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Advances in Microgeophysics for Engineering and Cultural Heritage

Journal of China University of geosciences 2009年第3期20卷 626-639页

作者： P L Cosentino P Capizzi g fiandaca R Martorana P Messina Department of Chemistry and Physics of the Earth and Applications to geo-Resources and Natural Risks Geophysical Section University of PalermoPalermo Italy

A large number of unconventional investigations have been implemented, tested, and validated in the field of microgeophysics, with the aim being to solve specific diagnostic and/or monitoring problems regarding civil engineering and cultural heritage studies. The investigations were carried out using different tomographic 2D and 3D approaches as well as different energy sources, namely sonic, ultrasonic and electromagnetic （radar） waves, electric potential fields, and infrared thermography. Many efforts have been made to modify instruments and procedures in order to improve the resolution of the surveys as well as to greatly reduce the time of the measurements without any loss of information. The main new methodologies here discussed are the sonic imprint, the global tomographic traveltime, the electrical resistivity tomography, and the control of external films （patinas） grown on stone monuments. The results seem to be very promising and suggest that it is the moment to dedicate time and effort to this new branch of geophysics, so that these methodologies can be used even more to diagnose, monitor, and safeguard not only engineering buildings and large structures but also ancient monuments and cultural artifacts, like pottery, statues, etc..

关键词： microgeophysics engineering cultural heritage tomography electrical sonic ultrasonic ground penetrating radar (gPR).

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Can population genomics guide future therapeutic gene transfer strategies for Parkinson’s disease?

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Open Journal of genetics 2013年第2期3卷 19-29页

作者： Massimo S. fiandaca Robert M. Padilla Ishmeal Conteh Howard J. Federoff 1Department of Neurology Georgetown University Medical Center Washington DC USA 2Department of Neuroscience Georgetown University Medical Center Washington DC USA

Medical and surgical therapies for patients with Parkinson’s disease (PD) are typically considered and initiated upon development of clinical signs, especially therapeutic gene transfer therapies. Early clinical trials delivering transgenes within the brains of PD patients have confirmed their safety and suggested mild to moderate efficacy. Confirmatory phase III trials have yet to be undertaken with any of the current treatment regimens. During the development of PD gene therapy, mapping of the human genome was finalized and provides major insights into the normal and pathogenic genetic variabilities of populations. genome wide association studies (gWAS) have expanded the genetic defects and risk factors accompanying clinical PD. Advanced genomic investigations may allow asymptomatic individuals with a high risk of developing PD, and evident presymptomatic nigrostriatal deficiencies, to consider early treatment approaches. Herein we propose that certain genomically and clinically defined PD patients may provide unique opportunities for testing neuronotrophic gene therapy in a pathobiological environment that is antecedent to overt motoric dysfunction. Such an approach may finally allow testing of the disease-altering capabilities of therapeutic gene transfer in PD.

关键词： Biomarkers Functional Imaging gene Therapy Parkinson’s Disease Population genomics Prodromal Phase

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每一个公司都是媒体公司

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中国广告 2013年第10期 99-99页

作者： Jonathan Cude Daniele fiandaca 夏珖玘美国 McKinney公司英国壳牌公司创新部门

如今．随着科技——消费者——媒体所营造的纽带．每个个人都能通过连接各种新媒体，迅速分享自己的所见所闻，同时浏览到世界各地人们的想法。这样的情况下，内容为王，到处存在着潜在的媒体渠道．离线和在线．每个品牌都有机会营销消... 详细信息

如今．随着科技——消费者——媒体所营造的纽带．每个个人都能通过连接各种新媒体，迅速分享自己的所见所闻，同时浏览到世界各地人们的想法。这样的情况下，内容为王，到处存在着潜在的媒体渠道．离线和在线．每个品牌都有机会营销消费者的行为。在这个新时代，品牌可以创造共享的媒体方案。

关键词：媒体公司消费者新媒体品牌营销

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