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Nutritional geometry framework of sucrose taste in Drosophila

Journal of genetics and genomics 2023年第4期50卷 233-240页

作者： An-Qi Li Sha-Sha Li Ruo-Xin Zhang Xin-Yuan Zhao Zhi-Ying Liu Yun Hu Bei Wang g gregory neely Stephen J.Simpson Qiao-Ping Wang Laboratory of Metabolism and Aging School of Pharmaceutical Sciences(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China The Dr.John and Anne Chong Laboratory for Functional genomics Charles Perkins Centre and School of Life&Environmental SciencesThe University of SydneySydneyNSW2006Australia Charles Perkins Centre and School of Life&Environmental Sciences The University of SydneySydneyNSW2006Australia

Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste ***,it remains unclear whether the balance of P and C influences the sweet taste ***,we use the nutritional geometry framework(NgF)to address the interaction of protein and carbohydrates on sweet taste using Drosophila as a *** results reveal that high-protein,low-carbohydrate(HPLC)diets sensitize to sweet taste and low-protein,high-carbohydrate(LPHC)diets desensitize sweet taste in both male and female *** further investigate the underlying mechanisms of the effects of two diets on sweet taste using RNA *** compared to the LPHC diet,the m RNA expression of genes involved in the metabolism of glycine,serine,and threonine is significantly upregulated in the HPLC diet group,suggesting these amino acids may mediate sweet taste *** further find that sweet sensitization occurs in flies fed with the LPHC diet supplemented with serine and *** study demonstrates that sucrose taste sensitivity is affected by the balance of dietary protein and carbohydrates possibly through changes in serine and threonine.

关键词： Nutritional geometry framework Sweet taste Sweet taste sensitivity Micronutrient Dietary balance Protein Carbohydrates Drosophila

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Corrigendum to“AMPK controls sucrose taste sensitization in Drosophila”[Journal of genetics and genomics(2023)50,50—53]

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Journal of genetics and genomics 2023年第2期50卷 139-139页

作者： Yun Hu Zhi-Ying Liu Sha-Sha Li An-Qi Li g gregory neely Qiao-Ping Wang Lab of Metabolism and Aging School of Pharmaceutical Sciences(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China The Dr.John and Anne Chong Laboratory for Functional genomics Chades Perkins Centre and School of Life d Environmental SciencesThe University of SydneySydneyNSW 2006Australia

This corrigendum clarifies information in the article“AMPK controls sucrose taste sensitization in Drosophila”by Hu et al.(2023).In the author list,“Yun Hu,Zhi-Ying Liu,Sha-Sha Li,An-Qi Li,Qiao-Ping Wang”should be corrected into“Yun Hu,Zhi-Ying Liu,Sha-Sha Li,An-Qi Li,g gregory neely,Qiao-Ping Wang”.The affiliation of g gregory neely is“The *** and Anne Chong Laboratory for Functional genomics,Charles Perkins Centre and School of Life&Environmental Sciences,The University of Sydney,Sydney,NSW 2006,Australia”.

关键词： Sydney taste Australia

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Lipopolysaccharide Modified Liposomes for Amyotropic Lateral Sclerosis Therapy: Efficacy in SOD1 Mouse Model

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Advances in Nanoparticles 2012年第3期1卷 44-53页

作者： Nicholas J. Wiley A. B. Madhankumar Ryan M. Mitchell Elizabeth B. neely Elias Rizk gregory L. Douds Zachary Simmons James R. Connor Department of Neurology Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA george M. Leader Family Laboratory Department of Neurosurgery Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA

Activation of microglia is a histological feature observed in neurodegenerative diseases like ALS. The oral administration of minocycline has been demonstrated to have minimal neuroprotection ability in the animal models and is also associated with inadvertent toxicity due to non-specific oral absorption of the drug. Nonetheless, the drug itself shows promise in a number of disease models suggesting it could be effective if delivered optimally. Thus, we utilized LPS modified liposomes to target TLR4 receptor on the microglia in SOD1g93A mice and compared its efficacy with non- targeted nanoliposomes. The in vitro results indicate that targeting the TLR4 receptor on microglia significantly increases (p g93A mouse model of ALS, targeted and non-targeted minocycline treatment significantly increased (p g93A mice, the non- targeted nanovesicles significantly increased the latency to rotarod failure and both targeted and non-targeted nanovesicles significantly delayed disease endpoints.

关键词： Amyotrophic Lateral Sclerosis Minocycline Liposomes Microglia TLR4 Lipopolysaccharides

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