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Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption

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World Journal of gastroenterology 2006年第47期12卷 7710-7714页

作者： Marco Montagnani Anna Abrahamsson Cecilia glman gsta.eggertsen Hanns-Ulrich Marschall Elisa Ravaioli Curt Einarsson Paul A Dawson Dipartimento di Medicina Interna e gastroenterologia Università di Bologna Bologna Italy Center for Applied Biomedi-cal Research Università di Bologna Bologna Italy Center for gastroenterology and Hepatology Karolinska University Hospital Huddinge Stockholm Sweden Center for Metabolism and Endocrinology Karolinska University Hospital Huddinge Stockholm Sweden Department of Laboratory Medicine Division of Clinical Chemistry Karolinska University Hospital Huddinge Stockholm Sweden Department of Internal Medicine Wake Forest University School of Medicine Winston-Salem NC 27157 United States

The etiology of most cases of idiopathic bile acid malabsorption （IBAH） is unknown. In this study, a Swedish family with bile acid malabsorption in three consecutive generations was screened for mutations in the ileal apical sodium-bile acid cotransporter gene （ASBT; gene symbol, SLC10A2） and in the genes for several of the nuclear receptors known to be important for ASBT expression： the farnesoid X receptor （FXR） and peroxisome proliferator activated receptor alpha （PPARα）. The patients presented with a clinical history of idiopathic chronic watery diarrhea, which was responsive to cholestyramine treatment and consistent with IBAH. Bile acid absorption was determined using ^75Se-homocholic acid taurine （SeHCAT）; bile acid synthesis was estimated by measuring the plasma levels of 7α-hydroxy-4-cholesten-3-one （C4）. The ASBT, FXR, and PPARα genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism （SSCP）, denaturing HPLC, and direct sequencing. No ASBT mutations were identified and the ASBT gene did not segregate with the bile acid malabsorption phenotype. Similarly, no mutations or polymorphisms were identified in the FXR or PPARα genes associated with the bile acid malabsorption phenotype. These studies indicate that the intestinal bile acid malabsorption in these patients cannot be attributed to defects in ASBT. In the absence of apparent ileal disease, alternative explanations such as accelerated transit through the small intestine may be responsible for the IBAM.

关键词： Bile acid malabsorption Diarrhea genetics ^75Se-homocholic acid taurine test Nuclear receptors

Performances of fissured red sandstone after thermal treatment with constant-amplitude and low-cycle impacts

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Journal of Rock Mechanics and geotechnical Engineering 2024年第2期16卷 561-587页

作者： Yongjun Chen Tubing Yin P.g.Ranjith Xibing Li Qiang Li Dengdeng Zhuang School of Resources and Safety Engineering Central South UniversityChangsha410083China Department of Civil Engineering Monash UniversityMelbourne3800Australia Oulu Mining School University of OuluOuluFI-90014Finland

In the engineering practices,it is increasingly common to encounter fractured rocks perturbed by temperatures and frequent dynamic *** this paper,the dynamic behaviors and fracture characteristics of red sandstone considering temperatures(25℃,200℃,400℃,600℃,and 800℃)and fissure angles(0°,30°,60°,and 90°)were evaluated under constant-amplitude and low-cycle(CALC)impacts actuated by a modified split Hopkinson pressure bar(SHPB)***,fracture morphology and second-order statistics within the grey-level co-occurrence matrix(gLCM)were examined using scanning electron microscopy(SEM).Meanwhile,the deep analysis and discussion of the mechanical response were conducted through the synchronous thermal analyzer(sta)test,numerical simulations,one-dimensional stress wave theory,and material *** multiple regression models between response variables and interactive effects of independent variables were established using the response surface method(RSM).The results demonstrate the fatigue strength and life diminish as temperatures rise and increase with increasing fissure angles,while the strain rate exhibits an inverse ***,the peak stress intensification and strain rate softening observed during CALC impact exhibit greater prominence at increased fissure *** failure is dominated by tensile damage with concise evolution paths and intergranular cracks as well as the compressor-crushed zone which may affect the failure mode after 400℃.The second-order statistics of gLCM in SEM images exhibit a considerable dependence on the ***,thermal damage dominated by thermal properties controls the material structure and wave impedance and eventually affects the incident wave *** tensile wave reflected from the fissure surface is the inherent mechanism responsible for the angle effect exhibited by the fatigue strength and ***,the peak stress intensification and strain rate softening during impact are determ

关键词： Red sandstone Temperature Fissure Constant-amplitude and low-cycle(CALC) impact Fatigue failure Response surface method(RSM)

Negative-pressure pneumatic separator:a new solution for hard-coal beneficiation

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International Journal of Coal Science & Technology 2021年第1期8卷 103-123页

作者： Kamil stańczyk Andrzej Bajerski Marian J.Łączny Central Mining Institute Plac Gwarków 140-166KatowicePoland

Hard coal is an important source of energy *** to the imperfections of excavation technology,most run-of-mine coals must be processed before they can be utilised as *** this study,tests on the dry separation process were performed with numerous different raw hard coal and coal waste material samples,using a newly designed and constructed negative-pressure pneumatic separator(NPPS).The experiments revealed the effects of the feed-material properties and material processing *** experiments were preceded by additional tests for evaluating the influence of each device operating parameter on the process,to determine the optimal method of supplying the feed *** calorific value of the processed materials was improved by 5%–40%,while a minimal output yield of products(60%–70%)was *** trials indicated that in coal material processing,the developed NPPS can be used for not only raw coal enrichment but also coal recovery from materials stored at coal-waste *** main advantages of the device are its mobility,low material processing cost,and lack of water consumption during operation.

关键词： Dry coal beneficiation Coal enrichment Coal waste processing Aerodynamic separation Deshaling Negative-pressure system

Symbolization of prosodic features in the IPA

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Symbolization of prosodic features in the IPA

第九届中国语音学学术会议

作者： gsta Bruce Lund University Sweden

The topic of the present paper is the symbolization of prosodic(suprasegmental) features in the transcription framework of the International Phonetic Alphabet(IPA).The goal of my contribution is exploratory and mainly...

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Journal of geriatric Cardiology 2018年第11期15卷 657-665页

作者： Aleksandra stańska Dariusz Jagielak Maciej Kowalik Maciej Brzeziński Rafal Pawlaczyk Jadwiga Fijalkowska Wojciech Karolak Jan Rogowski Peter Bramlage Department of Cardiac and Vascular Surgery Medical University of Gdansk Gdansk Poland Department of Radiology Medical University of Gdansk Gdansk Poland Institute far Pharmacology and Preventive Medicine Cloppenburg Germany

Objective To evaluate short- and long-term changes in quality of life (QoL) in patients undergoing transcatheter aortic valve implantation (TAVI) and to assess differences in patient QoL when using the TAVI transaortic (TAVI TAo) approach compared with the transfemoral approach (TAVI TF) and surgical aortic valve replacement (SAVR). Methods Ninety-seven patients were assessed. Thirty-two patients underwent TAVI TAo, 31 underwent TAVI TF and 34 patients underwent SAVR. QoL was assessed using the EQ-5D-3L questionnaire at baseline, after one month and one year. Results Mean patient age was 80 years (range, 61–92 years) and the mean logistic EuroSCORE was 12.45%(range, 1.39%?78.98%). Declared health state at baseline was significantly lower in TAVI TF (P groups (P = 0.99). After one year, SAVR patient results of the EQ-5D-3L index value were lower in comparison to both TAVI patient groups (P gnificant differences between the results of EQ-5D-3L index value over the one month and one year follow-up (TAVI TAo, P groups, the values significantly increased after one-month and one-year of follow-up in comparison to baseline value. Significant differences were also demonstrated between Visual Analogue Scale values (VAS). Conclusions A significant improvement in QoL was observed in all three patient groups. Regardless of the TAVI approach, EQ-5D-3L and VAS values were significantly increased after one-month and one-year follow up;the SAVR patients however, reported lower health status when compared to the TAVI patients.

关键词： Aortic valve stenosis Aortic valve replacement The elderly Transcatheter aortic valve implantation Quality of life

Effects of Ag1 and Ag2 QTLs on Nonstructural Carbohydrate and Seed Management Options for Rice Seedling growth and Establishment under Flooding Stress

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Rice science 2020年第6期27卷 515-528页

作者： Satyen MONDAL M.Jamil Hasan Tofayel Ahmed M.giashuddin Miah Pompe C.sta Cruz Abdel M.ISMAIL International Rice Research Institute DAPO Box 7777Metro Manilathe Philippines Bangladesh Rice Research Institute Gazipur 1701Bangladesh University of the Philippines Los Banos CollegeLaguna 4031the Philippines Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur 1706Bangladesh

Rice(Oryza sativa)plants acquired excess photosynthates in the form of nonstructural carbohydrates(NSCs)in their stems and *** keen interest in rice NSC,the dynamics of NSC accumulation,translocation and re-accumulation have not yet been well ***1 and Ag2 QTLs associated with flooding tolerance through catalyzing starch into soluble sugar in germinating *** we conducted three experiments,greenhouse and field to lay the groundwork for large-scale diversity studies on grain NSC and some agronomic traits under direct-seeded rice(DSR)system,using elite lines incorporating Ag1,Ag2 and Ag1-Ag2 QTLs into the popular varieties PSB Rc82 and Ciherang-Sub1 along with the donors Kho Hlan On(Ag1)and Ma-Zhan Red(Ag2).In germinating seedlings,soluble sugars increased,while starch concentration decreased gradually especially in the tolerant checks and Ag1-Ag2 introgression lines under flooded *** sugar accumulation in stem started to increase from the vegetative stage and peaked at the panicle initiation stage then gradually decreased towards the maturity *** Sub1-Ag lines had higher sugar and starch concentrations at different growth stages than other genotypes in wet season 2016 and dry season *** survival rate was positively correlated with the stem NSC at the early vegetative stage(21 days after sowing),and stem NSC was positively associated with plant height at different growth *** the tested seeding rate,the most suitable seeding rate,4 g/m2 with shallow burial depth(0.5 cm),resulted in better seedling establishment,relatively higher seedling vigor index and higher leaf area index under flooding in DSR *** of Ag1-Ag2 QTLs had no any negative impact on nonstructural carbohydrate,germination rate,and growth and biomass production.

关键词： anaerobic germination crop establishment direct-seeded rice flooding nonstructural carbohydrate seeding rate seeding depth

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Love as Beauty

China Today 2007年第4期56卷 15-21页

作者： sta reporter QIAO TIANBI

HE is a good teacher. As a part-time professor at a Shanghai university, he is loved by his students. He also showed potential as a lawyer, jour-nalist and a TV anchor. What did he become? A pastor. Many people can be excellent teachers, lawyers and journalists, but far fewer can become good pastors, particularly one who loves life and art.

关键词：梅康钧牧师访谈中国基督教宗教自由个人修养爱心

Analysis of the Interaction of Pulsed Laser with Nanoporous Activated Carbon Cloth

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Journal of Materials Science & Technology 2011年第11期27卷 979-984页

作者： B.V. Kaludjerovi M.S. Trtica B.B. Radak J.M. stai S.S. Krsti Muovi V.M. Dodevski Laboratory of Material Science Vina Institute for Nuclear Sciences University of BelgradeP.O. Box 522 11001 Serbia Laboratory of Physical Chemistry Vina Institute for Nuclear Sciences University of BelgradeP.O. Box 522 11001 Serbia

Interaction of pulsed transversely excited atmospheric （TEA） CO2-1aser radiation at 10.6 μm with nanoporous activated carbon cloth was investigated. Activated carbon cloth of different adsorption characteristics was used. Activated carbon cloth modifications were initiated by laser pulse intensities from 0.5 to 28 MW/cm^2, depending on the cloth adsorption characteristics. CO2 laser radiation was effectively absorbed by the used activated carbon cloth and largely converted into thermal energy. The type of modification depended on laser power density, number of pulses, but mostly on material characteristics such as specific surface area. The higher the surface area of activated carbon cloth, the higher the damage threshold.

关键词： Activated carbon cloth Transversely excited atmospheric (TEA) C02 laser Nanoporous material Laser-material interaction

个人所得税对高层次人才的影响探析——基于新质生产力视角

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国家税务总局税务干部学院学报 2024年第3期37卷 49-55页

作者：国家税务总局青海省税务局课题组袁继军李晓婷国家税务总局青海省税务局青海西宁810000

新质生产力是以科技创新为主导的生产力,是符合高质量发展要求的生产力,其主要载体是产业,核心引擎是创新,而高层次人才则是推动创新的动力之源。高层次人才具有创新能力强、数量稀缺、劳动回报率高等特点,对提升人力资源素质、驱动科... 详细信息

新质生产力是以科技创新为主导的生产力,是符合高质量发展要求的生产力,其主要载体是产业,核心引擎是创新,而高层次人才则是推动创新的动力之源。高层次人才具有创新能力强、数量稀缺、劳动回报率高等特点,对提升人力资源素质、驱动科技创新发展、推动产业结构优化升级等具有不可替代的作用。个人所得税在激发高层次人才创新动能、促进创新成果转化以及人力资本跨区域流动等方面的作用和影响不容小觑。只有不断优化个人所得税税制设计,扩大政策覆盖面,减轻税收负担,才能增强政策对高层次人才的吸引力,进而做好发展新质生产力这篇大文章。

关键词：新质生产力个人所得税高层次人才税收优惠