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World Journal of Nephrology 2024年第1期13卷 9-13页

作者： Benjamin Peticca Tomas M Prudencio Samuel g robinson Sunil S Karhadkar Department of Surgery Lewis Katz School of Medicine at Temple University HospitalPhiladelphiaPA 19140United States

Non-descriptive and convenient labels are uninformative and unfairly project blame onto *** language clinicians use in the Electronic Medical Record,research,and clinical settings shapes biases and subsequent behaviors of all providers involved in the enterprise of *** such as noncompliant and nonadherent serve as a reason for waitlist inactivation and limit access to life-saving *** labels fail to capture all the circum-stances surrounding a patient’s inability to follow their care regimen,trivialize social determinants of health variables,and bring unsubstantiated subjectivity into decisions regarding organ ***,insufficient Medicare coverage has forced patients to ration or stop taking medication,leading to allograft failure and their subsequent diagnosis of *** argue that perpetuating non-descriptive language adds little substantive information,in-creases subjectivity to the organ allocation process,and plays a major role in reduced access to *** patients with existing barriers to care,such as racial/ethnic minorities,these effects may be even more *** committees must ensure thorough documentation to correctly encapsulate the entirety of a patient’s position and give voice to an already vulnerable population.

关键词： End-stage renal disease Compliance Labeling Social determinants

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIgHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson g robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The george Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(gTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of gTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with glyceryl trinitrate in Hypertensive stroke Trial-2(RIgHT-2).Methods RIgHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,gTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting gTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal gTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(gTN)was associat-ed with less death and dependency in those w

关键词： glasgow nitrate random

Endocytosis： Is There Really a Recycling from Late Endosomes？

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Molecular Plant 2015年第10期8卷 1554-1556页

作者： David g. robinson Centre for Organismal Studies University Heidelberg 69120 Heidelberg Germany

Dear Editor,Over the last 15 years endocytosis has moved from being a process of only minor importance to plant physiologists to being one of the most exciting research areas in plant cell biology. These days, nobody doubts the operation of clathrin-mediated endocytosis as a mechanism for the internalization of a range of physiologically important transmembrane protein complexes at the plasma membrane （PM） of plant cells. These include both receptors and transporters. As in animal cells, most of these proteins are constitutively recycled back to the PM from an early endosome （EE）. However, some are destined for degradation and proceed further downstream in the endocytic pathway to late endosomes （LE）, where they are internalized into the intraluminal vesicles of the LE. Fusion of the LE with the lysosome/vacuole releases the vesicles leading to their degradation. The signal that marks PM proteins for degradation has been known in mammalian and yeast cells for quite some time and is polyubiquitination （Mukhopadhyay and Riezman, 2007）. In their Spotlight article, Zelazny and Vert （2015） highlight recent publications from the plant field that also demonstrate a key role for multiple monoubiquitination in the endocytosis of the metal transporters IRT1 （Barberon et al., 2011）, BOR1 （Kasai et al., 2011）, as well as lysine63-1inked polyubiquitination in vacuolar sorting of the auxin transporter PIN2 （Leitner et al., 2012）. They also draw attention to the discovery of a ubiquitin-binding protein （FREE1 ; also termed FYVE1 by Barberon et al., 2014） which locates to the LE in plant cells and is part of the ESCRT-I （endosomal sorting complex for transport） complex （gao et al., 2014）. This complex sequesters ubiquitinated membrane cargo proteins and internalizes them. Finally, Zelazny and Vert draw attention to the work of Ivanov et al. （2014） in showing an increase in IRT1 degradation and iron deficiency in SNX1 mutants. So far so good, but Zelazny and Vert go on to conclude

关键词： soundness scenario consider

Vacuolar Sorting Receptor （VSR） Proteins Reach the Plasma Membrane in germinating Pollen Tubes

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Molecular Plant 2011年第5期4卷 845-853页

作者： Hao Wang Xiao-Hong Zhuang Stefan Hillmer David g. robinson Li-Wen Jiang School of Life Sciences Centre for Cell and Developmental Biology The Chinese University of Hong Kong Shatin New Territories Hong Kong China State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong Shatin New Territories Hong Kong China Department of Cell Biology Heidelberg Institute for Plant Science University of Heidelberg Germany

Vacuolar sorting receptors （VSRs） are type I integral membrane proteins that mediate the vacuolar transport of soluble cargo proteins via prevacuolar compartments （PVCs） in plants. Confocal immunofluorescent and immunogold Electron Microscope （EM） studies have localized VSRs to PVCs or multivesicular bodies （MVBs） and trans-golgi network （TgN） in various plant cell types, including suspension culture cells, root cells, developing and germinating seeds. Here, we provide evidence that VSRs reach plasma membrane （PM） in growing pollen tubes. Both immunofluorescent and immunogold EM studies with specific VSR antibodies show that, in addition to the previously demonstrated PVC/MVB localization, VSRs also localize to PM in lily and tobacco pollen tubes prepared from chemical fixation or high-pressure freezing/frozen substitution. Such a PM localization suggests an additional role of VSR proteins in mediating protein transport to PM and endocytosis in growing pollen tubes. Using a high-speed Spinning Disc Confocal Microscope, the possible fusion between VSR-positive PVC organelles and the PM was also observed in living tobacco pollen tubes transiently expressing the PVC reporter gFP-VSR. In contrast, the lack of a prominent PM localization of gFP-VSR in living pollen tubes may be due to the highly dynamic situation of vesicular transport in this fast-growing cell type.

关键词： Plasma membrane pollen tube vacuolar sorting receptor.

The Importance of Entanglement and Neps in Worsted Processing

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The Importance of Entanglement and Neps in Worsted Processin...

第二届中国国际毛纺织会议

作者： g a robinson M W Prins M g Haigh CSIRO Division of Wool Technology P．O Box 21BelmontVictoria Australia 3216 CSIRO Division of Wool Technology P．O Box 21BelmontVictoria Australia 3216 CSIRO Division of Wool Technology P．O Box 21BelmontVictoria Australia 3216

＜正＞The results of interlaboratory trials for nep counting reveal how greatly nep counts in top can vary between testing laboratories. It is shown that neps can be generated at every stage in the topmaking and spinning preparation pipeline. The influences on nep generation may be traced back to pre- card fibre entanglement, that is the entanglement induced in scouring. Investigations with re-carded top have shown that the card can produce neps and also introduce fibre structures which later form neps. gilling is also responsible for introducing new neps. Although the comb is generally associated with the efficient removal of neps, it has been shown that it can also eventually be a source of yarn faults. Recombing has been shown to have a significant impact on yarn fault levels. The tracking of neps through the processing pipeline has revealed only a tenuous relationship between what is counted in top and the appearance of the final fabric, at least for a piece dyed route.

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用专家系统的技术实施地图的制图综合

地图 1989年第3期 24-28页

作者： D.W.Vicars g.J.robinson 王永宁

引言英国军械测量局(O.S.)在它的整个地形图系列中已经发展出一个独特的风格,这些作品完全能确定和表示英国的地貌特征,因此,许多人都认为英国军械测量局在世界上处于领先的地位。然而将这些风格上的细微差别以自动化的方式实现却不是... 详细信息

引言英国军械测量局(O.S.)在它的整个地形图系列中已经发展出一个独特的风格,这些作品完全能确定和表示英国的地貌特征,因此,许多人都认为英国军械测量局在世界上处于领先的地位。然而将这些风格上的细微差别以自动化的方式实现却不是容易的事。大比例尺1∶1250地图系列无疑是产生数字数据的起点,而1∶625000道路图便是当今已完成的最终产品。该产品组成了一个完整的数字数据库,该数据库具有能够生产符合出版质量的地图的输出模块。然而中小比例尺地图仍然徘徊在这一系列之外,虽然1∶50000系列地图尤其适宜用数字方式成图,但作为一项独立的商业产品,经济上却不合算。显然,从现有的数字数据到中间比例尺地图。

关键词：地图数据制图综合小比例尺测量局地图系列系列地图专家系统出版质量商业产品数字数据

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油气资产评估的标准化风险分析

吐哈油气 2000年第3期5卷 84-91页

作者： J.g.robinson 王琦

评估油气资产采用的每一个因素都会随其有关的不确定程度而变化;因为,评估人员必须具备一些利用统计方法处理问题的一定知识,有许多统计技术可以处理不确定因素这个问题,比如:蒙特卡罗模拟法,期望值方法,以及决策树分析法。这些方法即... 详细信息

评估油气资产采用的每一个因素都会随其有关的不确定程度而变化;因为,评估人员必须具备一些利用统计方法处理问题的一定知识,有许多统计技术可以处理不确定因素这个问题,比如:蒙特卡罗模拟法,期望值方法,以及决策树分析法。这些方法即可以简单地加以利用,也可以深入细致地加以利用,这取决于所拥有的资料、储量、以及需要导出统计的手段。本文目的在于强调对风险评估应用的具体要求及统一方式,并对储量的经济评估提出一种改进的期望值方法,简化在统计中困难、耗时、昂贵的算法。

关键词：期望储量风险分析期望值资产评估控制储量立方英尺储量评估标准化评估人员不确定因素

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逻辑卷积和离散Walsn、付立叶功率谱

声学技术 1977年第2期 60-74页

作者： g.S.robinson 单荣华

引言一个随机抽样序列的 Walsh 功率谱,定义为这个随机序列的逻辑自相关函数的 Walsh 变换或有序序列的 Hadamard 变换。"逻辑"自相关函数定义成与"算术"自相关函数有相似的形式。定义为算术自相关函数的付立叶变换的付立叶功率谱,可以... 详细信息

引言一个随机抽样序列的 Walsh 功率谱,定义为这个随机序列的逻辑自相关函数的 Walsh 变换或有序序列的 Hadamard 变换。"逻辑"自相关函数定义成与"算术"自相关函数有相似的形式。定义为算术自相关函数的付立叶变换的付立叶功率谱,可以利用线性变换由 Walsh 功率谱来求得。这一系列变换可概括为:

关键词：自相关函数算术递归关系初等数学马尔可夫过程 Walsn 对角线矩阵形式谱(数学) 功率谱

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人类对天气和气候的无意识影响

气象科技 1982年第5期 62-65页

作者： g.D.robinson 李丽

前言对天气或气候的无意识影响是指人类某些活动对天气或气候产生的影响,而这些活动当初并没有要造成这类影响的目的。这类无意识影响并非是不可预见的,而且也不一定就令人讨厌到欲消除这种影响而去禁止某些人类的活动。对大气科学家来... 详细信息

前言对天气或气候的无意识影响是指人类某些活动对天气或气候产生的影响,而这些活动当初并没有要造成这类影响的目的。这类无意识影响并非是不可预见的,而且也不一定就令人讨厌到欲消除这种影响而去禁止某些人类的活动。对大气科学家来说,他们的任务是论证这些影响是可以预见的,并对它们做出定量描述,弄清楚人类活动究竟会对天气和气候产生怎样的实际的和潜在的影响。要弄清上述问题,基本方法就是对大气过程进行数值模拟。这种方法适用于大气科学的许多方面及其实际应用。我们认为,就目前情况来看,用于大

关键词：气候平流层低层大气天气人类

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船员手记：MoonBlue2上的处女航

游艇业 2011年第1期 88-91页

作者： Ann（ie） g．robinson 《游艇业》编辑部

这是个从没有经历过帆船比赛的加拿大女孩，帆船上的一切都令她感到新奇有趣。更让人羡慕的是，她的处女航是在亚洲最大的帆船赛事泰王杯，她登上的是Premier组别最精美的帆船之一MoonBlue2。

关键词：帆船比赛船员加拿大