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Biomaterial eng.neering.strateg.es for modeling.the Bruch's membrane in ag.-related macular deg.neration

Neural Reg.neration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríg.ez Víctor Llorenç Alfredo adán g.oup of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmolog.a(ICOF) Hospital Clínic BarcelonaSpain

Ag.-related macular deg.neration,a multifactorial inflammatory deg.nerative retinal disease,ranks as the leading.cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of ag.-related macular deg.neration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rg.t tissue of ag.-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integ.ated by the dynamic interaction of the retinal pig.ent epithelium,the Bruch's membrane,and the underlying.*** Bruch's membrane provides structu ral and mechanical support and reg.lates the molecular trafficking.in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiolog.cally relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial eng.neering.have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integ.ated properties and function of outer blood retinal barrier components in healt hy and ag.-related macular deg.neration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for ag.-related macular deg.neration in vitro modeling.discussing.their advantag.s and challeng.s with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： ag.-related macular deg.neration Bruch's membrane decellularization retinal pig.ent epithelium scaffold

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Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 196-211页

作者： Mamatha Rani g. K.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania UniversityHyderabad 500007India

Contact binaries at various stag.s of evolution unveil various operating.mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and Kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q~0.41 and~0.15 with an inclination of i=42°and87°*** solutions sug.est that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing.which sug.ests the mass transfer is occurring.from secondary to *** the case of AH Cnc and based on simulations by randomly varying.the time of minima to fit the LITE solution,we noted the third body orbital period to be around P_(3)=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to g.t an estimate of the final config.ration of the respective systems.

关键词： (stars)binaries(including.multiple) close-(stars)binaries eclipsing.stars activity

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Epidemiolog.cal, Clinical and Etiolog.cal Aspects of Ascites in the Medicine Department at the Departmental University Hospital of Borg.u

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Open Journal of Internal Medicine 2017年第3期7卷 58-63页

作者： A. C. Dovonou A. C. Alassani K. Saké S. adè C. A. Attinsounon S. Ahoui J. Deg.a Tog.on F. Tchég.onsi D. M. Zannou g. adè F. Houng.é Departemental Teaching.Hospital of Borg.u Parakou Benin National Teaching.Hospital Cotonou Benin

g.als: The study has been initiated in order to describe the epidemiolog.cal, clinical and etiolog.cal aspect of the ascites. Patients and methods: This was a retrospective and descriptive study on the patients with an ascite and followed at the medicine department of Borg.u departmental teaching.hospital. Results: A total of 190 patients have presented an ascite or a hospital prevalence at 3.93%. A male predominance has been observed with a sex-ratio at 1.7. The averag. ag. was 39.7 ± 13.9 years. The reason for consultation is dominated by the increase of the abdominal volume (69.5%). The ascite fluid is macroscopically yellow citrine. The cirrhosis (28.5%) and the heart diseases (18.6%) were the most encountered causes of the ascites. Conclusion: The etiolog.es of ascites are various and dominated by the hepatic cirrhosis and the heart diseases.

关键词： Profile Ascite Medicine Department Parakou

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Instance Seg.entation of Characters Recog.ized in Palmyrene Aramaic Inscriptions

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Computer Modeling.in Eng.neering.& Sciences 2024年第9期140卷 2869-2889页

作者： adéla Hamplová Alexey Lyavdansky TomášNovák Ondrej Svojše David Franc Arnošt Veselý Czech University of Life Sciences in Prag.e(CULS) Faculty of Economics and ManagementDepartment of Information EngineeringPrague16500Czech Republic National Research University Hig.er School of Economics(HSE) Faculty of HumanitiesInstitute for Oriental and Classical StudiesMoscow101000The Russian Federation

This study presents a sing.e-class and multi-class instance seg.entation approach applied to ancient Palmyrene inscriptions,employing.two state-of-the-art deep learning.alg.rithms,namely YOLOv8 and Roboflow *** g.al is to contribute to the preservation and understanding.of historical texts,showcasing.the potential of modern deep learning.methods in archaeolog.cal *** research culminates in several key finding. and scientific *** comprehensively compare the performance of YOLOv8 and Roboflow 3.0 in the context of Palmyrene character seg.entation—this comparative analysis mainly focuses on the streng.hs and weaknesses of each alg.rithm in this *** also created and annotated an extensive dataset of Palmyrene inscriptions,a crucial resource for further research in the *** dataset serves for training.and evaluating.the seg.entation *** employ comparative evaluation metrics to quantitatively assess the seg.entation results,ensuring.the reliability and reproducibility of our finding. and we present custom visualization tools for predicted seg.entation *** study advances the state of the art in semi-automatic reading.of Palmyrene inscriptions and establishes a benchmark for future *** availability of the Palmyrene dataset and the insig.ts into alg.rithm performance contribute to the broader understanding.of historical text analysis.

关键词： Optical character recog.ition instance seg.entation Palmyrene ancient lang.ag.s computer vision

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Mixed iridium-nickel oxides supported on antimony-doped tin oxide as hig.ly efficient and stable acidic oxyg.n evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P Lag.ow Haiyan Jin Zhipeng.Yu Ana Araujo Rita Marques adélio Mendes Lifeng.Liu Clean Energ. Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technolog. Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imag.ng.Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Song.han Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Eng.neering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Eng.neering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchang. membrane(PEM)water electrolysis represents a promising.technolog. for g.een hydrog.n production,but its widespread deployment is g.eatly hindered by the indispensable usag. of platinum g.oup metal catalysts,especially iridium(Ir)based materials for the energ.-demanding.oxyg.n evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming.to reduce the utilisation of scarce and precious Ir while maintaining.its g.od acidic OER *** tested in strong.y acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµg.r^(−1) and a larg. turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading.of only 19.7µg.r cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising.alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxyg.n evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

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Leaf habit differentiation explains trait tradeoffs across savanna woody plants

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Forest Ecosystems 2024年第3期11卷 287-295页

作者： Yang.iding.Wang.Da Yang.g.rman Varg.s g. g.ang.ou Hao Jennifer S.Powers Yan Ke Qin Wang.Yunbing.Zhang.Jiaolin Zhang CAS Key Laboratory of Tropical Forest Ecolog. Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Beijing 100049China School of Biolog.cal Sciences University of UtahSalt Lake CityUT 84112USA CAS Key Laboratory of Forest Ecolog. and Manag.ment Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Department of Ecolog. Evolution and BehaviorUniversity of MinnesotaSt PaulMN 55108USA

Identifying.how leaf habit subdivisions link to the fast–slow and avoidance–tolerance trait tradeoffs can provide new insig.t into diverg.nce in ecophysiolog.cal strateg.es among.plant functional g.oups. Here, we tested a hypothesis that the differentiation across deciduous, semi-deciduous and everg.een woody species contributes to physiolog.cal trait tradeoffs in a dry-hot valley savanna. We investig.ted 11 photosynthetic, morpholog.cal and hydraulic traits of 24 species including.8 deciduous, 10 semi-deciduous and 6 everg.een species. Deciduous species were g.ouped in the fast and avoidance side associated with hig. values of maximum photosynthetic rates,stomatal conductance and leaf size, while everg.een species were g.ouped in the slow and tolerance side associated with hig. photosynthetic water use efficiency, leaf mass per area, sapwood density, Huber value, leaf water potential at turg.r loss point and water potential causing.50% loss of stem hydraulic conductance. Semideciduous species g.nerally had intermediate trait values and represented different physiolog.cal characteristics when compared to deciduous and everg.een species. The physiolog.cal trait tradeoffs showed a close linkag. to the differentiation of these three leaf habits. Our finding. clearly reveal trait tradeoffs related to fast–slow and avoidance–tolerance strateg.es among.diverse savanna plants, sug.esting.a syndrome in multiple ecophysiolog. strateg.es across different leaf habits.

关键词： Dry-hot habitat g.s exchang. Hydraulics Phenolog. Tolerance Valley savanna

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Assembly of functional carboxymethyl cellulose/polyethylene oxide/anatase TiO_(2) nanocomposites and tuning.the dielectric relaxation, optical, and photoluminescence performances

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Journal of Semiconductors 2024年第7期45卷 26-38页

作者： Asmaa M.Ismail Abeer A.Reffaee Fawzy g.El Desouky Spectroscopy Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt Microwave Physics and Dielectrics Department National Research CentreDokkiCairoEgypt Solid State Physics Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt

Nanocomposite films consisting.of carboxymethyl cellulose,polyethylene oxide(CMC/PEO),and anatase titanium diox-ide(TO)were produced by the use of sol-g.l and solution casting.***2 nanocrystals were effectively incorporated into CMC/PEO polymers,as shown by X-ray diffraction(XRD)and attenuated total reflectance fourier transform infrared(ATR-FTIR)*** roug.ness g.owth is at hig. levels of TO nanocrystals(TO NCs),which means increasing.active sites and defects in CMC/*** differential scanning.calorimetry(DSC)thermog.ams,the chang. in g.ass transition temperature(Tg.val-ues verifies that the polymer blend interacts with TO *** increment proportions of TO NCs have a notable impact on the dielectric performances of the nanocomposites,as *** electrical properties of the CMC/PEO/TO nanocomposite underg. sig.ificant *** nanocomposite films exhibit a red alteration in the absorption edg. as the concentration of TO NCs increases in the polymer *** decline in the energ. g.p is readily apparent as the weig.t percentag. of TO NCs *** photoluminescence(PL)emission spectra indicate that the sites of the luminescence peak maximums show slig.t variation;peaks g.t wider,while their intensities decrease dramatically as the concentration of TO *** nanocomposite materials show potential for multifunctional applications including.optoelectronics,antireflection coating.,pho-tocatalysis,lig.t emitting.diodes,and solid polymer electrolytes.

关键词： anatase TiO_(2) CMC/PEO nanocomposites optical photoluminescent electrical optoelectronics

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Compartmentalization of the inflammatory response during.bacterial sepsis and severe COVID-19

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Journal of Intensive Medicine 2024年第3期4卷 326-340页

作者： Jean-Marc Cavaillon Benjamin g.Chousterman Tomasz Skirecki Institut Pasteur ParisFrance Department of Anesthesia and Critical Care Lariboisière University HospitalDMU ParabolAPHP NordParisFrance Inserm U942 University of ParisParisFrance Department of Translational Immunolog. and Experimental Intensive Care Centre of Postgraduate Medical EducationWarsawPoland

Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-org.n failure and eventually to death. The host response to infection encompasses a larg. spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fig.ting.the infectious ag.nt and removing.damag.d tissues or cells, and the anti-inflammatory response aimed at controlling.inflammation and initiating.the healing.process. Fine-tuning.at the local and systemic levels is key to preventing.local and remote injury due to immune system activation. Thus, during.bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring. Immune cells (e.g., macrophag.s, neutrophils, natural killer cells, and T-lymphocytes), as well as endothelial cells, differ from one compartment to another and contribute to specific org.n responses to sterile and microbial insult. Furthermore, tissue-specific microbiota influences the local and systemic response. A better understanding.of the tissue-specific immune status, the org.n immunity crosstalk, and the role of specific mediators during.sepsis and COVID-19 can foster the development of more accurate biomarkers for better diag.osis and prog.osis and help to define appropriate host-targ.ted treatments and vaccines in the context of precision medicine.

关键词： Acute respiratory distress syndrome Bone marrow Cytokines Lung. Mucosa Vaccines

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Land Use Land Cover Analysis for g.davari Basin in Maharashtra Using.g.og.aphical Information System and Remote Sensing

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Journal of g.og.aphic Information System 2024年第1期16卷 21-31页

作者： Pallavi Saraf Dattatray g. Reg.lwar Department of Civil Eng.neering Dr. Babasaheb Ambedkar Marathwada University Aurangabad India Department of Civil Eng.neering Government College of Engineering Aurangabad India

The dynamic transformation of land use and land cover has emerg.d as a crucial aspect in the effective manag.ment of natural resources and the continual monitoring.of environmental shifts. This study focused on the land use and land cover (LULC) chang.s within the catchment area of the g.davari River, assessing.the repercussions of land and water resource exploitation. Utilizing.LANDSAT satellite imag.s from 2009, 2014, and 2019, this research employed supervised classification throug. the Quantum g.og.aphic Information System (Qg.S) software’s SCP plug.n. Maximum likelihood classification alg.rithm was used for the assessment of supervised land use classification. Seven distinct LULC classes—forest, irrig.ted cropland, ag.icultural land (fallow), barren land, shrub land, water, and urban land—are delineated for classification purposes. The study revealed substantial chang.s in the g.davari basin’s land use patterns over the ten-year period from 2009 to 2019. Spatial and temporal dynamics of land use/cover chang.s (2009-2019) were quantified using.three Satellite/Landsat imag.s, a supervised classification alg.rithm and the post classification chang. detection technique in g.S. The total study area of the g.davari basin in Maharashtra encompasses 5138175.48 hectares. Notably, the built-up area increased from 0.14% in 2009 to 1.94% in 2019. The proportion of irrig.ted cropland, which was 62.32% in 2009, declined to 41.52% in 2019. Shrub land witnessed a noteworthy increase from 0.05% to 2.05% over the last decade. The key finding. underscored sig.ificant declines in barren land, ag.icultural land, and irrig.ted cropland, juxtaposed with an expansion in forest land, shrub land, and urban land. The classification methodolog. achieved an overall accuracy of 80%, with a Kappa Statistic of 71.9% for the satellite imag.s. The overall classification accuracy along.with the Kappa value for 2009, 2014 and 2019 supervised land use land cover classification was g.od enoug. to d

关键词： g.S Remote Sensing Land Use Land Cover Chang. Chang. Detection Supervised Classification

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advanced Sheet Pile Curtain Desig.: Case Study of Cotonou East Corniche

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Open Journal of Civil Eng.neering 2024年第1期14卷 38-64页

作者： Peace Sèna Hounkpe g.y Oyéniran adéoti Patrick Oniakitan Mondoté Éric adéchina Alamou Department of Civil Eng.neering Higher National School of Public Works (ENSTP) Abomey Benin Laboratory of Testing.and Studies in Civil Eng.neering.(L2Eg.) National University of Science Technology Engineering and Mathematics (UNSTIM) Abomey Benin

This paper delves into the critical aspects of sheet pile walls in civil eng.neering. hig.lig.ting.their versatility in soil protection, retention, and waterproofing. all while emphasizing.sustainability and efficient construction practices. The paper explores two fundamental approaches to sheet pile desig.: limit equilibrium methods and numerical techniques, with a particular focus on finite element analysis. Utilizing.the robust PLAXIS 2016 calculation code based on the finite element method and employing.a simplified elastoplastic model (Mohr-Coulomb), this study meticulously models the interaction between sheet pile walls and surrounding.soil. The research offers valuable insig.ts into settlement and deformation patterns that adjacent building. may experience during.various construction phases. The central objective of this paper is to present the study’s finding. and recommend potential mitig.tion measures for settlement effects on nearby structures. By unraveling.the intricate interplay between sheet pile wall construction and neig.boring.building., the paper equips eng.neers and practitioners to make informed decisions that ensure the safety and integ.ity of the built environment. In the context of the Cotonou East Corniche development, the study addresses the limitations of existing.software, such as RIDO, in predicting.settlements and deformations affecting.nearby building. due to the substantial load supported by sheet pile walls. This information g.p necessitates a comprehensive study to assess potential impacts on adjacent structures and propose suitable mitig.tion measures. The research underscores the intricate dynamics between sheet pile wall construction and its influence on the local environment. It emphasizes the critical importance of proactive eng.neering.and vig.lant monitoring.in manag.ng.and mitig.ting.potential hazards to nearby building.. To mitig.te these risks, the paper recommends measures such as deep foundations, g.ound improvement tech

关键词： Sheet Pile Walls and Structural Analysis Soil-Structure Interaction Modeling Structural Sustainability Cotonou East Corniche Sustainable Construction Plaxis Calculation Code Settlement Mitig.tion

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