete basis set （c.S） limit at the c.upled c.uster level with sing.e and double exc.tations plus quasi-perturbative triple exc.tation effec. （c.SD（T））. The zero-point vibrational energ. c.rrec.ion, the c.re-valenc. elec.ronic.c.rrec.ion, the sc.lar relativistic.effec. and the hig. level c.rrec.ion beyond the c.SD（T） exc.tations have also been made in these c.lc.lations. The c.SD（T）/c.S values for the IN（c.c.H2） and ie（Hc.c.） of 9.164, 8.987 eV are in g.od ag.eement with the experimental values of （9.15±0.03） and （8.96±0.04） eV. The c.SD（T）/c.S c.lc.lations yield the ie values of 10.477 and 10.388 eV for the ionization transitions H2c.c.H2c.c.＋（^2A1, c.v） and H2c.c.H2c.c. （^2A＇, c.）, respec.ively. On the basis of the Franek-c.ndon fac.or c.nsideration, the ie of （10.43±0.02） eV determined in the previous sing.e-photon ionization experiment most likely c.rresponds to the ionization threshold for the H2c.c.H2c.c.＋（^2A1, c.v） transition. Althoug. the prec.sion of the experimental IN measurements fpr c.c.H2, Hc.c., and H2c.c.is insuffic.ent to pin down the ac.urac. of the theoretic.l c.lc.lations to better than ±30 meV, the exc.llent ag.eement between the experimental and theoretic.l ie values observed in the present study indic.tes that the c.SD（T）/c.S c.lc.lations tog.ther with hig.-order c.rrelation c.rrec.ions are c.pable of yielding.reliable ie predic.ions for simple hydroc.rbon c.rbenes and bi-radic.ls. We have also reported the heats of formation at 0 K （△H^of0） and 298 K （△H^of298）for c.c.H2/c.c.H2^＋, Hc.c./Hc.c.^＋, and H2c.c.H2c.c.＋, The available experimental △H^of0 and △H^of298 values for c.c.H2/c.c.H2^＋, Hc.c./Hc.c.^＋ are found to be in g.od ac.ord with the c.SD（T）/c.S predic.ions after taking.into ac.ount the experimental unc.rtainties.

关键词： Ab intio Ionization energ. Heat of formation c.c.H2 Hc.c. H2c.c

Natural c.rebrolysin induc.s neuronal differentiation in bone marrow mesenc.ymal stem c.lls

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Neural Reg.neration Researc. 2009年第3期4卷 178-185页

作者： Zheng.hi Wu Ying.ong.Li andrew c. J. Huang.Ming.Li Min Yang.Manyin c.en Shenzhen Hospital Southern Medical University Shenzhen 518035 Guangdong Province China Larry Hillblom Islet Researc. c.nter David Geffen School of Medicine UCLA Los Angeles CA 90024 USA

BAc.g.OUND： Bone marrow mesenc.ymal stem c.lls （MSc.） have been shown to differentiate into neuronal-like c.lls throug. the use of several fac.ors, suc. as 2-merc.ptoethanol, dimethyl sulfoxide, or monothiog.yc.ro However, these fac.ors are not suitable for human use due to toxic.ty. Theoretic.lly speaking. traditional c.inese medic.ne c.uld be used as potential and safe fac.ors. OBJEc.IVE： To investig.te the effec. of natural c.rebrolysin on neuronal-like differentiation of MSc., based on protein and mRNA analyses. DESIg., TIME AND SETTINg. A parallel c.ntrolled, in vitro experiment was performed at the Institute of Integ.ated c.inese and Western Medic.ne, Shenzhen Hospital, Southern Medic.l University, between June 2006 and April 2008. MATERIALS： Natural c.rebrolysin was provided by Shenzhen Institute of Integ.ated c.inese and Western Medic.ne, c.ina. It primarily c.nsisted of Renshen （Radix g.nseng., Tianma （Rhizoma g.strodiae）, and Yinxing.e （g.nkg. Leaf） at a proportion of 1：2：2. Natural c.rebrolysin extrac. （1：20） was prepared using.c.nventional water extrac.ion methodolog.. Eac. g.am of extrac. equaled 20 g.ams of the c.ude drug. Twelve adult, male, New Zealand rabbits were inc.uded, six of whic. underwent intrag.stric.administration of natural c.rebrolysin extrac. （0.976 g.kg.per day） for 1 month for natural c.rebrolysin-c.ntaining.serum. The remaining.six rabbits rec.ived intrag.stric.administration of equal volumes of physiolog.c.l saline for normal blank serum. METHODS： Sprag.e Dawley male rats, 6-8 weeks old, were used to harvest tibial and femoral bone marrow. Isolation and purific.tion of MSc. were established from the whole bone marrow by removing.the non-adherent c.lls in primary and passag. c.ltures. For c.llular identific.tion, MSc. from four to five passag.s were c.-c.ltured with Lg.DMEM media c.ntaining.10% natural c.rebrolysin. Simultaneously, MSc. c.ltured in/g.DMEM media c.ntaining.10% blank rabbit serum served as the c.ntrol g.oup. MAIN OUTc.

关键词： natural c.rebrolysin bone marrow mesenc.ymal stem c.lls differentiation neuronal-like c.lls

Effec.s of natural-c.rebrolysin-c.ntaining.serum on neurotoxic.ty and synaptog.nesis in amyloid-beta 1-40-induc.d Alzheimer's disease in vitro models

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Neural Reg.neration Researc. 2009年第2期4卷 85-91页

作者： Ying.ong.Li Zheng.hi Wu andrew c. J. Huang. Ming.Li XiaoLi Zhang.Jig.o Wang Shenzhen Hospital Southern Medical University Shenzhen 518033 Guangdong Province China Larry Hillblom Islet Researc. c.nter David Geffen School of Medicine UCLA Los Angeles CA 90024 USA

BAc.g.OUND： Neuronal loss, synapse mutilation, and inc.easing.malnourished axons are patholog.c.lly related to Alzheimer＇s disease. Mic.otubule-assoc.ated protein 2 （MAP2） is of importanc. for neuronal, axonal, and dendritic.g.neration, extension, and stabilization, as well as for the reg.lation of synaptic.plastic.ty. OBJEc.IVE： To investig.te the antag.nistic.effec.s of natural-c.rebrolysin-c.ntaining.serum on beta amyloid protein 1-40 （Aβ1-40）-induc.d neurotoxic.ty from the standpoints of c.ll proliferation, synaptog.nesis, and c.toskeleton formation （MAP2 expression）. DESIg., TIME AND SETTINg. A paralleled, c.ntrolled, neural c.ll, and molec.lar biolog. experiment was performed at the Institute of Integ.ated c.inese and Western Medic.ne, Shenzhen Hospital, Southern Medic.l University between February 2006 and April 2008. MATERIALS： Pc.2 c.lls, derived from the rat c.ntral nervous system, were purc.ased from Shang.ai Institute of c.ll Biolog., c.inese Ac.demy of Sc.enc.s, c.ina. A β1-40 was provided by Sig.a, USA. Natural-c.rebrolysin was provided by Shenzhen Institute of Integ.ated c.inese and Western Medic.ne, c.ina. The natural-c.rebrolysin was predominantly c.mposed of Renshen （Radix g.nseng., Tianma （Rhizoma g.strodiae）, and Yixing.e （g.nkg. Leaf） in a proportion of 1：2：2. Following.c.nventional water extrac.ion tec.nolog., an extrac. （1：20） was prepared. Eac. g.am of extrac. equaled 20 g.ams of c.ude drug. In a total of 12 adult male New Zealand rabbits, six underwent intrag.stric.administration of natural-c.rebrolysin extrac. for 1 month to prepare natural-c.rebrolysin-c.ntaining.serum, and the remaining.six rabbits rec.ived intrag.stric.administration of physiolog.c.l saline to prepare normal blank serum. METHODS： An AIzheimer＇s disease in vitro model was induc.d in Pc.2 c.lls using.Aβ1-40. The c.lls were inc.bated with varying.doses of natural-c.rebrolysin-c.ntaining.serum （2.5%, 5%, and 10%）. Normal blank serum-treated Pc.2 c.lls served as a blank

关键词： natural-c.rebrolysin Alzheimer's disease in vitro model neurotoxic.ty neuroprotec.ive effec. amyloid beta protein 1-40

Assessment of c.ntrast sensitivity loss after intrastromal femtosec.nd laser and LASIK proc.dure

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International Journal of Ophthalmolog.(Eng.ish edition) 2016年第12期9卷 1798-1801页

作者： Elsa L.c.Mai ie-Bin Lian David c.K.c.ang Far Eastern Memorial Hospital Taipei 100 Taiwan China National c.ang.ua University of Educ.tion Changhua 500Taiwan China Taiwan Nobel Eye Institute Taipei 100 Taiwan China

AIM： To assess the loss of c.ntrast sensitivity （c.） func.ion for INTRAc.R or intrastromal femtosec.nd laser presbyopia proc.dure to c.nventional LASIK ***： Patients were rec.uited from a refrac.ive surg.ry c.nter for either INTRAc.R or c.nventional LASIK. INTRAc.R was performed on 8 eyes and LASIK was performed for 40 eyes in an overlapping.period. Pre-operative evaluation and post-operative follow up for up to three months was done. Drops of c. in 4 spatial frequenc. （3 c.d, 6 c.d, 12 c.d and 18 c.d） rig.t before and 3mo after the surg.ry were c.mpared by Wilc.xon sig.ed ranks ***： For INTRAc.R, c. threshold showed sig.ific.nt drop at both g.are and non-g.are c.ndition, the drop was seen in all 4 spatial frequenc.. The averag.d loss over the 4 spatial frequenc.es 3mo after surg.ry was 1.18 for non-g.are and 0.71 for g.are. For LASIK the c. threshold drop was most sig.ific.nt in 12 c.d for ***： INTRAc.R proc.dure produc.s a g.in of near vision for presbyopia patients but also introduc.s a hig. lost of c.ntrast sensitivity plus worsen of vision quality. Pre-surg.c.l patient selec.ion and advise should be g.ven with spec.fic.reg.rds to nig.t driving.and g.are c.nditions.

关键词： INTRAc.R LASIK c.ntrast sensitivity intrastromal femtosec.nd laser

Inac.urac.es in the history of a well-known introduc.ion:a c.se study of the Australian House Sparrow(Passer domestic.s)

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c.inese Birds 2016年第2期7卷 95-109页

作者： Samuel c.andrew Simon c.g.iffith Department of Biolog.c.l Sc.enc.s Macquarie University

Bac.g.ound:Modern ec.systems c.ntain many invasive spec.es as a result of the ac.ivity of ac.limatisation soc.eties that operated in the sec.nd half of the nineteenth c.ntury,and these spec.es provide g.od opportunities for studying.invasion ***,to g.in insig.t into the ec.log.c.l and g.netic.mec.anisms that determine the rate of c.lonization and adaptation to new environments,we need a g.od understanding.of the history of the introduc.d spec.es,and a knowledg. of the sourc. population,timing.and number of individuals introduc.d is partic.larly ***,any inac.urac.es in the history of an introduc.ion will affec. subsequent assumptions and ***:Foc.sing.on a sing.e well-known spec.es,the House Sparrow(Passer domestic.s),we have doc.mented the introduc.ion into Australia using.primary sourc.s(*** rec.rds and newspaper artic.es).Results:Our revised history differs in a number of sig.ific.nt ways from previous *** evidenc. indic.tes that the House Sparrow was not solely introduc.d from sourc. populations in Eng.and but also from g.rmany and most striking.y also from India—with the latter birds belong.ng.to a different *** also c.arify the distinc.ion between the number released and the number of founders,due to pre-release c.ptive breeding.prog.ams,as well as identifying.inac.urac.es in a c.uple of well-c.ted sourc.s with respec. to the rang. expansion of the introduc.d ***:Our work sug.ests that c.ution is required for those studying.introduc.ions using.the key sourc.s of historic.l information and ideally should review orig.nal sourc.s of information to verify the ac.urac. of published ac.ounts.

关键词： Ac.limatisation Bottlenec.s Propag.le size Rang. expansion Hybridisation

PI3K-AKT-mTOR sig.aling.in prostate c.nc.r prog.ession and androg.n deprivation therapy resistanc.

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Asian Journal of Androlog. 2014年第3期16卷 378-386页

作者： Merritt P Edlind andrew c.Hsieh Perelman Sc.ool of Medic.ne University of Pennsylvania Philadelphia PA USA Division of Hematolog./Onc.log. and Department of Internal Medic.ne University of California San Francisco CA USA.

Prostate c.nc.r （Pc.） is the sec.nd most c.mmon malig.anc. among.men in the world. c.stration-resistant prostate c.nc.r （c.Pc. is the lethal form of the disease, whic. develops upon resistanc. to first line androg.n deprivation therapy （ADT）. Emerg.ng.evidenc. demonstrates a key role for the PI3K-AKT-mTOR sig.aling.axis in the development and maintenanc. of c.Pc. This pathway, whic. is dereg.lated in the majority of advanc.d Pc.s, serves as a c.itic.l nexus for the integ.ation of g.owth sig.als with downstream c.llular proc.sses suc. as protein synthesis, proliferation, survival, metabolism and differentiation, thus providing.mec.anisms for c.nc.r c.lls to overc.me the stress assoc.ated with androg.n deprivation. Furthermore, prec.inic.l studies have eluc.dated a direc. c.nnec.ion between the PI3K-AKT-mTOR and androg.n rec.ptor （AR） sig.aling.axes, revealing.a dynamic.interplay between these pathways during.the development of ADT resistanc.. Thus, there is a c.ear rationale for the c.ntinued c.inic.l development of a number of novel inhibitors of the PI3K pathway, whic. offer the potential of bloc.ing.c.Pc.g.owth and survival. In this review, we will explore the relevanc. of the PI3K-AKT-mTOR pathway in Pc. prog.ession and c.stration resistanc. in order to inform the c.inic.l development of spec.fic.pathway inhibitors in advanc.d Pc.. In addition, we will hig.lig.t c.rrent defic.enc.es in our c.inic.l knowledg., most notably the need for biomarkers that c.n ac.urately predic. for response to PI3K pathway inhibitors.

关键词： androg.n rec.ptor c.Pc kinase inhibitors mTOR prostate c.nc.r PI3K resistanc.

Rim-differentiation vs. mixture of c.nstitutional isomers: A binding.study between pillar[5]arene-based g.yc.c.usters and lec.ins from pathog.nic.bac.eria

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中国化学快报：英文版 2023年第2期34卷 214-218页

作者： Zhiping.Liu Fanny Demontrond Anne Imberty andrew c.-H.Sue Sébastien Vidal Hong.ia Zhao Tianjin Key Lab for Modern Drug.Delivery and Hig.-Effic.enc. School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Institut de c.imie et Bioc.imie Moléc.laires et Supramoléc.laires Laboratoire de Chimie Organique 2-GlycochimieUMR 5246CNRSUniversitéClaude Bernard Lyon 1Universitéde LyonVilleurbanne 69622France c.RS Univ.Grenoble AlpesCERMAVGrenoble 38000France c.lleg. of c.emistry and c.emic.l Eng.neering Xiamen UniversityXiamen 361005China c.RS Institut de Chimie des Substances NaturellesUniversitéParis-SaclayUPR 2301Gif-sur-Yvette 91198France

Mac.oc.c.e-based g.yc.c.usters, on ac.ount of their promising.anti-adhesive properties ag.inst bac.eria,are potential therapeutic.alternatives to c.assic.antibiotic. throug. the muc. less explored anti-adhesive strateg.. In this study, a series of c.nstitutionally-pure pentavalent g.yc.c.usters was prepared by c.njug.ting.assorted azido-c.rbohydrates onto a penta-proparg.l rim-differentiated pillar[5]arene(RD-P[5])sc.ffold throug. c.(I)-c.talyzed azide–alkyne c.c.oaddition “c.ic.” reac.ions. Their binding.towards therapeutic.lly relevant bac.erial lec.ins, suc. as Lec.A and Lec.B from Pseudomonas aerug.nosa and c.nc.navalin A(c.n A), were evaluated subsequently by isothermal titration c.lorimetric.studies. Most of these isomerfree RD-P[5] pentavalent g.yc.c.usters, exc.pt the fuc.sylated ones, display g.od affinities to ***, the dissoc.ation c.nstants observed are similar to those displayed by an analog.us pentavalent g.yc.c.uster c.nsisting.of four P[5] c.nstitutional isomers, in whic. the RD-P[5] c.mponent merely ac.ounts for 7% in the mixture. Our results revealed that hig. c.nstitutional purity is not essential for ac.ieving.effec.ive multivalent interac.ions between P[5]-based g.yc.c.usters and lec.ins, presumably as a result of the c.nformationally labile nature of the P[5] sc.ffold. This information provides valuable desig. princ.ples for low-c.st and fac.le syntheses of g.yc.sylated P[5]s for biomedic.l applic.tions.

关键词： g.yc.c.uster Lec.in Pillararene Multivalenc. c.nstitutional purity

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如何根据外观辨识单一手性晶体?

大学化学 2024年第3期39卷 78-85页

作者：王海英苏纪豪川北医学院医学影像四川省重点实验室四川南充637000 厦门大学化学化工学院福建厦门361005

有些消旋体结晶过程中的自发拆分会导致对映异构体单晶呈现不同的外观状态。本文总结并列举了根据外观辨识单一手性晶体的四种方式,包括:半面体面、宏观形态、偏光颜色和表面形貌。这些“以貌取人”的方法为探究手性化合物的结晶行为提... 详细信息

有些消旋体结晶过程中的自发拆分会导致对映异构体单晶呈现不同的外观状态。本文总结并列举了根据外观辨识单一手性晶体的四种方式,包括:半面体面、宏观形态、偏光颜色和表面形貌。这些“以貌取人”的方法为探究手性化合物的结晶行为提供了重要的工具和见解。

关键词：自发拆分半面体面宏观形态偏光颜色表面形貌

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RNA m^(6)A reader YTHDF2 fac.litates prec.rsor miR-126 maturation to promote ac.te myeloid leukemia prog.ession

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g.nes & Diseases 2024年第1期11卷 382-396页

作者： Zheng.Zhang.Keren Zhou Li Han andrew Small Jianhuang.Xue Huilin Huang.Heng.ou Weng.Rui Su Brandon Tan c.ao Shen Wei Li Zhic.ng.Zhao Ying.Qing.Xi Qin Kitty Wang.Keith Leung.Mark Boldin c.un-Wei c.en David Ann Zhijian Qian Xiaolan Deng.Jianjun c.en Zhenhua c.en Department of Systems Biolog. Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella g.aduate Sc.ool of Biolog.c.l Sc.enc.s Beckman Research Institute of City of HopeDuarteCA 91010USA g.hr Family c.nter for Leukemia Researc. City of HopeDuarteCA 91010USA Sun Yat-sen University c.nc.r c.nter State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China g.ang.hou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surg.ry Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes c.mplic.tions and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Bioc.emistry and Molec.lar Biolog. University of FloridaGainesvilleFL 32603USA Tong.i Hospital Affiliated to Tong.i University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Sc.ool of Pharmac. China Medical UniversityShenyangLiaoning 110001China

As the most c.mmon internal modific.tion of mRNA,Ne-methyladenosine(m^(6)A)and its reg.lators modulate g.ne expression and play c.itic.l roles in various biolog.c.l and patholog.ic.l proc.sses inc.uding.*** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary mic.oRNAs(pri-miRNAs)and fa-c.litates its proc.ssing.into prec.rsor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modific.tion also plays a role in the maturation proc.ss of pre-miRNAs and(if so)whether suc. a func.ion c.ntributes to ***,we found that YTHDF2 is aberrantly overexpressed in ac.te myeloid leukemia(AML)patients,espec.ally in relapsed patients,and plays an onc.-g.nic.role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main produc. of prec.rsor miR-126(pre-miR-126)),a miRNA that was reported as an onc.miRNA in AML,throug. fac.litating.the proc.ssing.of pre-miR-126 into mature ***,YTHDF2 rec.g.izes m^(6)A modific.tion in pre-miR-126 and rec.uits Ag.2,a reg.lator of pre-miRNA proc.ssing.to promote the maturation of ***2 posi-tively and neg.tively c.rrelates with miR-126 and miR-126's downstream targ.t g.nes,respec.tively,in AML patients,and forc.d expression of miR-126 c.uld larg.ly resc.e YTHDF2/Ythdf2 depletion-mediated suppression on AML c.ll g.owth/proliferation and leukemog.nesis,indi-c.ting.that miR-126 is a func.ionally important targ.t of YTHDF2 in ***,our studies not only reveal a previously unapprec.ated YTHDF2/miR-126 axis in AML and hig.lig.t the ther-apeutic.potential of targ.ting.this axis for AML treatment,but also sug.est that m^(6)A plays a role in pre-miRNA proc.ssing.that c.ntributes to tumorig.nesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2