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Boosting Mechanical Properties of Polymer Materials by building Nacre-like Hierarchy Micro-sheet Structure in Bulk Polymer

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Boosting Mechanical Properties of Polymer Materials by build...

Creation and validation of a novel low-cost dry lab for early resident training and assessment of robotic prostatectomy technical proficiency

2009年全国高分子学术论文报告会

作者： günter reiter Stephen S.D.Cheng Department of physics The University of FreiburgGermany

＜正＞Can we mimic,for example,the bio-sheeted structure in nacre to design and fabricate synthetic polymer materials?Although much progress in fabricating micro-sheet structures of organic-inorganic thin films have been achieved in recent years,it has proven to be great challenge to transcribe nacre-like sheeted architectural designs into synthetic bulk *** major

关键词： Bioinspired design nacre-like microsheet hierachiray structure

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Current Urology 2024年第2期18卷 133-138页

作者： Kevin Kunitsky Abhishek Venkataramana Katherine E.Fero Jorge Ballon Jacob Komberg Robert reiter Wayne Brisbane Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFLUSA

Purpose:To evaluate the preliminary validity and acceptability of a low-cost low-fidelity robotic surgery dry lab for training and assessing residents’technical proficiency with key robotic radical prostatectomy *** and methods:Three standardized inanimate tasks were created to simulate the radical prostatectomy steps of posterior dissection,neurovascular bundle release,and urethrovesical *** trainees and faculty at a single institution completed and evaluated each dry lab *** validity was evaluated by comparing task completion times and global Evaluative Assessment of Robotic Skills scores across four participant cohorts:medical students(n=5),junior residents(n=5),senior residents(n=5),and attending surgeons(n=7).Content validity,face validity,and acceptabilitywere evaluated through a posttask survey using a 5-point Likert ***:There was a significant difference in the individual and composite task completion times and global Evaluative Assessment of Robotic Skills scores across all participant cohorts(all pg key robotic prostatectomy technical steps and can be used to augment robot-assisted laparoscopic prostatectomy surgical training.

关键词： Robotic surgery education Radical prostatectomy Simulation Dry laboratory Validation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 97-104页

作者： Mihai A.Bentan Evan R.reiter Richard M.Costanzo Daniel H.Coelho Department of Otolaryngology-Head&Neck Surgery Virginia Commonwealth University School of MedicineRichmondVirginiaUSA

Objective:The aim of this study was to review findings from a large prospective national database of chemosensory disturbances associated with coronavirus disease 2019(COVID-19)*** Sources:The Virginia Commonwealth University Smell and Taste Center national database of COVID-19 chemosensory ***:A series of online surveys,first opened on April 10,2020,was made accessible nationwide to any adult with sudden chemosensory dysfunction since January *** received subsequent follow-up surveys 14 days,1 month,3 months,and 6 months after *** additional survey was sent to all participants on May 28,2022 to assess long-term *** pertaining to demographics,symptoms,comorbidities,treatments,and life impact was ***:Of 363 participants who reported complete smell recovery,51.2%recovered within 1 month,70%within 3 months,and 79%within 6 months,while 8.8%took over 1 year to completely *** all participants,7.5%had no smell *** predictors of recovery included agegender,and the presence of nasal *** predictors included difficulty breathing and prior head *** participants reported a decrease in quality of life and the presence of potential safety hazards associated with decreased smell ***:Most subjects with COVID-19-related chemosensory dysfunction recover,with the majority noting complete recovery within weeks of *** aged over 40 years and female gender were associated with lower rates of recovery.A considerable number of participants reported significant impact on quality of life and safety.

关键词： anosmia COVID-19 smell

Risk-Layering for Indirect Effects

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International Journal of Disaster Risk Science 2021年第5期12卷 770-778页

作者： Stefan Hochrainer-Stigler Karina reiter IIASA-International Institute for Applied Systems Analysis A-2361 Laxenburg.Austria

Environmental risks are one of the greatest threats in the twenty-first *** in the last years,the cascading impacts and risks associated with such events have received great attention as economic losses and consequences have mounted in their *** concerns about these ripple effects are rising,strategies to prevent and manage indirect risks are in urgent ***,such effects are currently barely considered in most countries and can seriously threaten global agendas such as achieving the Sustainable Development goals by 2030 or the targets set out in the Sendai Framework for Disaster Risk Reduction *** discuss how the concept of risk-layering,which,though already applied in disaster risk management,could be expanded to include indirect *** point out some of the benefits,limitations,and ways forward for using this *** do so,we first delineate the transition of the risk-layering concept,which originated from the insurance industry,from its original use to its application in a wider *** bring special focus to the application of risk-layering in disaster risk management and identify strategies that allow for the inclusion of indirect *** main suggestion is that,while a probabilistic approach is appropriate for evaluating direct risks,a focus on connectedness is appropriate for indirect risks,which still allows for an easy link to direct ***,so we argue,facilitates more comprehensive risk management systems apt to deal with the multi-dimensional challenges ahead.

关键词： Connectedness Indirect risks Natural hazards and disasters Risk-layering Risk management

Melatonin,tunneling nanotubes,mesenchymal cells,and tissue regeneration

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Neural Regeneration Research 2023年第4期18卷 760-762页

作者： Francesca Luchetti Silvia Carloni Maria g.Nasoni Russel J.reiter Walter Balduini Department of Biomolecular Sciences University of Urbino Carlo BoUrbinoItaly Department of Cell Systems and Anatomy Long School of MedicineUT HealthSan AntonioTXUSA

Mesenchymal stem cells are multipotent stem cells that reside in many human tissues and *** stem cells are widely used in experimental and clinical regenerative medicine due to their capability to transdifferentiate into various ***,when transplanted,they lose part of their multipotency and immunomodulatory properties,and most of them die after injection into the damaged *** this review,we discuss the potential utility of melatonin in preserving mesenchymal stem cells’survival and function after *** is a pleiotropic molecule regulating critical cell functions including apoptosis,endoplasmic reticulum stress,and *** is also synthesized in the mitochondria where it reduces oxidative stress,the opening of the mitochondrial permeability transition pore and the downstream caspase activation,activates uncoupling proteins,and curtails the proinflammatory *** addition,recent findings showed that melatonin also promotes the formation of tunneling nanotubes and the transfer of mitochondria between cells through the connecting *** mitochondrial dysfunction is a primary cause of mesenchymal stem cells death and senescence and a critical issue for survival after transplantation,we propose that melatonin by favoring mitochondria functionality and their transfer through tunneling nanotubes from healthy to suffering cells could improve mesenchymal stem cellbased therapy in a large number of diseases for which basic and clinical trials are underway.

关键词： brain ischemia cell transplantation melatonin mesenchymal stem cell mitochondria mitochondrial transplantation regenerative therapy senescence tunneling nanotubes

Some Characteristics of Cumulus Convection over the Tibetan Plateau

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Advances in Atmospheric Sciences 1990年第1期7卷 87-97页

作者：段廷扬 Elmar R.reiter Chengdu Institute of Meteorology Chengdu 610041 Sichuan Province Center lor Cybernetic Communication Research Colorado Slate University Fort Collins CO.80523 U. S. A.he diagnostic model of the cumulus convection proposed by Yanai et al. (1973) was applied to the atmosphere over the Tibetan Plateau and used to estimate the vertical mass flux entrainment and detrainment excess temperature and moisture liquid water content and condensation and precipitation rates of highland cloud clusters. The results illustrated that in clouds over the Tibetan Plateau the water vapor condensation rate liquid water content and efficiency of the rain generation process are less than those in the tropics (represented by the Marshall Islands region). Therefore the condensational latent heat released over the Tibetan Plateau overall is much smaller than that in the tropics. The water vapor and liquid water detrainment from shallow nonprecipitating cumulus clouds and their entrainment into deep cumulus clouds serve as a growing mechanism for the deep precipitating cumulus towers over the Tibetan Plateau. It should be noted that there is a stronger detrainment of liquid water from cumulus clouds and a stronger re-evaporation rate in environment. The process of the condensation-detrainment-re-evaporation-cnlrainmcnt is repeatedly in progress. It would play an important role in maintaining of cumulus convection on the condition that the supply of moisture is not plentiful over the Tibetan Plateau.The analyses also showed that the cloud mass flux Mc over the Tibetan Plateau is less and the large-scale average upward motion is much less than those over the Marshall Islands. Stronger compensating downward motion in the cloud environment over the Tibetan Plateau responsible for the area's strong environmental heating rate Was revealed and would link to the stability of the South Asian High in summer.

The diagnostic model of the cumulus convection proposed by Yanai et al. (1973) was applied to the atmosphere over the Tibetan Plateau, and used to estimate the vertical mass flux, entrainment and detrainment, excess temperature and moisture, liquid water content, and condensation and precipitation rates of highland cloud clusters. The results illustrated that in clouds over the Tibetan Plateau, the water vapor condensation rate, liquid water content, and efficiency of the rain generation process are less than those in the tropics (represented by the Marshall Islands region). Therefore, the condensational latent heat released over the Tibetan Plateau, overall, is much smaller than that in the tropics. The water vapor and liquid water detrainment from shallow nonprecipitating cumulus clouds, and their entrainment into deep cumulus clouds, serve as a growing mechanism for the deep precipitating cumulus towers over the Tibetan Plateau. It should be noted that there is a stronger detrainment of liquid water from cumulus clouds and a stronger re-evaporation rate in environment. The process of the condensation-detrainment-re-evaporation-cnlrainmcnt is repeatedly in progress. It would play an important role in maintaining of cumulus convection on the condition that the supply of moisture is not plentiful over the Tibetan *** analyses also showed that the cloud mass flux Mc over the Tibetan Plateau is less, and the large-scale average upward motion is much less than those over the Marshall Islands. Stronger compensating downward motion in the cloud environment over the Tibetan Plateau, responsible for the area's strong environmental heating rate Was revealed, and would link to the stability of the South Asian High in summer.

关键词： Some Characteristics of Cumulus Convection over the Tibetan Plateau over

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell Lines

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genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward Simpson Steven Chen Jill L.reiter Yunlong Liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBgLM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ELAVL RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBgLM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

A phantom gallbladder on endoscopic retrograde cholangiopancreatography

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World Journal of gastroenterology 2007年第46期13卷 6274-6276页

作者： Jeremy Rochester Caroline K Messer Bruce P reiter Mark A Korsten gastroenterology and Radiology Programs James J.Peters VA Medical CenterBronxNY 10468Montefiore Medical CenterBronxNYMount Sinai School of MedicineNew YorkNY and Albert Einstein College of MedicineBronxNew York 10468United States

Various complications have been related to laparoscopic cholecystectomy but most occur shortly after the procedure. In this report, we present a case with very late complications in which an abscess developed within the gallbladder fossa 6 years after laparoscopic cholecystectomy. The abscess resolved after treatment with CT-guided extrahepatic aspiration. However, 4 years later, an endoscopic retrograde cholangiopancreatography （ERCP） performed for choledocholithiasis demonstrated a “gallbladder” which communicated with the common bile duct via a patent cystic duct. This unique case indicates that a cystic duct stump may communicate with the gallbladder fossa many years following cholecystectomy.

关键词： Laparoscopic cholecystectomy Complication Abscess gallbladder Endoscopic retrograde cholangio-pancreatography

Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia

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World Journal of gastroenterology 2011年第21期17卷 2646-2651页

作者： Cezary Chojnacki Tomasz Poplawski grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J reiter Department of gastroenterology Medical University of Lodz90-647 LodzPoland Department of Molecular genetics University of Lodz90-131 LodzPoland Department of Cellular and Structural Biology University of Texas Health Science CenterSan AntonioTX 78229-3901United States

To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin （6-OHMS）, in functional dyspepsia （FD）. METHODS： Ninety individuals were enrolled in the study： 30 in each study group： patients with postprandial distress syndrome （PDS）, epigastric pain syndrome （EPS）, and controls. Blood samples were drawn at 02：00 and 09：00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. RESULTS： Serum melatonin concentration at night and in the morning was significantly （P 〈 0.001） higher inPDS patients [at 02：00 h-93.3 pg/mL, quartile range （QR）： 79.8-116.2; at 09.00 h-14.3 pg/mL, QR： 7.06-19.0] than in EPS （57.2 pg/mL, QR： 42.6-73.1, 8.1 pg/mL, QR： 4.2-9.3） and control patients （57.7 pg/mL, QR： 51.2-62.5; 8.1 pg/mL, QR： 5.4-10.3）. A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate ***： Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

关键词： Functional dyspepsia Postprandial distress syndrome Epigastric pain syndrome Melatonin 6-sulfatoxymelatonin