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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Monte Carlo generator photon jets used for luminosity at e^+e^- colliders

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Chinese Physics C 2010年第6期34卷 877-882页

作者： g.V.Fedotovich e.A.Kuraev A.L.Sibidanov Budker Institute of Nuclear Physics Novosibirsk State University Joint Institute of Nuclear Research

A Monte-Carlo generator Photon Jets （MCgPJ） to simulate Bhabha scattering as well as production of two charged muons and two photons events is discussed. The theoretical precision of the cross sections with radiative corrections （RC） is estimated to be smaller than 0.2%. The Next Leading Order （NLO） radiative corrections proportional to α are treated exactly, whereas the all logarithmically enhanced contributions, related to photon jets emitted in the collinear region, are taken into account in frame of the Structure Function approach. Numerous tests of the MCgPJ as well as a detailed comparison with other MC generators are presented.

关键词： luminosity e^+e^- hadrons detectors

enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

estimating costs of salvage logging for large-scale burned forest lands: A case study on Turkey's Mediterranean coast

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Journal of Forestry Research 2021年第5期32卷 1899-1909页

作者： Neşe gülci Faculty of Forestry Kahramanmaras Sutcu Imam University46100 KahramanmarasTurkey

Different forest fires causing different degrees of effects occur in fire-sensitive forests due to various reasons such as climate *** as well as harmful aspects of forest fires are a multi-disciplinary research *** information systems(gIS)and remote sensing(RS)methods offer a number of benefits for researchers and operators in the field of forest fire *** present study analyses timber pricing based on forest contractor demands of post-salvage logging *** effect of timber obtained from compartment units on producers’pricing policy was *** forest fire area(2500 ha)located in Antalya in Turkey was selected as the main study *** parameters(aspect,slope and slope position),stand types(diameter class and crown closure),and burn severity were analyzed together using gIS and R software packages.A multi-linear regression model(R^(2)=0.752)demonstrated that factors that had the most impact on pricing were slope position,aspect,stand age,crown closure and burn *** model can be used to estimate salvage logging prices in Calabrian pine(Pinus brutia Ten.)stands with similar *** administrators and contractors may readily address the unit price of timber by estimating approximate costs in a given forest area for which they are going to *** will help reduce operational planning times of harvesting procedures in burned stands.

关键词： Timber extraction Forest fires Stumpage sale Cost estimation Sustainability Crown fire

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal g-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

embedded Atom Method-Based geometry Optimization Aspects of Body-Centered Cubic Metals

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Chinese Physics Letters 2013年第5期30卷 112-115页

作者： M.güler e.güler Department of Physics Hitit University19030 CorumTurkey

We present embedded atom method-based geometry optimization calculations for Fe, Cr, Mo, Nb, Ta, V and W body-centered cubic metals with Finnis–Sinclair potentials. After the optimization, we determine their typical elastic constants, bulk modulus, shear modulus, Young's modulus, Poisson's ratios, elastic wave velocities and cohesive energies. Additionally, we perform a benchmark between the experiments and the available density functional theory results. In general, our results show a good consistency with previous findings on the elastic and cohesive energy properties of the considered metals.

关键词： modulus optimization cubic

Tempering Behavior of M50 Steel with Different Austenite Proportion Induced by High Current Pulsed electron Beam

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稀有金属材料与工程 2012年第S1期41卷 475-477页

作者： g.e.Ozure Institute of High Current electronics 4Academichesky Av.Tomsk 634055Russia

M50 steel was irradiated by high current pulsed electron beam(HCPeB)with different *** subsequent tempering was carried out between 500 and 625℃.Microstructure evolution was analyzed by scanning electron microscopy and X-ray *** is found that the HCPeB treatment could constrain martainsite transformation in the surface layer of the *** behavior of HCPeB remelted layer strongly depends on the proportion of retained *** saturated more carbon and metallic elements depict higher tempering *** tempered process,carbides precipitates among the grain and phase *** decreased solution of the elements promotes the retained austenite into martensite.

关键词： electron beam irradiation M50 steel tempering microstructure

Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings

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原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI e DíAZ J g gIOMIA KeMPF R A National Atomic energy Commission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Comisión Nacional de energía Atómica (CNeA) has the responsibility for restoring uranium mining facilities once the operations have ***,within its environmental Program and in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining and processing of uranium *** Malargüe Site is located within the Province of Mendoza in the city of Malargü*** is the first site to successfully complete its *** activities consist of relocation of tailings to an engineering *** tailings management(encapsulation) and rehabilitation of the area was finished in June *** remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for *** objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination and rehabilitation of the area (landscaping,post-closure monitoring and 20 years monitoring period).encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them and prevent pollutants from entering the environment through the transfer *** clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,and the filling was carried out with natural soils from the *** prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive *** progeny are solids,and when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust *** prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon *** tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public and pre

关键词： remediation radionuclide transfer tailings encapsulation solution sustainable