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Tuberculous peritonitis in children:Report of nine patients and review of the literature

World Journal of gastroenterology 2008年第47期14卷 7235-7239页

作者： gnül dinler gülnar Sensoy Deniz Helek Ayhan gazi Kalayc■ Division of Pediatric gastroenterology Hepatology and NutritionOndokuz May■s University HospitalSamsun55139Turkey Division of Pediatric Infectious Diseases Ondokuz May■s University HospitalSamsun55139Turkey Division of Pediatrics Ondokuz May■s University HospitalSamsun55139Turkey

AIM:To present our experience with tuberculous peritonitis treated in our hospital from 2002-2007. METHODS: We reviewed the medical records of 9 children with tuberculous peritonitis. RESUlTS: nine patients (5 boys, 4 girls) of mean age 14.2 years were diagnosed with peritoneal tuberculosis. All patients presented with abdominal distention. Abdominal pain was seen in 55.5% and fever in 44.4% of the patients. Four cases had coexisting pleural effusion and two had pulmonary tuberculosis with parenchymal consolidation. Ultrasonography found ascites with septation in 7 patients. Two patients had only ascites without septation. Ascitic fluid analysis of 8 patients yielded serum-ascite albumin gradients of less than 1.1 gr/dl. laparoscopy and laparotomy showed that whitish tuberculi were the most common appearance. Adhesions were also seen in three cases. The diagnosis of peritoneal tuberculosis was confirmed histo-pathologically in 7 patients and microbiologically in two. Two patients had been diagnosed by ascitic fluid diagnostic features and a positive response to antituberculous treatment. All patients completed the antituberculous therapy without any complications. COnClUSIOn: Tuberculous peritonitis has to be clinically suspected in all patients with slowly progressive abdominal distension, particularly when it is accompanied by fever and pain. laparoscopy and peritoneal biopsy are still the most reliable, quick and safe methods for the diagnosis of tuberculous peritonitis.

关键词： Child Clinical presentation Diagnosis Tuberculous peritonitis

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Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 78-82页

作者： Cavit l Kahraman dinler O■uz Hasdemir Oktay Büyüka■ik güler Bu■dayci Department of general Surgery Abant Izzet Baysal University Medical School Department of Biochemistry Abant Izzet Baysal University Medical School

BACKgROUnD:Melatonin (n-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal *** this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (gSH) levels in pancreatic tissue from rats with experimental acute ***:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal *** first group had only acute pancreatitis and served as the *** pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and gS in pancreatic ***:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and gSH in pancreatic ***:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis.

关键词： pineal gland acute pancreatitis melatonin oxidative damage

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Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies

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World Journal of gastroenterology 2018年第30期24卷 3347-3360页

作者： Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil gizem dinler Doganay levent Doganay Department of Molecular Biology and genetics Istanbul Technical University Department of gastroenterology and Hepatology Umraniye Teaching and Research Hospital

The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to ***-wide association studies(gWAS) identified key genetic factors influencing the pathogenesis of HBV-related *** this review,we discuss gWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver *** persistence is associated with multiple genes with diverse roles in immune *** strongest associations are found within the classical human leukocyte antigen(HlA) genes,highlighting the central role of antigen presentation in the immune response to *** variants affect both epitope binding specificities and expression levels of HlA *** other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs *** persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic *** the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV *** findings of these gWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection.

关键词： genome-wide association studies Hepatitis B infection Hepatocellular carcinoma Cirrhosis Antigen presentation Immune response to hepatitis B virus

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Inflammatory bowel disease in Turkish children

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World Journal of Pediatrics 2015年第4期11卷 331-337页

作者： Murat Cakir Fatih Unal gonul dinler Masallah Baran Hasan Ali Yuksekkaya gokhan Tumgor Erhun Kasirga Ayhan gazi Kalayci Sema Aydogdu Department of Pediatric gastroenterology Hepatology and nutrition Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Dortcelik Children Hospital BursaTurkey 19 Mayis University SamsunTurkey Tepecik Education and Research Hospital IzmirTurkey necmettin Erbakan University KonyaTurkey Cukurova University AdanaTurkey Celal Bayar University ManisaTurkey Ege University IzmirTurkey

Background:This study was undertaken to evaluate demographics,clinical manifestations,laboratoryfi ndings and outcomes of children with inflammatory bowel disease(IBD)in ***:We analyzed the medical records of 127 children diagnosed with IBD(under 18 years old)between January 2004 and January 2012 in 8 pediatric gastroenterology ***:Of the 127 patients,90(70.9%)suffered from ulcerative colitis(UC),29(22.8%)from Crohn's disease(CD),and 8(6.3%)from IBD *** mean age of the 127 patients was 11.6±4.1 years,and 11.8%of the patients were below 5 years *** the patients,49.6%were male,and males were more predominant in patients with CD than in those with UC(72.4%vs.42.2%,P=0.008;a male/female ratio of 2.62 in CD,P=0.0016).Approximately one fifth of the patients had extra-intestinal manifestations and 13.3%of the patients had associated *** manifestations and associated diseases were more common in early onset disease[P=0.017,odds ratio(OR)=4.02;P=0.03,OR=4.1].Of the patients,15%had normal laboratory parameters including anemia,high platelet count,hypoalbuminemia,hypoferritinemia,and high sedimentation *** under receiver operation characteristics was used to predict pancolitis in patients with *** values of C-reactive protein,sedimentation rate and pediatric ulcerative colitis activity were 0.61(P=0.06),0.66(P=0.01)and 0.76(P=0.0001),***(4.4%)patients with UC underwent colectomy,andfi nally two(1.5%,95%confidence interval:0-3.7%)patients died from primary disease or ***:IBD is an increasing clinical entity in *** of IBD are similar to those in other populations,but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.

关键词： associated diseases Crohn's disease infl ammatory bowel disease outcome ulcerative colitis

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Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B

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World Journal of gastroenterology 2014年第25期20卷 8179-8186页

作者： levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer gizem dinler Doganay Department of gastroenterology Goz-tepe Teaching and Research HospitalMedeniyet University Department of gastroen-terology Umraniye Teaching and Research Hospital Department of Molecular Biology and genetics Istanbul Tech-nical University

AIM: To investigate the effect of human leukocyte antigen (HlA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.

关键词： Chronic active hepatitis Cirrhosis Hepatitis B Human leukocyte antigen DQ Human leukocyte antigen DR

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