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Influence of age on outcome of total laparoscopic fundoplication for gastroesophageal reflux disease

World Journal of gastroenterology 2007年第5期13卷 740-747页

作者： F Pizza g Rossetti P Limongelli g Del genio V Maffettone V Napolitano L Brusciano g russo S Tolone M Di Martino A Del genio 1st Division of general and gastrointestinal Sur-gery Second University of Naples Via Pansini 5 Naples 80131 Italy

AIM: To demonstrate that age does not influence the choice of treatment for gastroesophageal reflux disease (gERD). We hypothesized that the outcome of total fun-doplication in patients > 65 years is similar to that of patients aged ≤ 65 ***: Four hundred and twenty consecu-tive patients underwent total laparoscopic fun-doplication for gERD. Three hundred and fifty-five patients were younger than 65 years (group Y), and 65 patients were 65 years or older (group E). The following elements were considered: pres-ence, duration, and severity of gERD symptoms; presence of a hiatal hernia; manometric evalu- ation, 24 h pH-monitoring data, duration of operation; incidence of complications; and length of hospital stay. RESULTS: Elderly patients more often had atypical symptoms of gERD and at manometric evaluation had a higher rate of impaired esophageal peristalsis in compari-son with younger patients. A mild intensity of heartburn often leads physicians to underestimate the severity of erosive esophagitis. The duration of the operation was similar between the two groups. The incidence of intra-operative and postoperative complications was low and the difference was not statistically significant between the two groups. An excellent outcome was observed in 92.9% young patients and 91.9% elderly patients. CONCLUSION: Laparoscopic antireflux surgery is a safe and effective treatment for gERD even in elderly pa-tients, warranting low morbidity and mortality rates and a significant improvement of symptoms comparable to younger patients.

关键词： gastroesophageal reflux disease Esophagitis Impaired peristalsis Hiatal hernia Laparoscopic totalfundoplication

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Prediction of the seismic behavior of an underground railway station and a tunnel in Napoli(Italy)

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Underground Space 2017年第2期2卷 88-105页

作者： S.Fabozzi V.Licata S.Autuori E.Bilotta g.russo F.Silvestri University of Napoli Federico II NapoliItaly

The assessment of the seismic safety of underground structures,either tunnels or large station boxes,should not be overlooked especially in densely populated areas,even with low to moderate *** underground structures,an important issue is the estimation of the seismic actions acting on the structure;only few experimental evidences are available for multi-level propped *** tunnels,it is generally assumed that their seismic behavior in soft ground is governed by the surrounding soil,while the inertial load contribution of the underground structure itself is *** both cases,recent numerical studies proved that advanced dynamic analyses can provide satisfactory interpretation of non-linear soil-structure interaction during *** this paper,a real case study,represented by a large open multi-propped excavation and a circular segmented tunnel in a densely urbanized area of the city center in Napoli,has been used to investigate some of the mentioned *** geotechnical characterization and choice of the reference input motions lead to a first estimate of the free-field ground motion,which was subsequently used for pseudo-static decoupled *** the complexity of both excavation geometry and staged construction,a full dynamic analysis was considered neither affordable nor reliable for the multi-propped station box;thus two conventional pseudo-static analyses,applying either a displacement-based or a force-based approach,were carried *** the case of the tunnel,the seismic increments of internal forces in the lining could be calculated through both a simplified pseudostatic analysis and a full dynamic analysis,showing a satisfying ***,the results of the study demonstrated that the seismic increments of internal forces in the diaphragm walls of the station and in the segmented lining of the tunnel were quite *** case study encourages improving the reliability of simplified methods based on the more

关键词： Underground structures Tunnels Diaphragm walls Seismic behavior Pseudo-static analysis Dynamic analysis Soil-Structure interaction

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Semi-real time systems for subsidence monitoring in areas affected by underground mining:the example of the Nuraxi-Figus coal district(Sardinia,Italy)

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International Journal of Coal Science & Technology 2022年第6期9卷 112-126页

作者： L.Ammirati D.Di Martire F.Bordicchia D.Calcaterra g.russo N.Mondillo Department of Earth Sciences Environment and ResourcesUniversity of NaplesFedericoⅡ80126 NaplesItaly Department of Earth Sciences Natural History MuseumLondon SW75BDUK Sardinia Region Company Carbosulcis S.P.A. 09010 GonnesaCIItaly

Underground mining can produce subsidence,which can be coincident with mining activities or delayed in response to the time-dependent deformation of the ***,in these cases,it is essential to effectively monitor the soil deformations at different times during and after mining *** the present work,an integrated approach based on geotechnical numeri-cal modeling and Advanced Differential Interferometric Synthetic Aperture Radar(A-DInSAR)method has been applied to detect,study and monitor the subsidence related to mining activity in the Nuraxi Figus coal district(Sardinia,Italy).Two datasets of high-resolution COSMO-Skymed images were acquired,respectively in two covering periods:from 2011 and 2014,and from 2013 to ***-DInSAR results show that the predominant displacement rates are located in correspond-ence with the *** cumulated satellite-based LoS displacements vary in the first period between-130 and+28 mm and-293 and+28.4 mm,while,during the second period between-6.9 and+1.6 mm and-8.72 and+4.33 mm in ascend-ing and descending geometries,*** geotechnical numerical model allowed to obtain a value for the maximum *** using the vertical and horizontal components it was possible to reconstruct the kinematics of the deformation considering three phases:pre-mining,syn-mining,and post-mining *** temporal evolution of displacements started during the mining extraction in 2011,achieved the major values in correspondence of post-mining operations,during the period from 2013 to 2014 and continued slowly until *** near real-time monitoring system applied in this study proved to be very useful for detecting subsidence during the mining activity and the post-mining period.

关键词： Mining monitoring A-DInSAR Numerical modeling Subsidence Underground mining

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Problems of Connectivity between the Sylow graph,the Prime graph and the Non-Commuting graph of a group

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Advances in Pure Mathematics 2012年第6期2卷 391-396页

作者： Francesco g. russo DIEETCAM Università degli Studi di Palermo Palermo Italy

The Sylow graph of a finite group originates from recent investigations on certain classes of groups, defined in terms of normalizers of Sylow subgroups. The connectivity of this graph has been proved only last year with the use of the classification of finite simple groups (CFSg). A series of interesting questions arise naturally. First of all, it is not clear whether it is possible to avoid CFSg or not. On the other hand, what happens for infinite groups? Since the status of knowledge of the non-commuting graph and of the prime graph is satisfactory, is it possible to find relations between these two graphs and the Sylow graph? In the present note we make the point of the situation and formulate the above questions in appropriate way.

关键词： Sylow graph Normalizers Prime graph Non-Commuting graph

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Investigating the Fluid Seal of Supraglottic Airway Devices in Humans Using Indicator Dye via the Drainage Tube:A Potential Roadmap for Future Studies

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Open Journal of Anesthesiology 2012年第2期2卷 18-22页

作者： Sebastian g.russo Stephan Cremer Ulrike Muhlhauser Christoph Eich Michael Quintel Martin Bauer Department of Anaesthesiology Emergency and Intensive Care MedicineUniversity of Gottingen Medical CentreGottingenGermany

Background: The fluid seal of supraglottic airway devices (SgA) protects the airway from fluid contamination. We evaluated the suitability of indicator dye placement in the upper digestive tract of anesthetized patients combined with fiberoptical tracing to investigate the fluid seal of SgA. Methods: Patients swallowed a capsule of indigo carmine green (ICg) prior to induction of anaesthesia. After induction of anesthesia, one of two different SgA (either an i-gelTM or an LMA-SupremeTM (LMA-S)) was inserted after randomization. Methylene blue stained normal saline was injected through the proximal opening of drainage tube during mechanical ventilation as well as spontaneous breathing. We monitored regurgitation of ICg with a flexible fiberscope (FO) inserted through the drainage tube and checked for the appearance of methylene blue in the mask bowl with the FO inserted through the airway tube. Results: In thirty-six patients with an i-gelTM and 37 with a LMA-S no regurgitation of ICg was observed at the level of the upper oesophageal sphincter (UES). Methylene blue stained saline was not visible in any patient during pressure-controlled ventilation, but was detected in two of the 36 patients with the i-gelTM during spontaneous breathing. Conclusion: Instilling dye through the drainage tube of SgA models with a built-in drainage tube represents a useful method to examine and to compare the fluid seal of different SgA. Our protocol presented in this study proved to be an easy and reproducible approach for future studies. Furthermore, the clinical results gained during this evaluation highlight the necessity for further investigations regarding the fluid seal competencies of SgAs in humans under clinical conditions.

关键词： Laryngeal Mask Airway Supraglottic Airway Aspiration

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局限性脑皮质发育不良继发顽固性癫痫的手术治疗

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中华神经外科杂志 2006年第6期22卷 351-354页

作者：赵国光 F.Cardinale M.Cossu L.Tassi g.Lo russo 凌锋首都医科大学宣武医院神经外科 Centmdell' Epilepssia Ospedale Niguarda Ca' gfanda Milano 20162

目的探讨局限性脑皮质发育不良(FCD)的诊断、影像学和电生理学特点,以及手术治疗的策略与方法。方法1996年6月至2003年12月在意大利米兰Niguarda Ca'granda医院手术治疗的442例癫痫患者中,根据该中心提出的FCD病理学分类标准,对81例诊断... 详细信息

目的探讨局限性脑皮质发育不良(FCD)的诊断、影像学和电生理学特点,以及手术治疗的策略与方法。方法1996年6月至2003年12月在意大利米兰Niguarda Ca'granda医院手术治疗的442例癫痫患者中,根据该中心提出的FCD病理学分类标准,对81例诊断为FCD的病例进行同顾性研究。其中皮层组织结构发育异常(AD)42例、细胞组织结构发育异常(CD)12例、Taylor脑皮质发育不良(TFCD)27例。患者术前均行MRI、VEEg检查,61%的患者还接受了立体脑电图检查(SEEg)。结果术前MRI检查阳性率65%。癫痫术后随访1年以上总治愈率为54%(Engle Ia),其中AD组为49%、CD组45%、TFCD组69%。FCD病理分型的不同与癫痫发作频率、致痫灶部位以及手术效果有关。AD组致痫灶常见于颞叶,癫痫发作次数少于CD和TFCD组。而TFCD常发生于颞叶以外的部位,SEEg发作间期显示有典型的放电节律,且手术愈后较好。结论该分类标准简单且易于操作,对分析临床表现与判定手术效果有指导意义。SEEg技术在研究FCD,特别是TFCD电生理特征有独特的优势,并为术前准确定位致痫灶范围、保证手术效果提供了重要保障。

关键词：局限性脑皮质发育不良顽固性癫痫手术立体脑电图

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立体定向融合影像技术在治疗脑动静脉畸形引发癫痫的定位作用

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中国脑血管病杂志 2005年第7期2卷 298-302页

作者：赵国光 F Cardinale M Cossu g Lo russo 首都医科大学宣武医院神经外科北京100053 Centrodell' Epilepssia Ospedale Niguarda Ca'GrandaMi-lano

目的探讨立体定向结合脑血管造影与MRI影像融合在治疗脑动静脉畸形引发癫痫时对脑功能区、脑内病变和致痫灶空间范围的定位作用。方法对17例患者采用Talairach立体定向系统,绘制脑皮质表面血管图,并与三维MRI成像进行融合,标注脑功能区... 详细信息

目的探讨立体定向结合脑血管造影与MRI影像融合在治疗脑动静脉畸形引发癫痫时对脑功能区、脑内病变和致痫灶空间范围的定位作用。方法对17例患者采用Talairach立体定向系统,绘制脑皮质表面血管图,并与三维MRI成像进行融合,标注脑功能区并设计术前深部电极放置部位和手术方案。结果17例患者获得了清晰的立体脑血管造影与MRI图像,涉及手术部位包括额叶8例、顶叶6例、颞叶2例和枕叶1例。手术完整切除动静脉畸形。术后随访1年,8例未见癫痫发作。结论该技术可以保证术前准确定位病灶,有利于术中判断脑沟回和功能区,避免损伤皮质功能区和血管。

关键词：脑动静脉畸形定位作用融合影像技术治疗立体脑血管造影立体定向系统脑功能区 MRI成像 MRI图像影像融合定向结合脑内病变手术方案放置部位深部电极手术部位完整切除术后随访癫痫发作定位病灶致痫灶血管图

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Latest results from gRAAL collaboration

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Chinese Physics C 2009年第12期33卷 1249-1253页

作者： V. Vegna V. Bellini J.P. Bouquet L. Casano A. D'Angelo J.P. Didelez R. Di Salvo A. Fantini D. Franco g. gervino F. ghio g. giardina B. girolami A. giusa M. guidal E. Hourany A.S. Ignatov R. Kunnel A. Lapik A. Lleres P. Levi Sandri F. Mammoliti g. Mandaglio M. Manganaro M. Moricciani A.N. Mushkarenkov V.g. Nedorezov C. Randieri D. Rebreyend N.V. Rudnev g. russo C. Schaerf M.L. Sperduto M.C. Sutera A.Turinge Dip. di Fisica Università degli Studi di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy INFN - Sezione di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy Dip. di Fisica e Astronomia Università di Catania via Santa Sofia 44 I-95123 Catania Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy LPSC Universit Joseph Fourier Grenoble 1 CNRS/IN2P3 Institut National Polytechnique de Grenoble 53 Avenue des Martyres 38026 Grenoble France IPNO Universit de Paris-Sud 11 CNRS/IN2P3 15 rue Georges Clemenceau 91406 Orsay France Dip. di Fisica Sperimentale Università di Torino via P.Giuria I-00125 Torino Italy INFN - Sezione di Torino via P.Giuria I-00125 Torino Italy Istituto Superiore di Sanità viale Regina Elena 299 I-00161 Roma Italy INFN - Sezione di Roma piazzale Aldo Moro 2 I-00185 Roma Italy Dip. di Fisica Universitàdi Messina salita Sperone 31 I-98166 Messina Italy Institute for Nuclear Research RAS 117312 Moscow Russia INFN - Laboratori Nazionali di Frascati via E.Fermi 40 I-00044 Frascati Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy

The gRAAL experimental set-up consists of a polarized and tagged photon beam that covers an energy range from a minimum of 600 MeV up to a maximum of 1500 MeV, of a liquid Hydrogen or Deuterium target and of the 4π Lagrange detector optimized for photon detection. It allows the study of pseudo-scalar and vector meson photoproduCtion on the nucleon in the energy range corresponding to the second and the third resonance regions. In the following, the ∑ beam asymmetries in η and π0 photoproduction on quasi-free nucleon are shown. Also single and double polarization observables in K＋A photoproduction on free proton are shown; they are important to confirm the role of new or poorly known resonances in the 1900 MeV mass region.

关键词： polarized photon meson photoproduction polarization observables

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Nano-confinement of biomolecules： Hydrophilic confinement promotes structural order and enhances mobility of water molecules

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Nano Research 2016年第2期9卷 273-281页

作者： Bachir Aoun Daniela russo Argonne National Laboratory Chicago IL 60439 USA CNR-IOM c/o Institut Laue-Langevin 38400 Grenoble France Institut Lumiere Matiere Universite de Lyon 69622 Lyon France

Molecular dynamics simulations have been used to investigate the confinement packing characteristics of small hydrophilic （N-acetyl-glycine-methylamide, Nagma） and hydrophobic （N-acetyl-leucine-methylamide, Nalma） biomolecules in large diameter single-wall carbon nanotubes （SWCNTs）. We find that hydrophilic biomolecules easily fill the nanotube and self organize into a geometrical configuration which reminds the water structural organization under SWCNT confinement. The packing of hydrophilic biomolecules inside the cylinder confines all water molecules in its core, which enhances their mobility. Conversely, hydrophobic biomolecules accommodate into the nanotubes with a trend for homogeneous filling, which generate unstable small pockets of water and drive toward a state of dehydration. These results shed light on key parameters important for the encapsulation of biomolecules with direct relevance for long-term storage and prevention of degradation.

关键词： nano-confinement protein folding hydration water carbon nanotube drug delivery

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The role of LRRK2 on PKA-NFκB pathway in microglia cells: implications for Parkinson’s disease

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Neural Regeneration Research 2019年第10期14卷 1713-1714页

作者： Isabella russo Biology and genetic Unit Department of Molecular and Translational Medicine University of Brescia

Leucine-rich repeat kinase 2 (LRRK2), a gene linked to autosomal- dominantly inherited and sporadic Parkinson’s disease (PD) as a risk factor, encodes a large and complex protein with a dual enzymatic activity. LRRK2 contains several domains involved in protein-protein interactions, however, the presence of both a kinase and gTPase domain points to intracellular signaling functions (Marin, 2006). While LRRK2 has been linked to several molecular pathways important for neuronal activity (Martin et al., 2014), the observation that its expression is high in microglia has attracted the attention of different groups to understand whether LRRK2 dysfunctions in these cells may impact neuronal activity as secondary event.

关键词： cells NFκB Parkinson protein gTPase impact gene has

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