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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Characterization of Intracellular gold Nanoparticles Synthesized by Biomass of Aspergillus terreus

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 569-572页

作者： Baskar gurunathan Pranav Vasanthi Bathrinarayanan Vasanth Kumar muthukumarasamy Dilliganesh Thangavelu Department of Biotechnology St.Joseph’s College of EngineeringChennai 600 119India

greener synthesis of nanoparticle is a revolutionizing area in research *** method of reduction of metal ions is often preferred because they are clean,safe,biocompatible,and environmentally acceptable than physical,chemical,and mechanical *** wet biomass of Aspergillus terreus（***） was utilized for the intracellular synthesis of gold *** nanoparticles were produced when an aqueous solution of chloroauric acid was reduced by *** biomass as the reducing *** of gold nanoparticles was confirmed by the color change of biomass from yellow to pinkish *** produced nanoparticles were then characterized by FT-IR,SEM,EDS,and *** SEM images revealed that the nanoparticles were spherical,irregularly shaped with no definite *** size of the biosynthesized gold nanoparticles was 186 *** presence of the gold nanoparticle was confirmed by EDS *** nature of synthesized gold nanoparticle was confirmed by XRD pattern.

关键词： gold nanoparticles Biosynthesis Characterization Scanning electron microscope Energy dispersive spectroscopy

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Influence of the Cd/S Molar Ratio on the Optical and Structural Properties of Nanocrystalline CdS Thin Films

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Journal of Materials Science & Technology 2010年第3期26卷 193-199页

作者： M.Thambidurai N.Murugan N.muthukumarasamy S.Agilan S.Vasantha R.Balasundaraprabhu3 Department of Physics Coimbatore Institute of Technology Department of Mechanical Engineering Coimbatore Institute of Technology Department of Physics PSG College of Technology

Nanocrystalline CdS thin films have been deposited using precursors with different thiourea concentrationonto glass substrates by sol-gel spin coating *** crystalline nature of the films has been observedto be strongly dependent on thiourea concentration and annealing *** CdS films are found tobe nanocrystalline in nature with hexagonal *** grain size is found to be in the range of 7.6 to11.5 nm depending on the thiourea concentration and annealing *** high resolution transmissionelectron microscopy （HRTEM） results of the CdS films prepared using cadmium to thiourea molar ratio of0.3：0.3 indicate the formation of nanocrystalline CdS with grain size of 5 *** transform infrared （FTIR）analysis shows the absorption bands corresponding to Cd and *** optical study carried out to determinethe band gap of the nanostructured CdS thin films shows a strong blue *** band gap energy has beenobserved to lie in the range of 3.97 to 3.62 eV following closely the quantum confinement dependence ofenergy on crystallite *** dependence of band gap of the CdS films on the annealing temperature andthiourea concentration has also been *** photoluminescence （PL） spectra display two main emissionpeaks corresponding to the blue and green emissions of CdS.

关键词： Sol-gel CdS quantum dots High resolution transmission electronmicroscopy (HRTEM)

Xiamen after 20 Years of Ecological Transformation

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China Today 2025年第1期74卷 66-68页

作者： ZACHARY g.LUNDQUIST 不详

The efforts Xiamen has made in ecological protection over the last 20 years have helped it become a beautiful and clean *** years ago,I had the opportunity to travel to the city of Xiamen in southeastern China’s Fujian ***,due to the fact that I was in a rush,I did not have the chance to see the whole *** memory of Xiamen was its pleasant climate and unforgettable beauty-I knew if I ever got the opportunity,I would revisit this *** years went by until I was able to return to this city *** emerging from the airport,I realized that I had grown older,while Xiamen was becoming increasingly youthful and *** exactly had given this city such vitality?

关键词： Ecological Xiamen Transformation

SMS 2.0: An Updated Database to Study the Structural Plasticity of Short Peptide Fragments in Non-redundant Proteins

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genomics, Proteomics & Bioinformatics 2012年第1期10卷 44-50页

作者： Dheeraj Ravella muthukumarasamy Uthaya Kumar Durairaj Sherlin Mani Shankar Marthandan Kirti Vaishnavi Kanagaraj Sekar Bioinformatics Centre (Centre of Excellence in Structural Biology and Bio-computing) Supercomputer Education and Research Centre Indian Institute of Science Bangalore 560012 India

The function of a protein molecule is greatly influenced by its three-dimensional （3D） structure and therefore structure prediction will help identify its biological function. We have updated Sequence, Motif and Structure （SMS）, the database of structurally rigid peptide fragments, by combining amino acid sequences and the corre- sponding 3D atomic coordinates of non-redundant （25%） and redundant （90%） protein chains available in the Protein Data Bank （PDB）. SMS 2.0 provides information pertaining to the peptide fragments of length 5-14 resi- dues. The entire dataset is divided into three categories, namely, same sequence motifs having similar, intermedi- ate or dissimilar 3D structures. Further, options are provided to facilitate structural superposition using the pro- gram structural alignment of multiple proteins （STAMP） and the popular JAVA plug-in （Jmol） is deployed for visualization. In addition, functionalities are provided to search for the occurrences of the sequence motifs in other structural and sequence databases like PDB, genome Database （gDB）, Protein Information Resource （PIR） and Swiss-Prot. The updated database along with the search engine is available over the World Wide Web through the following URL http：//***/sms/.

关键词： non-redundant protein chains sequence motifs 3D structure structural superposition

Homepeptide Repeats:Implications for Protein Structure,Function and Evolution

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genomics, Proteomics & Bioinformatics 2012年第4期10卷 217-225页

作者： muthukumarasamy Uthayakumar Bowdadu Benazir Sanjeev Patra Marthandan Kirti Vaishnavi Manickam gurusaran Kanagarajan Sureka Jeyaraman Jeyakanthan Kanagaraj Sekar Supercomputer Education and Research Centre Indian Institute of ScienceBangalore 560012India Department of Bioinformatics Alagappa UniversityKaraikudi 630003India

Analysis of protein sequences from Mycobacterium tuberculosis H37Rv （Mtb H37Rv） was performed to identify homopeptide repeat- containing proteins （HRCPs）. Functional annotation of the HRCPs showed that they are preferentially involved in cellular metabolism. Furthermore, these homopeptide repeats might play some specific roles in protein-protein interaction. Repeat length differences among Bacteria, Archaea and Eukaryotes were calculated in order to identify the conservation of the repeats in these divergent kingdoms. From the results, it was evident that these repeats have a higher degree of conservation in Bacteria and Archaea than in Eukaryotes. In addi- tion, there seems to be a direct correlation between the repeat length difference and the degree of divergence between the species. Our study supports the hypothesis that the presence of homopeptide repeats influences the rate of evolution of the protein sequences in which they are embedded. Thus, homopeptide repeat may have structural, functional and evolutionary implications on proteins.

关键词： Homopeptide repeats Disordered regions Replication slippage Protein domains Rate of evolution