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DoS攻击下的幂次趋近律滑模控制系统稳定性分析

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控制与决策 2024年第6期39卷 1986-1994页

作者：都海波李申申陈维乐朱文武合肥工业大学电气与自动化工程学院合肥230009 东南大学自动化学院南京210018

研究拒绝服务(denial-of-service,DoS)攻击下的n阶受扰系统基于幂次趋近律的滑模控制.首先,通过构造状态预测器重建攻击活跃期间丢失的系统状态,基于预测器状态和非光滑函数,设计能量受限型DoS攻击情况下的幂次趋近律滑模控制器,进一步... 详细信息

研究拒绝服务(denial-of-service,DoS)攻击下的n阶受扰系统基于幂次趋近律的滑模控制.首先,通过构造状态预测器重建攻击活跃期间丢失的系统状态,基于预测器状态和非光滑函数,设计能量受限型DoS攻击情况下的幂次趋近律滑模控制器,进一步分析保持系统稳定性的充分条件;其次,当系统存在外部干扰情况下,证明幂次趋近律滑模控制方法仍能保持非光滑控制器的强抗干扰能力;最后,通过数值仿真对所提出的理论证明结果进行验证.

关键词：拒绝服务攻击滑模控制状态预测器幂次趋近律

Dysfunction of the adhesion g protein-coupled receptor latrophilin 1(ADgRL1/LPHn1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg Andrénguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana le Duc Laura lehmann Stefan lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany german Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.g protein-coupled receptors(gPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some gPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion gPCR latrophilin 1(ADgRL1/LPHn1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADgRL1/LPHn1 in a patient suffering from ***,we propose that LPHn1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Characterization of Evolutionarily ConservedMotifs Involved in Activity and Regulation of theABA-InSEnSITIVE （ABI） 4 Transcription Factor

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Molecular Plant 2014年第2期7卷 422-436页

作者： Josefat gregorio Alma Fabiola Hernández-Bernal Elizabeth Cordoba Patricia le.n Departamento de Biología Molecular de Plantas Instituto de Biotecnología Universidad Nacional Autónoma de México Av. Universidad # 2001 Col. Chamilpa Cuernavaca Morelos C.p. 62210 Mexico

In recent years, the transcription factor ABI4 has emerged as an important node of integration for externaland internal signals such as nutrient status and hormone signaling that modulates critical transitions during the growthand development of plants. For this reason, understanding the mechanism of action and regulation of this protein rep-resents an important step towards the elucidation of crosstalk mechanisms in plants. However, this understanding hasbeen hindered due to the negligible levels of this protein as a result of multiple posttranscriptional regulations. To betterunderstand the function and regulation of the ABI4 protein in this work, we performed a functional analysis of severalevolutionarily conserved motifs. Based on these conserved motifs, we identified ortholog genes of ABI4 in differentplant species. The functionality of the putative ortholog from Theobroma cacao was demonstrated in transient expres-sion assays and in complementation studies in plants. The function of the highly conserved motifs was analyzed aftertheir deletion or mutagenesis in the Arabidopsis ABI4 sequence using mesophyll protoplasts. This approach permitted usto immunologically detect the ABI4 protein and identify some of the mechanisms involved in its regulation. We identi-fied sequences required for the nuclear localization （AP2-associated motif） as well as those for transcriptional activationfunction （LRP motif）. Moreover, this approach showed that the protein stability of this transcription factor is controlledthrough protein degradation and subcellular localization and involves the AP2-associated and the PEST motifs. We dem-onstrated that the degradation of ABI4 protein through the PEST motif is mediated by the 26S proteasome in responseto changes in the sugar levels.

关键词： ABI4 posttranslational regulation transcription factor sugar signaling abscisic acid-insensitive protea-some nuclear localization signals

Habitat use and demography of Mus musculus in a rural landscape of Argentina

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Integrative Zoology 2013年第1期8卷 18-29页

作者： Vanina A.le.n Jimena FRASCHInA Juan S.gUIDOBOnO Maria BUSCH Department of Ecology Genetics and EvolutionUniversity of Buenos AiresBuenos AiresArgentina

The main goal of the paper was to determine the habitat distribution of the house mouse(Mus musculus)within a rural landscape of Buenos Aires province,*** also studied the seasonal variation in abundance and reproductive *** habitats studied were poultry farms,human houses in a small village,cropfields,pastures,cropfield and pasture edges,riparian habitats(streams),railway embankments and *** captured 817 *** and 690 individuals of 5 native rodent *** was captured in poultry farms,houses,riparian habitats,cropfield and borders,but it showed a significantly higher abundance in poultry farms compared to the other *** presence outside poultry farms was significantly related to the distance to streams and poultry *** mean trapping success index of *** did not show significant variations between periods,but the proportion of active males was significantly higher in the spring-summer period than in the autumn-winter *** captures of *** in cropfields,borders and riparian habitats occurred in the spring-summer *** capture of *** in many types of habitats suggests that it can disperse outside poultry farms,and streams may be used as corridors.

关键词： abundance variation habitat distribution house mice reproductive activity

微创手术对高血压脑出血患者炎性因子、神经因子水平的影响

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四川生理科学杂志 2024年第3期46卷 520-522,554页

作者：邵亚乐河南科技大学第一附属医院手术室河南洛阳471003

目的:探究微创手术治疗高血压脑出血(Hypertensive Cerebral Hemorrhage,HCH)的效果.方法:随机将2021年1月至2022年1月我院收治的80例HCH患者分为两组(n=40).对照组行开颅血肿清除术(Craniotomy to cle.n hematoma,CCH),研究组行微创手术,对比手术情况及临床疗效.同时,采用改良Rankin量表问卷(ModifiedRankinScale,mRS)、美国国立卫生研究院卒中量表(national Institutesof Health Stroke Scale.nIHSS)评估患者术前与术后1 m、3 m神经损伤程度,以酶联免疫法检测降钙素原(Procalcitonin,PCT)、超敏C反应蛋白(Highsensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TnF-α)、胶质纤维酸性蛋白(glial fibrillary acidic protein,gFAP)、中枢神经特异蛋白(Soluble protein-100β,S100β),采用化学发光法检测血清神经肽(neuropetide Y,nPY)水平,记录术后并发症发生率.结果:研究组血肿清除率高于对照组,手术耗时及失血量少于对照组(PnIHSS评分、PCT、hs-CRP、TnF-α、nPY、gFAP、S100β蛋白均低于对照组(P<0.05);研究组并发症总发生率低于对照组(P<0.05).结论:微创手术是HCH安全可靠的治疗方案,临床值得推广.

关键词：高血压脑出血并发症炎性因子

A reference-grade genome of the xerophyte Ammopiptanthus mongolicus sheds light on its evolution history in legumes and droughttolerance mechanisms

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Plant Communications 2024年第7期5卷 157-177页

作者： lei Feng Fei Teng na Li Jia-Cheng Zhang Bian-Jiang Zhang Sau-na Tsai Xiu-le Yue Li-Fei gu guang-Hua Meng Tian-Quan Deng Suk-Wah Tong Chun-Ming Wang Yan Li Wei Shi Yong-Lun Zeng Yue-Ming Jiang Weichang Yu Sai-Ming ngai Li-Zhe An Hon-Ming Lam Jun-Xian He School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongSha TinNew TerritoriesHong KongChina guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China BgI-Shenzhen Tech Co. Ltd.Beishan Industrial ZoneYantian DistrictShenzhen 518083China School of Life Sciences and Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations Lanzhou UniversityLanzhou 730030China State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China guangdong Provincial Key Laboratory of Applied Botany&Key Laboratory of South China Agricultural Plant Molecular Analysis and genetic Improvement South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Life Sciences and Oceanography Shenzhen UniversityShenzhen 518060China State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China

Plants that grow in extreme environments represent unique sources of stress-resistance genes and *** mongolicus(leguminosae)is a xerophytic evergreen broadleaf shrub native to semi-arid and desert regions;however,its drought-tolerance mechanisms remain poorly ***,we report the assembly of a reference-grade genome for ***,describe its evolutionary history within the legume family,and examine its drought-tolerance *** assembled genome is 843.07 Mb in length,with 98.7%of the sequences successfully anchored to the nine chromosomes of *** genome is predicted to contain 47611 protein-coding genes,and 70.71%of the genome is composed of repetitive sequences;these are dominated by transposable elements,particularly longterminal-repeat *** analyses revealed two whole-genome duplication(WgD)events at 130 and 58 million years ago(mya)that are shared by the genus Ammopiptanthus and other legumes,but no species-specific WgDs were found within this *** genome reconstruction revealed that the *** genome has undergone fewer rearrangements than other genomes in the legume family,confirming its status as a"relict plant".Transcriptomic analyses demonstrated that genes involved in cuticular wax biosynthesis and transport are highly expressed,both under normal conditions and in response to polyethylene glycol-induced *** induction of genes related to ethylene biosynthesis and signaling was also observed in leaves under dehydration stress,suggesting that enhanced ethylene response and formation of thick waxy cuticles are two major mechanisms of drought tolerance in *** expression of AmERF2,an ethylene response factor unique to ***,can markedly increase the drought tolerance of transgenic Arabidopsis thaliana plants,demonstrating the potential for application of *** genes in crop improvement.

关键词： Ammopiptanthus mongolicus genome sequencing genome evolution drought tolerance cuticular wax ethylene

Metformin and colorectal cancer

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BIOCELL 2022年第1期46卷 51-59页

作者： gASTÓn AMABle EDUARDO MARTÍnEZ-le.n MARÍA E.PICCO OSVALDO REY Consejo nacionalde Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal cancer(CRC)is one of the main causes of cancer-related mortality in the deweloped world despite recent developments in detection and treatment Several epidemiologial studis indicate that metformin,a widdy prescribed antidiabetic drug,exerts a protective effect on different cancers incuding ***,a recent double blind placebo controlled,randomized trial showed that metformin significantly decreased colorectal adenoma *** exploring the medhanism of action of metformin in cells derived from different types of ancers reported many efects including rapiratory chain complex 1 inhibition,Akt phosphorylation inhibition,ATP depltion,PKA activation and Wnt signaling ***,many of these results were obtained employing metformin at concentrations several fold higher than those achieved in target tissuas in diabetic patients receiving therapeutic recommended doses of *** contrast,recent studies obtained with metformin at concentrations compatible with those detected in human intestins revealed that metformin dicit responses that targetβ-catenin,PI3KAkt,E-adherin,pl20-catenin and focal adhesion kinase which are key molecules and signaling pathways associated to colorectal cancar *** brief review revisit several know aspects as well as nowd ones on the effects of metformin on cancer cells.

关键词： Metformin β-Catenin E-Cadherin Colorectal cancer AMPK PI3K/AKT FAK

Finite Morse Index Solutions of a nonlinear Schr?dinger Equation

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Acta Mathematica Sinica,English Series 2023年第3期39卷 513-522页

作者： Phuong le Faculty of Economic Mathematics University of Economics and LawHo Chi Minh CityVietnam Vietnam national University Ho Chi Minh CityVietnam

We prove Liouville type theorems for stable and finite Morse index H_(loc)^(1)∩L_(loc)^(∞)solutions of the nonlinear Schrodinger equation -Δu+λ|x|^(a)u=|x|b|^(u)|^(p-1)u in R^(n),where n≥2,λ>0,a,b>-2 and p>1,Our analysis reveals that all stable solutions of the equation must be zero for all p>1,Furthermore,finite Morse index solutions must be zero if n≥3 an p≥(n+2+2b)/(n-2).The main tools we use are integral estimates,a Pohozaev type identity and a monotonicity formula.

关键词： Schrodinger equation Liouville type theorems stable solutions finite Morse index solutions monotonicity formula

Contrasting arthropod communities associated with dwarf mistletoes Arceuthobium globosum and A. vaginatum and their host Pinus hartwegii

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Journal of Forestry Research 2018年第5期29卷 1351-1364页

作者： le.n F.Chávez-Salcedo Mónica E.Queijeiro-Bolanos Víctor López-gómez Zenón Cano-Santana Blanca E.Mejía-Recamier Aurea Mojica-guzmán Laboratorio de Interacciones y Procesos Ecologicos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autonoma de Moico Av.Universidad 3000 04510 Mexico City Mexico Laboratorio de Ecología y Sistemática de Microartr dpodos Departamento de Ecología y Recursos Naturales Facultad de Ciencias Universidad Nacional Autónoma de M4xico Av.Universidad 3000 04510 Mexico City Mexico Instituto de Biologia Universidad Nacional Autdnoma de Mexico Av. Universidad 3000 04510 Mexico City Mexico Departamento de Ecologia Facultad de Ciencias Naturales Universidad Autdnoma de Quer6taro Av.de las Ciencias s/n 76230 Queretaro Queretaro Mexico

Arthropod communities and epiphytic plants associated with tree canopies have been widely studied and have revealed a great diversity of organisms; however,the community hosted by parasitic plants,such as dwarf mistletoes,remains poorly *** the coniferous forests of north America,dwarf mistletoe infection（Arceuthobium spp.） significantly damages the health of the forest,causing large financial losses for the forest industry,but it also positively affects diversity,especially of mammals and *** study examined the attributes of the arthropod communities associated with two species of dwarf mistletoe [Arceuthobium globosum Hawksw.＆ Wiens and ***（Humb.＆ *** Willd.） ***] and their host Pinus hartwegii *** 2010,in five sites located in Zoquiapan（Central Mexico）,we collected plant tissue from the three species *** were separated from the plant tissue and identified to the finest level *** collected 32,059 individuals,for which51 morphospecies were identified,belonging to 15 taxonomic orders; the most abundant orders for the three plants were Prostigmata,Thysanoptera and *** community associated with *** had the highest value of diversity（H＇= 1.47; ***,H＇= 0.64; ***,H＇= 0.68） and species richness（S = 40; ***,S = 30; ***,S = 35）; while abundance was significantly higher for the mistletoes（***,n = 407 individuals/sample; ***,n = 536 individuals/sample; ***,n = 134 individuals/sample）.Species richness,abundance and diversity were significantly different for the three studied plants,as well for sampling month and the interaction of these two factors（except for diversity）.The results suggest that the canopy of *** is an important element in the ecosystem,providing a mosaic of resources and conditions to the associated *** also propose that mistletoes are key species within the forest canopy,as they greatly influence the establishment of d

关键词： Arceuthobium spp Pinus hartwegii Arthropod community Thrips Mites Hemiparasitic plants