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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIgNESH balaji E DIVYA RAMESH MANISHA CHUNgAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANgANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

绵羊皮手套革的加工：加脂剂及合成鞣剂对手套革制作性能的影响

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北京皮革（中外皮革信息版）（中） 2008年第11期 99-104页

作者： B．Madhan g．balaji R．Aravindhan Swarna V Kanth S．Sadulla J．Raghava Rao 王康建（译）人力和组织资源开发中心中央皮革研究所化学实验室Adyar Chennai600620印度四川大学生物质与皮革工程系四川成都610065

众所周知，助鞣剂如合成鞣剂和加脂剂对手套革制作性能的影响极大。正确选用的合成鞣剂和加脂剂，对获得性能优良的手套革至关重要。本工作尝试系统研究不同合成鞣剂和加脂剂对山羊皮手套革制作性能的影响。采用六种不同种类的加脂剂与... 详细信息

众所周知，助鞣剂如合成鞣剂和加脂剂对手套革制作性能的影响极大。正确选用的合成鞣剂和加脂剂，对获得性能优良的手套革至关重要。本工作尝试系统研究不同合成鞣剂和加脂剂对山羊皮手套革制作性能的影响。采用六种不同种类的加脂剂与四种合成鞣剂相组合，研究它们对手套制作性能如裁剪性，柔软度、强度及其他主管感受如平滑度、延伸性的影响。观察得知，亚硫酸化鱼油加脂剂、磺基氯化石蜡、卵磷脂加脂剂与戊二醛鞣剂和聚合复鞣剂配合，能得到更好手套制作性能的革。

关键词：磷脂加脂剂合成鞣剂手套革性能制作绵羊皮加工亚硫酸化鱼油

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加脂剂和合成鞣剂对手套革性能的影响

中国皮革 2009年第15期38卷 55-57页

作者： Swarna V Kanth S Sadulla J Raghava Rao 刘显奎(译校) 吴雄虎(译校) 王久江(译校) 人类和环境资源发展中心Adyar Chennai-600020印度皮革研究所化学实验中心Adyar Chennai-600020印度中国皮革和制鞋工业研究院北京100016 山东济宁化工研究所山东济宁272017

系统地研究了各种加脂剂和合成鞣剂对绵羊手套革性能的影响。结合6种不同种类的加脂剂和4种合成鞣剂对绵羊手套革性能的影响进行了研究，如对弹性、柔软度、强度和其他感官指标如光滑度、延伸性的影响。试验结果表明：基于亚硫酸化鱼油... 详细信息

系统地研究了各种加脂剂和合成鞣剂对绵羊手套革性能的影响。结合6种不同种类的加脂剂和4种合成鞣剂对绵羊手套革性能的影响进行了研究，如对弹性、柔软度、强度和其他感官指标如光滑度、延伸性的影响。试验结果表明：基于亚硫酸化鱼油、磺酰氯化乳液和卵磷脂制成的加脂剂，同戊二醛及聚合物鞣剂共同应用于皮革，可得到具有较好性能的手套革。

关键词：加脂剂合成鞣剂手套革

gray-Hole Attack Minimization in IoMT with 5g Based D2D Networks

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Computer Systems Science & Engineering 2022年第9期42卷 1289-1303页

作者： V.balaji P.Selvaraj Department of Computing Technologies College of Engineering and TechnologyFaculty of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203TamilnaduIndia

Reliable transmission is vital to the success of the next generation ofcommunications technologies and Fifth generation (5g) networks. Many sensitive applications, such as eHealth and medical services, can benefit from a 5g network. The Internet of Medical Things (IoMT) is a new field that fosters themaintenance of trust among various IoMT Device to Device (D2D) modern technologies. In IoMT the medical devices have to be connected through a wirelessnetwork and constantly needs to be self-configured to provide consistent and effi-cient data transmission. The medical devices need to be connected with sophisticated protocols and architecture to handle the synergy of the monitoring ***, one of the commonly used algorithms in D2D communication is the Optimized Link State Routing protocol (OLSR). The OLSR is considerably good ateffectively utilizing the bandwidth and reserving the paths. One of the majorattack against the OLSR is the Node isolation attack, also known as the gray holedenial of service attack. The gray hole attack exploits the vulnerabilities presentwith sharing the topological information of the network. The attackers may usethis topological information to maliciously disconnect the target nodes from theexisting network and stops rendering the communication services to the victimnode. Hence, considering the sensitivity and security concerns of the data usedin e-Health applications, these types of attacks must be detected and disabledproactively. In this work, a novel Node Authentication (NA) with OLSR is proposed. The simulation experiments illustrated that the proposed protocol has anexcellent Packet Delivery Ratio, minimal End-End delay, and minimal Packet losswhen compared to the Ad-hoc On-Demand Distance Victor (AODV) protocol andthe proposed authentication scheme was able to protect the OLSR protocol from anode isolation attack.

关键词： 5g AODV D2D IoMT OLSR security issues

Contraceptive behaviors and awareness in an urban slum community of south India

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Asian pacific Journal of Reproduction 2024年第4期13卷 160-168页

作者： Monica Albert Sekhar Shanthi Edward Angeline grace Sushmitha g Shirley Esther Priscilla Department of Community Medicine Sree Balaji Medical College and Hospital(SBMCH)ChennaiIndia

Objective:To assess the factors associated with knowledge,attitude and behavior of contraception use among urban slum population in ***:A cross-sectional study was conducted in the urban slum of Anakaputhur,*** couples between ages of 19-49 years and living in slum areas were taken up for the study by simple random *** women,postnatal and postmenopausal women were excluded from the *** collection was done using a pretested structured questionnaire focusing on details regarding contraception knowledge,attitude,and *** analysis was done using IBM SPSS version *** test like Chi square and odds ratio(OR)were used to identify association between knowledge,attitude,and behavior of contraception with the associated variables and enter method of logistic regression analysis was ***:Out of the 360 respondents,228 were females,with a mean age of(34±5)*** 43%demonstrated adequate knowledge of contraception use,and 91%were aware of at least one contraceptive ***,72%exhibited a positive attitude towards contraceptive ***,43%(155 individuals)did not utilize any contraceptive *** contraceptive users,intrauterine devices were the most commonly adopted,followed by barrier methods and female *** was significant association between knowledge of contraception and education(aOR 7.29,95%CI 2.93-18.10,Pge(aOR 2.04,95%CI 1.19-3.50,Pgarding attitude towards contraception use,education(aOR 8.54,95%CI 2.35-31.03,Pge(aOR 0.53,95%CI 0.28-0.99,Pgnificant ***:These findings underscore the imperative for enhanced d

关键词： Family planning Unmet need Sterilization Knowledge Practice Urban slum

Networking Controller Based Real Time Traffic Prediction in Clustered Vehicular Adhoc Networks

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Intelligent Automation & Soft Computing 2023年第2期35卷 2189-2203页

作者： T.S.balaji S.Srinivasan Saveetha School of Engineering Saveetha Institute of Medical and Technical SciencesSaveetha UniversitySaveetha NagarThandalamChennai602105India Department of Electronics and Communication Engineering College of Engineering and TechnologySRM Institute of Science and TechnologyVadapalani CampusChennai600026India Department of Biomedical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesSaveetha UniversitySaveetha NagarThandalamChennai602105India

The vehicular ad hoc network(VANET)is an emerging network tech-nology that has gained popularity because to its low cost,ﬂexibility,and seamless *** deﬁned networking(SDN)technology plays a critical role in network administration in the future generation of VANET withﬁfth generation(5g)*** of the beneﬁts of VANET,energy economy and trafﬁc control are signiﬁcant architectural *** and real-time trafﬁcﬂow prediction(TFP)becomes critical for managing trafﬁc effectively in the *** controllers are a critical issue in VANET,which has garnered much interest in recent *** this objective,this study develops the SDNTFP-C technique,a revolutionary SDN controller-based real-time trafﬁcﬂow forecasting technique for clustered *** proposed SDNTFP-C technique combines the SDN controller’s scalability,ﬂexibility,and adaptability with deep learning(DL)***,a novel arithmetic optimization-based clustering technique(AOCA)is developed to cluster automobiles in a *** TFP procedure is then performed using a hybrid convolutional neural network model with atten-tion-based bidirectional long short-term memory(HCNN-ABLSTM).To optimise the performance of the HCNN-ABLSTM model,the dingo optimization techni-que was used to tune the hyperparameters(DOA).The experimental results ana-lysis reveals that the suggested method outperforms other current techniques on a variety of evaluation metrics.

关键词： VANET trafﬁcﬂow prediction clustering metaheuristics SDN controller deep learning

Hybridization of graphene-reinforced two polymer nanocomposites

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International Journal of Smart and Nano Materials 2016年第3期7卷 179-201页

作者： Velram balaji Mohan Krishnan Jayaraman Debes Bhattacharyya Centre for Advanced Composite Materials Department of Mechanical EngineeringThe University of AucklandAucklandNew Zealand

This article focuses on the hybridization of thermoplastic polymer matrices with conducting polymers and graphene ***(PP),polymethylmethacrylate(PMMA)and polyox-ymethylene(POM)were used as primary polymer matrices and polypyrrole(PPY)and polyaniline(PANI)as secondary conducting *** conductive-reduced graphene oxide(rgO)and graphene(g)have been used as reinforcements.A Taguchi analy-sis has been performed for the blends to find the optimal combi-nation of the blends with respect to electrical conductivity(σ)and mechanical *** electrical and mechanical properties were improved by the hybridization *** maximum elec-trical conductivity of 0.85 ***^(−1) has been acquired with POM/PPY/g blend with 3 wt.%and 5 wt.%of PPY and graphene load-ing,*** mechanical properties have been found to improve with all the blends but,PP/PPY/g blend with 3 wt.%and 6 wt.%of PPY and graphene loading displays overall better prop-erties in comparison with other blends.

关键词： Hybridization graphene composites electrical conductivity ultimate tensile strength statistical analysis crystallinity morphology

Insecticidal,antimicrobial and antioxidant activities of bulb extracts of Allium sativum

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 391-395页

作者： balaji Meriga Ramgopal Mopuri T.MuraliKrishna Department of Biochemistry Sri Venkateswara UniversityTirupati-517501.India Department of Entomology Regional Agricultural Research StationTirupatiIndia

Objective:To evaluate the insecticidal,antimicrobial and antioxidant activities of bulb extracts of Allium sativum(***).Methods:Dried bulbs of *** were extracted with different solvents and evaluated for insecticidal,antimicrobial and antioxidant ***: Aqueous and methanol extracts showed highest insecticidal activity(mortality rate of 81%and 64%respectively) against the larvae of Spodoptera litura(***) at a concentration of 1000 *** regard to antimicrobial activity,aqueous extract exhibited antibacterial activity against gram positive(Bacillus subtilis,Staphylococcus aureu,) and gram negative(Escherichia coli and Klebsiella pneumonia) strains and antifungal activity against Candida *** methanol extract showed antimicrobial activity against all the tested micro organisms except two(Staphylococcus aureus and Candida albicans),the extracts of hexane,chloroform and ethyl acetate did not show any anti microbial *** inhibitory concentration of aqueous and methanol extracts against tested bacterial and fungal strains was 100-150μg/mL. Antioxidant activity of the bulb extracts was evaluated in terms of inhibition of free radicals by 2.2’-*** and methanol extracts exhibited strong antioxidant activity(80%-90%of the standard).Conclusions:Antioxidant and antimicrobial activity of *** against the tested organisms therefore,provides scientific basis for its utilization in traditional and folk ***,our results demonstrated the insecticidal efficacy of A. sativum against ***,a polyphagous insect.

关键词： Allium sativum Insecticidal activity Antimicrobial activity Antioxidant property

SDN assisted Stackelberg game model for LTE-WiFi offloading in 5g networks

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Digital Communications and Networks 2019年第4期5卷 268-275页

作者： Sudha Anbalagan Dhananjay Kumar gunasekaran Raja Alkondan balaji Department of Computer Science and Engineering SRM Institute of Science and TechnologyKattankulathurIndia Department of Information Technology Anna UniversityChennaiIndia Department of Computer Technology Anna UniversityChennaiIndia

The data traffic that is accumulated at the Macro Base Station(MBS)keeps on increasing as almost all the people start using mobile *** MBS cannot accommodate all user’s demands,and attempts to offload some users to the nearby small cells so that the user could get the expected *** the MBS to offload data traffic to an Access Point(AP),it should offer an optimal economic incentive in a way its utility is ***,the APs should choose an optimal traffic to admit load for the price that it gets from *** balance this tradeoff between the economic incentive and the admittance load to achieve optimal offloading,Software Defined Networking(SDN)assisted Stackelberg game(SaSg)model is *** this model,the MBS selects the users carefully to aggregate the service with AP,so that the user experiencing least service gets aggregated *** MBS uses the Received Signal Strength Indicator(RSSI)value of the users as the main parameter for aggregating a particular user for a contract period with LTE and *** player involved in the game tries to maximize their payoff utilities,and thus,while incorporating those utilities in real-time scenario,we obtain maximum throughput per user which experiences best data service without any lack in Quality of Experience(QoE).Thus,the proposed SaSg model proves better when compared with other game theory models,and hence an optimal data offloading is achieved.

关键词： LTE WiFi Aggregation Software Defined Networking Stackelberg game