检索结果-南通市图书馆

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Stepping up after spinal cord injury:negotiating an obstacle during walking

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSds)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSds,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSds,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Boundary conditions for porous solids saturated with viscous fluid

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2009年第7期30卷 821-832页

作者： M.d.sharma department of Mathematics Kurukshetra University

Boundary conditions are derived to represent the continuity requirements at the boundaries of a porous solid saturated with viscous fluid. They are derived from the physically grounded principles with a mathematical check on the conservation of energy. The poroelastic solid is a dissipative one for the presence of viscosity in the interstitial fluid. The dissipative stresses due to the viscosity of pore-fluid are well represented in the boundary conditions. The unequal particle motions of two constituents of porous aggre~ gate at a boundary between two solids are explained in terms of the drainage of pore-fluid leading to imperfect bonding. A mathematical model is derived for the partial connec- tion of surface pores at the porous-porous interface. At this interface, the loose-contact slipping and partial pore opening/connection may dissipate a part of strain energy. A numerical example shows that, at the interface between water and oil-saturated sandstone, the modified boundary conditions do affect the energies of the waves refracting into the isotropic porous medium.

关键词： porous solid dissipative boundary conditions

Existence and uniqueness theorem for flow and heat transfer of a non-Newtonian fluid over a stretching sheet

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 766-771页

作者： SAHOO Bikash sharma H.g. department of Mathematics Indian Institute of Technology RoorkeeUttaranchal 247667India

Analysis is carried out to study the existence, uniqueness and behavior of exact solutions of the fourth order nonlinear coupled ordinary differential equations arising in the flow and heat transfer of a viscoelastic, electrically conducting fluid past a continuously stretching sheet. The ranges of the parametric values are obtained for which the system has a unique pair of solutions, a double pair of solutions and infinitely many solutions.

关键词： Viscoelastic fluid Stretching sheet MHd flow Heat transfer Nonlinear systems Existence Uniqueness

View Creation for Queriesin Object Oriented databases

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 1999年第4期14卷 349-362页

作者： RajeshNarang K.d.sharma departmentofComputerScience UniversityofDelhiDelhi110007，I departmentofComputerScience Universityof

A view in object oriented databases corresponds to virtual schemawith restructured generalization and decomposition hierarchies. Numbers of viewcreation methodologies have been proposed. A major drawback of existing method-ologies is that they do not maintain the closure property. That is, the result of aquery does not have the same semantics as embodied in the object oriented datamodel. Therefore, this paper presents a view creation methodology that derives aclass in response to a user's query, integrates derived class in global schema (i.e.,considers the problem of classes moving in class hierarchy) and selects the requiredclasses from global schema to create the view for user's query. Novel idea of viewcreation includes: (a) an object algebra for class derivation and customization (wherethe derived classes in terms of object instances and procedure/methods are studied),(b) maintenance of closure property, and (c) classification algorithm which providesmechanism to deal with the problem of a class moving in a class hierarchy.

关键词： object manipulation type level operation instance level operation,object algebra object operator operator syntax operator semantics derived class,class integration view creation algorithm

Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching

在线全文

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2024年第2期11卷 111-122页

作者： Heena dhawan d.K.sharma ANRF Ministry of ScienceNew DelhiIndia department of Energy Science and Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective *** would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF *** aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching *** and process intensification studies were carried *** than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed *** repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of *** integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals.

关键词： Alkali–acid leaching demineralisation Integrated process Rare earth elements

MHd flow and heat transfer from continuous surface in uniform free stream of non-Newtonian fluid

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2007年第11期28卷 1467-1477页

作者： Bikash Sahoo H.g sharma department of Mathematics Indian Institute of Technology RoorkeeRoorkeeUttarakhand-247667India

An analysis is carried out to study the steady flow and heat transfer characteristics from a continuous flat surface moving in a parallel free stream of an electrically conducting non-Newtonian viscoelastic fluid. The flow is subjected to a transverse uniform magnetic field. The constitutive equation of the fluid is modeled by that for a second grade fluid. Numerical results are obtained for the distribution of velocity and temperature profiles. The effects of various physical parameters like viscoelastic parameter, magnetic parameter and Prandtl number on various momentum and heat transfer characteristics are discussed in detail and shown graphically.

关键词： second grade fluid free stream heat transfer magnetic field finite difference method